Predictors of Mortality in Adults with Acute Kidney Injury Requiring Dialysis: A Cohort Analysis.

IF 1.7 Q3 UROLOGY & NEPHROLOGY

International Journal of Nephrology Pub Date : 2022-09-12 eCollection Date: 2022-01-01 DOI:10.1155/2022/7418955

Charles Kangitsi Kahindo, Olivier Mukuku, Vieux Momeme Mokoli, Ernest Kiswaya Sumaili, Stanis Okitotsho Wembonyama, Zacharie Kibendelwa Tsongo

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引用次数: 1

Abstract

Introduction: Acute kidney injury (AKI) requiring renal replacement therapy is accompanied by considerable mortality. This present study evaluated predictors of mortality at initiation of hemodialysis (HD) in AKI patients in Goma (in the Democratic Republic of the Congo (DRC)).

Methods: A single-centre cohort survey evaluated the clinical profile and survival rates of AKI patients admitted to HD in the only HD centre in Goma, North Kivu province (DRC). Data were collected from patients who underwent HD for AKI. Patient demographics, comorbidities, clinical presentation, laboratory tests, and mortality were reviewed and analyzed. The survival study used the Kaplan-Meier curve. Predictors of mortality were evaluated using Cox regression.

Results: Of the 131 eligible patients, the mean age was 43.69 ± 16.56 years (range: 18-90 years). Men represented 54.96% of the cohort. The overall HD mortality rate was 25.19% (n = 33). In multivariate analysis, independent predictors of mortality in AKI stage 3 patients admitted to HD were as follows: age ≥ 60 years (adjusted hazard ratio (AHR) = 15.89; 95% CI: 3.98-63.40; p < 0.0001), traditional herbal medicine intake (AHR = 5.10; 95% CI: 2.10-12.38; p < 0.0001), HIV infection (AHR = 5.55; 95% CI: 1.48-20.73; p=0.011), anemia (AHR = 9.57; 95% CI: 2.08-43.87; p=0.004), hyperkalemia (AHR = 6.23; 95% CI: 1.26-30.72; p=0.025), respiratory distress (AHR = 4.66; 95% CI: 2.07-10.50; p < 0.0001), and coma (AHR = 11.39; 95% CI: 3.51-36.89; p < 0.0001).

Conclusion: Initiation of hemodialysis with AKI has improved survival in patients with different complications.

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需要透析的急性肾损伤成人死亡率预测因素:一项队列分析。

急性肾损伤(AKI)需要肾脏替代治疗，伴随着相当高的死亡率。本研究评估了戈马(刚果民主共和国)AKI患者开始血液透析(HD)时死亡率的预测因素。方法:一项单中心队列调查评估了在北基伍省戈马唯一的HD中心住院的AKI患者的临床概况和生存率。数据收集自因AKI而接受HD治疗的患者。对患者人口统计、合并症、临床表现、实验室检查和死亡率进行了回顾和分析。生存研究使用Kaplan-Meier曲线。使用Cox回归评估死亡率预测因子。结果:131例符合条件的患者，平均年龄43.69±16.56岁(范围:18-90岁)。男性占队列的54.96%。HD总死亡率为25.19% (n = 33)。在多因素分析中，AKI 3期合并HD患者死亡率的独立预测因素如下:年龄≥60岁(校正风险比(AHR) = 15.89;95% ci: 3.98-63.40;p < 0.0001)，传统草药摄入量(AHR = 5.10;95% ci: 2.10-12.38;p < 0.0001)， HIV感染(AHR = 5.55;95% ci: 1.48-20.73;p=0.011)，贫血(AHR = 9.57;95% ci: 2.08-43.87;p=0.004)、高钾血症(AHR = 6.23;95% ci: 1.26-30.72;p=0.025)、呼吸窘迫(AHR = 4.66;95% ci: 2.07-10.50;p < 0.0001)和昏迷(AHR = 11.39;95% ci: 3.51-36.89;P < 0.0001)。结论:AKI患者开始血液透析可提高不同并发症患者的生存率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Nephrology UROLOGY & NEPHROLOGY-

CiteScore

3.40

自引率

4.80%

发文量

审稿时长

17 weeks

期刊介绍： International Journal of Nephrology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies focusing on the prevention, diagnosis, and management of kidney diseases and associated disorders. The journal welcomes submissions related to cell biology, developmental biology, genetics, immunology, pathology, pathophysiology of renal disease and progression, clinical nephrology, dialysis, and transplantation.