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HPTLC and IR Spectral studies of the ethanolic extract of Phallusia nigra 黑凤仙花乙醇提取物的hplc和IR光谱研究
International Journal of Pharmaceutical Chemistry Pub Date : 2016-10-30 DOI: 10.7439/ijpc.v6i10.3645
D. Priya, S. Sankaravadivu, H. Christy
{"title":"HPTLC and IR Spectral studies of the ethanolic extract of Phallusia nigra","authors":"D. Priya, S. Sankaravadivu, H. Christy","doi":"10.7439/ijpc.v6i10.3645","DOIUrl":"https://doi.org/10.7439/ijpc.v6i10.3645","url":null,"abstract":"Ascidians, commonly called as Sea Squirts are sedentary tunicates. Phallusia nigra is a simple ascidian belonging to the family Ascidiidae found in plenty throughout the year. The ethanolic extract of Phallusia nigra was subjected to HPTLC and IR spectral analysis to determine the possible bioactive components. In HPTLC studies, gallic acid, ferulic acid, caffeic acid and flavonoids such as rutin, isoquercitrin and quercetin were found to be present. The interpretation of the spectrum showed the presence of aliphatic bromo compounds, phenol or tertiary alcohols, carbonyl compound, carboxylic acids, lipids, proteins, alkanes and aromatic compound.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"25 1","pages":"218-223"},"PeriodicalIF":0.0,"publicationDate":"2016-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83070281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Similarity Analysis studies on (Sulfonyl) Benzene Derivatives as Anti HIV Agents (磺酰基)苯衍生物抗HIV药物的相似性分析研究
International Journal of Pharmaceutical Chemistry Pub Date : 2016-10-15 DOI: 10.5958/2394-2797.2016.00025.3
Shweta Sharma, Smrita Singh, M. Akhter, S. Paliwal
{"title":"Similarity Analysis studies on (Sulfonyl) Benzene Derivatives as Anti HIV Agents","authors":"Shweta Sharma, Smrita Singh, M. Akhter, S. Paliwal","doi":"10.5958/2394-2797.2016.00025.3","DOIUrl":"https://doi.org/10.5958/2394-2797.2016.00025.3","url":null,"abstract":"Introduction: The present investigation was undertaken to understand the overlaying problems of mutation in HIV virus leading to failure to combat AIDS. \u0000Materials and Methods: In present study Multiple Linear Regression (MLR) analysis was carried on a series of 71(sulfonyl) benzene analogs reported as viral nucleocapsid protein zinc finger modulators for HIV. \u0000Results: The MLR model obtained using carbo method (N*N) similarity showing good predictive ability, r2 (training) = 0.655, r2(test) = 0.605. \u0000Conclusion: The results indicated that Refractivity Similarity (polarizability and volume) and Shape Similarity are important parameters in predicting the activity of viral nucleocapsid protein zinc finger inhibitors. \u0000 \u0000Keywords: Refractivity Similarity, Shape Simliarity, Carbo, MLR, Viral Nucleocapsid Protein Zinc Finger, HIV","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"68 1","pages":"174-182"},"PeriodicalIF":0.0,"publicationDate":"2016-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75713679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stability Indicating Liquid Chromatographic Method for Estimation of Xylometazoline Hydrochloride in Pharmaceutical Dosage Form 稳定性指示液相色谱法测定药物剂型中盐酸木美唑啉的含量
International Journal of Pharmaceutical Chemistry Pub Date : 2016-10-15 DOI: 10.5958/2394-2797.2016.00019.8
Nilesh Prajapati, M. Dalal, H. Raj
{"title":"Stability Indicating Liquid Chromatographic Method for Estimation of Xylometazoline Hydrochloride in Pharmaceutical Dosage Form","authors":"Nilesh Prajapati, M. Dalal, H. Raj","doi":"10.5958/2394-2797.2016.00019.8","DOIUrl":"https://doi.org/10.5958/2394-2797.2016.00019.8","url":null,"abstract":"A simple, specific, precise, and accurate RP-HPLC method has been developed and validated for Xylometazoline Hydrochloride. The mobile phase has been used for separation consisting of buffer (Acetate buffer in water, pH adjusted to 5 with triethyl amine)-Acetonitrile (30: 70, v/v) using phenomenax C18 column with flow rate 1.0 ml/min. Detection wavelength was 240 nm. The method has been linear for the range of 1 – 300 μg/mL with r2 0.999. Drug has been shows 99 to 101% recovery. ICH Q2R1 guideline has been used for validation of developed analytical method. Drug was exposing to forced degradation condition like hydrolysis, oxidation, thermal and photolytic. Method can well resolve all degraded product as compare to Xylometazoline. The isolate alkali degraded product was characterized by NMR, MASS and IR data. Developed method can routinely used for the estimation of Xylometazoline drug from the dosage form and also for stability sample. \u0000 \u0000Keywords: Xylometazoline, HPLC, Stability Indicating method, Acidic, Basic and Water degraded products, pharmaceutical dosage form","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"38 1 1","pages":"124-132"},"PeriodicalIF":0.0,"publicationDate":"2016-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85657721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A Brief Review on NIR Spectroscopy and its Pharmaceutical Applications 近红外光谱技术及其医药应用综述
International Journal of Pharmaceutical Chemistry Pub Date : 2016-10-15 DOI: 10.5958/2394-2797.2016.00018.6
P. Prajapati, Ragini Solanki, V. Modi, T. Basuri
{"title":"A Brief Review on NIR Spectroscopy and its Pharmaceutical Applications","authors":"P. Prajapati, Ragini Solanki, V. Modi, T. Basuri","doi":"10.5958/2394-2797.2016.00018.6","DOIUrl":"https://doi.org/10.5958/2394-2797.2016.00018.6","url":null,"abstract":"Near-infrared spectroscopy (NIRS) is fast, non-destructive analytical method hence NIRS is suitable for analysis of solid, liquid and pharmaceutical forms. NIRS can also be implemented during pharmaceutical development, for production by process monitoring or in QC laboratories. Based on the principle and range of electromagnetic radiation spectroscopy is classified into several types. In the following review various aspects of NIR its introduction, principle, instrumentation, and its application in pharmaceutical industry have been implemented.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"41 1","pages":"117-123"},"PeriodicalIF":0.0,"publicationDate":"2016-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87711285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
RP-HPLC Method Development and Validation for Simultaneous Estimation of Duloxetin and Methylcobalamine in Combined Dosage Form 联合剂型度洛西汀和甲钴胺同时测定的反相高效液相色谱方法建立及验证
International Journal of Pharmaceutical Chemistry Pub Date : 2016-09-30 DOI: 10.7439/ijapa.v6i2.3834
K. Lavanya, Nutan N. Rao, V. Rao, K. Venkanna
{"title":"RP-HPLC Method Development and Validation for Simultaneous Estimation of Duloxetin and Methylcobalamine in Combined Dosage Form","authors":"K. Lavanya, Nutan N. Rao, V. Rao, K. Venkanna","doi":"10.7439/ijapa.v6i2.3834","DOIUrl":"https://doi.org/10.7439/ijapa.v6i2.3834","url":null,"abstract":"A simple, precise, accurate, simultaneous stability indicating RP-HPLC method for the estimation of DLU (Duloxetin) and MCB (Methylcobalamine) in combined dosage form was developed using Intersil-C18 (4.6 x 250mm, 5m) in an Isocratic mode with mobile phase comprising of Phosphate buffer (pH 4.5) The flow rate was 1 mL/ min and effluent was monitored at 255.0 nm. The retention times were found to be 5.32 min for DLU and 3.59 min for MCB. The assay exhibited a linear dynamic range of 20- 120 g/mL for DLU and 10- 60 g/mL for MCB. The calibration curves were linear (r 2 = 0.999 for DLU and r 2 = 0.999 for MCB) over the entire linear range. Mean % recovery was found to be 99.68 % for DLU and 100.3 % for MCB with % RSD was NMT 2 for both estimations which fully agrees with system suitability which is in good agreement with labeled amount of formulation. The % RSD for Intra- Day & Inter-Day Precision was NMT than 2 for both the drugs. The developed method was validated as per ICH guidelines.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"40 1","pages":"09-15"},"PeriodicalIF":0.0,"publicationDate":"2016-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86383647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, in vitro Antibacterial and Cytotoxic studies of novel Naphthofurans 新型萘呋喃的合成、体外抗菌及细胞毒性研究
International Journal of Pharmaceutical Chemistry Pub Date : 2016-09-30 DOI: 10.7439/IJPC.V6I9.3606
K. Mathiyazhagan, P. Arjun, S. Vennila
{"title":"Synthesis, in vitro Antibacterial and Cytotoxic studies of novel Naphthofurans","authors":"K. Mathiyazhagan, P. Arjun, S. Vennila","doi":"10.7439/IJPC.V6I9.3606","DOIUrl":"https://doi.org/10.7439/IJPC.V6I9.3606","url":null,"abstract":"A simple, convenient and reproducible naphthofuran derivatives (1-5) were synthesized from 1,4-naphthoquinones and characterized by 1 H-NMR, 13 C-NMR, FT-IR, and Mass spectral studies. All the newly synthesized compounds were evaluated for in vitro antibacterial activity against Staphylococcus aureus (ATCC 6538) , Staphylococcus epidermidis (ATCC 155) and Bacillus cereus (ATCC 11778) as Gram positive bacteria; Escherichia coli (ATCC 25922) , Klebsiella pneumonia (ATCC 29665) and Pseudomonas aeruginosa (ATCC 25619) as Gram negative bacteria and their minimal inhibitory concentrations were determined. Amongst the tested organisms, compound 1 was the most active compound against all the tested organisms. All the compounds were evaluated for in vitro cytotoxicity potential using the standard MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay against  human cervical cancer cell line (HeLa) and compound 3 showed more  potent than other compounds.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"59 1","pages":"200-208"},"PeriodicalIF":0.0,"publicationDate":"2016-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89171467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Process Validation of Sertraline Hydrochloride 50 mg tablets 盐酸舍曲林50mg片的工艺验证
International Journal of Pharmaceutical Chemistry Pub Date : 2016-09-30 DOI: 10.7439/ijpc.v6i9.3554
P. Prajapati, D. Rathod, V. Modi, Tarasankar Basuri
{"title":"Process Validation of Sertraline Hydrochloride 50 mg tablets","authors":"P. Prajapati, D. Rathod, V. Modi, Tarasankar Basuri","doi":"10.7439/ijpc.v6i9.3554","DOIUrl":"https://doi.org/10.7439/ijpc.v6i9.3554","url":null,"abstract":"The purpose of present research work wasto study Process Validation of Sertraline hydrochloride 50 mg tablet dosage form. As in a pharmaceutical product the quality cannot be directly incorporated or assured by in process and finished products inspections and testing rather it has to be incorporated in the manufacturing process itself. Process Validation helps in controlling all the parameters so that the finished product meets all the specifications and quality attributes. Various critical parameters involved in the process were identified with the help of process capability and thereby evaluating and challenging its lower and upper specifications. Three initial batches of same size, method, equipment and validation criteria were chosen. Other critical parameters involved in sifting, dry mixing, wet mixing, granulation, drying, sifting and sizing, lubrication, compression and coating stages were identified as per the Validation Master Plan. The outcome of the research work was that the process validation is providing the products that provide high degree of assurance that manufacturing process is producing products meeting its predetermined specifications and quality attributes.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"58 1","pages":"209-217"},"PeriodicalIF":0.0,"publicationDate":"2016-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82992058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro antioxidant and spectrophotometric studies of a colonial ascidian Didemnum psammathodes 海鞘群体外抗氧化及分光光度研究
International Journal of Pharmaceutical Chemistry Pub Date : 2016-08-30 DOI: 10.7439/IJPC.V6I8.3466
P. Shanmuga, S. Sankaravadivu, H. Christy
{"title":"In vitro antioxidant and spectrophotometric studies of a colonial ascidian Didemnum psammathodes","authors":"P. Shanmuga, S. Sankaravadivu, H. Christy","doi":"10.7439/IJPC.V6I8.3466","DOIUrl":"https://doi.org/10.7439/IJPC.V6I8.3466","url":null,"abstract":"Didemnum psammathodes commonly available in Tuticorin coast was screened for its chemical value. Analysis of phenols and flavonoids were done by Spectrophotometry method. A maximum of 86.13% phenol and 69.07% Flavonoids were observed in Didemnum Psammathodes . This study is designed to examine the invitro antioxidant activity of phenolic compounds in the ethanolic extract of Didemnum psammathodes by DPPH method. In DPPH system the strongest radical scavenging activity was exhibited by the ethanolic extract (IC 50 - 49.22) when compared to standard drug ascorbic acid (25.98).An increase in dose have significantly increased the percentage of antioxidant activity. This result free radical induced oxidative reveal that Didemnum psammathodes ethanolic extract a promising antioxidant potential against free radical induced oxidative damage. The present observation suggests need for further investigation of Didemnum Psammathodes so as to isolate secondary metabolites.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"57 1","pages":"192-195"},"PeriodicalIF":0.0,"publicationDate":"2016-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85243282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A spectrophotometric method for the determination of Taxim-AZ and Vanadium(V) 分光光度法测定噻肟- az和钒
International Journal of Pharmaceutical Chemistry Pub Date : 2016-08-30 DOI: 10.7439/IJPC.V6I8.3331
B. Rao, T. R. Kishore, V. Rao
{"title":"A spectrophotometric method for the determination of Taxim-AZ and Vanadium(V)","authors":"B. Rao, T. R. Kishore, V. Rao","doi":"10.7439/IJPC.V6I8.3331","DOIUrl":"https://doi.org/10.7439/IJPC.V6I8.3331","url":null,"abstract":"A new simple, accurate method have been developed for the analysis of Taxim-AZ and vanadium(V) in pharmaceutical dosage forms. It is possible to determine the V(V) and Taxim-AZ in the range of 0.636 to 4.45 ?g/25ml and 0.1 to 0.6 mg/ml.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"50 1","pages":"196-199"},"PeriodicalIF":0.0,"publicationDate":"2016-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91202728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel Synthesis of N-substituted Glutarimides using ZnCl2 Catalyst: A green approach 用ZnCl2催化剂合成n -取代戊二酰亚胺的新方法:绿色途径
International Journal of Pharmaceutical Chemistry Pub Date : 2016-07-30 DOI: 10.7439/IJPC.V6I7.3424
A. P. Rajput, D. V. Nagarale
{"title":"A Novel Synthesis of N-substituted Glutarimides using ZnCl2 Catalyst: A green approach","authors":"A. P. Rajput, D. V. Nagarale","doi":"10.7439/IJPC.V6I7.3424","DOIUrl":"https://doi.org/10.7439/IJPC.V6I7.3424","url":null,"abstract":"The glutarimides containing piperidine ring is a structural feature of many alkaloids and starting material for drug synthesis. Many piperidine type of compounds are mentioned in clinical and preclinical analysis. The piperidine ring system is one of the commonest structural sub units in natural compounds. Several substituted piperidines display important biological properties like antiviral activity. We have optimised and used a simple ZnCl 2 catalysed and highly efficient method for the synthesis of 1-(4-chlorophenyl) piperidine-2,6-diones(Glutarimides) using ethanol solvent. The synthesized compounds are used as precursor for 2,6-dichlorodialdehydes 1, 4-DHP[1-2]. All the synthesized glutarimides are characterized by analytical and modern spectral methods such as FTIR, 1 H-NMR, GC-MS. The resulting compounds possess symmetrical structures and have high yields.","PeriodicalId":14317,"journal":{"name":"International Journal of Pharmaceutical Chemistry","volume":"11 1","pages":"181-185"},"PeriodicalIF":0.0,"publicationDate":"2016-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78348109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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