International Journal of Molecular Sciences最新文献_第9页

Chitosan Biomaterials: Advances and Challenges-2nd Edition. 壳聚糖生物材料：进展与挑战-第二版。

IF 5.6 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-05-19 DOI: 10.3390/ijms26104836

Lăcrămioara Popa, Mihaela Violeta Ghica, Cristina-Elena Dinu-Pîrvu

引用次数: 0

Exploring the Multifunctional Role of Alpha-Fetoprotein in Cancer Progression: Implications for Targeted Therapy in Hepatocellular Carcinoma and Beyond. 探索甲胎蛋白在癌症进展中的多功能作用：肝细胞癌及其他疾病靶向治疗的意义。

IF 5.6 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-05-19 DOI: 10.3390/ijms26104863

Hyunjung Kim, Minji Jang, Eunmi Kim

{"title":"Exploring the Multifunctional Role of Alpha-Fetoprotein in Cancer Progression: Implications for Targeted Therapy in Hepatocellular Carcinoma and Beyond.","authors":"Hyunjung Kim, Minji Jang, Eunmi Kim","doi":"10.3390/ijms26104863","DOIUrl":"https://doi.org/10.3390/ijms26104863","url":null,"abstract":"Alpha-fetoprotein (AFP) is a well-known biomarker for liver cancer, and its clinical utility is widely recognized. Recent studies have revealed that AFP plays a multifaceted role in various malignant tumors, including liver cancer. This suggests that AFP is not merely a biomarker but also contributes significantly to the complex process of tumor formation, emphasizing the importance of targeting AFP in therapeutic approaches. Consequently, innovative research and development are essential to overcome the current limitations of AFP-targeted therapies, enhance treatment efficacy, and minimize side effects. This review explores the role of AFP in cancer development and progression, highlights the biological functions of AFP and related pathways, and discusses the clinical implications of AFP-targeted therapies. Ongoing research on AFP will significantly contribute to our understanding of the biological mechanisms of cancer and aid in developing effective and safe treatments. Ultimately, advancements in AFP-targeted therapeutic approaches are expected to play a crucial role in the future of cancer management.","PeriodicalId":14156,"journal":{"name":"International Journal of Molecular Sciences","volume":"26 10","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genome-Wide Analysis of bZIP Transcription Factor Family and Its Expression in Graft Healing of Soapberry (Sapindus mukorossi Gaertn.). bZIP转录因子家族的全基因组分析及其在接枝愈合中的表达。

IF 5.6 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-05-19 DOI: 10.3390/ijms26104862

Na Chen, Lixian Wang, Jing Zhong, Liming Jia, Zhong Chen

{"title":"Genome-Wide Analysis of bZIP Transcription Factor Family and Its Expression in Graft Healing of Soapberry (Sapindus mukorossi Gaertn.).","authors":"Na Chen, Lixian Wang, Jing Zhong, Liming Jia, Zhong Chen","doi":"10.3390/ijms26104862","DOIUrl":"https://doi.org/10.3390/ijms26104862","url":null,"abstract":"The Basic Leucine Zipper (bZIP) transcription factors play a vital role in plant responses to abiotic stress. Despite being studied in various plant species, the function of the bZIP gene family in Soapberry (Sapindus mukorossi Gaertn.), a significant tree species for forestry biomass energy, remains unclear. In this study, we conducted a genome-wide analysis of the bZIP gene family in Soapberry, based on the observation that bZIP transcription factors were enriched in the transcriptome data of Soapberry-grafted stem segments, as revealed by both GO and KEGG analyses. For the first time, we identified 31 SmbZIPs and provided detailed information regarding their physicochemical characteristics, gene structures, protein motifs, phylogenetic relationships, cis-regulatory elements (CREs), and predicted transcriptional regulatory networks. According to our prediction of the SmbZIP-mediated regulatory network and CREs in the promoter region, SmbZIPs may be associated with plant growth and development as well as responses to mechanical wounding stress. By integrating RT-qPCR and RNA-seq analyses, we determined that the expression patterns of SmbZIPs were specific to the graft-healing stages and locations. In conclusion, our study elucidates the potential role of the bZIP gene family in responding to plant wounding stress and facilitating graft healing, thereby providing valuable insights for future functional genomics studies of Soapberry.","PeriodicalId":14156,"journal":{"name":"International Journal of Molecular Sciences","volume":"26 10","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Black Soldier Fly Larvae Oil on Immunometabolic Processes. 黑虻幼虫油对免疫代谢过程的影响。

IF 5.6 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-05-19 DOI: 10.3390/ijms26104855

Hadas Inbart Richter, Ofer Gover, Amit Hamburg, Keren Bendalak, Tamar Ziv, Betty Schwartz

{"title":"Impact of Black Soldier Fly Larvae Oil on Immunometabolic Processes.","authors":"Hadas Inbart Richter, Ofer Gover, Amit Hamburg, Keren Bendalak, Tamar Ziv, Betty Schwartz","doi":"10.3390/ijms26104855","DOIUrl":"https://doi.org/10.3390/ijms26104855","url":null,"abstract":"The oil extract derived from black soldier fly (Hermetia illucens) larvae (BSFL) is characterized by a distinctive fatty acid composition and bioactive compounds with demonstrated anti-inflammatory properties, as shown in our previous work. The present study aims to mechanistically explore the immunomodulatory effects of a saponified form of BSFL oil (MBSFL) and its potential interaction with metabolic signaling pathways. Using Pam3CSK4-polarized M1 primary human peripheral blood mononuclear cells (PBMCs), we demonstrate that MBSFL phenotypically suppressed the secretion of pro-inflammatory cytokines TNFα, IL-6, IL-17, and GM-CSF (p < 0.01) without altering anti-inflammatory cytokine levels (TGFβ1, IL-13, and IL-4). A phosphoproteomic analysis of Pam3CSK4-stimulated THP-1 macrophages revealed MBSFL-mediated downregulation of CK2 and ERK kinases (p < 0.05), key regulators of NF-κB signaling activation. We confirmed that MBSFL directly inhibits NF-κB p65 nuclear translocation (p < 0.05), using both immunofluorescence staining and a western blot analysis of nuclear and cytoplasmic fractions. In the context of metabolism, using a luciferase reporter assay, we demonstrate that MBSFL functions as a weak agonist of PPARγ and PPARδ (p < 0.05), which are nuclear receptors involved in lipid metabolism and immune regulation. However, subsequent immunoblotting revealed a macrophage polarization-dependent regulation: MBSFL upregulated PPARγ in M0 macrophages but did not prevent its suppression upon Pam3CSK4 stimulation, whereas it specifically enhanced PPARδ expression during M1 polarization (p < 0.05). This study provides novel experimental evidence supporting our hypothesis of MBSFL's role in immunometabolism. We demonstrate for the first time that MBSFL acts as a dual regulator by suppressing NF-κB-mediated inflammation while promoting PPARδ activity-an inverse relationship with potential relevance to immunometabolic disorders.","PeriodicalId":14156,"journal":{"name":"International Journal of Molecular Sciences","volume":"26 10","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melanoma Glycome Regulates the Pro-Oncogenic Properties of Extracellular Galectin-3. 黑色素瘤Glycome调节细胞外半乳糖凝集素-3的促癌特性。

IF 5.6 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-05-19 DOI: 10.3390/ijms26104882

Norhan B B Mohammed, Rajib K Shil, Charles J Dimitroff

{"title":"Melanoma Glycome Regulates the Pro-Oncogenic Properties of Extracellular Galectin-3.","authors":"Norhan B B Mohammed, Rajib K Shil, Charles J Dimitroff","doi":"10.3390/ijms26104882","DOIUrl":"https://doi.org/10.3390/ijms26104882","url":null,"abstract":"Metastatic melanoma is an aggressive skin cancer with a five-year survival rate of only 35%. Despite recent advances in immunotherapy, there is still an urgent need for the development of innovative therapeutic approaches to improve clinical outcomes of patients with metastatic melanoma. Prior research from our laboratory revealed that loss of the I-branching enzyme β1,6 N-acetylglucosaminyltransferase 2 (GCNT2), with consequent substitution of melanoma surface I-branched poly-N-acetyllactosamines (poly-LacNAcs) with i-linear poly-LacNAcs, is implicated in driving melanoma metastasis. In the current study, we explored the role of galectin-3 (Gal-3), a lectin that avidly binds surface poly-LacNAcs, in dictating melanoma aggressive behavior. Our results show that Gal-3 favors binding to i-linear poly-LacNAcs, while enforced GCNT2/I-branching disrupts this interaction, thereby suppressing Gal-3-dependent malignant characteristics, including extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) pathway activation, BCL2 expression, cell proliferation, and migration. This report establishes the crucial role of extracellular Gal-3 interactions with i-linear glycans in promoting melanoma cell aggressiveness, placing GCNT2 as a tumor suppressor protein and suggesting both extracellular Gal-3 and i-linear glycans as potential therapeutic targets for metastatic melanoma.","PeriodicalId":14156,"journal":{"name":"International Journal of Molecular Sciences","volume":"26 10","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topical Molecular Iodine: An Optimal Biocide Constrained by Inadequate Formulations. 局部分子碘：受配方不足限制的最佳杀菌剂。

IF 5.6 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-05-19 DOI: 10.3390/ijms26104853

Jack Kessler, Sarah E Hooper

{"title":"Topical Molecular Iodine: An Optimal Biocide Constrained by Inadequate Formulations.","authors":"Jack Kessler, Sarah E Hooper","doi":"10.3390/ijms26104853","DOIUrl":"https://doi.org/10.3390/ijms26104853","url":null,"abstract":"The only biocidal iodine species in topical iodine disinfectants is molecular iodine (I2). I2, a biomolecule, has broad-spectrum antimicrobial activity and does not generate resistance. Physicians, regulatory agencies, and scientists have assumed that I2 is responsible for the skin staining and irritation associated with the clinical use of iodine disinfectants; this assumption is deeply embedded in the medical community but is not supported with empirical data. This study provides the first experimental data that measure the biocompatibility of I2 with human skin. Human skin explants in tissue culture were evaluated at 3, 7, and 24 h after being exposed to I2 (500 to 15,000 ppm). Cell viability was measured relative to phosphate-buffered saline using 3-[4,5-dimethylthiazol-2yl]-2,5-diphenyl-tetrazolium bromide (MTT). The biocidal activity of I2 vapor emitted from silicone was demonstrated against bacteria growing on agar to confirm I2 off-gassing from skin was an active biocide. Additionally, statistically significant bacterial reductions with both gas and solution phase I2 were observed in a static and dynamic five-species wound biofilm. The data suggest that high, e.g., 50-5000 ppm, levels of I2 should be incorporated into topical iodine disinfectants instead of the very low (0.2-10 ppm) levels found in 10% povidone iodine products currently in use.","PeriodicalId":14156,"journal":{"name":"International Journal of Molecular Sciences","volume":"26 10","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dumpling GNN: Hybrid GNN Enables Better ADC Payload Activity Prediction Based on the Chemical Structure. 饺子型GNN：混合GNN基于化学结构实现更好的ADC有效载荷活动预测。

IF 5.6 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-05-19 DOI: 10.3390/ijms26104859

Shengjie Xu, Lingxi Xie, Rujie Dai, Zehua Lyu

{"title":"Dumpling GNN: Hybrid GNN Enables Better ADC Payload Activity Prediction Based on the Chemical Structure.","authors":"Shengjie Xu, Lingxi Xie, Rujie Dai, Zehua Lyu","doi":"10.3390/ijms26104859","DOIUrl":"https://doi.org/10.3390/ijms26104859","url":null,"abstract":"Antibody-drug conjugates (ADCs) are promising cancer therapeutics, but optimizing their cytotoxic payloads remains challenging. We present DumplingGNN, a novel hybrid Graph Neural Network architecture for predicting ADC payload activity and toxicity. Integrating MPNN, GAT, and GraphSAGE layers, DumplingGNN captures multi-scale molecular features using both 2D and 3D structural information. Evaluated on a comprehensive ADC payload dataset and MoleculeNet benchmarks, DumplingGNN achieves state-of-the-art performance, including BBBP (96.4% ROC-AUC), ToxCast (78.2% ROC-AUC), and PCBA (88.87% ROC-AUC). On our specialized ADC payload dataset, it demonstrates 91.48% accuracy, 95.08% sensitivity, and 97.54% specificity. Ablation studies confirm the hybrid architecture's synergy and the importance of 3D information. The model's interpretability provides insights into structure-activity relationships. DumplingGNN's robust toxicity prediction capabilities make it valuable for early safety evaluation and biomedical regulation. As a research prototype, DumplingGNN is being considered for integration into Omni Medical, an AI-driven drug discovery platform currently under development, demonstrating its potential for future practical applications. This advancement promises to accelerate ADC payload design, particularly for Topoisomerase I inhibitor-based payloads, and improve early-stage drug safety assessment in targeted cancer therapy development.","PeriodicalId":14156,"journal":{"name":"International Journal of Molecular Sciences","volume":"26 10","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioimaging and Sensing Properties of Curcumin and Derivatives. 姜黄素及其衍生物的生物成像和传感特性。

IF 5.6 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-05-19 DOI: 10.3390/ijms26104871

Chiara Maria Antonietta Gangemi, Salvatore Mirabile, Maura Monforte, Anna Barattucci, Paola Maria Bonaccorsi

{"title":"Bioimaging and Sensing Properties of Curcumin and Derivatives.","authors":"Chiara Maria Antonietta Gangemi, Salvatore Mirabile, Maura Monforte, Anna Barattucci, Paola Maria Bonaccorsi","doi":"10.3390/ijms26104871","DOIUrl":"https://doi.org/10.3390/ijms26104871","url":null,"abstract":"Curcumin (Cur) is one of the most studied natural polyphenolic compounds, with many pharmacological properties and a luminescent skeleton. Natural fluorescent molecules are peculiar tools in nanomedicine for bioimaging and sensing, and this review focuses on the photophysical properties and applications of Cur in these biomedical fields. The first part of the review opens with a description of the Cur chemical skeleton and its connection with the luminescent nature of this molecule. The 1,6-heptadiene-3,5-dionyl chain causes the involvement of Cur in a keto-enol tautomerism, which influences its solvatochromism. The polyphenolic nature of its skeleton justifies the Cur generation of singlet oxygen and ROS upon photoexcitation, and this is responsible for the photophysical processes that may be related to the photodynamic therapy (PDT) effects of Cur. In the second part of the review, bioimaging based on Cur derivatives is reviewed, with a deeper attention paid to the molecular diagnostic and nano-formulations in which Cur is involved, either as a drug or a source of fluorescence. Theragnostics is an innovative idea in medicine based on the integration of diagnosis and therapy with nanotechnology. The combination of diagnostics and therapy provides optimal and targeted treatment of the disease from its early stages. Curcumin has been involved in a series of nano-formulations exploiting its pharmacological and photophysical characteristics and overcoming its strong lipophilicity using biocompatible nanomaterials. In the third part of the review, modifications of the Cur skeleton were employed to synthesize probes that change their color in response to specific stimuli as a consequence of the trapping of specific molecules. Finally, the methodologies of sensing biothiols, anions, and cations by Cur are described, and the common features of such luminescent probes reveal how each modification of the skeleton can deeply influence its natural luminescence.","PeriodicalId":14156,"journal":{"name":"International Journal of Molecular Sciences","volume":"26 10","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Icariin Ameliorates Cyclophosphamide-Induced Renal Encephalopathy by Modulating the NF-κB and Keap1-Nrf2 Signaling Pathways. 淫羊藿苷通过调节NF-κB和Keap1-Nrf2信号通路改善环磷酰胺诱导的肾性脑病

IF 5.6 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-05-19 DOI: 10.3390/ijms26104838

Meiling Shi, Hong Kan, Yijia Tang, Lanshi Tian, Xiangjuan Guo, Weijia Chen, Jianan Geng, Ying Zong, Yunfeng Bi, Zhongmei He

{"title":"Icariin Ameliorates Cyclophosphamide-Induced Renal Encephalopathy by Modulating the NF-κB and Keap1-Nrf2 Signaling Pathways.","authors":"Meiling Shi, Hong Kan, Yijia Tang, Lanshi Tian, Xiangjuan Guo, Weijia Chen, Jianan Geng, Ying Zong, Yunfeng Bi, Zhongmei He","doi":"10.3390/ijms26104838","DOIUrl":"https://doi.org/10.3390/ijms26104838","url":null,"abstract":"Chemotherapy-induced renal encephalopathy (RE) is a disease characterized by cognitive impairment of the brain caused by impaired kidney function for which there is no definitive treatment. Icariin (ICA), the main active component of Epimedium, has a good nervous system protection and anti-neuroinflammation effect, but its effect on the brain injury caused by renal insufficiency as a result of chemotherapy remains unclear. In this study, we demonstrated that 100 mg/kg ICA can not only successfully interface with serotonin and regulate hormone levels but also ameliorates kidney damage and cognitive impairment in cyclophosphamide (CTX)-induced RE mouse models and inhibits inflammation, oxidation, and apoptosis by regulating NF-κB, keap1-Nrf2, and apoptosis pathways. In order to further study the protective effect of ICA on RE, we used CTX-induced HT22 and HEK293 cell injury models, and the ICA intervention showed that ICA could prevent apoptosis by regulating the expression of the apoptosis-related proteins caspase-3, Bcl-2, Bax and BDNF. Overall, our study provides a basis for further investigation of the therapeutic potential of ICA in the treatment of neurodegenerative diseases in the context of renal dysfunction, and further studies are needed at a later stage to fully elucidate the underlying molecular mechanisms.","PeriodicalId":14156,"journal":{"name":"International Journal of Molecular Sciences","volume":"26 10","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ketone Bodies in the Regulation of Myocardial Perfusion in Cardiovascular Disease: Metabolic and Vasodilatory Effects. 酮体在心血管疾病心肌灌注调节中的代谢和血管舒张作用。

IF 5.6 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-05-19 DOI: 10.3390/ijms26104856

Afolasayo A Aromiwura, Kara R Gouwens, Daniel C Nguyen, Maryta Sztukowska, Luanne Didelot, Dinesh K Kalra

{"title":"Ketone Bodies in the Regulation of Myocardial Perfusion in Cardiovascular Disease: Metabolic and Vasodilatory Effects.","authors":"Afolasayo A Aromiwura, Kara R Gouwens, Daniel C Nguyen, Maryta Sztukowska, Luanne Didelot, Dinesh K Kalra","doi":"10.3390/ijms26104856","DOIUrl":"https://doi.org/10.3390/ijms26104856","url":null,"abstract":"Ketone bodies (KBs) serve as an alternative energy source for healthy and failing hearts and have important effects on myocardial blood perfusion in both physiological and pathological states. Early animal studies suggest that KBs may provide protective benefits in ischemic heart disease and heart failure. Under normal circumstances, coronary blood flow regulation is an intricate system with contributions from metabolic, autonomic, compressive, and endothelial factors, with the metabolic regulatory pathway being the most significant contributor. We conducted a non-systematic review of studies published between 1987 and 2024. In this review, we explored the physiological autoregulation of normal coronary blood flow, the role of ketone bodies in myocardial perfusion in health and disease, and the potential role of exogenous ketone body supplementation in producing salutary effects on myocardial blood flow (MBF) and metabolism in exercise and cardiac disease states including ischemia, heart failure, and the aging heart. Overall, our findings demonstrated that KBs improve MBF and ejection fraction in healthy human subjects and have beneficial effects on cardiac output and left heart filling pressures in patients with decompensated heart failure. Although resting myocardial blood flow decreases with age, further studies are required to assess the impact of KBs on MBF in aging populations. Additionally, more research is needed to investigate the effects of KBs during exercise and in instances of myocardial ischemia.","PeriodicalId":14156,"journal":{"name":"International Journal of Molecular Sciences","volume":"26 10","pages":""},"PeriodicalIF":5.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0