International Journal of Radiation Oncology Biology Physics最新文献

{"title":"In Silico Interim Adaptation of Proton Therapy in Head and Neck Cancer by Simultaneous Dose and Linear Energy Transfer Escalation.","authors":"Guillermo Garrido-Hernandez, Kristian Smeland Ytre-Hauge, René M Winter, Signe Danielsen, Mirjam K D Alsaker, Kathrine Røe Redalen, Helge Henjum","doi":"10.1016/j.ijrobp.2025.02.015","DOIUrl":"10.1016/j.ijrobp.2025.02.015","url":null,"abstract":"<p><strong>Purpose: </strong>The outcome of proton therapy for head and neck cancer (HNC) varies considerably. We investigated the feasibility of adapting proton therapy plans based on ¹⁸F-fluorodeoxyglucose-positron emission tomography-defined biologic tumor volumes (BTVs) reflecting remaining aggressive tumor subvolumes 2 weeks into treatment (interim). Recognizing the potential to improve proton therapy response with increasing linear energy transfer (LET), we simulated a combined dose-LET escalation to the BTVs and compared it to pure dose escalation. In addition, the impact of relative biological effectiveness (RBE) was evaluated by comparing the constant RBE of 1.1 (RBE_1.1) with a variable-RBE model.</p><p><strong>Methods and materials: </strong>A semiautomated method was used to segment the BTV from ¹⁸F-fluorodeoxyglucose-positron emission tomography-defined for 9 patients with HNC, assuming high standardized uptake value at interim to reflect tumor radioresistance. An in-house Monte Carlo-based recalculation and reoptimization tool simulated proton therapy plans with both constant RBE_1.1 and variable-RBE, aimed to deliver 68 Gy (RBE) to high-risk target volumes, 10% dose escalation to the BTV, and a LET boost to the BTV. Dose distributions were prioritized over LET optimization goals. Results were quantified by dose and LET distributions to target volumes and organs at risk, as well as normal tissue complication probabilities (NTCPs) for xerostomia and dysphagia.</p><p><strong>Results: </strong>Dose-LET adapted proton therapy plans achieved 10% dose escalation and mean dose-averaged LET (LET_d) increases to the BTV above 1.0 keV/μm, with no significant LET increases to organs at risk. NTCP for xerostomia and dysphagia from dose-LET and dose-only escalation were similar. However, NTCPs increased 6% to 10% when variable-RBE was used instead of the constant RBE_1.1.</p><p><strong>Conclusions: </strong>Our in silico study showed that dose-LET escalation in proton therapy integrating a variable-RBE model may improve proton therapy for patients with HNC. Clinical evaluation of such a biological image-based dose-LET escalation in proton therapy of HNC remains to be investigated.</p>","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early prediction of radiation pneumonitis in patients with lung cancer treated with immunotherapy through monitoring of plasma chemokines.","authors":"Lingyan Xiao, Ying Li, Sheng Wang, Lihua Fan, Qian Li, Zhijie Fan, Xi Wang, Li Ma, Duo Xu, Yulong Yu, Guang Han, Xianglin Yuan, Bo Liu","doi":"10.1016/j.ijrobp.2025.02.011","DOIUrl":"https://doi.org/10.1016/j.ijrobp.2025.02.011","url":null,"abstract":"<p><strong>Objective: </strong>This study is aimed to identify biomarkers for symptomatic radiation pneumonitis (RP) in patients with lung cancer treated with immune checkpoint inhibitors (ICIs).</p><p><strong>Methods: </strong>This multicenter, prospective study enrolled lung cancer patients receiving thoracic radiotherapy (RT) between 2021 and 2023. Plasma cytokines were measured using Luminex assays. Cox proportional hazards model was used to identify risk factors and biomarkers for RP. Sensitivity analysis was conducted using Fine-Gray competing risk analyses. Receiver operating characteristic (ROC) curves were used to assess the predictive value of the cytokines.</p><p><strong>Results: </strong>A total of 214 patients receiving thoracic RT were included in this study, with 75 (31.12%) patients developing symptomatic RP. Among the 71 patients with prior ICI treatment, 32 (45.07%) developed symptomatic RP. Patients with prior ICI treatment had higher incidence of symptomatic RP and plasma chemokines than those without prior ICI treatment. For patients with prior ICI treatment, plasma CXCL10 before RT (hazard ratio[HR]=1.29, 95% confidence interval[CI]: 1.03-1.64) and at 2 weeks (HR=1.28, 95%CI: 1.03-1.59) and 4 weeks during RT (HR=1.65, 95%CI: 1.19-2.28) were significant associated with RP. The area under the curves (AUC) of plasma CXCL10 at baseline, 2w and 4w during RT were 0.625, 0.680, and 0.679, respectively. Plasma CXCL14 before RT and CXCL2 during RT were also predictors of RP. A risk score integrating CXCL10, CXCL14, CXCL2, and mean lung dose (MLD) showed better predictive performance than individual factors (AUC=0.757).</p><p><strong>Conclusions: </strong>In this prospective study, plasma chemokines predict future risk of symptomatic RP in patients with lung cancer who have received prior immunotherapy. Despite with moderate AUC, the scoring system based on plasma chemokines and MLD is a feasible tool for predicting symptomatic RP, aiding in tailoring personalized and optimal treatment for patients.</p>","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining the Role of Radiation Therapy for Central Nervous System Metastases in a Rapidly Evolving Landscape of Novel Therapeutics","authors":"Christoph Straube MD ,&nbsp;Martin C. Tom MD ,&nbsp;William G. Breen MD ,&nbsp;Christina Cramer MD ,&nbsp;Erqi L. Pollom MD, MS ,&nbsp;Michelle M. Kim MD","doi":"10.1016/j.ijrobp.2025.01.002","DOIUrl":"10.1016/j.ijrobp.2025.01.002","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"121 4","pages":"Pages 847-850"},"PeriodicalIF":6.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mind Over Matter: Complete Craniospinal Irradiation or Just Treat the Spine","authors":"Adam Kessel MD,&nbsp;Eric J. Lehrer MD, MS","doi":"10.1016/j.ijrobp.2024.11.093","DOIUrl":"10.1016/j.ijrobp.2024.11.093","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"121 4","pages":"Pages 851-852"},"PeriodicalIF":6.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Marrow–Moving Toward a Systemic Perspective of Radiation-Induced Cytopenias","authors":"Sabrina L. Browning MD ,&nbsp;Mendez Lourdes MD, PhD ,&nbsp;Natalia Neparidze MD ,&nbsp;Timothy J. Robinson MD, PhD","doi":"10.1016/j.ijrobp.2024.11.100","DOIUrl":"10.1016/j.ijrobp.2024.11.100","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"121 4","pages":"Pages 1039-1041"},"PeriodicalIF":6.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Highlights","authors":"","doi":"10.1016/S0360-3016(25)00035-5","DOIUrl":"10.1016/S0360-3016(25)00035-5","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"121 4","pages":"Pages A8-A10"},"PeriodicalIF":6.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Craniospinal Irradiation, or Tumor-Sparing Approach?","authors":"Susan M. Hiniker MD,&nbsp;Dana L. Casey MD","doi":"10.1016/j.ijrobp.2024.12.004","DOIUrl":"10.1016/j.ijrobp.2024.12.004","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"121 4","pages":"Pages 854-855"},"PeriodicalIF":6.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143452941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Reply to Dionisi and Sanguineti","authors":"Meredith E. Giuliani MBBS, MEd, PhD,&nbsp;Rohan Salunkhe MD,&nbsp;Andrew Warner MSc,&nbsp;David A. Palma MD, PhD","doi":"10.1016/j.ijrobp.2024.11.111","DOIUrl":"10.1016/j.ijrobp.2024.11.111","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"121 4","pages":"Page 1089"},"PeriodicalIF":6.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Personalized Approach to Spinal Cord Ependymoma","authors":"Eric L. Chang MD ,&nbsp;Arjun Sahgal MD","doi":"10.1016/j.ijrobp.2024.11.095","DOIUrl":"10.1016/j.ijrobp.2024.11.095","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"121 4","pages":"Page 853"},"PeriodicalIF":6.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balancing Mind and Matter: Tailoring Radiation Therapy for Brain and Spine in Ependymoma","authors":"David J. Crompton MD,&nbsp;Daniel M. Trifiletti MD","doi":"10.1016/j.ijrobp.2024.11.090","DOIUrl":"10.1016/j.ijrobp.2024.11.090","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"121 4","pages":"Page 854"},"PeriodicalIF":6.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143453298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}