International Journal of Radiation Oncology Biology Physics最新文献

{"title":"Association between brain substructure dose and scholastic performance in pediatric brain tumor survivors who received radiotherapy.","authors":"Raymond B Mailhot Vega, Daniel J Indelicato, Julie A Bradley, Erin M Mobley, Emma Viviers, Christopher G Morris, Adeel Markatia, Yousef Ramahi, Christine F Delgado, Carla L Fisher, Nancy P Mendenhall, Kimberly P Raghubar, Amy M Crisp, M David Miller","doi":"10.1016/j.ijrobp.2025.07.1418","DOIUrl":"https://doi.org/10.1016/j.ijrobp.2025.07.1418","url":null,"abstract":"<p><strong>Purpose: </strong>Radiotherapy may cause cognitive deficits in pediatric brain tumor survivors (PBTS). Scholastic data provides pre-diagnostic measurements, is practical for patients and families, and aligns with student learning before and after treatment. We evaluated the association between radiation dose to organs at risk (OARs) and scholastic achievement in PBTS.</p><p><strong>Materials/methods: </strong>With IRB approval, we retrospectively analyzed scholastic achievement in PBTS treated with radiation from 2007-2021 at our institution. The state's Department of Education (DOE) provided scholastic data, merged with institutional clinical data. DOE also provided scholastic data on healthy children matched 3:1. A general linear mixed-effects model was performed with scholastic dependent variables from the post-treatment phase and the independent variable of mean OAR dose to the hippocampus, corpus callosum (CC), and frontal lobe (FL). Sensitivity analysis was conducted, limited to only children in the treatment group. Exploratory analyses evaluating volumetric associations between OARs and scholastic outcomes were conducted.</p><p><strong>Results: </strong>Fifty PBTS and 150 matched controls were included with a median age of 11.6 years at treatment and 7 years of follow-up. In the primary model, increasing mean dose to the hippocampus (p = 0.048), CC (p = 0.053), and FL (p = 0.097) were negatively associated with standard grade promotion. In the secondary model restricted to PBTS, only hippocampal dose remained significantly associated with grade promotion (p = 0.092). Volumetric analyses determined negative associations between higher V5-V20 to the hippocampus and FL and Mathematics and higher V25-V40 to the FL and Reading.</p><p><strong>Conclusions: </strong>We present the first ever report evaluating associations between dosimetry and scholastic performance. We demonstrate a novel method using scholastic performance data as a patient-centered metric, leveraging prospectively state-collected scholastic outcomes.</p>","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Second Malignancies Following Chemotherapy with or without Radiation Therapy for the Treatment of Locally Advanced Rectal Cancer.","authors":"Kathryn R Tringale, Kush H Patel, Lara Hilal, Abraham J Wu, Lily Boe, Zhigang Zhang, Neal Kim, John Navilio, Marsha Reyngold, John Cuaron, Paul Romesser, Andrea Cercek, Emmanouil Pappou, Sean Berry, Rona Yaeger, Philip Paty, Martin Weiser, Julio Garcia Aguilar, Leonard Saltz, Christopher H Crane, Carla Hajj","doi":"10.1016/j.ijrobp.2025.07.1424","DOIUrl":"https://doi.org/10.1016/j.ijrobp.2025.07.1424","url":null,"abstract":"<p><strong>Purpose: </strong>We sought to identify factors associated with second pelvic malignancies (SPM), as well as second non-pelvic malignancies (SNPM), after chemotherapy with or without RT for locally advanced rectal cancer (LARC).</p><p><strong>Methods: </strong>Patients diagnosed with stage II-III LARC. Cumulative incidence (CI) of second malignancies was analyzed using a 2-year landmark analysis with death as a competing risk.</p><p><strong>Results: </strong>Among 2,624 patients with LARC, 460 received chemotherapy and 2,164 received RT with concurrent chemotherapy (CXRT). With a median follow-up of 6 years in both cohorts, 7 SPMs were diagnosed in the chemotherapy cohort and 68 SPMs were diagnosed in the CXRT cohort. The 5- and 10- year CI of SPM in the chemotherapy cohort were 2.3% and 4.2% respectively, compared to 2.1% and 5.8% in the CXRT cohort (P=0.3). Older age (>50) was significantly associated with development of SPM on multivariable analysis (hazard ratio [HR] 3.03, p=0.005). Intensity modulated RT was associated with reduced risk of SPM compared to conventional RT (p=0.014). Of the total 75 SPMs, 72 were genitourinary cancers and only 3 were sarcomas. For SNPM, the 10-year CI was significantly higher in the CXRT group vs chemotherapy (11.0% vs 4.4%). Older age (>50) was associated with increased risk of SNPM (HR 2.48, p<0.001). Diabetes was associated with more SNPM (HR 1.51, p=0.028) while abstaining from tobacco was associated with decreased risk of SNPM (HR 0.63, p=0.013).</p><p><strong>Conclusion: </strong>The CI of SPM was not significantly higher in patients who received CXRT compared to chemotherapy alone for LARC. SNPM CI was increased in the CXRT vs chemotherapy alone cohort, and higher in smokers, diabetics, and patients >50 years.</p>","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limitations in the Application of Clinicopathologic Factors Alone in Predicting Radiation Benefit for Women with Low-Risk Ductal Carcinoma in Situ after Breast Conserving Surgery: The Impact of a 7-gene Biosignature based on 10-Year Ipsilateral Breast Recurrence (IBR) Rates.","authors":"Frank Vicini, Chirag Shah, Karuna Mittal, Sheila Weinmann, Michael Leo, G Bruce Mann, Fredrik Warnberg, Rachel Rabinovitch, Brian Czerniecki, Icro Meattini, Atif Jalees Khan, Sachin Jhawar, Naamit Gerber, Shawna C Willey, Pat Borgen, Zahraa AlHilli, Megan Kruse, David Dabbs, Steven C Shivers, Anna Daily, Pat Whitworth, Michael Alvarado, Jason A Mouabbi, Meena Moran, Hope Rugo, Joyce A O'Shaughnessy, Troy Bremer","doi":"10.1016/j.ijrobp.2025.07.1411","DOIUrl":"https://doi.org/10.1016/j.ijrobp.2025.07.1411","url":null,"abstract":"<p><p>Clinicopathologic (CP) factors are used to estimate 10-year ipsilateral breast recurrence (IBR) risk and inform shared decision-making regarding post-operative radiation treatment (RT) for ductal carcinoma in situ (DCIS) patients. This study assesses the clinical value of the 7-gene biosignature (Lab-Location) compared to traditional CP definitions for predicting IBR rates and RT benefit. DCIS patients (n=926) treated with breast conserving surgery (BCS) ±RT were categorized as CP low-risk or high-risk based on established CP factors, study criteria, and nomograms. Women were classified as molecular Low Risk or High Risk by the biosignature. Ten-year IBR rates for CP risk groups were compared to and stratified by the biosignature. There were 37% of women classified as molecular Low Risk by the biosignature, while on average 47% were classified as low-risk by various CP definitions (range: 35-60%). Overall, CP low-risk groups had a mean absolute IBR benefit with RT of 6% (HR, 0.46; p<.001). The biosignature reclassified 53% of CP low-risk patients to molecular High Risk. These reclassified patients experienced higher IBR rates when RT was omitted and benefited from RT (HR, 0.30; p<.001) with an absolute reduction of 11.6% (17.7% vs. 6.1%). CP low-risk patients with concordant biosignature Low Risk demonstrated no significant RT benefit. On average, 28% of high-risk CP patients were reclassified as biosignature Low Risk and had no significant RT benefit (5.9% vs. 4.0%). This observational study supports optimizing de-escalation/escalation treatment strategies for DCIS, the 7-gene biosignature reliably discriminated a low-risk group without significant RT benefit compared to CP factors alone and an elevated risk group that benefitted from RT, facilitating improved shared decision making. A randomized clinical trial (NRG CC-016) will provide Level 1A evidence for the impact of RT treatment on IBR rates for patients in the 7-gene biosignature Low Risk group, including those with CP high-risk.</p>","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Dose-Averaged LET Contributes to Local Recurrence of Pancreatic Cancer Treated with Carbon Ion Radiotherapy.","authors":"Soichiro Sakamoto, Takahiro Oike, Daijiro Kobayashi, Yuhei Miyasaka, Makoto Sakai, Masahiko Okamoto, Shintaro Shiba, Kento Tomizawa, Narisa Dewi Maulany Darwis, Hanae Yoshida, Mutsumi Tashiro, Tatsuya Ohno","doi":"10.1016/j.ijrobp.2025.07.1406","DOIUrl":"https://doi.org/10.1016/j.ijrobp.2025.07.1406","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effects of dose-averaged linear energy transfer (LET_d) profiles on local control of pancreatic cancer treated with carbon ion radiotherapy (CIRT).</p><p><strong>Methods and materials: </strong>Data from patients with inoperable pancreatic cancer, treated with CIRT and concurrent chemotherapy between 2013 and 2021, were analyzed retrospectively. The prescribed dose was 55.2 Gy (relative biological effectiveness), administered in 12 fractions. The LET_d of CIRT plans were calculated using a previously reported in-house pipeline. The association between tumor LET_d profiles and local recurrence (LR) was analyzed.</p><p><strong>Results: </strong>The study analyzed 106 patients. The 2-year cumulative LR rate was 20.2% (95% confidence interval [CI], 12.8%-28.9%). Analysis of LET_d parameters using a Fine-Gray regression model showed that the minimum LET_d (L_min) for the clinical target volume (CTV) had a significant effect on LR (p = 0.023). According to the cutoff value of 42.2 keV/μm, determined by time-dependent Receiver Operating Characteristic analysis at 18 months, patients with low CTV L_min had a significantly greater cumulative LR rate than those with high CTV L_min (p = 0.020; 2-year cumulative LR rate, 32.4% [95% CI, 16.6%-49.3%] vs. 12.7% [95% CI, 5.8%-22.5%]). Cause-specific proportional hazards models identified CTV L_min as a significant predictor of LR (hazard ratio, 0.83 [95% CI, 0.71-0.98], p = 0.030). CTV L_min showed a strong significant negative correlation with CTV (p < 0.0001, r = -0.52).</p><p><strong>Conclusions: </strong>This is the largest study investigating the association between tumor LET_d profiles and local control post-CIRT. The results suggest that low LET_d within the CTV is associated with poor local control in patients with pancreatic cancer treated with CIRT.</p>","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Cardiac Radiation Dose on Cardiotoxicity in Patients With Breast Cancer Undergoing Adjuvant Trastuzumab Therapy","authors":"Suparna C. Clasen MD, MSCE ,&nbsp;Jose Bazan MD, MS ,&nbsp;Carmen Bergom MD, PhD","doi":"10.1016/j.ijrobp.2025.03.091","DOIUrl":"10.1016/j.ijrobp.2025.03.091","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"122 5","pages":"Pages 1125-1127"},"PeriodicalIF":6.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Regard to Santos et al.","authors":"Roberta Muni MD,&nbsp;Maurizio Portaluri MD,&nbsp;Angelo Di Naro MSc,&nbsp;Francesco Filippone MD,&nbsp;Alessandra Castelluccia MD,&nbsp;Francesco Tramacere MD,&nbsp;Suela Vukcaj MD","doi":"10.1016/j.ijrobp.2025.04.027","DOIUrl":"10.1016/j.ijrobp.2025.04.027","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"122 5","pages":"Page 1393"},"PeriodicalIF":6.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beneath the Surface: Peeling Back Layers of Management Complexity for Leptomeningeal Disease From EGFR-mutant Lung Cancer","authors":"Ory Haisraely MD, MPH,&nbsp;Martin C. Tom MD","doi":"10.1016/j.ijrobp.2024.12.050","DOIUrl":"10.1016/j.ijrobp.2024.12.050","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"122 5","pages":"Pages 1082-1083"},"PeriodicalIF":6.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Highlights","authors":"","doi":"10.1016/S0360-3016(25)00568-1","DOIUrl":"10.1016/S0360-3016(25)00568-1","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"122 5","pages":"Pages A10-A13"},"PeriodicalIF":6.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consolidation of Metastatic Sites in Pediatric Sarcoma: Evidence and Opportunities","authors":"Susan M. Hiniker MD ,&nbsp;Steve E. Braunstein MD, PhD ,&nbsp;Jeannette D. Parkes MD ,&nbsp;Derek S. Tsang MD, MSc ,&nbsp;Kilian E. Salerno MD","doi":"10.1016/j.ijrobp.2025.02.043","DOIUrl":"10.1016/j.ijrobp.2025.02.043","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"122 5","pages":"Pages 1077-1081"},"PeriodicalIF":6.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prone Positioning for Regional Nodal Irradiation in Breast Cancer: Are We Ready for This?","authors":"Dominique Rash MD ,&nbsp;Bethany Anderson MD","doi":"10.1016/j.ijrobp.2025.03.021","DOIUrl":"10.1016/j.ijrobp.2025.03.021","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"122 5","pages":"Pages 1140-1142"},"PeriodicalIF":6.4,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}