International Journal of Neuroscience最新文献

{"title":"The patients with intrathecal baclofen pump in the age of COVID-19: a single center study.","authors":"Ece Unlu Akyuz, Damla Cankurtaran, Nihal Tezel","doi":"10.1080/00207454.2023.2273769","DOIUrl":"10.1080/00207454.2023.2273769","url":null,"abstract":"<p><strong>Purpose: </strong>Intrathecal baclofen pump treatment is employed in the treatment of various diseases. Despite the benefits of intrathecal baclofen pump, patients may occasionally encounter severe complications. These complications may necessitate urgent assessment or intervention for patients with intrathecal baclofen pumps. This study aimed to evaluate the intrathecal baclofen pump-related problems, the utilization of health services, physical-psychosocial status, and the quality of life of patients with intrathecal baclofen pumps during the coronavirus disease 2019 pandemic.</p><p><strong>Materials and methods: </strong>We conducted a cross-sectional, phone-based survey study between 1 June 2021 and 15 July 2021 with a sample of 23 patients with intrathecal baclofen pumps. The patients' quality of life before the implantation of the pump, after one year of implantation, and during the pandemic was evaluated with the 3-level version of EQ-5D.</p><p><strong>Results: </strong>Catheter migration developed in one of the patients, after which the pump was changed. While the dose of baclofen was altered in eight (38.1%) patients during the pandemic period, the filling period was modified in three (14.3%) patients. While 61.9% of the patients reported that their general health, mobility, spasticity and joint mobility were worse than before the pandemic, 90.5% of the patients stated that their communication and mood were worse than before the pandemic. The 3-level version of EQ-5D and EQ-Visual Analogue Scale scores of the patients were significantly decreased during pandemic (<i>p</i> < .05).</p><p><strong>Conclusions: </strong>Due to the complications of the intrathecal baclofen pump, its management should continue uninterruptedly during the pandemic period.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1594-1600"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49677309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-convulsive status epilepticus versus periodic EEG pattern in sporadic Creutzfeldt-Jakob disease: two sides of the same coin?","authors":"Martina Fanella, Giada Valente, Laura Borrello, Fabiana Marinelli, Martina Bracaglia, Ottavio Di Marco, Filippo Costanzo, Fabrizio Apponi, Roberto De Simone","doi":"10.1080/00207454.2023.2273775","DOIUrl":"10.1080/00207454.2023.2273775","url":null,"abstract":"<p><p>Sporadic Creutzfeldt-Jakob disease is characterized by rapid cognitive and neuropsychiatric impairment. The Heidenhain variant of Creutzfeldt-Jakob disease is known for isolated visual disturbance that precedes other features. Periodic sharp wave complexes on EEG are typical of sporadic Creutzfeldt-Jakob disease, but at the onset, the electroclinical pattern may be unclear and suggest the hypothesis of a non-convulsive status epilepticus. Furthermore, non-convulsive status epilepticus and sporadic Creutzfeldt-Jakob disease could coexist simultaneously. We report the case of a patient admitted to our hospital for progressive psychiatric and cognitive disorders. In the initial phase, based on clinical, EEG, and neuroradiological features, a diagnosis of possible non-convulsive status epilepticus was made. Subsequently, the rapid neurological degeneration led to the diagnosis of Creutzfeldt-Jakob disease confirmed by cerebrospinal fluid real-time quaking-induced conversion. Non-convulsive status epilepticus could mimic Creutzfeldt-Jakob disease or be present in overlap. Antiseizure drugs may be started when the etiology is unclear, but overtreatment should be avoided when invasive treatment protocols fail, and the neurological progression suggests an encephalopathy.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1606-1610"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49677297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exaggerated response to pattern reversal visual evoked potential among migraineurs.","authors":"Ruchi Singh, Nirendra Kumar Rai, Ashish Gupta, Sunil Chouhan, Ankur Joshi, Manish Goyal","doi":"10.1080/00207454.2023.2269472","DOIUrl":"10.1080/00207454.2023.2269472","url":null,"abstract":"<p><strong>Objective: </strong>Visual evoked potential recording has reported ambiguous results among migraineurs, thus the present study explored the association of check-size and reversal rates on the latency and amplitude of pattern reversal VEP among migraineurs.</p><p><strong>Method and material: </strong>Monocular VEP responses for both eyes were recorded in 133 migraineurs and 111 controls. Checkerboard pattern with phase reversal frequency of 0.5, 1, 2 and 4 Hz and check-size of 16 × 16, 32 × 32, 64 × 64 and 128 × 128, i.e. spatial frequency of 0.475, 1.029, 2.056 and 4.112 cycle per degree (cpd) were used to record 100 responses each. Three-minutes gap was given after change of reversal frequency to a higher rate for next cycle of 4 check-size records.</p><p><strong>Result: </strong>A linear increase in latencies was observed with decreasing check-size in both groups, but migraineurs had significantly higher latencies at a given reversal rate. Amplitudes A1 and A2 were higher among migraineurs and amplitude A2 showed an inverted 'U' shaped trend with maximum amplitude at 32 × 32 check size (1.029 cpd) in both groups, with an exaggerated response among migraineurs. Check-size 32 × 32 i.e. spatial frequency of 1.029 behaves differently than other larger or smaller check-sizes.</p><p><strong>Conclusion: </strong>Variable VEP response for different visual stimuli may be due to differential activation of respective retinocortical pathways and cortical areas. The highest amplitude at modest check-size suggests a contributory role of foveal-parafoveal fibres in migraineurs. Exaggerated physiological response to visual stimuli may be responsible for higher amplitudes and prolonged latencies among migraineurs.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1460-1469"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41152549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of extracorporeal shock wave therapy on spasticity, walking and quality of life in poststroke lower limb spasticity: a systematic review and meta-analysis.","authors":"Binash Afzal, Rabiya Noor, Nazia Mumtaz, Muhammad Salman Bashir","doi":"10.1080/00207454.2023.2271164","DOIUrl":"10.1080/00207454.2023.2271164","url":null,"abstract":"<p><strong>Objective: </strong>To determine the effects of extracorporeal shock wave therapy (ESWT) on lower limb function, walking, and quality of life in patients with lower limb poststroke spasticity.</p><p><strong>Data sources: </strong>A comprehensive and systematic electronic database search of PubMed, Web of Science, ProQuest thesis Dissertation checks, Google Scholar was conducted from January 2010 to March 2022.</p><p><strong>Review method: </strong>Initially, the bibliography was screened to identify randomized and nonrandomized controlled trials evaluating the effects of ESWT on lower limb spasticity and functional outcomes in stroke patients. Two reviewers independently screened the title and abstract, full-text articles, extracted data, and assessed the quality of the selected studies. The primary evaluation outcome was spasticity assessed by Modified Ashworth Scale (MAS), and the secondary outcomes were walking performance and quality of life measured on different scales.</p><p><strong>Data synthesis: </strong>Out of the total of 483 records, 15 studies (389 participants) were finally found eligible for inclusion. A meta-analysis was performed and beneficial effects of ESWT were observed in the experimental group compared with the control group on spasticity. MAS: Standard mean difference (SMD = 0.626), (95%CI = -0.133, 1.119), (<i>p</i> < 0.01), ROM: (SMD = 0.573), (95%CI = 0.074, 1.072), (<i>p</i> < 0.02). The result for before and after ESWT application on TUG: (SMD = 0.174), (95%CI=-0.151, 0.499), (<i>p</i> = 0.29). The results for walking performance were not significant and inconclusive which may be due to the heterogeneity of the studies included.</p><p><strong>Conclusion: </strong>Evidence suggests that ESWT has promising effects in reducing spasticity and improving lower limb motor function. However, uncertainty exists regarding its effectiveness in walking performance.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1503-1517"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41201032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The best indices of anaesthesia depth monitored by electroencephalogram in different age groups.","authors":"Feixiang Li, Bingqing Gong, Huaichen Sheng, Zichen Song, Yonghao Yu, Yongyan Yang","doi":"10.1080/00207454.2024.2432893","DOIUrl":"10.1080/00207454.2024.2432893","url":null,"abstract":"<p><p><b>Introduction:</b> Current electroencephalogram (EEG) indices for monitoring the depth of anaesthesia have not been adjusted for age. This study aims to identify the most suitable EEG indices for monitoring anaesthesia depth across different age groups.</p><p><p><b>Method:</b> In here, we conducted a prospective observational trial to observe whether different EEG features in different age groups can detect anaesthesia depth and compare their performance.</p><p><p><b>Results:</b> In Group 1, absolute θ had the highest prediction probability (Pk) value (0.78 ± 0.07), while relative <i>γ</i> had the lowest relative coefficient of variation (CV) value in states 1 (0.160), 2 (0.153), 3 (0.214) and 4 (0.144). In Group 2, absolute <i>θ</i> had the highest Pk value (0.81 ± 0.09), and relative <i>γ</i> had the lowest CV value in states 1 (0.159), 2 (0.178), 3 (0.140) and 4 (0.095). In Group 3, absolute δ had the highest Pk value (0.79 ± 0.08), with absolute slow wave having the lowest CV value in States 1 (0.196), 2 (0.258), 3 (0.295) and 4 (0.181). In Group 4, absolute δ had the highest Pk value (0.75 ± 0.10), and absolute slow wave had the lowest CV value in States 1 (0.176), 2 (0.192), 3 (0.185) and 4 (0.144).</p><p><p><b>Conclusion:</b> In this study, we found that absolute <i>θ</i> and relative <i>γ</i> are the most suitable choices for young and middle-aged patients, while absolute <i>δ</i> and absolute slow wave are the most suitable choices for young elderly and elderly patients.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"40 Hz binaural beats entrainment enhances the mood and cognition of medical students.","authors":"Rubina Shakya, Piotr Suffczynski, Sachin Shrestha, Srijana Dangol, Prithuja Poudyal, Dil Islam Mansur","doi":"10.1080/00207454.2024.2429495","DOIUrl":"10.1080/00207454.2024.2429495","url":null,"abstract":"<p><p><b>Background:</b> Many medical students experience psychological distress from high academic demands, potentially harming their performance and mental health. Binaural beats (BB) stimulation, particularly gamma band entrainment, has been suggested to enhance neural communication, cognition, and reduce anxiety.</p><p><p><b>Objective:</b> This study aimed to determine whether 40 Hz BB could improve cognitive performance and mood in medical students.</p><p><p><b>Method:</b> Forty participants, selected based on the inclusion criteria of good health, normal hearing, and no mental illness were recruited considering factors such as all sessions availability and consent. Participants listened to BB for 15 min, three times a week, over three consecutive weeks. Electroencephalogram recordings confirmed that 40 Hz BB induced gamma neural oscillations in the brain. Emotional states were assessed using the 32-item Brunel Mood Scale (BRUMS) with ratings on a 5-point Likert scale, whereas cognitive function was measured with the Stroop's test, based on reaction time in milliseconds. Pre- and post-BB comparisons and gender-related differences were analyzed using paired and unpaired t-tests or appropriate non-parametric tests.</p><p><p><b>Result:</b> Listening to BB significantly reduced negative emotions (<i>p</i> < 0.001), enhanced positive emotions (<i>p</i> < 0.001), and facilitated improvements in cognitive performance. However, the effects of BB were gender-specific, with female students showing greater improvements in 'happiness' and 'calmness', (<i>p</i> < 0.001), while males experienced more pronounced enhancements in cognitive performance (<i>p</i> < 0.001). Additionally, time-dependent effects of BB were also observed.</p><p><p><b>Conclusion:</b> 40 Hz BB appears to be an effective tool for helping students manage their challenges calmly and more efficiently.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1-13"},"PeriodicalIF":1.7,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction.","authors":"","doi":"10.1080/00207454.2024.2410086","DOIUrl":"https://doi.org/10.1080/00207454.2024.2410086","url":null,"abstract":"","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1"},"PeriodicalIF":1.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction.","authors":"","doi":"10.1080/00207454.2024.2410079","DOIUrl":"https://doi.org/10.1080/00207454.2024.2410079","url":null,"abstract":"","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1"},"PeriodicalIF":1.7,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible involvement of GABAergic system on central amygdala Mediated anxiolytic effect of agmatine in rats.","authors":"Nikhilesh P Paliwal, Brijesh G Taksande, Shirish P Jain, Sachin P Borikar","doi":"10.1080/00207454.2023.2268262","DOIUrl":"10.1080/00207454.2023.2268262","url":null,"abstract":"<p><strong>Objectives: </strong>To study the pharmacological interactions between agmatine and gamma aminobutyric acid (GABA) modulatory agents in the regulation of anxiety-like behavior in rats.</p><p><strong>Materials and methods: </strong>Male Wistar rats were treated drugs per se or in combination and 15 min after last injection were subjected to elevated plus-maze (EPM) test. Anxiety-like behavior was evaluated by measuring behavioral conventional readout, open arm activity (duration and/or entries) for 5-minute duration.</p><p><strong>Results: </strong>Acute intra-central amygdala (CeA) injection of agmatine (0.1-0.6 μmol/site/rat), muscimol (0.25-1 nmol/site/rat), diazepam (5-20 μg/site/rat) and allopregnanolone (2-8 μg/site/rat) increased open arm entries of the rats in EPM suggesting anxiolytic effect in dose dependent manner. Moreover, the anxiolytic effect at subeffective dose of agmatine (0.1 μmol/site/rat) was potentiated by subeffective dose of muscimol (0.25 nmol/site/rat), diazepam (5 μg/site/rat) and allopregnanolone (4 μg/site/rat). Whereas, pretreatment with GABA_A receptor antagonist, bicuculline (10 ng/site/rat) blocked the anxiolytic effect of agmatine and its synergistic effect of agmatine plus muscimol. Similarly, benzodiazepine (BZD) receptor antagonist, flumazenil (15 μg/site/rat) and GABA allosteric modulator antagonist, RO 15-45 13 (10 μg/site/rat) reduced the anxiolytic effect of agmatine, given alone and with diazepam and allopregnanolone, respectively.</p><p><strong>Conclusion: </strong>These results indicated that anxiolytic effect of agmatine is medicated via GABAergic mechanisms, probably conciliated by the GABA_A receptor subtypes. Modulation of interplay between agmatine and GABA_A receptor activity might be a pertinent solution for the regulation of anxiety.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1346-1356"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41141573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of patient with GFAP-IgG: a review of 31 patients from two tertiary referral centers in China.","authors":"Qiang Liu, Xiao Yang, Jingzi Zhang Bao, Boya Ma, Xiaoyan Niu, Xu Wang, Qing Zhang, Chao Quan","doi":"10.1080/00207454.2023.2277664","DOIUrl":"10.1080/00207454.2023.2277664","url":null,"abstract":"<p><strong>Objective: </strong>This study presents a comprehensive analysis of the clinical characteristics of 31 patients exhibiting cerebrospinal fluid (CSF) and/or serum positivity for GFAP-IgG, with a specific emphasis on 24 cases demonstrating only GFAP-IgG positivity. The investigation thoroughly evaluates their clinical, radiological, and laboratory features, as well as treatment responses, with the objective of offering clinicians potential diagnostic and therapeutic approaches.</p><p><strong>Methods: </strong>A total of 31 patients with GFAP-IgG in the CSF and/or serum were registered between August 2016 and August 2021 at the General Hospital of Ningxia Medical University and Huashan Hospital of Fudan University. We retrospectively reviewed their clinical records.</p><p><strong>Results: </strong>Overall, the patients were positive with GFAP-IgG in their CSF (15/31), in serum (6/31), and both CSF and serum (10/31). Among them, two were eventually diagnosed with astroglioma and primary central nervous system lymphoma, respectively; one patient had typical multiple sclerosis; three exhibited overlapping GFAP-IgG and aquaporin-4-IgG (AQP4-IgG); and one patient was coexisting N-methyl-D-aspartate receptor IgG. The remaining 24 patients were only GFAP-IgG positive. In total, 22 out of the 24 patients had abnormal MRI outcomes, involving the brain, meninges, and spinal cord. Besides, seven of the 24 patients developed optic neuritis. The CSF protein levels positively correlated with the Expanded Disability Status Scale score (EDSSs). Significantly decreased EDSSs, modified Rankin Scale score, GFAP-IgG titer, CSF protein level, and CSF white blood cell counts were observed after immunomodulatory therapy.</p><p><strong>Conclusion: </strong>The clinical manifestations of GFAP-IgG exhibit a wide range of phenotypes that lack specificity. These findings emphasize the significance of not exclusively relying on the presence of antibodies to diagnose GFAP-A, but rather integrating them with the clinical phenotypes. GFAP-IgG testing enables the diagnosis of autoimmune GFAP astrocytopathy, a treatable autoimmune disease affecting the central nervous system. This condition provides opportunities for investigating innovative mechanisms of CNS autoimmunity and inflammation.</p>","PeriodicalId":14161,"journal":{"name":"International Journal of Neuroscience","volume":" ","pages":"1383-1394"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66783856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}