1-[18F]fluoro-2-propanol p-toluenesulfonate: a synthon for the preparation of N-([18F]fluoroisopropyl)amines

Abstract

The new radiochemical synthon 1-[¹⁸F]fluoro-2-propanol p-toluenesulfonate 2′a is prepared with a radiochemical yield of 45% [corrected for decay to beginning of synthesis (BOS), synthesis time 40 min]. This compound is used to prepare the [¹⁸F]fluoroisopropyl-alkylated derivatives of benzylamine and norephedrine with a yield of 7 and 2% respectively (BOS, synthesis time 90 min). This alkylation reaction with 2′a gives a good perspective for the preparation of [¹⁸F]fluoro-labelled analogues of β₁-adrenergic receptor binding ligands for PET.