脊柱定向微波消融:计算模型的实验评估。

IF 3 3区 医学 Q2 ONCOLOGY
International Journal of Hyperthermia Pub Date : 2024-01-01 Epub Date: 2024-02-18 DOI:10.1080/02656736.2024.2313492
Austin Pfannenstiel, Haileigh Avellar, Clay Hallman, Brandon L Plattner, Margaret A Highland, Francois H Cornelis, Warren L Beard, Punit Prakash
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引用次数: 0

摘要

背景:尽管利用微波消融(MWA)治疗转移性骨病具有理论上的优势,但有关微波在骨中的吸收和生物传热特性的报道却很少。本报告介绍了一种基于计算建模的脊柱定向微波消融(dMWA)模拟方法,并辅以猪椎体的体内外试验:开发了猪椎体内微波消融的三维计算模型。使用 dMWA 施用器进行的猪椎体体外实验测得的温度为:微波辐射方向距施用器径向约 10.1 毫米(T1)和反外侧方向约 2.4 毫米(T2)。对消融的体外组织进行了组织学评估,并将实验结果与模拟结果进行了比较。在猪椎体中进行的试验性体内实验从组织学角度并通过 CT 和 MRI 评估了消融区:实验 T1 和 T2 温度分别为模拟温度值的 3-7% 和 11-33%。可见消融区(如灰色组织所示)小于其他软组织中的典型消融区。体内消融后的核磁共振成像显示出高强度。体内实验表明,在猪椎体中创建定向微波消融区在技术上是可行的:计算模型和实验研究说明了在骨组织中控制定向微波消融的可行性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Directional microwave ablation in spine: experimental assessment of computational modeling.

Background: Despite the theoretical advantages of treating metastatic bone disease with microwave ablation (MWA), there are few reports characterizing microwave absorption and bioheat transfer in bone. This report describes a computational modeling-based approach to simulate directional microwave ablation (dMWA) in spine, supported by ex vivo and pilot in vivo experiments in porcine vertebral bodies.

Materials and methods: A 3D computational model of microwave ablation within porcine vertebral bodies was developed. Ex vivo porcine vertebra experiments using a dMWA applicator measured temperatures approximately 10.1 mm radially from the applicator in the direction of MW radiation (T1) and approximately 2.4 mm in the contra-lateral direction (T2). Histologic assessment of ablated ex vivo tissue was conducted and experimental results compared to simulations. Pilot in vivo experiments in porcine vertebral bodies assessed ablation zones histologically and with CT and MRI.

Results: Experimental T1 and T2 temperatures were within 3-7% and 11-33% of simulated temperature values. Visible ablation zones, as indicated by grayed tissue, were smaller than those typical in other soft tissues. Posthumous MRI images of in vivo ablations showed hyperintensity. In vivo experiments illustrated the technical feasibility of creating directional microwave ablation zones in porcine vertebral body.

Conclusion: Computational models and experimental studies illustrate the feasibility of controlled dMWA in bone tissue.

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来源期刊
CiteScore
5.90
自引率
12.90%
发文量
153
审稿时长
6-12 weeks
期刊介绍: The International Journal of Hyperthermia
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