International Journal of Radiation Oncology Biology Physics最新文献

{"title":"Classic Radiation, Modern Precision: A Timeless Cure for Hodgkin Lymphoma","authors":"Preston Perez BS, Nicholas B. Figura MD","doi":"10.1016/j.ijrobp.2025.01.013","DOIUrl":"10.1016/j.ijrobp.2025.01.013","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"122 1","pages":"Page 8"},"PeriodicalIF":6.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resistance is Futile: Stereotactic Body Radiation Therapy for Oligoprogressive Non-small Cell Lung Cancer","authors":"Florence Keane MD , Megan Daly MD , Alexander Louie MD, PhD , Jeremy Harris MD, MPhil , Pamela Samson MD, MPHS , Clifford Robinson MD","doi":"10.1016/j.ijrobp.2025.01.015","DOIUrl":"10.1016/j.ijrobp.2025.01.015","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"122 1","pages":"Pages 1-4"},"PeriodicalIF":6.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in Radiation Therapy Treatment Workflows for Precision Medicine: A Review and Forward Looking.","authors":"Yi Rong, Riley Tegtmeier, Edward L Clouser, Sujay A Vora, Chang-Shiun Lin, Thomas R Mackie, Robert Timmerman, Mu-Han Lin","doi":"10.1016/j.ijrobp.2025.04.010","DOIUrl":"https://doi.org/10.1016/j.ijrobp.2025.04.010","url":null,"abstract":"<p><p>The conventional radiation therapy (RT) workflow, standardized over the past 3 decades, comprises 4 key phases: computed tomography (CT) simulation, treatment planning, quality assurance, and treatment delivery. This workflow relies heavily on the acquisition of planning CT scans for accurate 3-dimensional planning and patient positioning. Advancements in on-board 3-dimensional imaging, such as fan-beam or cone-beam CT and magnetic resonance imaging, now offer improved dosimetric accuracy directly or through synthetic CT generation, image deformation, and bulk density override techniques. These developments enable margin reduction, dose escalation, and online adaptive therapy, optimizing clinical outcomes. Additionally, various workflows integrating diagnostic CT and daily on-board 3-dimensional imaging, omitting the need for the planning CT acquisition, have shown feasibility, efficiency, and treatment accuracy. This article reviews simulation-omitted RT workflows, evaluating their procedures, dosimetric advantages, staffing requirements, billing challenges, and limitations. The convergence of improved imaging capabilities and adaptive strategies marks a significant opportunity for clinical innovation, offering pathways to refine RT workflows and enhance patient outcomes.</p>","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Old but Gold Radiation","authors":"Maryam Ebadi MD,&nbsp;Yolanda D. Tseng MD, MPhil","doi":"10.1016/j.ijrobp.2024.12.042","DOIUrl":"10.1016/j.ijrobp.2024.12.042","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"122 1","pages":"Pages 7-8"},"PeriodicalIF":6.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"No Chemo, No Problem: Radiate for Cure","authors":"Eduardo Urias MD,&nbsp;Randa Tao MD","doi":"10.1016/j.ijrobp.2024.12.043","DOIUrl":"10.1016/j.ijrobp.2024.12.043","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"122 1","pages":"Page 7"},"PeriodicalIF":6.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"About the cover image","authors":"","doi":"10.1016/S0360-3016(25)00208-1","DOIUrl":"10.1016/S0360-3016(25)00208-1","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"122 1","pages":"Page A9"},"PeriodicalIF":6.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deformable Image Registration Uncertainty-Encompassing Dose Accumulation for Adaptive Radiation Therapy.","authors":"Sebastian Meyer, Yu-Chi Hu, Andreas Rimner, James Mechalakos, Laura Cerviño, Pengpeng Zhang","doi":"10.1016/j.ijrobp.2025.04.004","DOIUrl":"https://doi.org/10.1016/j.ijrobp.2025.04.004","url":null,"abstract":"<p><strong>Purpose: </strong>Deformable image registration (DIR) represents an inherently ill-posed problem, and its quality highly depends on the algorithm and user input, which can severely affect its applications in adaptive radiation therapy. We propose an automated framework for integrating DIR uncertainty into dose accumulation.</p><p><strong>Methods and materials: </strong>A hyperparameter perturbation approach was applied to estimate an ensemble of deformation vector fields for a given computed tomography (CT) to cone beam CT (CBCT) DIR. For each voxel, a principal component analysis was performed on the distribution of homologous points to construct voxel-specific DIR uncertainty confidence ellipsoids. During the resampling process for dose mapping, the complete dose within each ellipsoid was evaluated via interpolation to estimate the upper and lower dose limits for the particular voxel. We applied the proposed framework in a retrospective dose accumulation study of 20 patients with lung cancer who underwent image guided radiation therapy with weekly CBCTs.</p><p><strong>Results: </strong>The average computational time was around 30 minutes, making the approach clinically feasible for automated offline evaluations. The uncertainty (ie, largest ellipsoid semiaxis length) for the fifth week CBCT DIR was 3.8 ± 1.8, 2.5 ± 0.7, 1.5 ± 0.4, 3.2 ± 1.3, and 4.5 ± 1.8 mm for the gross tumor volume, esophagus, spinal cord, lungs, and heart, respectively. Confidence ellipsoids were markedly elongated, with the largest semiaxis 5.5 and 2.5 times longer than the other axes. The dosimetric uncertainties were mainly within 4 Gy but exhibited significant spatial variation because of the interplay between dose gradient and DIR uncertainty. When DIR uncertainty was considered in dose accumulation, 3 cases exceeded institutional limits for dose-volume histogram metrics, highlighting the importance of considering the inherent uncertainty of DIR.</p><p><strong>Conclusions: </strong>This framework has the potential to facilitate the clinical implementation of dose accumulation, which can improve clinical decision-making in adaptive radiation therapy and provide more personalized radiation therapy treatments.</p>","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Regard to Qiu et al","authors":"Trent Kite BS,&nbsp;Matthew J. Shepard MD,&nbsp;Rodney E. Wegner MD","doi":"10.1016/j.ijrobp.2025.01.010","DOIUrl":"10.1016/j.ijrobp.2025.01.010","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"122 1","pages":"Page 210"},"PeriodicalIF":6.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Reply to Kite et al","authors":"Yanfang Qiu MD,&nbsp;Yanxian Li MM,&nbsp;Cuihong Jiang MM,&nbsp;Xiangwei Wu MB,&nbsp;Wen Liu MB,&nbsp;Changgen Fan MB,&nbsp;Xu Ye MD,&nbsp;Lili He MM,&nbsp;Shuai Xiao MM,&nbsp;Qi Zhao MM,&nbsp;Wenqiong Wu MM,&nbsp;Kailin Chen MD,&nbsp;Chao Tan MB,&nbsp;Yuyi Li MB,&nbsp;Hui Wang MD,&nbsp;Feng Liu MD","doi":"10.1016/j.ijrobp.2025.01.011","DOIUrl":"10.1016/j.ijrobp.2025.01.011","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"122 1","pages":"Pages 210-211"},"PeriodicalIF":6.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Blast From the Past: Definitive Management of Favorable Early-Stage Hodgkin Lymphoma Ineligible for Systemic Therapy","authors":"Khaled Dibs MD,&nbsp;Austin J. Sim MD, JD","doi":"10.1016/j.ijrobp.2024.12.041","DOIUrl":"10.1016/j.ijrobp.2024.12.041","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"122 1","pages":"Pages 5-6"},"PeriodicalIF":6.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}