{"title":"一种制备含TcN多键的99mtc -放射性药物的新方法","authors":"Roberto Pasqualini , Veronique Comazzi , Emmanuel Bellande , Adriano Duatti , Andrea Marchi","doi":"10.1016/0883-2889(92)90004-X","DOIUrl":null,"url":null,"abstract":"<div><p>An improved method for the preparation of <sup>99m</sup>Tc-radiopharmaceuticals containing the TcN multiple bond, in sterile and apyrogen conditions, is described. This method is based on the reaction of [<sup>99m</sup>Tc]pertechnetate with ligands derived from S-methyl dithiocarbazate [H<sub>2</sub>NN(R)C(S)SCH<sub>3</sub> [R = H, CH<sub>3</sub>], in the presence of HCl and tertiary phosphines. It was found that these derivatives can behave both as sources of nitride nitrogen ions (N<sup>3−</sup>) and as coordinating ligands. The reaction leads to the formation of intermediate technetium-nitrido complexes in high yield. These intermediate species can be used as suitable prereduced substrates for the preparation of technetium-nitrido radiopharmaceuticals through simple substitution reactions with appropriate exchanging ligands.</p></div>","PeriodicalId":14288,"journal":{"name":"International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes","volume":"43 11","pages":"Pages 1329-1333"},"PeriodicalIF":0.0000,"publicationDate":"1992-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0883-2889(92)90004-X","citationCount":"63","resultStr":"{\"title\":\"A new efficient method for the preparation of 99mTc-radiopharmaceuticals containing the TcN multiple bond\",\"authors\":\"Roberto Pasqualini , Veronique Comazzi , Emmanuel Bellande , Adriano Duatti , Andrea Marchi\",\"doi\":\"10.1016/0883-2889(92)90004-X\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>An improved method for the preparation of <sup>99m</sup>Tc-radiopharmaceuticals containing the TcN multiple bond, in sterile and apyrogen conditions, is described. This method is based on the reaction of [<sup>99m</sup>Tc]pertechnetate with ligands derived from S-methyl dithiocarbazate [H<sub>2</sub>NN(R)C(S)SCH<sub>3</sub> [R = H, CH<sub>3</sub>], in the presence of HCl and tertiary phosphines. It was found that these derivatives can behave both as sources of nitride nitrogen ions (N<sup>3−</sup>) and as coordinating ligands. The reaction leads to the formation of intermediate technetium-nitrido complexes in high yield. These intermediate species can be used as suitable prereduced substrates for the preparation of technetium-nitrido radiopharmaceuticals through simple substitution reactions with appropriate exchanging ligands.</p></div>\",\"PeriodicalId\":14288,\"journal\":{\"name\":\"International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes\",\"volume\":\"43 11\",\"pages\":\"Pages 1329-1333\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1992-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0883-2889(92)90004-X\",\"citationCount\":\"63\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/088328899290004X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/088328899290004X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A new efficient method for the preparation of 99mTc-radiopharmaceuticals containing the TcN multiple bond
An improved method for the preparation of 99mTc-radiopharmaceuticals containing the TcN multiple bond, in sterile and apyrogen conditions, is described. This method is based on the reaction of [99mTc]pertechnetate with ligands derived from S-methyl dithiocarbazate [H2NN(R)C(S)SCH3 [R = H, CH3], in the presence of HCl and tertiary phosphines. It was found that these derivatives can behave both as sources of nitride nitrogen ions (N3−) and as coordinating ligands. The reaction leads to the formation of intermediate technetium-nitrido complexes in high yield. These intermediate species can be used as suitable prereduced substrates for the preparation of technetium-nitrido radiopharmaceuticals through simple substitution reactions with appropriate exchanging ligands.
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