Charles Kangitsi Kahindo, Olivier Mukuku, Vieux Momeme Mokoli, Ernest Kiswaya Sumaili, Stanis Okitotsho Wembonyama, Zacharie Kibendelwa Tsongo
{"title":"需要透析的急性肾损伤成人死亡率预测因素:一项队列分析。","authors":"Charles Kangitsi Kahindo, Olivier Mukuku, Vieux Momeme Mokoli, Ernest Kiswaya Sumaili, Stanis Okitotsho Wembonyama, Zacharie Kibendelwa Tsongo","doi":"10.1155/2022/7418955","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Acute kidney injury (AKI) requiring renal replacement therapy is accompanied by considerable mortality. This present study evaluated predictors of mortality at initiation of hemodialysis (HD) in AKI patients in Goma (in the Democratic Republic of the Congo (DRC)).</p><p><strong>Methods: </strong>A single-centre cohort survey evaluated the clinical profile and survival rates of AKI patients admitted to HD in the only HD centre in Goma, North Kivu province (DRC). Data were collected from patients who underwent HD for AKI. Patient demographics, comorbidities, clinical presentation, laboratory tests, and mortality were reviewed and analyzed. The survival study used the Kaplan-Meier curve. Predictors of mortality were evaluated using Cox regression.</p><p><strong>Results: </strong>Of the 131 eligible patients, the mean age was 43.69 ± 16.56 years (range: 18-90 years). Men represented 54.96% of the cohort. The overall HD mortality rate was 25.19% (<i>n</i> = 33). In multivariate analysis, independent predictors of mortality in AKI stage 3 patients admitted to HD were as follows: age ≥ 60 years (adjusted hazard ratio (AHR) = 15.89; 95% CI: 3.98-63.40; <i>p</i> < 0.0001), traditional herbal medicine intake (AHR = 5.10; 95% CI: 2.10-12.38; <i>p</i> < 0.0001), HIV infection (AHR = 5.55; 95% CI: 1.48-20.73; <i>p</i>=0.011), anemia (AHR = 9.57; 95% CI: 2.08-43.87; <i>p</i>=0.004), hyperkalemia (AHR = 6.23; 95% CI: 1.26-30.72; <i>p</i>=0.025), respiratory distress (AHR = 4.66; 95% CI: 2.07-10.50; <i>p</i> < 0.0001), and coma (AHR = 11.39; 95% CI: 3.51-36.89; <i>p</i> < 0.0001).</p><p><strong>Conclusion: </strong>Initiation of hemodialysis with AKI has improved survival in patients with different complications.</p>","PeriodicalId":14177,"journal":{"name":"International Journal of Nephrology","volume":null,"pages":null},"PeriodicalIF":1.7000,"publicationDate":"2022-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484972/pdf/","citationCount":"1","resultStr":"{\"title\":\"Predictors of Mortality in Adults with Acute Kidney Injury Requiring Dialysis: A Cohort Analysis.\",\"authors\":\"Charles Kangitsi Kahindo, Olivier Mukuku, Vieux Momeme Mokoli, Ernest Kiswaya Sumaili, Stanis Okitotsho Wembonyama, Zacharie Kibendelwa Tsongo\",\"doi\":\"10.1155/2022/7418955\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Acute kidney injury (AKI) requiring renal replacement therapy is accompanied by considerable mortality. This present study evaluated predictors of mortality at initiation of hemodialysis (HD) in AKI patients in Goma (in the Democratic Republic of the Congo (DRC)).</p><p><strong>Methods: </strong>A single-centre cohort survey evaluated the clinical profile and survival rates of AKI patients admitted to HD in the only HD centre in Goma, North Kivu province (DRC). Data were collected from patients who underwent HD for AKI. Patient demographics, comorbidities, clinical presentation, laboratory tests, and mortality were reviewed and analyzed. The survival study used the Kaplan-Meier curve. Predictors of mortality were evaluated using Cox regression.</p><p><strong>Results: </strong>Of the 131 eligible patients, the mean age was 43.69 ± 16.56 years (range: 18-90 years). Men represented 54.96% of the cohort. The overall HD mortality rate was 25.19% (<i>n</i> = 33). In multivariate analysis, independent predictors of mortality in AKI stage 3 patients admitted to HD were as follows: age ≥ 60 years (adjusted hazard ratio (AHR) = 15.89; 95% CI: 3.98-63.40; <i>p</i> < 0.0001), traditional herbal medicine intake (AHR = 5.10; 95% CI: 2.10-12.38; <i>p</i> < 0.0001), HIV infection (AHR = 5.55; 95% CI: 1.48-20.73; <i>p</i>=0.011), anemia (AHR = 9.57; 95% CI: 2.08-43.87; <i>p</i>=0.004), hyperkalemia (AHR = 6.23; 95% CI: 1.26-30.72; <i>p</i>=0.025), respiratory distress (AHR = 4.66; 95% CI: 2.07-10.50; <i>p</i> < 0.0001), and coma (AHR = 11.39; 95% CI: 3.51-36.89; <i>p</i> < 0.0001).</p><p><strong>Conclusion: </strong>Initiation of hemodialysis with AKI has improved survival in patients with different complications.</p>\",\"PeriodicalId\":14177,\"journal\":{\"name\":\"International Journal of Nephrology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2022-09-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484972/pdf/\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Nephrology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1155/2022/7418955\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Nephrology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2022/7418955","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
Predictors of Mortality in Adults with Acute Kidney Injury Requiring Dialysis: A Cohort Analysis.
Introduction: Acute kidney injury (AKI) requiring renal replacement therapy is accompanied by considerable mortality. This present study evaluated predictors of mortality at initiation of hemodialysis (HD) in AKI patients in Goma (in the Democratic Republic of the Congo (DRC)).
Methods: A single-centre cohort survey evaluated the clinical profile and survival rates of AKI patients admitted to HD in the only HD centre in Goma, North Kivu province (DRC). Data were collected from patients who underwent HD for AKI. Patient demographics, comorbidities, clinical presentation, laboratory tests, and mortality were reviewed and analyzed. The survival study used the Kaplan-Meier curve. Predictors of mortality were evaluated using Cox regression.
Results: Of the 131 eligible patients, the mean age was 43.69 ± 16.56 years (range: 18-90 years). Men represented 54.96% of the cohort. The overall HD mortality rate was 25.19% (n = 33). In multivariate analysis, independent predictors of mortality in AKI stage 3 patients admitted to HD were as follows: age ≥ 60 years (adjusted hazard ratio (AHR) = 15.89; 95% CI: 3.98-63.40; p < 0.0001), traditional herbal medicine intake (AHR = 5.10; 95% CI: 2.10-12.38; p < 0.0001), HIV infection (AHR = 5.55; 95% CI: 1.48-20.73; p=0.011), anemia (AHR = 9.57; 95% CI: 2.08-43.87; p=0.004), hyperkalemia (AHR = 6.23; 95% CI: 1.26-30.72; p=0.025), respiratory distress (AHR = 4.66; 95% CI: 2.07-10.50; p < 0.0001), and coma (AHR = 11.39; 95% CI: 3.51-36.89; p < 0.0001).
Conclusion: Initiation of hemodialysis with AKI has improved survival in patients with different complications.
期刊介绍：
International Journal of Nephrology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies focusing on the prevention, diagnosis, and management of kidney diseases and associated disorders. The journal welcomes submissions related to cell biology, developmental biology, genetics, immunology, pathology, pathophysiology of renal disease and progression, clinical nephrology, dialysis, and transplantation.
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