International Journal of Hyperthermia最新文献

Therapeutic effects of focused ultrasound on vulvar squamous intraepithelial lesions in rat. 聚焦超声对大鼠外阴鳞状上皮内病变的治疗作用

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-09-10 DOI: 10.1080/02656736.2024.2401417

Yijin Fan,Xi Wang,Yao Liu,Huajun Tang,Chengzhi Li

{"title":"Therapeutic effects of focused ultrasound on vulvar squamous intraepithelial lesions in rat.","authors":"Yijin Fan,Xi Wang,Yao Liu,Huajun Tang,Chengzhi Li","doi":"10.1080/02656736.2024.2401417","DOIUrl":"https://doi.org/10.1080/02656736.2024.2401417","url":null,"abstract":"OBJECTIVEIn this study, we established a Sprague-Dawley rat model of vulvar squamous intraepithelial lesions and investigated the impact of focused ultrasound on the expression of hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) and mutant type p53 (mtp53) in the vulvar skin of rats with low-grade squamous intraepithelial lesions (LSIL).MATERIALS AND METHODSThe vulvar skin of 60 rats was treated with dimethylbenzanthracene (DMBA) and mechanical irritation three times a week for 14 weeks. Rats with LSIL were randomly allocated into the experimental group or the control group. The experimental group was treated with focused ultrasound, while the control group received sham treatment.RESULTSAfter 14 weeks treatment of DMBA combined with mechanical irritation, LSIL were observed in 44 (73.33%) rats, and high-grade squamous intraepithelial lesions (HSIL) were observed in 14 (23.33%) rats. 90.91% (20/22) of rats showed normal pathology and 9.09% (2/22) of rats exhibited LSIL in the experimental group at four weeks after focused ultrasound treatment. 22.73% (5/22) of rats exhibited LSIL, 77.27% (17/22) of rats progressed to HSIL in the control group. Compared with the control-group rats, the levels of HIF-1α, VEGF and mtp53 were significantly decreased in experimental-group rats (p < 0.05).CONCLUSIONSThese results indicate that DMBA combined with mechanical irritation can induce vulvar squamous intraepithelial lesion in SD rats. Focused ultrasound can treat LSIL safely and effectively, prevent the progression of vulvar lesions, and improve the microenvironment of vulvar tissues by decreasing the localized expression of HIF-1α, VEGF, and mtp53 in rats.","PeriodicalId":14137,"journal":{"name":"International Journal of Hyperthermia","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142213662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the therapeutic efficacy of high-intensity focused ultrasound ablation combined with different drugs in the treatment of adenomyosis 评估高强度聚焦超声消融联合不同药物治疗子宫腺肌症的疗效

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-09-09 DOI: 10.1080/02656736.2024.2384471

Yu Dai, Ling Liu, Guiyuan Yu, Yan Peng, Na Chen, Jiahong Gao, Qiuling Shi, Ping Jin

引用次数: 0

Heat shock protein-related diagnostic signature and molecular subtypes in ankylosing spondylitis: new pathogenesis insights 强直性脊柱炎的热休克蛋白相关诊断特征和分子亚型：对发病机制的新认识

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-04-28 DOI: 10.1080/02656736.2024.2336149

Geqiang Wang, Yongji Li, Jiaxing Liu, Qian Zhang, Weixin Cai, Xiaodong Li

引用次数: 0

Hyperthermia and cisplatin combination therapy promotes caspase-8 accumulation and activation to enhance apoptosis and pyroptosis in cancer cells 热疗和顺铂联合疗法可促进 Caspase-8 的积累和激活，从而增强癌细胞的凋亡和热解作用

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-04-18 DOI: 10.1080/02656736.2024.2325489

Guanghui Zi, Jin Chen, Yatu Peng, Yue Wang, Baowei Peng

引用次数: 0

Intravoxel incoherent motion (IVIM)-derived perfusion fraction mapping for the visual evaluation of MR-guided high intensity focused ultrasound (MR-HIFU) ablation of uterine fibroids 体外非相干运动（IVIM）推导的灌注分数图用于对磁共振引导下的高强度聚焦超声（MR-HIFU）消融子宫肌瘤进行可视化评估

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-04-14 DOI: 10.1080/02656736.2024.2321980

Derk J. Slotman, Lambertus W. Bartels, Ingrid M. Nijholt, Martijn Froeling, Judith A. F. Huirne, Chrit T.W Moonen, Martijn F. Boomsma

引用次数: 0

Microwave hyperthermia enhances radiosensitization by decreasing DNA repair efficiency and inducing oxidative stress in PC3 prostatic adenocarcinoma cells 微波热疗通过降低 PC3 前列腺腺癌细胞的 DNA 修复效率和诱导氧化应激增强放射增敏作用

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-04-07 DOI: 10.1080/02656736.2024.2335201

Yajun Wu, Pengyuan Liu, Wendy Chen, Shiting Bai, Sisi Chen, Jianglin Chen, Xiaogang Xu, Jindan Xia, Yufei Wu, Jianjun Lai, Chuan Sun, Zhenghong Lao, Xiaoqing Wan, Zhibing Wu

引用次数: 0

Deregulated JNK signaling enhances apoptosis during hyperthermia 失调的 JNK 信号在热疗过程中会促进细胞凋亡

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-04-02 DOI: 10.1080/02656736.2024.2335199

Atsushi Enomoto, Takemichi Fukasawa, Hiroshi Terunuma, Keiichi Nakagawa, Ayumi Yoshizaki, Shinichi Sato, Noriko Hosoya, Kiyoshi Miyagawa

引用次数: 0

Percutaneous microwave ablation on management of hereditary renal cell carcinoma in Von Hippel-Lindau disease. 经皮微波消融治疗 Von Hippel-Lindau 病遗传性肾细胞癌。

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-01-01 Epub Date: 2024-02-12 DOI: 10.1080/02656736.2024.2308079

Jiye Chen, Lin Zheng, Wei Zhang, Zhen Wang, Jie Yu, Ping Liang

{"title":"Percutaneous microwave ablation on management of hereditary renal cell carcinoma in Von Hippel-Lindau disease.","authors":"Jiye Chen, Lin Zheng, Wei Zhang, Zhen Wang, Jie Yu, Ping Liang","doi":"10.1080/02656736.2024.2308079","DOIUrl":"10.1080/02656736.2024.2308079","url":null,"abstract":"Background: The effect of microwave ablation (MWA) for the renal cell carcinoma (RCC) in Von Hippel-Lindau (VHL) disease is unclear.Objective: To assess the safety, Technique efficacy, renal function and oncological outcome of MWA for RCC in VHL patients.Methods: Consecutive patients with RCCs in VHL disease treated by MWA were retrospectively collected from November 2009 to October 2020. The technical efficacy rate and complications were assessed. The outcomes of pre- and post-ablative eGFR were compared. The local recurrent-free survival (LRFS), renal-cancer-free survival (RCFS), cancer-specific survival (CSS), overall survival (OS) and complications were presented.Results: A total of 10 patients (mean age, 39.0 years ± 10.7 [SD]; 3 women) with 28 RCCs (mean tumor size, 3.0 cm ± 0.34; mean tumor volume, 20.7 mL ± 43.3) treated with MWA were included. Th median follow-up time was 52 months(IQR:27-80). The overall technical efficacy rate was 100% with no major complications occurred. No significant statistical difference between pre-ablative and postablative creatinine level (102.0 µmol/L ± 30.4 vs 112.3 µmol/L ± 38.7, p = 0.06), but the pre-ablative eGFR level was significantly higher than the post-ablative eGFR (78.0 mL/(min*1.73m2) ± 28.6 vs 72 mL/(min*1.73m2) ± 31.4, p = 0.04), with the mean decrease of 5.86 ml/(min*1.73m2). The local recurrent-free survival(LRFS) and renal-cancer-free survival (RCFS) were 100% and 60%, respectively. The cancer specifical survival (CSS) and overall survival (OS) were 95.5% and 100%, respectively.Conclusion: Microwave ablation is a safe and feasible method for the treatment of RCC in VHL disease, preserving renal function and yielding satisfactory oncological outcomes.","PeriodicalId":14137,"journal":{"name":"International Journal of Hyperthermia","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139722486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complications and adverse events of high-intensity focused ultrasound in its application to gynecological field - a systematic review and meta-analysis. 高强度聚焦超声应用于妇科领域的并发症和不良事件--系统回顾和荟萃分析。

IF 3 3区医学

International Journal of Hyperthermia Pub Date : 2024-01-01 Epub Date: 2024-06-30 DOI: 10.1080/02656736.2024.2370969

Shan-Shan Lu, Lei-Lei Yang, Wei Yang, Jing Wang, Xia-Lin Zhang, Liu Yang, Yi Wen

{"title":"Complications and adverse events of high-intensity focused ultrasound in its application to gynecological field - a systematic review and meta-analysis.","authors":"Shan-Shan Lu, Lei-Lei Yang, Wei Yang, Jing Wang, Xia-Lin Zhang, Liu Yang, Yi Wen","doi":"10.1080/02656736.2024.2370969","DOIUrl":"10.1080/02656736.2024.2370969","url":null,"abstract":"Objective: To analyze and summarize the types, incidence rates and relevant influencing factors of adverse events (AEs) after high-intensity focused ultrasound ablation of gynecological diseases and provide reference and basis for handling such events in clinical practice.Method: We searched PubMed, Cochrane Library, Web of Science and Embase databases to retrieve all literature since its establishment until February 2024. We evaluated the quality of included literature and publication bias and conducted a meta-analysis of single group rates for various AEs using Stata 17.0.Results: This systematic review finally included 41 articles. We summarized 34 kinds of AEs in 7 aspects and conducted a single group rate meta-analysis and sub-group analysis of 16 kinds of AEs. Among the common AEs of High-Intensity Focused Ultrasound (HIFU), the incidence of lower abdominal pain/pelvic pain is 36.1% (95% CI: 24.3%∼48.8%), vaginal bleeding is 20.6% (95% CI: 13.9%∼28.0%), vaginal discharge is 14.0% (95% CI: 9.6%∼19.1%), myoma discharge is 24% (95% CI: 14.6%∼34.8%), buttock pain is 10.8% (95% CI: 6.0%∼16.5%) and sacral pain is 10% (95% CI: 8.8%∼11.2%). Serious complications include uterine rupture, necrotic tissue obstruction requiring surgical intervention, third degree skin burns and persistent lower limb pain or movement disorders.Conclusion: The common AEs after HIFU surgery are mostly mild and controllable, and the incidence of serious complications is extremely low. By reasonable prevention and active intervention, these events can be further reduced, making it a safe and effective treatment method. It is a good choice for patients who crave noninvasive treatment or have other surgical contraindications.","PeriodicalId":14137,"journal":{"name":"International Journal of Hyperthermia","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperbaric oxygen therapy attenuates heatstroke-induced hippocampal injury by inhibiting microglial pyroptosis. 高压氧疗法通过抑制小胶质细胞的脓毒症减轻中暑诱发的海马损伤

IF 3 3区医学

International Journal of Hyperthermia Pub Date : 2024-01-01 Epub Date: 2024-07-23 DOI: 10.1080/02656736.2024.2382162

Ancong Xu, Fan Huang, Er Chen, Zhiqiang Zhang, Yanxuan He, Xichong Yu, Guoxin He

{"title":"Hyperbaric oxygen therapy attenuates heatstroke-induced hippocampal injury by inhibiting microglial pyroptosis.","authors":"Ancong Xu, Fan Huang, Er Chen, Zhiqiang Zhang, Yanxuan He, Xichong Yu, Guoxin He","doi":"10.1080/02656736.2024.2382162","DOIUrl":"https://doi.org/10.1080/02656736.2024.2382162","url":null,"abstract":"Background: Central nervous system (CNS) injury is the most prominent feature of heatstroke and the hippocampus is prone to damage. However, the mechanisms underlying the heatstroke-induced hippocampal injury remain unclear. Hyperbaric oxygen (HBO) therapy prevents CNS injury in heatstroke mice. However, the underlying mechanisms of HBO in heatstroke-induced hippocampal injury remain unclear. This study aimed to elucidate the protective effects of HBO against hippocampal injury and its potential role in microglial pyroptosis in heatstroke rats.Methods: A rat heatstroke model and a heat stress model with a mouse microglial cell line (BV2) were, respectively, used to illustrate the effect of HBO on heat-induced microglial pyroptosis in vivo and in vitro. We used a combination of molecular and histological methods to assess microglial pyroptosis and neuroinflammation both in vivo and in vitro.Results: The results revealed that HBO improved heatstroke-induced survival outcomes, hippocampal injury, and neurological dysfunction in rats. In addition, HBO mitigates microglial pyroptosis and reduces the expression of pro-inflammatory cytokines in the hippocampus of heatstroke rats. In vitro experiments showed that HBO attenuated BV2 cell injury under heat stress. Furthermore, HBO prevented heat-induced pyroptosis of BV2 cells, and the expression of pro-inflammatory cytokines IL-18 and IL-1β was reduced. Mechanistically, HBO alleviates heatstroke-induced neuroinflammation and hippocampal injury by preventing microglial pyroptosis. Conclusions: In conclusion, HBO attenuates heatstroke-induced neuroinflammation and hippocampal injury by inhibiting microglial pyroptosis.","PeriodicalId":14137,"journal":{"name":"International Journal of Hyperthermia","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0