A short review on sulphonamides with antimicrobial activity

Abstract

Sulfonamides are one of the organosulphur compounds containing the -SO 2 NH 2 and/or -SO 2 NH- group(s). The sulphonamides or sulfa drugs competitively inhibit folic acid synthesis in micro-organisms and subsequently inhibit multiplication of bacteria but do not actively kill them. They have been used against most gram-positive and many gram-negative bacteria, some fungi, and certain protozoa. Medically important sulphonamides