International Journal of Nephrology最新文献

{"title":"Effects of Standardized Brazilian Green Propolis Extract (EPP-AF®) on Inflammation in Haemodialysis Patients: A Clinical Trial.","authors":"Marcelo Augusto Duarte Silveira,&nbsp;Hayna Malta-Santos,&nbsp;Jéssica Rebouças-Silva,&nbsp;Flávio Teles,&nbsp;Erica Batista Dos Santos Galvão,&nbsp;Sergio Pinto de Souza,&nbsp;Fábio Ricardo Dantas Dutra,&nbsp;Marcel Miranda Dantas Gomes,&nbsp;Maurício Brito Teixeira,&nbsp;Luis Filipe Miranda Rebelo da Conceição,&nbsp;Carolina Sa Nascimento,&nbsp;Carolina Kymie Vasques Nonaka,&nbsp;Rodrigo Silva Cezar,&nbsp;Paulo Benigno Pena Batista,&nbsp;Andresa Aparecida Berretta,&nbsp;Valeria M Borges,&nbsp;Rogerio da Hora Passos","doi":"10.1155/2022/1035475","DOIUrl":"https://doi.org/10.1155/2022/1035475","url":null,"abstract":"<p><strong>Background: </strong>Patients on haemodialysis (HD) present a significant inflammatory status, which has a pronounced negative impact on their outcomes. Propolis is a natural resin with anti-inflammatory and immunomodulatory properties. We assessed the safety and impact of a standardized Brazilian green propolis extract (EPP-AF®) on the inflammatory status in patients under conventional HD.</p><p><strong>Methods: </strong>Patients were assigned to receive 200 mg/day of EPP-AF® for 4 weeks followed by 4 weeks without the drug, and changes in plasma levels of interleukins (ILs), interferon gamma (IFN-<i>γ</i>), tumour necrosis factor-alpha (TNF-<i>α</i>), and high-sensitivityc-reactive protein (HsCRP) were measured. A heatmap was used to illustrate trends in data variation.</p><p><strong>Results: </strong>In total, 37 patients were included in the final analysis. Patients presented an exacerbated inflammatory state at baseline. During EPP-AF® use, there was a significant reduction in IFN-<i>γ</i> (<i>p</i>=0.005), IL-13 (<i>p</i>=0.04 2), IL-17 (<i>p</i>=0.039), IL-1ra (<i>p</i>=0.008), IL-8 (<i>p</i>=0.009), and TNF-<i>α</i> (<i>p</i>  <  0.001) levels compared to baseline, and significant changes were found in Hs-CRP levels. The heatmap demonstrated a pattern of pronounced proinflammatory status at baseline, especially in patients with primary glomerulopathies, and a clear reduction in this pattern during the use of EPP-AF®. There was a tendency to maintain this reduction after suspension of EPP-AF®. No significant side effects were observed.</p><p><strong>Conclusion: </strong>Patients under haemodialysis presented a pronounced inflammatory status, and EPP-AF® was demonstrated to be safe and associated with a significant and maintained reduction in proinflammatory cytokines in this population. This trial is registered with Clinicaltrials.gov NCT04072341.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":" ","pages":"1035475"},"PeriodicalIF":2.1,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9708369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40461190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal Denervation Influences Angiotensin II Types 1 and 2 Receptors.","authors":"Hajaralsadat Hosseini-Dastgerdi,&nbsp;Fatemeh Kharazmi,&nbsp;Ali-Asghar Pourshanazari,&nbsp;Mehdi Nematbakhsh","doi":"10.1155/2022/8731357","DOIUrl":"https://doi.org/10.1155/2022/8731357","url":null,"abstract":"<p><p>The sympathetic and renin-angiotensin systems (RAS) are two critical regulatory systems in the kidney which affect renal hemodynamics and function. These two systems interact with each other so that angiotensin II (Ang II) has the presynaptic effect on the norepinephrine secretion. Another aspect of this interaction is that the sympathetic nervous system affects the function and expression of local RAS receptors, mainly Ang II receptors. Therefore, in many pathological conditions associated with an increased renal sympathetic tone, these receptors' expression changes and renal denervation can normalize these changes and improve the diseases. It seems that the renal sympathectomy can alter Ang II receptors expression and the distribution of RAS receptors in the kidneys, which influence renal functions.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":" ","pages":"8731357"},"PeriodicalIF":2.1,"publicationDate":"2022-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9576444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40668599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of Direct Immunofluorescence Test on Paraffin-Embedded Blocks in Comparison with Frozen Section Blocks in Renal Biopsies.","authors":"Sahand Mohammadzadeh,&nbsp;Fatemeh Aghakhaninejad,&nbsp;Fariborz Azad,&nbsp;Dorna Derakhshan,&nbsp;Neda Soleimani","doi":"10.1155/2022/4974031","DOIUrl":"https://doi.org/10.1155/2022/4974031","url":null,"abstract":"<p><strong>Background: </strong>In several published research, the evaluation of renal disorders using immunofluorescence on formalin-fixed, paraffin-embedded (FFPE) tissue sections versus immunofluorescence on frozen sections was compared. Each technique's accuracy varies greatly. This study's objective was to assess IF-P as a potential replacement for IF-F in the diagnosis of renal biopsy specimens.</p><p><strong>Materials and methods: </strong>To show immunoglobulin IgA, IgG, IgM, and C3 immune deposits, proteinase K digestion of paraffin-embedded renal biopsy was standardized and used in 51 renal biopsies. Sensitivity, specificity, false-positive, and false-negative values were calculated.</p><p><strong>Results: </strong>IF-P showed a sensitivity of 93.1%, 76.9%, 63.6%, and 33.3%, and a specificity of 100%, 97.3%, 95%, and 100% for IgG, IgA, IgM, and C3, respectively. Compared to cases that had both routine IF and IF-P, 50 of 51 showed either the same amount of staining for the diagnostic immunoglobulin/complement or a small amount of difference. In most of the cases (49 of 51), diagnostic findings were found.</p><p><strong>Conclusion: </strong>IF-P is a sensitive and precise approach for assessing immune deposits in renal tissue biopsies. We come to the conclusion that IF-P serves as a beneficial salvage immunohistochemistry method for renal biopsies that do not contain enough cortical tissue for IF-F.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":" ","pages":"4974031"},"PeriodicalIF":2.1,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33527729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Mortality in Adults with Acute Kidney Injury Requiring Dialysis: A Cohort Analysis.","authors":"Charles Kangitsi Kahindo,&nbsp;Olivier Mukuku,&nbsp;Vieux Momeme Mokoli,&nbsp;Ernest Kiswaya Sumaili,&nbsp;Stanis Okitotsho Wembonyama,&nbsp;Zacharie Kibendelwa Tsongo","doi":"10.1155/2022/7418955","DOIUrl":"https://doi.org/10.1155/2022/7418955","url":null,"abstract":"<p><strong>Introduction: </strong>Acute kidney injury (AKI) requiring renal replacement therapy is accompanied by considerable mortality. This present study evaluated predictors of mortality at initiation of hemodialysis (HD) in AKI patients in Goma (in the Democratic Republic of the Congo (DRC)).</p><p><strong>Methods: </strong>A single-centre cohort survey evaluated the clinical profile and survival rates of AKI patients admitted to HD in the only HD centre in Goma, North Kivu province (DRC). Data were collected from patients who underwent HD for AKI. Patient demographics, comorbidities, clinical presentation, laboratory tests, and mortality were reviewed and analyzed. The survival study used the Kaplan-Meier curve. Predictors of mortality were evaluated using Cox regression.</p><p><strong>Results: </strong>Of the 131 eligible patients, the mean age was 43.69 ± 16.56 years (range: 18-90 years). Men represented 54.96% of the cohort. The overall HD mortality rate was 25.19% (<i>n</i> = 33). In multivariate analysis, independent predictors of mortality in AKI stage 3 patients admitted to HD were as follows: age ≥ 60 years (adjusted hazard ratio (AHR) = 15.89; 95% CI: 3.98-63.40; <i>p</i> < 0.0001), traditional herbal medicine intake (AHR = 5.10; 95% CI: 2.10-12.38; <i>p</i> < 0.0001), HIV infection (AHR = 5.55; 95% CI: 1.48-20.73; <i>p</i>=0.011), anemia (AHR = 9.57; 95% CI: 2.08-43.87; <i>p</i>=0.004), hyperkalemia (AHR = 6.23; 95% CI: 1.26-30.72; <i>p</i>=0.025), respiratory distress (AHR = 4.66; 95% CI: 2.07-10.50; <i>p</i> < 0.0001), and coma (AHR = 11.39; 95% CI: 3.51-36.89; <i>p</i> < 0.0001).</p><p><strong>Conclusion: </strong>Initiation of hemodialysis with AKI has improved survival in patients with different complications.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":" ","pages":"7418955"},"PeriodicalIF":2.1,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33466262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time on Therapy of Automated Peritoneal Dialysis with and without Remote Patient Monitoring: A Cohort Study.","authors":"Mauricio Sanabria,&nbsp;Jasmin Vesga,&nbsp;Bengt Lindholm,&nbsp;Angela Rivera,&nbsp;Peter Rutherford","doi":"10.1155/2022/8646775","DOIUrl":"https://doi.org/10.1155/2022/8646775","url":null,"abstract":"<p><strong>Background: </strong>Remote patient monitoring (RPM) of patients undergoing automated peritoneal dialysis (APD-RPM) may potentially enhance time on therapy due to possible improvements in technique and patient survival.</p><p><strong>Objective: </strong>To evaluate the effect of APD-RPM as compared to APD without RPM on time on therapy.</p><p><strong>Methods: </strong>Adult incident APD patients undergo APD for 90 days or more in the Baxter Renal Care Services (BRCS) Colombia network between January 1, 2017, and June 30, 2019, with the study follow-up ending June 30, 2021. The exposure variable was APD-RPM vs. APD-without RPM. The outcomes of time on therapy and mortality rate over two years of follow-up were estimated in the full sample and in a matched population according to the exposure variable. A propensity score matching (PSM) 1:1 without replacement utilizing the nearest neighbor within caliper (0.035) was used and created a pseudopopulation in which the baseline covariates were well balanced. Fine & Gray multivariate analysis was performed to assess the effect of demographic, clinical, and laboratory variables on the risk of death, adjusting for the competing risks of technique failure and kidney transplantation.</p><p><strong>Results: </strong>In the matched sample, the time on APD therapy was significantly longer in the RPM group than in the non-RPM group, 18.95 vs. 15.75 months, <i>p</i> < 0.001. The mortality rate did not differ between the two groups: 0.10 events per patient-year in the RPM group and 0.12 in the non-RPM group, <i>p</i>=0.325.</p><p><strong>Conclusion: </strong>Over two years of follow-up, the use of RPM vs. no RPM in APD patients was associated with a significant increase in time on therapy, by 3.2 months. This result indicates that RPM-supported APD therapy may improve the clinical effectiveness and the overall quality of APD.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":" ","pages":"8646775"},"PeriodicalIF":2.1,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40335859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early, Noninvasive Clinical Indicators of Kidney Prognosis in Primary Nephrotic Syndrome: A Retrospective Exploratory Study.","authors":"Keiji Fujimoto,&nbsp;Takatoshi Haraguchi,&nbsp;Sho Kumano,&nbsp;Keita Yamazaki,&nbsp;Nobuhiko Miyatake,&nbsp;Kanae Nomura,&nbsp;Kiyotaka Mukai,&nbsp;Kazuaki Okino,&nbsp;Norifumi Hayashi,&nbsp;Hiroki Adachi,&nbsp;Hitoshi Yokoyama,&nbsp;Yasuo Iida,&nbsp;Kengo Furuichi","doi":"10.1155/2022/2718810","DOIUrl":"https://doi.org/10.1155/2022/2718810","url":null,"abstract":"<p><p>This retrospective exploratory study aimed to identify early clinical indicators of kidney prognosis in primary nephrotic syndrome (NS). Univariate Cox proportional hazards regression analysis identified clinical parameters in the 2-month period after initiating immunosuppressive therapy (IST); it predicted 40% reduction in the estimated glomerular filtration rate (eGFR) in 36 patients with primary NS. Time-dependent receiver operating characteristic curve analysis was used to evaluate the performance of the predictors for the cumulative incidence of 40% reduction in the eGFR up to 8 years after initiating IST. The mean follow-up period was 71.9 months. The eGFR was reduced by 40% in four patients. Significant predictors for time to 40% reduction in the eGFR were as follows: an increase in the serum soluble urokinase plasminogen activator receptor (s-suPAR) 2 months after initiating IST (Δs-suPAR (2M); hazard ratio (HR) for every 500 pg/mL increase: 1.36, <i>P</i>=0.006), s-suPAR at 2 months after initiating IST (s-suPAR (2M); HR for every 500 pg/mL increase: 1.13, <i>P</i>=0.015), urinary protein-to-creatinine ratio (u-PCR) (u-PCR (2M); HR for every 1.0 g/gCr increase: 2.94, <i>P</i>=0.003), and urinary liver-type fatty acid-binding protein (u-L-FABP) (u-L-FABP (2M); HR for every 1.0 <i>μ</i>g/gCr increase: 1.14, <i>P</i>=0.006). All four factors exhibited high predictive accuracy for cumulative incidence of 40% reduction in the eGFR up to 8 years after initiating IST, with areas under the receiver operating characteristic curve of 0.92 for Δs-suPAR (2M), 0.87 for s-suPAR (2M), 0.93 for u-PCR (2M), and 0.93 for u-L-FABP (2M). These findings suggest that Δs-suPAR (2M), s-suPAR (2M), u-PCR (2M), and u-L-FABP (2M) could be useful indicators of initial therapeutic response for predicting kidney prognosis in primary NS.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":" ","pages":"2718810"},"PeriodicalIF":2.1,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40638665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenging, Safe, and Effective Use of External Iliac Vein for Insertion of Tunneled Cuffed Hemodialysis Catheters: A Single-Center Prospective Study.","authors":"Ayman R Abd El-Hameed,&nbsp;Walid A R Abdelhamid","doi":"10.1155/2022/4576781","DOIUrl":"https://doi.org/10.1155/2022/4576781","url":null,"abstract":"<p><strong>Background: </strong>Providing well-functioning vascular access is crucial for patients undergoing chronic hemodialysis. Peripheral arteriovenous fistulas and grafts are the preferred accesses in hemodialysis patients. Patients with bilateral obstruction of internal jugular veins and subclavian veins require a suitable vascular access. Thus, the insertion of iliac vein tunneled cuffed catheters (TCCs) by interventional nephrologists may be a good option for these patients. We aimed to evaluate the outcomes of iliac vein TCCs in patients lacking other vascular options.</p><p><strong>Methods: </strong>80 tunneled cuffed hemodialysis catheters were inserted through the iliac veins of 80 patients with an end-stage kidney disease. Catheter insertion was guided by Doppler ultrasonography followed by plain radiography to detect the catheter tip and exclude complications.</p><p><strong>Results: </strong>The insertion success rate was 100%. 25 patients developed catheter-related infections. The mean survival time per catheter was 328 days. At the end of the study, 40 catheters were still functioning, 15 patients were shifted to continuous ambulatory peritoneal dialysis and 5 patients were referred to the interventional radiology department for insertion of transhepatic inferior vena cava tunneled catheters. Resistant catheter-related infection was the main cause of catheter removal in 11 patients (17.5%) in this study. Catheter malfunction was the second most common cause of catheter removal in 9 patients (11.25%).</p><p><strong>Conclusion: </strong>This study concluded that iliac vein TCCs can provide suitable vascular access in hemodialysis patients with bilateral obstruction of internal jugular veins and subclavian veins.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":" ","pages":"4576781"},"PeriodicalIF":2.1,"publicationDate":"2022-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9381280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40638666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Phospholipase A2 Receptor Antibody Expression at Different Stages of Idiopathic Membranous Nephropathy.","authors":"Keying Fu,&nbsp;Pei Zhang,&nbsp;Yeguang Han,&nbsp;Ru Wang,&nbsp;Junhong Cai","doi":"10.1155/2022/5962195","DOIUrl":"https://doi.org/10.1155/2022/5962195","url":null,"abstract":"<p><p>The significance of blood anti-phospholipase A2 receptor (PLA₂R) antibodies in the diagnosis of different stages of idiopathic membranous nephropathy (IMN) was investigated. The expression and distribution of anti-PLA₂R antibodies in renal biopsy tissue of patients with different stages of IMN were examined by immunohistochemistry. In addition, blood anti-PLA₂R antibodies were determined by indirect immunofluorescence for the same patients, and the results were compared with the anti-PLA₂R antibody expression in renal biopsy tissue. The positive fluorescence intensities of IMN stages I, IV, and V were mostly ± or + (40/80). There was no significant difference in fluorescence titer between these stages (<i>p</i> > 0.05). These results were consistent with the immunohistochemistry results, and the kappa statistic was 0.95. The positive fluorescence intensities of IMN stages II and III were mostly ++ to ++++ (33/60). There was no significant difference in fluorescence intensities between these two stages (<i>p</i> > 0.05), but there was a significant difference in fluorescence intensities between stages II and III and stages I, IV, and V (<i>p</i> < 0.001). These results were consistent with the immunohistochemistry results, and the kappa statistic was 0.97 (<i>p</i> < 0.001). Therefore, blood anti-PLA₂R levels were positively correlated with anti-PLA₂R expression in renal biopsy tissue in patients with different stages of IMN. In addition, the fluorescence intensities of IMN stages II and III were significantly different from those of stages I, IV, and V. Therefore, blood anti-PLA₂R levels can be used for in vitro differential diagnosis and the monitoring of treatment, as it can distinguish stage II; and III; from stage I, IV, and V IMN.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":" ","pages":"5962195"},"PeriodicalIF":2.1,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40596117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laparoscopic Surgery for Pheochromocytoma in Hemodialysis Patients.","authors":"Shuichi Tatarano,&nbsp;Akihiko Mitsuke,&nbsp;Takashi Sakaguchi,&nbsp;Ryosuke Matsushita,&nbsp;Satoru Inoguchi,&nbsp;Hirofumi Yoshino,&nbsp;Hiroaki Nishimura,&nbsp;Yasutoshi Yamada,&nbsp;Hideki Enokida","doi":"10.1155/2022/3060647","DOIUrl":"https://doi.org/10.1155/2022/3060647","url":null,"abstract":"<p><strong>Objectives: </strong>We analyzed the clinical outcomes of laparoscopic adrenalectomy for pheochromocytomas in hemodialysis compared with nonhemodialysis patients.</p><p><strong>Methods: </strong>Fifty-seven patients (7 hemodialysis and 50 nonhemodialysis) were included in the study. We analyzed the differences in clinical parameters and outcomes between the hemodialysis patient groups and nonhemodialysis patient groups as well as identified predictors for an intraoperative hypertensive spike.</p><p><strong>Results: </strong>The increasing intravascular volume before surgery in hemodialysis patients made perioperative hemodynamic management safer. No significant difference in clinical parameters between the two groups was observed except for the length of hospitalization that was significantly longer in the hemodialysis patients (9 vs. 6 days, <i>P</i>=0.005). An increase in systolic blood pressure at CO₂ insufflation was an independent predictor of a hypertensive spike with a cutoff value of 22.5 mmHg (odds ratio 1.038, 95% confidence interval 1.012-1.078).</p><p><strong>Conclusion: </strong>Laparoscopic adrenalectomy for pheochromocytomas in hemodialysis was safe and feasible. An increase in systolic blood pressure at CO₂ insufflation was a predictor of the intraoperative hypertensive spike. The research in this manuscript is not registered. This is a retrospective study.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":" ","pages":"3060647"},"PeriodicalIF":2.1,"publicationDate":"2022-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40659152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal Amyloidosis: Epidemiological, Clinical, and Laboratory Profile in Adults from One Nephrology Center.","authors":"Hayet Kaaroud,&nbsp;Amel Harzallah,&nbsp;Mariem Hajji,&nbsp;Soumaya Chargui,&nbsp;Samia Barbouch,&nbsp;Sami Turki,&nbsp;Raja Trabelsi,&nbsp;Rim Goucha,&nbsp;Fatma Ben Moussa,&nbsp;Hedi Ben Maiz,&nbsp;Fethi Ben Hamida,&nbsp;Ezzeddine Abderrahim","doi":"10.1155/2022/8493479","DOIUrl":"https://doi.org/10.1155/2022/8493479","url":null,"abstract":"<p><strong>Background: </strong>Renal amyloidosis is one of the main differential diagnoses of nephrotic proteinuria in adults and the elderly. The aim of this study with the most important series in our country is to contribute to the epidemiological, clinical, and etiological study of the renal amyloidosis.</p><p><strong>Methods: </strong>In a retrospective study carried out between 1975 and 2019, 310 cases of histologically proven and typed renal amyloidosis were selected for this study.</p><p><strong>Results: </strong>There were 209 men and 101 women with a mean age of 53.8 ± 15.4 years (range, 17-84 years). Of the 310 cases, 255 (82.3%) were diagnosed with AA renal amyloidosis and 55 (17.7%) with non-AA amyloidosis. Infections were the main cause of AA amyloidosis, and tuberculosis was the most frequent etiology. The period from the onset of the underlying disease to diagnosis of the renal amyloidosis was an average of 177 months. The most frequent manifestations at the time of diagnosis were nephrotic syndrome (84%), chronic renal failure (30.3%), and end-stage renal disease (37.8%). After a medium follow-up of 16 months (range, 0-68 months), mortality occurred in 60 cases.</p><p><strong>Conclusions: </strong>Given the high frequency of AA amyloidosis in our country, awareness of the proper management of infectious and chronic inflammatory diseases remains a priority in reducing the occurrence of this serious disease.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":" ","pages":"8493479"},"PeriodicalIF":2.1,"publicationDate":"2022-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9314002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40551542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}