International Journal of Molecular Sciences最新文献_第3页

ARGOS Genes in Cauliflower: Genome-Wide Identification and Functional Validation of BobARL2 Under Abiotic Stresses. 花椰菜ARGOS基因：BobARL2在非生物胁迫下的全基因组鉴定和功能验证

IF 4.9 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-10-09 DOI: 10.3390/ijms26199810

Mengmeng Duan, Guixiang Wang, Mei Zong, Shuo Han, Ning Guo, Fan Liu

{"title":"ARGOS Genes in Cauliflower: Genome-Wide Identification and Functional Validation of BobARL2 Under Abiotic Stresses.","authors":"Mengmeng Duan, Guixiang Wang, Mei Zong, Shuo Han, Ning Guo, Fan Liu","doi":"10.3390/ijms26199810","DOIUrl":"10.3390/ijms26199810","url":null,"abstract":"The Auxin-Regulated Gene Involved in Organ Size (ARGOS) proteins have crucial regulatory effects on organ size and responses to environmental stresses. Despite their importance, Brassica oleracea ARGOS gene members and their functions in response to abiotic stresses have not been thoroughly investigated. In this study, we identified 40 ARGOS genes via a genome wide analysis of cauliflower and two other B. oleracea morphotypes as well as Brassica rapa, Brassica nigra, and Raphanus sativus. Expression pattern analyses indicated that these genes are responsive to multiple abiotic stresses, including salinity, heat, cold, and diverse hormones. Notably, the expression of an ARGOS-like gene (BobARL2) was upregulated in cauliflower treated with 1-aminocyclopropane-1-carboxylic acid (ACC). Moreover, the overexpression of BobARL2 decreased ethylene sensitivity, resulting in less inhibition of root elongation compared to the wild-type. Additionally, the overexpression lines exhibited enhanced salt tolerance. A yeast two-hybrid assay and luciferase complementation imaging (LCI) assay confirmed that BobARL2 can interact with Reversion-to-ethylene sensitivity Like4 (BobRTL4), which negatively regulates ethylene signal transduction. These findings advance our understanding of the evolution and functional roles of ARGOS genes in cauliflower and other Brassicaceae species, particularly in relation to abiotic stress responses, while also offering valuable insights relevant to the genetic improvement and breeding of novel varieties.","PeriodicalId":14156,"journal":{"name":"International Journal of Molecular Sciences","volume":"26 19","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12524420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Special Issue "Skeletal Muscle Adaptations to Oxidative Stress". 特刊“骨骼肌适应氧化应激”。

IF 4.9 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-10-09 DOI: 10.3390/ijms26199809

Guglielmo Duranti

引用次数: 0

Comparative Analysis of Crystal Violet-Binding Aptamers as Potential Cores for Binary Sensors. 晶体紫结合适体作为二元传感器潜在核心的比较分析。

IF 4.9 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-10-09 DOI: 10.3390/ijms26199833

Gleb A Bobkov, Gleb S Yushkov, Andrei D Kuzmin, Tatiana D Popysheva, Elena I Stepchenkova, Maria S Rubel

引用次数: 0

Metformin Induces Changes in Sphingosine-1-Phosphate-Related Signaling in Diabetic Mice Brain. 二甲双胍诱导糖尿病小鼠脑鞘氨醇-1-磷酸相关信号的变化

IF 4.9 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-10-09 DOI: 10.3390/ijms26199832

Przemysław Leonard Wencel, Kinga Czubowicz, Magdalena Gewartowska, Małgorzata Frontczak-Baniewicz, Robert Piotr Strosznajder

{"title":"Metformin Induces Changes in Sphingosine-1-Phosphate-Related Signaling in Diabetic Mice Brain.","authors":"Przemysław Leonard Wencel, Kinga Czubowicz, Magdalena Gewartowska, Małgorzata Frontczak-Baniewicz, Robert Piotr Strosznajder","doi":"10.3390/ijms26199832","DOIUrl":"10.3390/ijms26199832","url":null,"abstract":"Type 2 diabetes mellitus (T2DM) is a chronic disease that has become a serious health problem worldwide. Moreover, increased systemic and cerebrovascular inflammation is one of the major pathophysiological features of T2DM, and a growing body of evidence emphasizes T2DM with memory and executive function decline. Bioactive sphingolipids regulate a cell's survival, inflammatory response, as well as glucose and insulin signaling/metabolism. Moreover, current research on the role of sphingosine kinases (SPHKs) and sphingosine-1-phosphate receptors (S1PRs) in T2DM is not fully understood, and the results obtained often differ. The aim of the present study was to evaluate the effect of metformin (anti-diabetic agent, MET) on the brain's sphingosine-1-phosphate-related signaling and ultrastructure in diabetic mice. Our results revealed elevated mRNA levels of genes encoding sphingosine kinase 2 (SPHK2) and sphingosine-1-phosphate receptor 3 (S1PR3), which was accompanied by downregulation of sphingosine-1-phosphate receptor 1 (S1PR1) in the hippocampus of diabetic mice. Simultaneously, upregulation of genes encoding pro-inflammatory cytokines interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) was observed. Administration of MET significantly reversed changes in mRNA levels in the hippocampus and reduced Sphk2, Il6, and Tnf, with concomitant upregulation of S1pr1 gene expression. Ultrastructural analysis of diabetic mice hippocampus revealed morphological alterations in neurons, neuropil, and capillaries that were manifested as mitochondria swelling, blurred synaptic structure, and thickened basal membrane of capillaries. The use of MET partially reversed those changes. Our research emphasizes the important role of insulin sensitivity modulation by metformin in the regulation of SPHKs and S1PRs and inflammatory gene expression in a murine model of T2DM.","PeriodicalId":14156,"journal":{"name":"International Journal of Molecular Sciences","volume":"26 19","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12525125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CTCF Mediates the Cis-Regulatory Hubs in Mouse Hearts. CTCF介导小鼠心脏顺式调控中心

IF 4.9 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-10-09 DOI: 10.3390/ijms26199834

Mick Lee, Loïc Mangnier, Cory C Padilla, Dominic Paul Lee, Wilson Tan, Wen Hao Zheng, Louis Hanqiang Gan, Ching Kit Chen, Yee Phong Lim, Rina Miao Qin Wang, Peter Yiqing Li, Yonglin Zhu, Steve Bilodeau, Alexandre Bureau, Roger Sik-Yin Foo, Chukwuemeka George Anene-Nzelu

{"title":"CTCF Mediates the Cis-Regulatory Hubs in Mouse Hearts.","authors":"Mick Lee, Loïc Mangnier, Cory C Padilla, Dominic Paul Lee, Wilson Tan, Wen Hao Zheng, Louis Hanqiang Gan, Ching Kit Chen, Yee Phong Lim, Rina Miao Qin Wang, Peter Yiqing Li, Yonglin Zhu, Steve Bilodeau, Alexandre Bureau, Roger Sik-Yin Foo, Chukwuemeka George Anene-Nzelu","doi":"10.3390/ijms26199834","DOIUrl":"10.3390/ijms26199834","url":null,"abstract":"The 3D chromatin architecture establishes a complex network of genes and regulatory elements necessary for transcriptomic regulation in development and disease. This network can be modeled by cis-regulatory hubs (CRH), which underscore the local functional interactions between enhancers and promoter regions and differ from other higher-order chromatin structures such as topologically associated domains (TAD). The activity-by-contact (ABC) model of enhancer-promoter regulation has been recently used in the identification of these CRHs, but little is known about the role of transcription factor CCTC binding factor (CTCF) on ABC scores and their consequent impact on CRHs. Here, we show that the loss of CTCF leads to a reorganization of the ABC-derived rankings of putative enhancers in the mouse heart, a global reduction in the total number of CRHs and an increase in the size of CRHs. Furthermore, CTCF loss leads to a higher percentage of CRHs that cross TAD boundaries. These results provide additional evidence to support the importance of CTCF in forming the regulatory networks necessary for gene regulation.","PeriodicalId":14156,"journal":{"name":"International Journal of Molecular Sciences","volume":"26 19","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12524426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Signatures of Schizophrenia and Insights into Potential Biological Convergence. 精神分裂症的分子特征和潜在生物学趋同的见解。

IF 4.9 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-10-09 DOI: 10.3390/ijms26199830

Malak Saada, Shani Stern

{"title":"Molecular Signatures of Schizophrenia and Insights into Potential Biological Convergence.","authors":"Malak Saada, Shani Stern","doi":"10.3390/ijms26199830","DOIUrl":"10.3390/ijms26199830","url":null,"abstract":"Schizophrenia is a highly polygenic and clinically heterogeneous disorder. In this paper, we first review layer-specific evidence across genetics, epigenetics, transcriptomics, proteomics, and patient-derived induced pluripotent stem cell (iPSC) models, then integrate cross-layer findings. Genetics research identifies widespread risk architecture. Hundreds of loci from common, rare, and CNV analyses. Epigenetics reveals disease-associated DNA methylation and histone-mark changes. These occur at neuronally active enhancers and promoters, together with chromatin contacts that link non-coding risk to target genes. Transcriptomics show broad differential expression, isoform-level dysregulation, and disrupted co-expression modules. These alterations span synaptic signaling, mitochondrial bioenergetics, and immune programs. Proteomics demonstrates coordinated decreases in postsynaptic scaffold and mitochondrial respiratory-chain proteins in cortex, with complementary inflammatory signatures in serum/plasma. iPSC models recapitulate disease-relevant phenotypes: including fewer synaptic puncta and excitatory postsynaptic currents, electrophysiological immaturity, oxidative stress, and progenitor vulnerability. These same models show partial rescue under targeted perturbations. Integration across layers highlights convergent pathways repeatedly supported by ≥3 independent data types: synaptic signaling, immune/complement regulation, mitochondrial/energetic function, neurodevelopmental programs and cell-adhesion complexes. Within these axes, several cross-layer convergence genes/proteins (e.g., DLG4/PSD-95, C4A, RELN, NRXN1/NLGN1, OXPHOS subunits, POU3F2/BRN2, PTN) recur across cohorts and modalities. Framing results through cross-layer and shared-pathway convergence organizes heterogeneous evidence and prioritizes targets for mechanistic dissection, biomarker development, and translational follow-up.","PeriodicalId":14156,"journal":{"name":"International Journal of Molecular Sciences","volume":"26 19","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12525312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunoinformatic Prediction of HIV-1 Glycoprotein gp120 and Nef Epitopes Conjugated to HBsAg-Binding Protein (SBP) to Induce the Humoral and Cellular Immune Response. 结合hbsag结合蛋白（SBP）的HIV-1糖蛋白gp120和Nef表位诱导体液和细胞免疫应答的免疫信息学预测

IF 4.9 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-10-09 DOI: 10.3390/ijms26199828

Arslan Habib, Xinyi Xu, Jun Xie, Naishuo Zhu

{"title":"Immunoinformatic Prediction of HIV-1 Glycoprotein gp120 and Nef Epitopes Conjugated to HBsAg-Binding Protein (SBP) to Induce the Humoral and Cellular Immune Response.","authors":"Arslan Habib, Xinyi Xu, Jun Xie, Naishuo Zhu","doi":"10.3390/ijms26199828","DOIUrl":"10.3390/ijms26199828","url":null,"abstract":"Acquired Immunodeficiency Syndrome (AIDS) is caused by Human Immunodeficiency Virus (HIV), and continues to be responsible for a substantial number of deaths worldwide each year. Development of a robust and efficient HIV-1 vaccine remains a critical priority. Structural analysis of viral proteins provides a foundational approach to designing peptide-based immunogenic vaccines. In the current experiment, we used computational prediction approaches alongside molecular docking and molecular dynamics (MD) simulations to identify potential epitopes within gp120 and Nef proteins. The selected co-epitopes were fused with the HBsAg-binding protein (SBP), a 344-amino acid protein previously identified in our laboratory through screening of a human liver cDNA expression library against HBsAg, to facilitate efficient delivery to and uptake by dendritic cells (DCs), thereby enhancing antigen (Ag) presentation. Flexible linkers are used to connect B cells, Helper T Lymphocytes (HTLs), and Cytotoxic T Lymphocytes (CTLs) in a sequential manner. The assembled vaccine construct comprises 757 amino acids, corresponding to a recombinant protein of 83.64 kDa molecular weight. Structural analysis through docking studies, MD simulations, and 3D structure validation revealed that the designed protein exhibits high structural stability and potential for interaction with Toll-like receptors (TLRs). These findings support the vaccine's ability to enhance cellular and humoral feedback, including the stimulation of T and B cells and induction of antibody (Ab) production. The results underscore the promise of this in silico designed co-epitope vaccine as a viable candidate for HIV-1 prevention and suggest that such constructs may serve as effective immunogens in future HIV-1 vaccine strategies.","PeriodicalId":14156,"journal":{"name":"International Journal of Molecular Sciences","volume":"26 19","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12524554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The NME7 Gene Is Involved in the Kinetics of Glucose Processing. NME7基因参与葡萄糖加工动力学。

IF 4.9 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-10-09 DOI: 10.3390/ijms26199821

Daniela Vejražková, Josef Včelák, Markéta Vaňková, Petra Lukášová, Michaela Svojtková, Tereza Grimmichová, Hana Kvasničková, Andrea Tura, Lucie Šedová, Ondřej Šeda, Kateřina Škultéty, Běla Bendlová

{"title":"The NME7 Gene Is Involved in the Kinetics of Glucose Processing.","authors":"Daniela Vejražková, Josef Včelák, Markéta Vaňková, Petra Lukášová, Michaela Svojtková, Tereza Grimmichová, Hana Kvasničková, Andrea Tura, Lucie Šedová, Ondřej Šeda, Kateřina Škultéty, Běla Bendlová","doi":"10.3390/ijms26199821","DOIUrl":"10.3390/ijms26199821","url":null,"abstract":"Given that type 2 diabetes mellitus is common in several ciliopathies, the NME7 gene (non-metastatic cells 7), encoding a recognized member of the ciliome, was studied in connection with glucose metabolism. The aim was to find out whether the variability in the gene is associated with the response to administered glucose during the 3 h oral glucose tolerance test. The study included 1262 individuals with different levels of glucose tolerance. Glycemic curves were categorized according to their shape as monophasic, biphasic, triphasic, and more complex multiphasic. The analysis showed a significant association of five linked NME7 polymorphisms with the biphasic course of the glycemic curve, a shape that has been shown to be metabolically protective. Specifically, minor alleles of rs4656659 and rs2157597 in combination with wild-type alleles of rs10732287, rs4264046, and rs10800438 were more frequent within the biphasic category. Moreover, haplotype analysis confirmed higher insulin sensitivity in carriers of this specific haplotype. In conclusion, a cluster of five linked NME7 polymorphisms showed an association with a biphasic glycemic curve. Considering the health benefits of the biphasic curve in terms of glycoregulation and taking into account the demonstrated link of the NME7 haplotype with insulin sensitivity, variability in the NME7 gene represents another piece of the complex mosaic influencing healthy energy processing.","PeriodicalId":14156,"journal":{"name":"International Journal of Molecular Sciences","volume":"26 19","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12524336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene-Exercise Interactions in Amyloid Metabolism and Clearance: Implications for Alzheimer's Disease. 淀粉样蛋白代谢和清除中的基因-运动相互作用：对阿尔茨海默病的影响。

IF 4.9 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-10-09 DOI: 10.3390/ijms26199816

Maria Francesca Astorino, Giovanni Luca Cipriano, Ivan Anchesi, Maria Lui, Ivana Raffaele, Marco Calabrò, Concetta Crisafulli

{"title":"Gene-Exercise Interactions in Amyloid Metabolism and Clearance: Implications for Alzheimer's Disease.","authors":"Maria Francesca Astorino, Giovanni Luca Cipriano, Ivan Anchesi, Maria Lui, Ivana Raffaele, Marco Calabrò, Concetta Crisafulli","doi":"10.3390/ijms26199816","DOIUrl":"10.3390/ijms26199816","url":null,"abstract":"Alzheimer's disease (AD), the most prevalent form of dementia, poses a critical global health challenge as its incidence rises with aging populations. Despite extensive research into its genetic and molecular underpinnings, effective therapeutic strategies remain limited. Growing evidence suggests that physical exercise may offer neuroprotective benefits, potentially mitigating AD progression through multifactorial mechanisms. This review synthesizes current findings on the interplay between aerobic exercise and AD pathophysiology, with a focus on amyloid-β (Aβ) metabolism, gene expression, and neuroinflammation. We explore how exercise influences Aβ clearance, modulates amyloid precursor protein (APP) processing, and impacts the activity of key enzymes such as secretases and neprilysin. Further, we highlight the gene-exercise crosstalk identified through transcriptomic data, particularly in the entorhinal cortex-an early site of Aβ deposition. Our analysis also discusses how exercise-induced modulation of molecular pathways-including mitochondrial function, oxidative stress responses, and neuroinflammatory cascades-may confer cognitive resilience. By integrating molecular, genetic, and systems biology data, this review underscores the potential of structured physical activity as a non-pharmacological intervention to delay or attenuate AD pathology. These insights support a precision medicine approach, which combines lifestyle interventions with molecular profiling, to improve prevention strategies and therapeutic outcomes in AD.","PeriodicalId":14156,"journal":{"name":"International Journal of Molecular Sciences","volume":"26 19","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12525307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Etiological Role of Impaired Neurogenesis in Schizophrenia: Interactions with Inflammatory, Microbiome and Hormonal Signaling. 精神分裂症中受损神经发生的病因学作用：与炎症、微生物组和激素信号的相互作用。

IF 4.9 2区生物学

International Journal of Molecular Sciences Pub Date : 2025-10-09 DOI: 10.3390/ijms26199814

Miu Tsz-Wai So, Ata Ullah, Abdul Waris, Fahad A Alhumaydhi

{"title":"The Etiological Role of Impaired Neurogenesis in Schizophrenia: Interactions with Inflammatory, Microbiome and Hormonal Signaling.","authors":"Miu Tsz-Wai So, Ata Ullah, Abdul Waris, Fahad A Alhumaydhi","doi":"10.3390/ijms26199814","DOIUrl":"10.3390/ijms26199814","url":null,"abstract":"Schizophrenia is a prevailing yet severely debilitating psychiatric disorder characterized by a convoluted etiology. Although antipsychotics have been available for over half a century, they primarily mitigate symptoms rather than providing definitive care. This limitation suggests that the neurotransmitter systems targeted by these medications are not the root cause of the disorder. Ongoing research seeks to elucidate the cellular, molecular, and circuitry pathways that contribute to the development of schizophrenia. Unfortunately, its precise pathogenesis remains incompletely understood. Accumulating evidence implicates dysregulated neurogenesis and aberrant neurodevelopmental processes as key contributors to disease progression. Recent advances in proteomics and imaging technology have facilitated the emergence of novel models of schizophrenia, emphasizing the roles of neuroinflammation, sex steroids, and cortisol. This paper aims to organize and map the intercorrelations and potential causal effects between various mechanistic models to gain deeper insight on how these mechanisms contribute to the cause, risks, and symptoms of the disorder. Furthermore, we discuss the potential therapeutic strategies that target these pathological pathways. Elucidating these mechanisms may ultimately advance our understanding of schizophrenia's etiological foundations and guide the development of curative interventions.","PeriodicalId":14156,"journal":{"name":"International Journal of Molecular Sciences","volume":"26 19","pages":""},"PeriodicalIF":4.9,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12524466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0