Tjibbe J. De Groot, Philip H. Elsinga, Gerben M. Visser, Willem Vaalburg
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1-[18F]fluoro-2-propanol p-toluenesulfonate: a synthon for the preparation of N-([18F]fluoroisopropyl)amines
The new radiochemical synthon 1-[18F]fluoro-2-propanol p-toluenesulfonate 2′a is prepared with a radiochemical yield of 45% [corrected for decay to beginning of synthesis (BOS), synthesis time 40 min]. This compound is used to prepare the [18F]fluoroisopropyl-alkylated derivatives of benzylamine and norephedrine with a yield of 7 and 2% respectively (BOS, synthesis time 90 min). This alkylation reaction with 2′a gives a good perspective for the preparation of [18F]fluoro-labelled analogues of β1-adrenergic receptor binding ligands for PET.
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