Zidan Gao, Zhuoma Danzhen, Junyu Zhu, Yao Li, Zhu Xu, Lan Chu
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引用次数: 0
摘要
目的目的：探讨中国贵州多发性硬化症（MS）患者血清维生素 D 水平与嗅觉障碍之间的可能关系：方法：我们纳入了2021年2月至2021年9月期间从贵州医科大学附属医院招募的25名多发性硬化症患者和18名健康对照组（HCs）。采用宾夕法尼亚大学嗅觉识别试验（UPSIT）测试患者的嗅觉，并测定血清25-羟乙基多聚蛋白D的水平：结果：血清维生素 D 水平和 UPSIT 评分在多发性硬化症组和对照组之间存在显著差异（均为 p p = 0.021）：结论：血清维生素D水平可能参与调节贵州MS患者的嗅觉功能障碍。
Vitamin D levels and olfactory dysfunction in multiple sclerosis patients.
Objective: The objective was to explore the possible relationship between the serum vitamin D level and olfactory impairment in a population of multiple sclerosis (MS) patients in Guizhou, China.
Methods: We included 25 patients with MS and 18 healthy controls (HCs) who were recruited from the Affiliated Hospital of Guizhou Medical University from February 2021 to September 2021. The University of Pennsylvania Smell Identification Test (UPSIT) was used to test the patients' sense of smell, and the level of serum 25-hydroxyethylene polyprotein D was measured.
Results: Serum vitamin D levels and UPSIT scores were significantly different between the MS group and the control group (both p < 0.001). Moreover, a significant positive correlation emerged between vitamin D levels and UPSIT scores in MS patients (r = 0.537, p = 0.021).
Conclusions: The serum vitamin D level may be involved in the regulation of olfactory dysfunction in MS patients in Guizhou, China.
期刊介绍：
The International Journal of Neuroscience publishes original research articles, reviews, brief scientific reports, case studies, letters to the editor and book reviews concerned with problems of the nervous system and related clinical studies, epidemiology, neuropathology, medical and surgical treatment options and outcomes, neuropsychology and other topics related to the research and care of persons with neurologic disorders. The focus of the journal is clinical and transitional research. Topics covered include but are not limited to: ALS, ataxia, autism, brain tumors, child neurology, demyelinating diseases, epilepsy, genetics, headache, lysosomal storage disease, mitochondrial dysfunction, movement disorders, multiple sclerosis, myopathy, neurodegenerative diseases, neuromuscular disorders, neuropharmacology, neuropsychiatry, neuropsychology, pain, sleep disorders, stroke, and other areas related to the neurosciences.
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