Charles Kangitsi Kahindo, Olivier Mukuku, Vieux Momeme Mokoli, Ernest Kiswaya Sumaili, Stanis Okitotsho Wembonyama, Zacharie Kibendelwa Tsongo
{"title":"需要透析的急性肾损伤成人死亡率预测因素:一项队列分析。","authors":"Charles Kangitsi Kahindo, Olivier Mukuku, Vieux Momeme Mokoli, Ernest Kiswaya Sumaili, Stanis Okitotsho Wembonyama, Zacharie Kibendelwa Tsongo","doi":"10.1155/2022/7418955","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Acute kidney injury (AKI) requiring renal replacement therapy is accompanied by considerable mortality. This present study evaluated predictors of mortality at initiation of hemodialysis (HD) in AKI patients in Goma (in the Democratic Republic of the Congo (DRC)).</p><p><strong>Methods: </strong>A single-centre cohort survey evaluated the clinical profile and survival rates of AKI patients admitted to HD in the only HD centre in Goma, North Kivu province (DRC). Data were collected from patients who underwent HD for AKI. Patient demographics, comorbidities, clinical presentation, laboratory tests, and mortality were reviewed and analyzed. The survival study used the Kaplan-Meier curve. Predictors of mortality were evaluated using Cox regression.</p><p><strong>Results: </strong>Of the 131 eligible patients, the mean age was 43.69 ± 16.56 years (range: 18-90 years). Men represented 54.96% of the cohort. The overall HD mortality rate was 25.19% (<i>n</i> = 33). In multivariate analysis, independent predictors of mortality in AKI stage 3 patients admitted to HD were as follows: age ≥ 60 years (adjusted hazard ratio (AHR) = 15.89; 95% CI: 3.98-63.40; <i>p</i> < 0.0001), traditional herbal medicine intake (AHR = 5.10; 95% CI: 2.10-12.38; <i>p</i> < 0.0001), HIV infection (AHR = 5.55; 95% CI: 1.48-20.73; <i>p</i>=0.011), anemia (AHR = 9.57; 95% CI: 2.08-43.87; <i>p</i>=0.004), hyperkalemia (AHR = 6.23; 95% CI: 1.26-30.72; <i>p</i>=0.025), respiratory distress (AHR = 4.66; 95% CI: 2.07-10.50; <i>p</i> < 0.0001), and coma (AHR = 11.39; 95% CI: 3.51-36.89; <i>p</i> < 0.0001).</p><p><strong>Conclusion: </strong>Initiation of hemodialysis with AKI has improved survival in patients with different complications.</p>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":" ","pages":"7418955"},"PeriodicalIF":16.4000,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484972/pdf/","citationCount":"1","resultStr":"{\"title\":\"Predictors of Mortality in Adults with Acute Kidney Injury Requiring Dialysis: A Cohort Analysis.\",\"authors\":\"Charles Kangitsi Kahindo, Olivier Mukuku, Vieux Momeme Mokoli, Ernest Kiswaya Sumaili, Stanis Okitotsho Wembonyama, Zacharie Kibendelwa Tsongo\",\"doi\":\"10.1155/2022/7418955\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Acute kidney injury (AKI) requiring renal replacement therapy is accompanied by considerable mortality. This present study evaluated predictors of mortality at initiation of hemodialysis (HD) in AKI patients in Goma (in the Democratic Republic of the Congo (DRC)).</p><p><strong>Methods: </strong>A single-centre cohort survey evaluated the clinical profile and survival rates of AKI patients admitted to HD in the only HD centre in Goma, North Kivu province (DRC). Data were collected from patients who underwent HD for AKI. Patient demographics, comorbidities, clinical presentation, laboratory tests, and mortality were reviewed and analyzed. The survival study used the Kaplan-Meier curve. Predictors of mortality were evaluated using Cox regression.</p><p><strong>Results: </strong>Of the 131 eligible patients, the mean age was 43.69 ± 16.56 years (range: 18-90 years). Men represented 54.96% of the cohort. The overall HD mortality rate was 25.19% (<i>n</i> = 33). In multivariate analysis, independent predictors of mortality in AKI stage 3 patients admitted to HD were as follows: age ≥ 60 years (adjusted hazard ratio (AHR) = 15.89; 95% CI: 3.98-63.40; <i>p</i> < 0.0001), traditional herbal medicine intake (AHR = 5.10; 95% CI: 2.10-12.38; <i>p</i> < 0.0001), HIV infection (AHR = 5.55; 95% CI: 1.48-20.73; <i>p</i>=0.011), anemia (AHR = 9.57; 95% CI: 2.08-43.87; <i>p</i>=0.004), hyperkalemia (AHR = 6.23; 95% CI: 1.26-30.72; <i>p</i>=0.025), respiratory distress (AHR = 4.66; 95% CI: 2.07-10.50; <i>p</i> < 0.0001), and coma (AHR = 11.39; 95% CI: 3.51-36.89; <i>p</i> < 0.0001).</p><p><strong>Conclusion: </strong>Initiation of hemodialysis with AKI has improved survival in patients with different complications.</p>\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":\" \",\"pages\":\"7418955\"},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2022-09-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484972/pdf/\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/2022/7418955\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2022/7418955","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
Predictors of Mortality in Adults with Acute Kidney Injury Requiring Dialysis: A Cohort Analysis.
Introduction: Acute kidney injury (AKI) requiring renal replacement therapy is accompanied by considerable mortality. This present study evaluated predictors of mortality at initiation of hemodialysis (HD) in AKI patients in Goma (in the Democratic Republic of the Congo (DRC)).
Methods: A single-centre cohort survey evaluated the clinical profile and survival rates of AKI patients admitted to HD in the only HD centre in Goma, North Kivu province (DRC). Data were collected from patients who underwent HD for AKI. Patient demographics, comorbidities, clinical presentation, laboratory tests, and mortality were reviewed and analyzed. The survival study used the Kaplan-Meier curve. Predictors of mortality were evaluated using Cox regression.
Results: Of the 131 eligible patients, the mean age was 43.69 ± 16.56 years (range: 18-90 years). Men represented 54.96% of the cohort. The overall HD mortality rate was 25.19% (n = 33). In multivariate analysis, independent predictors of mortality in AKI stage 3 patients admitted to HD were as follows: age ≥ 60 years (adjusted hazard ratio (AHR) = 15.89; 95% CI: 3.98-63.40; p < 0.0001), traditional herbal medicine intake (AHR = 5.10; 95% CI: 2.10-12.38; p < 0.0001), HIV infection (AHR = 5.55; 95% CI: 1.48-20.73; p=0.011), anemia (AHR = 9.57; 95% CI: 2.08-43.87; p=0.004), hyperkalemia (AHR = 6.23; 95% CI: 1.26-30.72; p=0.025), respiratory distress (AHR = 4.66; 95% CI: 2.07-10.50; p < 0.0001), and coma (AHR = 11.39; 95% CI: 3.51-36.89; p < 0.0001).
Conclusion: Initiation of hemodialysis with AKI has improved survival in patients with different complications.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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