Cosmika Goswami, Tanja Mueller, Amanj Kurdi, Ewan Pearson, Khaled Bedir, Alexandra Tolfrey, Hazel Close, Marion Bennie
{"title":"Data Resource Profile: Medicines in Acute and Chronic Care in Scotland (MACCS).","authors":"Cosmika Goswami, Tanja Mueller, Amanj Kurdi, Ewan Pearson, Khaled Bedir, Alexandra Tolfrey, Hazel Close, Marion Bennie","doi":"10.1093/ije/dyag187","DOIUrl":"10.1093/ije/dyag187","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"55 5","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13585169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148989768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Gabriela Almeida Rodrigues, Patrícia Carvalho Silva Balieiro, Alexandre Vilhena Silva-Neto, Fernando Almeida-Val, Patrícia Takako Endo, Vanderson de Souza Sampaio
{"title":"Clinical and social determinants of COVID-19 lethality and ICU admission across variant waves in the Brazilian Amazon.","authors":"Maria Gabriela Almeida Rodrigues, Patrícia Carvalho Silva Balieiro, Alexandre Vilhena Silva-Neto, Fernando Almeida-Val, Patrícia Takako Endo, Vanderson de Souza Sampaio","doi":"10.1093/ije/dyag190","DOIUrl":"10.1093/ije/dyag190","url":null,"abstract":"<p><strong>Background: </strong>The state of Amazonas, located in the Brazilian Amazon, was disproportionately affected during the first waves of the COVID-19 pandemic.</p><p><strong>Methods: </strong>We conducted a population-based cohort study including all confirmed COVID-19 cases (2020-2) in the state of Amazonas, located in northern Brazil, linking data from three surveillance systems with cases of influenza-like illness (ILI) and severe acute respiratory syndrome (SARS). Outcomes included death, intensive care unit (ICU) admission, and a composite severity outcome.</p><p><strong>Results: </strong>Among 420 819 cases, 378 142 (89.9%) had ILI and 42 677 (10.1%) had SARS. A substantial burden of severe outcomes was observed among SARS cases, with ∼25% (n = 8910/35 909) of patients admitted to the ICU, 21.1% (n = 7229/34 323) requiring invasive mechanical ventilation, and 36.7% (n = 14 971/40 837) dying. Male sex [odds ratio (OR) = 1.23; 95% confidence interval (CI): 1.15-1.31; P < .001], age of ≥70 years (OR = 13.73; 95% CI: 11.97-15.76; P < .001), Indigenous ethnicity (OR = 2.32; 95% CI: 1.85-2.91; P < .001), dyspnea (OR = 1.99; 95% CI: 1.82-2.19; P < .001), loss of smell (OR = 1.54; 95% CI: 1.31-1.81; P < .001), and comorbidities, including chronic kidney disease (OR = 1.94; 95% CI: 1.58-2.39; P < .001), chronic respiratory disease (OR = 1.38; 95% CI: 1.08-1.77; P < .05), diabetes (OR = 1.12; 95% CI: 1.03-1.22; P < .05), obesity (OR = 1.31; 95% CI: 1.13-1.51; P < .001), and immunosuppression (OR = 1.90; 95% CI: 1.48-2.44; P < .001), were independently associated with a higher risk of death. Lethality increased significantly during the Gamma wave (OR = 3.76; 95% CI: 3.34-4.24; P < .001).</p><p><strong>Conclusion: </strong>The severity of COVID-19 in Amazonas was shaped by biological, structural, and viral factors, highlighting the need for equitable strengthening of the health system.</p>","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"55 5","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148989709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The New Modern Medicine: Disease, Evidence, and Epidemiological Medicine, by Jonathan Fuller","authors":"Alex Broadbent","doi":"10.1093/ije/dyag147","DOIUrl":"https://doi.org/10.1093/ije/dyag147","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"12 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shubhankar Sharma, Jo Mhairi Hale, Angelo Lorenti, Solveig Cunningham
{"title":"Loneliness and cognitive function in later life: a population-based counterfactual analysis.","authors":"Shubhankar Sharma, Jo Mhairi Hale, Angelo Lorenti, Solveig Cunningham","doi":"10.1093/ije/dyag212","DOIUrl":"10.1093/ije/dyag212","url":null,"abstract":"<p><strong>Background: </strong>Loneliness is increasingly recognized as a major public health challenge. Yet, its impact on cognitive function remains poorly understood. A complex interplay of life-course risk factors makes it challenging to disentangle the effect of loneliness from other factors and to assess underlying mechanisms when using traditional approaches.</p><p><strong>Methods: </strong>We applied the parametric g-formula with the Health and Retirement Study (1996-2018; n = 34 774; aged 50-80 years) to simulate an intervention estimating the effect of preventing loneliness on cognitive function. We assessed whether this effect varies by gender. Formal mediation analysis was also performed to assess depression as a potential pathway.</p><p><strong>Results: </strong>Preventing loneliness was protective against cognitive decline at all ages, with the magnitude increasing with age. Averaged across all ages, an intervention to prevent loneliness would slow cognitive decline by 0.075 points at the population level [95% confidence interval (CI): 0.063-0.089] and by 0.157 points among individuals experiencing loneliness (95% CI: 0.138-0.178). Overall, 17.3% of the total effect of preventing loneliness was mediated via depression, with the proportion mediated being 19.4% among men and 16.9% among women.</p><p><strong>Conclusion: </strong>Employing an innovative counterfactual framework, this study shows that preventing loneliness could provide an insulative effect against cognitive decline, even at the population level. Importantly, with advancing age, addressing loneliness yields progressively greater cognitive benefits. The effects partly operate through reductions in depression, especially in men. Interventions against loneliness may help maintain cognitive function, with benefits extending to mental health, highlighting a promising avenue for public health strategies.</p>","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"55 5","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
John S Ji, Karl-Heinz Smalla, Yong-Guan Zhu, Samuel S Myers
{"title":"Planetary health and the developing brain: heat as a life course threat to human problem-solving capacity.","authors":"John S Ji, Karl-Heinz Smalla, Yong-Guan Zhu, Samuel S Myers","doi":"10.1093/ije/dyag195","DOIUrl":"https://doi.org/10.1093/ije/dyag195","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"55 5","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David Bann, Ed Lowther, Liam Wright, Yevgeniya Kovalchuk
{"title":"Reply to: Why epidemiology should not be automated: the case for slow epidemiology.","authors":"David Bann, Ed Lowther, Liam Wright, Yevgeniya Kovalchuk","doi":"10.1093/ije/dyag182","DOIUrl":"https://doi.org/10.1093/ije/dyag182","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"55 5","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148944690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jos P Kanning,Habibollah Pirnejad,Awa A Gassama,Coralie R Arends,Johanna H K Joosten,Natasja D Vijfschagt,Ralf E Harskamp,Otto R Maarsingh,Mirjam I Geerlings,Monika Hollander
{"title":"Data Resource Profile: The General Practice Database—Amsterdam, North Holland, Almere (GPD-ANHA)","authors":"Jos P Kanning,Habibollah Pirnejad,Awa A Gassama,Coralie R Arends,Johanna H K Joosten,Natasja D Vijfschagt,Ralf E Harskamp,Otto R Maarsingh,Mirjam I Geerlings,Monika Hollander","doi":"10.1093/ije/dyag175","DOIUrl":"https://doi.org/10.1093/ije/dyag175","url":null,"abstract":"","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"36 1","pages":""},"PeriodicalIF":7.7,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148896059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michael Leung, Justin G Farmer, Ian W Tang, Joyce J Y Lin, Lorelei Mucci, Murray A Mittleman, Kaleigh McAlaine, Joseph J Mangano, Marc G Weisskopf
{"title":"Mortality and childhood residence near the radiologically contaminated Coldwater Creek, St. Louis, Missouri.","authors":"Michael Leung, Justin G Farmer, Ian W Tang, Joyce J Y Lin, Lorelei Mucci, Murray A Mittleman, Kaleigh McAlaine, Joseph J Mangano, Marc G Weisskopf","doi":"10.1093/ije/dyag166","DOIUrl":"10.1093/ije/dyag166","url":null,"abstract":"<p><strong>Background: </strong>Under the top-secret Manhattan Project, improperly stored radioactive byproducts from the processing of uranium contaminated Coldwater Creek in north St. Louis County, Missouri. We used the original 1958 Baby Tooth Survey (BTS) linked with the National Death Index (NDI) to investigate whether childhood residential proximity to the creek, as a proxy for radiation exposure, was associated with mortality.</p><p><strong>Methods: </strong>There were 43 876 eligible participants from the BTS (those outside Greater St. Louis and/or had incomplete covariates were excluded). In December 2023, the NDI was searched for BTS participants who had died. We estimated the hazard ratio (HR) and 95% confidence intervals between distance to Coldwater Creek (per 10 km) and mortality (all-cause, cancer, and cardiovascular disease) adjusting for sex, birth year, and census tract-level socioeconomic indicators.</p><p><strong>Results: </strong>Living closer to Coldwater Creek was associated with a higher rate of all-cause mortality (HR: 1.05; 95% CI: 1.01-1.09; P = .01). There was suggestive evidence of an increased rate for cancer mortality: any cancer (HR: 1.06; 95% CI: 1.00-1.14; P = .06), solid cancer (HR: 1.07, 95% CI: 1.00-1.16; P = .06) and radiosensitive cancer (HR: 1.10; 95% CI: 1.00-1.21; P = .05). There was no association with non-radiosensitive cancer and cardiovascular mortality.</p><p><strong>Conclusions: </strong>Our study provides new data that suggest living near Coldwater Creek in childhood was positively associated with the rate of all-cause mortality, and to a lesser extent cancer mortality, but not cardiovascular disease mortality. However, these findings should be interpreted cautiously given the lack of data on internal radiation exposure and individual socioeconomic status.</p>","PeriodicalId":14147,"journal":{"name":"International journal of epidemiology","volume":"55 5","pages":""},"PeriodicalIF":5.7,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13539670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148792793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
