International Journal of Radiation Oncology Biology Physics最新文献

{"title":"Challenging the Children’s Oncology Group Whole Ventricular Irradiation Atlas: A Call for Standardized Guidelines","authors":"Melek Tugce Yilmaz MD , Alper Kahvecioglu MD , Gokcen Coban Cifci MD , Ahmet Ilkay Isikay MD , Gozde Yazici MD","doi":"10.1016/j.ijrobp.2024.12.021","DOIUrl":"10.1016/j.ijrobp.2024.12.021","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"122 1","pages":"Pages 164-165"},"PeriodicalIF":6.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation-Induced Lymphopenia: In Silico Replications of Preclinical Studies Suggest Importance of Dose to Lymphoid Organs.","authors":"Chris Beekman, Natalia Carrasco-Rojas, Julia Withrow, Robert Dawson, Wesley E Bolch, Harald Paganetti","doi":"10.1016/j.ijrobp.2025.03.080","DOIUrl":"https://doi.org/10.1016/j.ijrobp.2025.03.080","url":null,"abstract":"<p><strong>Purpose: </strong>To develop a computational framework to investigate the implications of lymphocyte recirculation for understanding radiation-induced lymphopenia (RIL) and to compare model predictions with preclinical in vivo studies.</p><p><strong>Methods and materials: </strong>A whole-body compartmental model of lymphocyte migration in mice was developed, and unknown rate parameters were fitted to published experimental data. Using a stochastic representation of the model in combination with detailed mouse phantom meshes, implicit lymphocyte trajectories were computed. In parallel, a module was developed to reproduce small animal irradiation plans using either photon or proton beams. Combining these computational tools, we calculated the dose distribution of the recirculating lymphocyte pool in different irradiation scenarios and simulated the subsequent redistribution of viable lymphocytes. The relative importance of irradiation of secondary lymphoid organs (SLOs) versus the blood was investigated through in silico replications of 3 preclinical studies in which mice were locally irradiated.</p><p><strong>Results: </strong>Lymphocyte recirculation between the blood and SLOs attenuates lymphocyte depletion in 1 compartment by distributing the loss throughout the system. Because only a relatively small fraction (∼17% for mice) of the recirculating lymphocyte pool is in the blood at any given time, with most lymphocytes in the SLOs, the effect of SLO irradiation is greater than that of the blood. Predicted depletion trends correlated with those observed in preclinical studies but underestimated the degree of lymphopenia. The finding that proton beams can avert lymphopenia after whole-brain irradiation by sparing head and neck lymph nodes was reproduced.</p><p><strong>Conclusions: </strong>The occurrence of RIL is associated with worse outcomes in patients with cancer but remains poorly understood. Therefore, a computational framework to replicate preclinical studies was developed to systematically investigate this phenomenon. Our simulations indicate that irradiation of SLOs contributes more to lymphocyte dose than blood irradiation. However, the expected cytotoxicity associated with the replicated preclinical studies could not fully account for the degree of lymphopenia observed.</p>","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation Is Your Friend: Somewhere in Between the Involved Field and Involved Site Is Back","authors":"Jeffrey Q. Cao MD, MBA, FRCPC,&nbsp;Alex Balogh MD, FRCPC","doi":"10.1016/j.ijrobp.2025.01.012","DOIUrl":"10.1016/j.ijrobp.2025.01.012","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"122 1","pages":"Pages 8-9"},"PeriodicalIF":6.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Reply to Mikropoulos et al","authors":"Juanita Crook MD","doi":"10.1016/j.ijrobp.2024.11.117","DOIUrl":"10.1016/j.ijrobp.2024.11.117","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"122 1","pages":"Pages 209-210"},"PeriodicalIF":6.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Software Support Tools for Reirradiation: A Report From Reirradiation Collaborative Group (ReCOG) 2024","authors":"Charles K. Matrosic PhD ,&nbsp;Piotr Andrzejewski ,&nbsp;Alanah Bergman ,&nbsp;Nick Chng ,&nbsp;Issam El Naqa ,&nbsp;Philipp Freislederer ,&nbsp;Lone Hoffmann ,&nbsp;Andrew Hope ,&nbsp;Dustin Jacqmin ,&nbsp;Colin Kelly ,&nbsp;LiCheng Kuo ,&nbsp;Haibo Lin ,&nbsp;Charles Mayo ,&nbsp;Donna H. Murrell ,&nbsp;Jakob Ödén ,&nbsp;Stina Svensson ,&nbsp;Stephen Thompson ,&nbsp;Eliana Vasquez Osorio ,&nbsp;Nick West ,&nbsp;Roman Wicha ,&nbsp;Kelly C. Paradis","doi":"10.1016/j.ijrobp.2024.12.023","DOIUrl":"10.1016/j.ijrobp.2024.12.023","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"122 1","pages":"Pages 181-185"},"PeriodicalIF":6.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Germ Cell Tumor Whole Ventricular Volume: Evolution of the Children's Oncology Group Atlas to Include the Prepontine Cistern","authors":"Erin Murphy MD ,&nbsp;Myrsini Ioakeim-Ioannidou MD ,&nbsp;Shannon MacDonald MD, FASTRO, FACRO","doi":"10.1016/j.ijrobp.2025.01.024","DOIUrl":"10.1016/j.ijrobp.2025.01.024","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"122 1","pages":"Pages 166-167"},"PeriodicalIF":6.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Regard to Crook et al","authors":"Christos Mikropoulos MD,&nbsp;Mohamed Metawe MD,&nbsp;Sophie Otter MD,&nbsp;Carla Perna MD,&nbsp;Sheel Mehta MD,&nbsp;William Hayhurst MD,&nbsp;Chee Goh MD,&nbsp;Jennifer Uribe PhD,&nbsp;Santiago Uribe PhD,&nbsp;Stephen Langley MD","doi":"10.1016/j.ijrobp.2024.12.029","DOIUrl":"10.1016/j.ijrobp.2024.12.029","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"122 1","pages":"Pages 208-209"},"PeriodicalIF":6.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classic Radiation, Modern Precision: A Timeless Cure for Hodgkin Lymphoma","authors":"Preston Perez BS,&nbsp;Nicholas B. Figura MD","doi":"10.1016/j.ijrobp.2025.01.013","DOIUrl":"10.1016/j.ijrobp.2025.01.013","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"122 1","pages":"Page 8"},"PeriodicalIF":6.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resistance is Futile: Stereotactic Body Radiation Therapy for Oligoprogressive Non-small Cell Lung Cancer","authors":"Florence Keane MD ,&nbsp;Megan Daly MD ,&nbsp;Alexander Louie MD, PhD ,&nbsp;Jeremy Harris MD, MPhil ,&nbsp;Pamela Samson MD, MPHS ,&nbsp;Clifford Robinson MD","doi":"10.1016/j.ijrobp.2025.01.015","DOIUrl":"10.1016/j.ijrobp.2025.01.015","url":null,"abstract":"","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":"122 1","pages":"Pages 1-4"},"PeriodicalIF":6.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in Radiation Therapy Treatment Workflows for Precision Medicine: A Review and Forward Looking.","authors":"Yi Rong, Riley Tegtmeier, Edward L Clouser, Sujay A Vora, Chang-Shiun Lin, Thomas R Mackie, Robert Timmerman, Mu-Han Lin","doi":"10.1016/j.ijrobp.2025.04.010","DOIUrl":"https://doi.org/10.1016/j.ijrobp.2025.04.010","url":null,"abstract":"<p><p>The conventional radiation therapy (RT) workflow, standardized over the past 3 decades, comprises 4 key phases: computed tomography (CT) simulation, treatment planning, quality assurance, and treatment delivery. This workflow relies heavily on the acquisition of planning CT scans for accurate 3-dimensional planning and patient positioning. Advancements in on-board 3-dimensional imaging, such as fan-beam or cone-beam CT and magnetic resonance imaging, now offer improved dosimetric accuracy directly or through synthetic CT generation, image deformation, and bulk density override techniques. These developments enable margin reduction, dose escalation, and online adaptive therapy, optimizing clinical outcomes. Additionally, various workflows integrating diagnostic CT and daily on-board 3-dimensional imaging, omitting the need for the planning CT acquisition, have shown feasibility, efficiency, and treatment accuracy. This article reviews simulation-omitted RT workflows, evaluating their procedures, dosimetric advantages, staffing requirements, billing challenges, and limitations. The convergence of improved imaging capabilities and adaptive strategies marks a significant opportunity for clinical innovation, offering pathways to refine RT workflows and enhance patient outcomes.</p>","PeriodicalId":14215,"journal":{"name":"International Journal of Radiation Oncology Biology Physics","volume":" ","pages":""},"PeriodicalIF":6.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}