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Evaluation of desferal as a bifunctional chelating agent for labeling antibodies with Zr-89 desferal作为Zr-89标记抗体的双功能螯合剂的评价
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes Pub Date : 1992-12-01 Epub Date: 2002-10-09 DOI: 10.1016/0883-2889(92)90170-J
Wilma E. Meijs , Jacobus D.M. Herscheid , Hidde J. Haisma , Herbert M. Pinedo
{"title":"Evaluation of desferal as a bifunctional chelating agent for labeling antibodies with Zr-89","authors":"Wilma E. Meijs ,&nbsp;Jacobus D.M. Herscheid ,&nbsp;Hidde J. Haisma ,&nbsp;Herbert M. Pinedo","doi":"10.1016/0883-2889(92)90170-J","DOIUrl":"10.1016/0883-2889(92)90170-J","url":null,"abstract":"<div><p>Zirconium-desferal was prepared and analysed by TLC, NMR and u.v.-spectroscopy. The stoichiometry of the complex was found to be 1:1. Chelation of desferal, coupled to resin, with <sup>88</sup>Zr appeared to be fast and almost quantitative in various buffer systems in a broad pH-range (4–7). A high <em>in vitro</em> stability of the zirconium-desferal complex was observed; less than 0.2% zirconium was lost within 24 h in plasma-solutions.</p></div>","PeriodicalId":14288,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes","volume":"43 12","pages":"Pages 1443-1447"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2889(92)90170-J","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12509117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 107
A universal water target loading system with direct in-target liquid level sensing 一种具有直接靶内液位传感的通用靶水加载系统
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes Pub Date : 1992-12-01 Epub Date: 2002-10-09 DOI: 10.1016/0883-2889(92)90176-F
Richard A. Ferrieri, David L. Alexoff, David J. Schlyer, Alfred P. Wolf
{"title":"A universal water target loading system with direct in-target liquid level sensing","authors":"Richard A. Ferrieri,&nbsp;David L. Alexoff,&nbsp;David J. Schlyer,&nbsp;Alfred P. Wolf","doi":"10.1016/0883-2889(92)90176-F","DOIUrl":"10.1016/0883-2889(92)90176-F","url":null,"abstract":"<div><p>A reliable remote water target loading system has been designed and fabricated around the operation of a single pneumatic syringe dispenser that accesses one of two water reservoirs, filling one or more targets depending on the system configuration. For multiple radionuclide configuration, reservoirs are filled with <sup>18</sup>O-enriched water for [<sup>18</sup>F]fluoride production, and natural abundance water for [<sup>13</sup>N]nitrate and [<sup>13</sup>N]nitrite production. When actuated, the system withdraws a calibrated volume of water from a selected reservoir, and automatically dispenses that charge through a short transfer line to the appropriate target. A second actuation then forces the dispenser to purge itself of residual water by dispensing a charge of helium gas through the same line thus completing the transfer of water to the target volume. Direct liquid level sensing inside the target, utilizing the specific resistance response of water, signals the operator that the target is loaded. For single radionuclide configuration, one or both reservoirs can be used with the same type of water, while dispensing is directed to a single target.</p></div>","PeriodicalId":14288,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes","volume":"43 12","pages":"Pages 1485-1491"},"PeriodicalIF":0.0,"publicationDate":"1992-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2889(92)90176-F","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12509118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Color-change and ESR dosimetry based on redox changes of stable radicals of metallodiphthalocyanines in organic solutions 金属酞菁在有机溶液中稳定自由基氧化还原变化的颜色变化和ESR剂量学研究
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes Pub Date : 1992-11-01 Epub Date: 2002-10-09 DOI: 10.1016/0883-2889(92)90019-B
E.V. Pykhtina, L.A. Ulanova, M.A. Kovaleva, N.A. Ovchinnikova, L.G. Tomilova, E.A. Luk'yanets
{"title":"Color-change and ESR dosimetry based on redox changes of stable radicals of metallodiphthalocyanines in organic solutions","authors":"E.V. Pykhtina,&nbsp;L.A. Ulanova,&nbsp;M.A. Kovaleva,&nbsp;N.A. Ovchinnikova,&nbsp;L.G. Tomilova,&nbsp;E.A. Luk'yanets","doi":"10.1016/0883-2889(92)90019-B","DOIUrl":"10.1016/0883-2889(92)90019-B","url":null,"abstract":"<div><p>The main dosimetry characteristics of new liquid systems consisting of Lu, Hf and Zr diphthalocyanine solutions in ethanol, chloroform and their mixtures are investigated. These systems are suitable for measurements of doses of photon and electron radiation and fast neutrons in the absorbed-dose range from 0.002 to 100 kGy at dose rates from 1.5 × 10<sup>−3</sup> to 3 × 10<sup>6</sup> Gy/s. The new systems can be used to manufacture compact detectors which acquire absorbed dose information both by measuring their responses with electron spin resonance (ESR) spectrometry or with visible spectrophotometry, and visually by solution color change.</p></div>","PeriodicalId":14288,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes","volume":"43 11","pages":"Pages 1417-1419"},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2889(92)90019-B","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73637385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simple, fast algorithm for gamma-ray absorbed dose rate calculations by computer 用计算机计算伽马射线吸收剂量率的简单、快速算法
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes Pub Date : 1992-11-01 Epub Date: 2002-10-09 DOI: 10.1016/0883-2889(92)90018-A
Peter L. Hargittai
{"title":"Simple, fast algorithm for gamma-ray absorbed dose rate calculations by computer","authors":"Peter L. Hargittai","doi":"10.1016/0883-2889(92)90018-A","DOIUrl":"10.1016/0883-2889(92)90018-A","url":null,"abstract":"","PeriodicalId":14288,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes","volume":"43 11","pages":"Pages 1412-1416"},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2889(92)90018-A","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83327773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Events 事件
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes Pub Date : 1992-11-01 Epub Date: 2002-10-09 DOI: 10.1016/0883-2889(92)90022-7
{"title":"Events","authors":"","doi":"10.1016/0883-2889(92)90022-7","DOIUrl":"https://doi.org/10.1016/0883-2889(92)90022-7","url":null,"abstract":"","PeriodicalId":14288,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes","volume":"43 11","pages":"Pages 1427-1429"},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2889(92)90022-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136494648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new efficient method for the preparation of 99mTc-radiopharmaceuticals containing the TcN multiple bond 一种制备含TcN多键的99mtc -放射性药物的新方法
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes Pub Date : 1992-11-01 Epub Date: 2002-10-09 DOI: 10.1016/0883-2889(92)90004-X
Roberto Pasqualini , Veronique Comazzi , Emmanuel Bellande , Adriano Duatti , Andrea Marchi
{"title":"A new efficient method for the preparation of 99mTc-radiopharmaceuticals containing the TcN multiple bond","authors":"Roberto Pasqualini ,&nbsp;Veronique Comazzi ,&nbsp;Emmanuel Bellande ,&nbsp;Adriano Duatti ,&nbsp;Andrea Marchi","doi":"10.1016/0883-2889(92)90004-X","DOIUrl":"10.1016/0883-2889(92)90004-X","url":null,"abstract":"<div><p>An improved method for the preparation of <sup>99m</sup>Tc-radiopharmaceuticals containing the TcN multiple bond, in sterile and apyrogen conditions, is described. This method is based on the reaction of [<sup>99m</sup>Tc]pertechnetate with ligands derived from S-methyl dithiocarbazate [H<sub>2</sub>NN(R)C(S)SCH<sub>3</sub> [R = H, CH<sub>3</sub>], in the presence of HCl and tertiary phosphines. It was found that these derivatives can behave both as sources of nitride nitrogen ions (N<sup>3−</sup>) and as coordinating ligands. The reaction leads to the formation of intermediate technetium-nitrido complexes in high yield. These intermediate species can be used as suitable prereduced substrates for the preparation of technetium-nitrido radiopharmaceuticals through simple substitution reactions with appropriate exchanging ligands.</p></div>","PeriodicalId":14288,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes","volume":"43 11","pages":"Pages 1329-1333"},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2889(92)90004-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83892426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 63
Synthesis of a 11C-labeled novel, quinuclidine based ligand for the 5-HT3 receptor 合成一种11c标记的新型5-HT3受体喹啉配体
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes Pub Date : 1992-11-01 Epub Date: 2002-10-09 DOI: 10.1016/0883-2889(92)90010-C
Srinivasan Rajagopal , Mirko Diksic , Barbara Francis , Christopher J. Swain , H.Donald Burns
{"title":"Synthesis of a 11C-labeled novel, quinuclidine based ligand for the 5-HT3 receptor","authors":"Srinivasan Rajagopal ,&nbsp;Mirko Diksic ,&nbsp;Barbara Francis ,&nbsp;Christopher J. Swain ,&nbsp;H.Donald Burns","doi":"10.1016/0883-2889(92)90010-C","DOIUrl":"10.1016/0883-2889(92)90010-C","url":null,"abstract":"<div><p>L-683,877, a high affinity, 5-HT<sub>3</sub> selective receptor ligand has been labeled with <sup>11</sup>C for use in PET studies to measure regional brain kinetics of L-683,877 and to determine if [<sup>11</sup>C]L-683,877 can be used for serotonin 5-HT<sub>3</sub> receptor imaging. [<sup>11</sup>C]L-683,877 was prepared by reacting [<sup>11</sup>C]methyl iodide with the desmethyl, borane-protected precursor, L-686,472, in DMF in the presence of tetrabutyl ammonium hydroxide. The average specific activity of [<sup>11</sup>C]L-683,877 was 2700 Ci/mmol and the average radiochemical yield (decay uncorrected) was 20% at the end of synthesis (22 min from EOB).</p></div>","PeriodicalId":14288,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes","volume":"43 11","pages":"Pages 1369-1373"},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2889(92)90010-C","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80396934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
1-[18F]fluoro-2-propanol p-toluenesulfonate: a synthon for the preparation of N-([18F]fluoroisopropyl)amines 1-[18F]氟-2-丙醇对甲苯磺酸:用于制备N-([18F]氟异丙基)胺的合成物
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes Pub Date : 1992-11-01 Epub Date: 2002-10-09 DOI: 10.1016/0883-2889(92)90005-Y
Tjibbe J. De Groot, Philip H. Elsinga, Gerben M. Visser, Willem Vaalburg
{"title":"1-[18F]fluoro-2-propanol p-toluenesulfonate: a synthon for the preparation of N-([18F]fluoroisopropyl)amines","authors":"Tjibbe J. De Groot,&nbsp;Philip H. Elsinga,&nbsp;Gerben M. Visser,&nbsp;Willem Vaalburg","doi":"10.1016/0883-2889(92)90005-Y","DOIUrl":"10.1016/0883-2889(92)90005-Y","url":null,"abstract":"<div><p>The new radiochemical synthon 1-[<sup>18</sup>F]fluoro-2-propanol <em>p</em>-toluenesulfonate <strong>2′a</strong> is prepared with a radiochemical yield of 45% [corrected for decay to beginning of synthesis (BOS), synthesis time 40 min]. This compound is used to prepare the [<sup>18</sup>F]fluoroisopropyl-alkylated derivatives of benzylamine and norephedrine with a yield of 7 and 2% respectively (BOS, synthesis time 90 min). This alkylation reaction with <strong>2′a</strong> gives a good perspective for the preparation of [<sup>18</sup>F]fluoro-labelled analogues of β<sub>1</sub>-adrenergic receptor binding ligands for PET.</p></div>","PeriodicalId":14288,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes","volume":"43 11","pages":"Pages 1335-1339"},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2889(92)90005-Y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73006517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
A simple synthesis of [11C]methyl triflate [11C]三氟酸甲酯的简单合成
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes Pub Date : 1992-11-01 Epub Date: 2002-10-09 DOI: 10.1016/0883-2889(92)90012-4
Douglas M. Jewett
{"title":"A simple synthesis of [11C]methyl triflate","authors":"Douglas M. Jewett","doi":"10.1016/0883-2889(92)90012-4","DOIUrl":"10.1016/0883-2889(92)90012-4","url":null,"abstract":"<div><p>[<sup>11</sup>C]Methyl triflate ([<sup>11</sup>C]methyl trifluoromethanesulfonate) was formed in high yield when [<sup>11</sup>C]methyl iodide in a nitrogen carrier was passed at 200°C through a column containing graphitized carbon impregnated with 50% by weight of silver triflate.</p></div>","PeriodicalId":14288,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes","volume":"43 11","pages":"Pages 1383-1385"},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2889(92)90012-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12507298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 313
Evaluation and measurement of 55Fe radioactivity in accelerator hardware activated at high energy accelerator facilities 高能加速器硬件中55Fe放射性的评价与测量
International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes Pub Date : 1992-11-01 Epub Date: 2002-10-09 DOI: 10.1016/0883-2889(92)90008-3
Yuichi Oki, Masaharu Numajiri, Takenori Suzuki, Taichi Miura, Kenjiro Kondo
{"title":"Evaluation and measurement of 55Fe radioactivity in accelerator hardware activated at high energy accelerator facilities","authors":"Yuichi Oki,&nbsp;Masaharu Numajiri,&nbsp;Takenori Suzuki,&nbsp;Taichi Miura,&nbsp;Kenjiro Kondo","doi":"10.1016/0883-2889(92)90008-3","DOIUrl":"10.1016/0883-2889(92)90008-3","url":null,"abstract":"<div><p>It was indicated that <sup>55</sup>Fe (EC decay, half-life: 2.7 y) is the most abundant radioisotope in the residual activities formed in hardware composed of iron and steel at high energy accelerator facilities. Its approximate activity could be evaluated on the basis of an integrated neutron flux measured by an activation method using a copper threshold detector. Both a low energy photon spectroscopy and a liquid scintillation counting method were confirmed to be applicable to <sup>55</sup>Fe measurement with high sensitivity.</p></div>","PeriodicalId":14288,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes","volume":"43 11","pages":"Pages 1355-1362"},"PeriodicalIF":0.0,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2889(92)90008-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82627805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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