Effects of Solitaire AB stent thrombectomy with tirofiban and butylphthalide on neurological function and inflammatory factors in acute cerebral infarction patients.

IF 1.7 4区医学 Q4 NEUROSCIENCES

International Journal of Neuroscience Pub Date : 2024-02-29 DOI:10.1080/00207454.2024.2309464

Le Bao, Ying Liu, Long Chen, Fei Wang, Yuzhi Zhu, Shuang Liang, Youbin Wang, Hetai Quan, Pengfei Li

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引用次数: 0

Abstract

Background: Acute cerebral infarction profoundly affects patients' neurological function and quality of life. This study explores the impact of Solitaire AB stent thrombectomy, combined with tirofiban and butylphthalide, on neurological function and inflammatory factors in patients with acute cerebral infarction.

Methods: Seventy-three eligible patients treated between 2021 and 2023 were divided into a control group (Solitaire AB stent thrombectomy) and a treatment group (Solitaire AB stent thrombectomy with tirofiban and butylphthalide). Postoperative neurological function scores and inflammatory factor levels were analyzed.

Results: The treatment group demonstrated a higher clinical effective rate, lower National Institutes of Health Stroke Scale scores at one day and seven days and higher Mini-Mental State Examination and Montreal Cognitive Assessment scores post-treatment. Inflammatory factor levels (Neuron Specific Enolase (NSE), S100-β, TNF-α and IL-6) were lower in the treatment group. No significant differences in adverse outcomes were observed.

Conclusion: Solitaire AB stent thrombectomy with tirofiban and butylphthalide shows superior efficacy, improving neurological function and inflammatory factors without increasing adverse outcomes. This offers valuable insights for clinical treatment of acute cerebral infarction.

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使用替罗非班和丁苯酞的 Solitaire AB 支架血栓切除术对急性脑梗塞患者神经功能和炎症因子的影响

背景：急性脑梗塞严重影响患者的神经功能和生活质量。本研究探讨了 Solitaire AB 支架血栓切除术联合替罗非班和丁苯酞对急性脑梗死患者神经功能和炎症因子的影响：将在2021年至2023年间接受治疗的73名符合条件的患者分为对照组（Solitaire AB支架血栓切除术）和治疗组（Solitaire AB支架血栓切除术联合替罗非班和丁苯酞）。对术后神经功能评分和炎症因子水平进行了分析：结果：治疗组的临床有效率更高，1d和7d的NIHSS评分更低，治疗后的MMSE和MoCA评分更高。治疗组的炎症因子水平（NSE、S100-β、TNF-α 和 IL-6）更低。结论：Solitaire AB支架血栓形成治疗组与对照组无明显差异：结论：使用替罗非班和丁苯酞进行Solitaire AB支架血栓切除术显示出卓越的疗效，在改善神经功能和炎症因子的同时不会增加不良后果。这为急性脑梗塞的临床治疗提供了宝贵的启示。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Neuroscience 医学-神经科学

CiteScore

5.10

自引率

0.00%

发文量

132

审稿时长

2 months

期刊介绍： The International Journal of Neuroscience publishes original research articles, reviews, brief scientific reports, case studies, letters to the editor and book reviews concerned with problems of the nervous system and related clinical studies, epidemiology, neuropathology, medical and surgical treatment options and outcomes, neuropsychology and other topics related to the research and care of persons with neurologic disorders. The focus of the journal is clinical and transitional research. Topics covered include but are not limited to: ALS, ataxia, autism, brain tumors, child neurology, demyelinating diseases, epilepsy, genetics, headache, lysosomal storage disease, mitochondrial dysfunction, movement disorders, multiple sclerosis, myopathy, neurodegenerative diseases, neuromuscular disorders, neuropharmacology, neuropsychiatry, neuropsychology, pain, sleep disorders, stroke, and other areas related to the neurosciences.