International Journal of Hyperthermia最新文献_第5页

Therapeutic effects of focused ultrasound on vulvar squamous intraepithelial lesions in rat. 聚焦超声对大鼠外阴鳞状上皮内病变的治疗作用

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-09-10 DOI: 10.1080/02656736.2024.2401417

Yijin Fan,Xi Wang,Yao Liu,Huajun Tang,Chengzhi Li

{"title":"Therapeutic effects of focused ultrasound on vulvar squamous intraepithelial lesions in rat.","authors":"Yijin Fan,Xi Wang,Yao Liu,Huajun Tang,Chengzhi Li","doi":"10.1080/02656736.2024.2401417","DOIUrl":"https://doi.org/10.1080/02656736.2024.2401417","url":null,"abstract":"OBJECTIVEIn this study, we established a Sprague-Dawley rat model of vulvar squamous intraepithelial lesions and investigated the impact of focused ultrasound on the expression of hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) and mutant type p53 (mtp53) in the vulvar skin of rats with low-grade squamous intraepithelial lesions (LSIL).MATERIALS AND METHODSThe vulvar skin of 60 rats was treated with dimethylbenzanthracene (DMBA) and mechanical irritation three times a week for 14 weeks. Rats with LSIL were randomly allocated into the experimental group or the control group. The experimental group was treated with focused ultrasound, while the control group received sham treatment.RESULTSAfter 14 weeks treatment of DMBA combined with mechanical irritation, LSIL were observed in 44 (73.33%) rats, and high-grade squamous intraepithelial lesions (HSIL) were observed in 14 (23.33%) rats. 90.91% (20/22) of rats showed normal pathology and 9.09% (2/22) of rats exhibited LSIL in the experimental group at four weeks after focused ultrasound treatment. 22.73% (5/22) of rats exhibited LSIL, 77.27% (17/22) of rats progressed to HSIL in the control group. Compared with the control-group rats, the levels of HIF-1α, VEGF and mtp53 were significantly decreased in experimental-group rats (p < 0.05).CONCLUSIONSThese results indicate that DMBA combined with mechanical irritation can induce vulvar squamous intraepithelial lesion in SD rats. Focused ultrasound can treat LSIL safely and effectively, prevent the progression of vulvar lesions, and improve the microenvironment of vulvar tissues by decreasing the localized expression of HIF-1α, VEGF, and mtp53 in rats.","PeriodicalId":14137,"journal":{"name":"International Journal of Hyperthermia","volume":"117 1","pages":"2401417"},"PeriodicalIF":3.1,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142213662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the therapeutic efficacy of high-intensity focused ultrasound ablation combined with different drugs in the treatment of adenomyosis 评估高强度聚焦超声消融联合不同药物治疗子宫腺肌症的疗效

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-09-09 DOI: 10.1080/02656736.2024.2384471

Yu Dai, Ling Liu, Guiyuan Yu, Yan Peng, Na Chen, Jiahong Gao, Qiuling Shi, Ping Jin

引用次数: 0

Heat shock protein-related diagnostic signature and molecular subtypes in ankylosing spondylitis: new pathogenesis insights 强直性脊柱炎的热休克蛋白相关诊断特征和分子亚型：对发病机制的新认识

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-04-28 DOI: 10.1080/02656736.2024.2336149

Geqiang Wang, Yongji Li, Jiaxing Liu, Qian Zhang, Weixin Cai, Xiaodong Li

引用次数: 0

Hyperthermia and cisplatin combination therapy promotes caspase-8 accumulation and activation to enhance apoptosis and pyroptosis in cancer cells 热疗和顺铂联合疗法可促进 Caspase-8 的积累和激活，从而增强癌细胞的凋亡和热解作用

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-04-18 DOI: 10.1080/02656736.2024.2325489

Guanghui Zi, Jin Chen, Yatu Peng, Yue Wang, Baowei Peng

引用次数: 0

Intravoxel incoherent motion (IVIM)-derived perfusion fraction mapping for the visual evaluation of MR-guided high intensity focused ultrasound (MR-HIFU) ablation of uterine fibroids 体外非相干运动（IVIM）推导的灌注分数图用于对磁共振引导下的高强度聚焦超声（MR-HIFU）消融子宫肌瘤进行可视化评估

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-04-14 DOI: 10.1080/02656736.2024.2321980

Derk J. Slotman, Lambertus W. Bartels, Ingrid M. Nijholt, Martijn Froeling, Judith A. F. Huirne, Chrit T.W Moonen, Martijn F. Boomsma

引用次数: 0

Microwave hyperthermia enhances radiosensitization by decreasing DNA repair efficiency and inducing oxidative stress in PC3 prostatic adenocarcinoma cells 微波热疗通过降低 PC3 前列腺腺癌细胞的 DNA 修复效率和诱导氧化应激增强放射增敏作用

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-04-07 DOI: 10.1080/02656736.2024.2335201

Yajun Wu, Pengyuan Liu, Wendy Chen, Shiting Bai, Sisi Chen, Jianglin Chen, Xiaogang Xu, Jindan Xia, Yufei Wu, Jianjun Lai, Chuan Sun, Zhenghong Lao, Xiaoqing Wan, Zhibing Wu

引用次数: 0

Deregulated JNK signaling enhances apoptosis during hyperthermia 失调的 JNK 信号在热疗过程中会促进细胞凋亡

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-04-02 DOI: 10.1080/02656736.2024.2335199

Atsushi Enomoto, Takemichi Fukasawa, Hiroshi Terunuma, Keiichi Nakagawa, Ayumi Yoshizaki, Shinichi Sato, Noriko Hosoya, Kiyoshi Miyagawa

引用次数: 0

Percutaneous microwave ablation on management of hereditary renal cell carcinoma in Von Hippel-Lindau disease. 经皮微波消融治疗 Von Hippel-Lindau 病遗传性肾细胞癌。

IF 3 3区医学

International Journal of Hyperthermia Pub Date : 2024-01-01 Epub Date: 2024-02-12 DOI: 10.1080/02656736.2024.2308079

Jiye Chen, Lin Zheng, Wei Zhang, Zhen Wang, Jie Yu, Ping Liang

{"title":"Percutaneous microwave ablation on management of hereditary renal cell carcinoma in Von Hippel-Lindau disease.","authors":"Jiye Chen, Lin Zheng, Wei Zhang, Zhen Wang, Jie Yu, Ping Liang","doi":"10.1080/02656736.2024.2308079","DOIUrl":"10.1080/02656736.2024.2308079","url":null,"abstract":"Background: The effect of microwave ablation (MWA) for the renal cell carcinoma (RCC) in Von Hippel-Lindau (VHL) disease is unclear.Objective: To assess the safety, Technique efficacy, renal function and oncological outcome of MWA for RCC in VHL patients.Methods: Consecutive patients with RCCs in VHL disease treated by MWA were retrospectively collected from November 2009 to October 2020. The technical efficacy rate and complications were assessed. The outcomes of pre- and post-ablative eGFR were compared. The local recurrent-free survival (LRFS), renal-cancer-free survival (RCFS), cancer-specific survival (CSS), overall survival (OS) and complications were presented.Results: A total of 10 patients (mean age, 39.0 years ± 10.7 [SD]; 3 women) with 28 RCCs (mean tumor size, 3.0 cm ± 0.34; mean tumor volume, 20.7 mL ± 43.3) treated with MWA were included. Th median follow-up time was 52 months(IQR:27-80). The overall technical efficacy rate was 100% with no major complications occurred. No significant statistical difference between pre-ablative and postablative creatinine level (102.0 µmol/L ± 30.4 vs 112.3 µmol/L ± 38.7, p = 0.06), but the pre-ablative eGFR level was significantly higher than the post-ablative eGFR (78.0 mL/(min*1.73m2) ± 28.6 vs 72 mL/(min*1.73m2) ± 31.4, p = 0.04), with the mean decrease of 5.86 ml/(min*1.73m2). The local recurrent-free survival(LRFS) and renal-cancer-free survival (RCFS) were 100% and 60%, respectively. The cancer specifical survival (CSS) and overall survival (OS) were 95.5% and 100%, respectively.Conclusion: Microwave ablation is a safe and feasible method for the treatment of RCC in VHL disease, preserving renal function and yielding satisfactory oncological outcomes.","PeriodicalId":14137,"journal":{"name":"International Journal of Hyperthermia","volume":"41 1","pages":"2308079"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139722486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Directional microwave ablation in spine: experimental assessment of computational modeling. 脊柱定向微波消融：计算模型的实验评估。

IF 3 3区医学

International Journal of Hyperthermia Pub Date : 2024-01-01 Epub Date: 2024-02-18 DOI: 10.1080/02656736.2024.2313492

Austin Pfannenstiel, Haileigh Avellar, Clay Hallman, Brandon L Plattner, Margaret A Highland, Francois H Cornelis, Warren L Beard, Punit Prakash

{"title":"Directional microwave ablation in spine: experimental assessment of computational modeling.","authors":"Austin Pfannenstiel, Haileigh Avellar, Clay Hallman, Brandon L Plattner, Margaret A Highland, Francois H Cornelis, Warren L Beard, Punit Prakash","doi":"10.1080/02656736.2024.2313492","DOIUrl":"10.1080/02656736.2024.2313492","url":null,"abstract":"Background: Despite the theoretical advantages of treating metastatic bone disease with microwave ablation (MWA), there are few reports characterizing microwave absorption and bioheat transfer in bone. This report describes a computational modeling-based approach to simulate directional microwave ablation (dMWA) in spine, supported by ex vivo and pilot in vivo experiments in porcine vertebral bodies.Materials and methods: A 3D computational model of microwave ablation within porcine vertebral bodies was developed. Ex vivo porcine vertebra experiments using a dMWA applicator measured temperatures approximately 10.1 mm radially from the applicator in the direction of MW radiation (T1) and approximately 2.4 mm in the contra-lateral direction (T2). Histologic assessment of ablated ex vivo tissue was conducted and experimental results compared to simulations. Pilot in vivo experiments in porcine vertebral bodies assessed ablation zones histologically and with CT and MRI.Results: Experimental T1 and T2 temperatures were within 3-7% and 11-33% of simulated temperature values. Visible ablation zones, as indicated by grayed tissue, were smaller than those typical in other soft tissues. Posthumous MRI images of in vivo ablations showed hyperintensity. In vivo experiments illustrated the technical feasibility of creating directional microwave ablation zones in porcine vertebral body.Conclusion: Computational models and experimental studies illustrate the feasibility of controlled dMWA in bone tissue.","PeriodicalId":14137,"journal":{"name":"International Journal of Hyperthermia","volume":"41 1","pages":"2313492"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11357707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139899826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salvage radiofrequency ablation followed by external beam radiotherapy for inoperable recurrent differentiated thyroid cancer. 对无法手术的复发性分化型甲状腺癌进行抢救性射频消融，然后进行体外放射治疗。

IF 3 3区医学

International Journal of Hyperthermia Pub Date : 2024-01-01 Epub Date: 2024-05-30 DOI: 10.1080/02656736.2024.2358054

Chung-Shih Chen, Sheng-Dean Luo, Yen-Hsiang Chang, Chen Kai Chou, Shun-Yu Chi, Shao-Chun Wu, Yen-Hao Chen, Johnson Chia-Shen Yang, Eng-Yen Huang, Yu-Ming Wang, Wei-Che Lin

{"title":"Salvage radiofrequency ablation followed by external beam radiotherapy for inoperable recurrent differentiated thyroid cancer.","authors":"Chung-Shih Chen, Sheng-Dean Luo, Yen-Hsiang Chang, Chen Kai Chou, Shun-Yu Chi, Shao-Chun Wu, Yen-Hao Chen, Johnson Chia-Shen Yang, Eng-Yen Huang, Yu-Ming Wang, Wei-Che Lin","doi":"10.1080/02656736.2024.2358054","DOIUrl":"10.1080/02656736.2024.2358054","url":null,"abstract":"Purpose: The treatment of recurrent thyroid cancer with critical organ invasion is challenging. The combination of radiofrequency ablation (RFA) and external beam radiation therapy (EBRT) has been proposed as an effective option. This study evaluates outcomes for inoperable residual/recurrent differentiated thyroid cancer (rDTC) patients treated with RFA followed by EBRT.Materials and methods: Patients with rDTC treated with RFA followed by EBRT were retrospectively studied. RFA was performed using a free-hand, 'moving-shot' technique under US or CT guidance. For lesions invading critical structures intolerant to 'en bloc' high-temperature RFA, limited-field EBRT using 6- or 10-MV photons was used for adjuvant treatment at a dose of 66 Gy in 33 daily fractions. Toxicities and outcomes were reviewed.Results: Between April 2020 and January 2022, 11 patients with 14 rDTC lesions underwent RFA followed by EBRT. Five patients had metastatic lesions at rDTC diagnosis. With a median follow-up period of 33.7 months, all patients maintained locoregional control, while achieving a 2-year survival rate of 90.9%. This combined treatment achieved a volume reduction ratio of 92.1% ± 5.1%. The mean nadir thyroglobulin level in patients without initial distant metastases after treatment was 1.40 ± 0.81 ng/ml. Regarding treatment-related complications, one patient (9%) experienced temporary hoarseness after RFA, grade 2 radiation dermatitis occurred in 3 patients (27.2%), and grade 2 dysphagia was noted in 4 patients (36.4%). No grade 3 or greater toxicities occurred.Conclusions: Salvage RFA followed by EBRT is feasible, effective and safe for patients with rDTC.","PeriodicalId":14137,"journal":{"name":"International Journal of Hyperthermia","volume":"41 1","pages":"2358054"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0