International Journal of Hyperthermia最新文献_第2页

Thyroid nodule rupture after thermal ablation for benign thyroid nodules: incidence, risk factors, and clinical management. 良性甲状腺结节热消融后破裂：发病率、危险因素和临床处理。

IF 3 3区医学

International Journal of Hyperthermia Pub Date : 2025-12-01 Epub Date: 2025-01-05 DOI: 10.1080/02656736.2024.2439536

Yu-Tong Liu, Ying Wei, Zhen-Long Zhao, Jie Wu, Shi-Liang Cao, Na Yu, Yan Li, Li-Li Peng, Ming-An Yu

{"title":"Thyroid nodule rupture after thermal ablation for benign thyroid nodules: incidence, risk factors, and clinical management.","authors":"Yu-Tong Liu, Ying Wei, Zhen-Long Zhao, Jie Wu, Shi-Liang Cao, Na Yu, Yan Li, Li-Li Peng, Ming-An Yu","doi":"10.1080/02656736.2024.2439536","DOIUrl":"https://doi.org/10.1080/02656736.2024.2439536","url":null,"abstract":"Background: Thyroid nodule rupture (TNR) is a rare and severe complication after thermal ablation (TA), mostly from benign thyroid nodules (BTN).Objective: To summarize the incidence of TNR after TA and analyze the causes and prevention strategies.Materials and methods: This retrospective study enrolled 3971 patients who underwent TA for BTN from January 2014 to March 2024. The incidence, causes, and risk factors of TNR were analyzed. Propensity score matching (PSM) controlled for confounding factors. Multivariate regression identified risk factors for TNR. ROC curves determined the optimal cutoff value for the maximum diameter (MD) for TNR.Results: TNR occurred in 8 cases [0.2% (8/3971)]. The mean time from TA to TNR was 29.6 ± 13.0 days (range, 20-60 days). After PSM, MD was larger in the TNR group than in the non-TNR group [mean 4.1 ± 1.6 cm vs. mean 1.8 ± 1.2 cm; p < 0.001]. The optimal cutoff value of MD for TNR was 2.75 cm. After PSM, the incidence of pressure on the ablation zone was significantly higher in the TNR group than in the non-TNR group [100% (8/8) vs. 0 (0/32); p < 0.001], which has been suspected as a case of TNR. Antibiotic drugs, aspiration, or incision drainage could successfully manage all TNR cases.Conclusion: TNR could be encountered in case of pressure on the BTN after TA. Protecting the ablation site from pressure might be crucial in preventing TNR, especially within two months. TNR is more likely to occur if the MD of BTN exceeds 2.75 cm under pressure. Observation, antibiotics, and aspiration could successfully manage all TNR cases.","PeriodicalId":14137,"journal":{"name":"International Journal of Hyperthermia","volume":"42 1","pages":"2439536"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic effects of focused ultrasound on vulvar squamous intraepithelial lesions in rat. 聚焦超声对大鼠外阴鳞状上皮内病变的治疗作用

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-09-10 DOI: 10.1080/02656736.2024.2401417

Yijin Fan,Xi Wang,Yao Liu,Huajun Tang,Chengzhi Li

{"title":"Therapeutic effects of focused ultrasound on vulvar squamous intraepithelial lesions in rat.","authors":"Yijin Fan,Xi Wang,Yao Liu,Huajun Tang,Chengzhi Li","doi":"10.1080/02656736.2024.2401417","DOIUrl":"https://doi.org/10.1080/02656736.2024.2401417","url":null,"abstract":"OBJECTIVEIn this study, we established a Sprague-Dawley rat model of vulvar squamous intraepithelial lesions and investigated the impact of focused ultrasound on the expression of hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) and mutant type p53 (mtp53) in the vulvar skin of rats with low-grade squamous intraepithelial lesions (LSIL).MATERIALS AND METHODSThe vulvar skin of 60 rats was treated with dimethylbenzanthracene (DMBA) and mechanical irritation three times a week for 14 weeks. Rats with LSIL were randomly allocated into the experimental group or the control group. The experimental group was treated with focused ultrasound, while the control group received sham treatment.RESULTSAfter 14 weeks treatment of DMBA combined with mechanical irritation, LSIL were observed in 44 (73.33%) rats, and high-grade squamous intraepithelial lesions (HSIL) were observed in 14 (23.33%) rats. 90.91% (20/22) of rats showed normal pathology and 9.09% (2/22) of rats exhibited LSIL in the experimental group at four weeks after focused ultrasound treatment. 22.73% (5/22) of rats exhibited LSIL, 77.27% (17/22) of rats progressed to HSIL in the control group. Compared with the control-group rats, the levels of HIF-1α, VEGF and mtp53 were significantly decreased in experimental-group rats (p < 0.05).CONCLUSIONSThese results indicate that DMBA combined with mechanical irritation can induce vulvar squamous intraepithelial lesion in SD rats. Focused ultrasound can treat LSIL safely and effectively, prevent the progression of vulvar lesions, and improve the microenvironment of vulvar tissues by decreasing the localized expression of HIF-1α, VEGF, and mtp53 in rats.","PeriodicalId":14137,"journal":{"name":"International Journal of Hyperthermia","volume":"117 1","pages":"2401417"},"PeriodicalIF":3.1,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142213662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the therapeutic efficacy of high-intensity focused ultrasound ablation combined with different drugs in the treatment of adenomyosis 评估高强度聚焦超声消融联合不同药物治疗子宫腺肌症的疗效

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-09-09 DOI: 10.1080/02656736.2024.2384471

Yu Dai, Ling Liu, Guiyuan Yu, Yan Peng, Na Chen, Jiahong Gao, Qiuling Shi, Ping Jin

引用次数: 0

Heat shock protein-related diagnostic signature and molecular subtypes in ankylosing spondylitis: new pathogenesis insights 强直性脊柱炎的热休克蛋白相关诊断特征和分子亚型：对发病机制的新认识

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-04-28 DOI: 10.1080/02656736.2024.2336149

Geqiang Wang, Yongji Li, Jiaxing Liu, Qian Zhang, Weixin Cai, Xiaodong Li

引用次数: 0

Hyperthermia and cisplatin combination therapy promotes caspase-8 accumulation and activation to enhance apoptosis and pyroptosis in cancer cells 热疗和顺铂联合疗法可促进 Caspase-8 的积累和激活，从而增强癌细胞的凋亡和热解作用

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-04-18 DOI: 10.1080/02656736.2024.2325489

Guanghui Zi, Jin Chen, Yatu Peng, Yue Wang, Baowei Peng

引用次数: 0

Intravoxel incoherent motion (IVIM)-derived perfusion fraction mapping for the visual evaluation of MR-guided high intensity focused ultrasound (MR-HIFU) ablation of uterine fibroids 体外非相干运动（IVIM）推导的灌注分数图用于对磁共振引导下的高强度聚焦超声（MR-HIFU）消融子宫肌瘤进行可视化评估

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-04-14 DOI: 10.1080/02656736.2024.2321980

Derk J. Slotman, Lambertus W. Bartels, Ingrid M. Nijholt, Martijn Froeling, Judith A. F. Huirne, Chrit T.W Moonen, Martijn F. Boomsma

引用次数: 0

Microwave hyperthermia enhances radiosensitization by decreasing DNA repair efficiency and inducing oxidative stress in PC3 prostatic adenocarcinoma cells 微波热疗通过降低 PC3 前列腺腺癌细胞的 DNA 修复效率和诱导氧化应激增强放射增敏作用

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-04-07 DOI: 10.1080/02656736.2024.2335201

Yajun Wu, Pengyuan Liu, Wendy Chen, Shiting Bai, Sisi Chen, Jianglin Chen, Xiaogang Xu, Jindan Xia, Yufei Wu, Jianjun Lai, Chuan Sun, Zhenghong Lao, Xiaoqing Wan, Zhibing Wu

引用次数: 0

Deregulated JNK signaling enhances apoptosis during hyperthermia 失调的 JNK 信号在热疗过程中会促进细胞凋亡

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-04-02 DOI: 10.1080/02656736.2024.2335199

Atsushi Enomoto, Takemichi Fukasawa, Hiroshi Terunuma, Keiichi Nakagawa, Ayumi Yoshizaki, Shinichi Sato, Noriko Hosoya, Kiyoshi Miyagawa

引用次数: 0

Percutaneous microwave ablation on management of hereditary renal cell carcinoma in Von Hippel-Lindau disease. 经皮微波消融治疗 Von Hippel-Lindau 病遗传性肾细胞癌。

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-01-01 Epub Date: 2024-02-12 DOI: 10.1080/02656736.2024.2308079

Jiye Chen, Lin Zheng, Wei Zhang, Zhen Wang, Jie Yu, Ping Liang

{"title":"Percutaneous microwave ablation on management of hereditary renal cell carcinoma in Von Hippel-Lindau disease.","authors":"Jiye Chen, Lin Zheng, Wei Zhang, Zhen Wang, Jie Yu, Ping Liang","doi":"10.1080/02656736.2024.2308079","DOIUrl":"10.1080/02656736.2024.2308079","url":null,"abstract":"Background: The effect of microwave ablation (MWA) for the renal cell carcinoma (RCC) in Von Hippel-Lindau (VHL) disease is unclear.Objective: To assess the safety, Technique efficacy, renal function and oncological outcome of MWA for RCC in VHL patients.Methods: Consecutive patients with RCCs in VHL disease treated by MWA were retrospectively collected from November 2009 to October 2020. The technical efficacy rate and complications were assessed. The outcomes of pre- and post-ablative eGFR were compared. The local recurrent-free survival (LRFS), renal-cancer-free survival (RCFS), cancer-specific survival (CSS), overall survival (OS) and complications were presented.Results: A total of 10 patients (mean age, 39.0 years ± 10.7 [SD]; 3 women) with 28 RCCs (mean tumor size, 3.0 cm ± 0.34; mean tumor volume, 20.7 mL ± 43.3) treated with MWA were included. Th median follow-up time was 52 months(IQR:27-80). The overall technical efficacy rate was 100% with no major complications occurred. No significant statistical difference between pre-ablative and postablative creatinine level (102.0 µmol/L ± 30.4 vs 112.3 µmol/L ± 38.7, p = 0.06), but the pre-ablative eGFR level was significantly higher than the post-ablative eGFR (78.0 mL/(min*1.73m2) ± 28.6 vs 72 mL/(min*1.73m2) ± 31.4, p = 0.04), with the mean decrease of 5.86 ml/(min*1.73m2). The local recurrent-free survival(LRFS) and renal-cancer-free survival (RCFS) were 100% and 60%, respectively. The cancer specifical survival (CSS) and overall survival (OS) were 95.5% and 100%, respectively.Conclusion: Microwave ablation is a safe and feasible method for the treatment of RCC in VHL disease, preserving renal function and yielding satisfactory oncological outcomes.","PeriodicalId":14137,"journal":{"name":"International Journal of Hyperthermia","volume":"41 1","pages":"2308079"},"PeriodicalIF":3.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139722486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Directional microwave ablation in spine: experimental assessment of computational modeling. 脊柱定向微波消融：计算模型的实验评估。

IF 3 3区医学

International Journal of Hyperthermia Pub Date : 2024-01-01 Epub Date: 2024-02-18 DOI: 10.1080/02656736.2024.2313492

Austin Pfannenstiel, Haileigh Avellar, Clay Hallman, Brandon L Plattner, Margaret A Highland, Francois H Cornelis, Warren L Beard, Punit Prakash

{"title":"Directional microwave ablation in spine: experimental assessment of computational modeling.","authors":"Austin Pfannenstiel, Haileigh Avellar, Clay Hallman, Brandon L Plattner, Margaret A Highland, Francois H Cornelis, Warren L Beard, Punit Prakash","doi":"10.1080/02656736.2024.2313492","DOIUrl":"10.1080/02656736.2024.2313492","url":null,"abstract":"Background: Despite the theoretical advantages of treating metastatic bone disease with microwave ablation (MWA), there are few reports characterizing microwave absorption and bioheat transfer in bone. This report describes a computational modeling-based approach to simulate directional microwave ablation (dMWA) in spine, supported by ex vivo and pilot in vivo experiments in porcine vertebral bodies.Materials and methods: A 3D computational model of microwave ablation within porcine vertebral bodies was developed. Ex vivo porcine vertebra experiments using a dMWA applicator measured temperatures approximately 10.1 mm radially from the applicator in the direction of MW radiation (T1) and approximately 2.4 mm in the contra-lateral direction (T2). Histologic assessment of ablated ex vivo tissue was conducted and experimental results compared to simulations. Pilot in vivo experiments in porcine vertebral bodies assessed ablation zones histologically and with CT and MRI.Results: Experimental T1 and T2 temperatures were within 3-7% and 11-33% of simulated temperature values. Visible ablation zones, as indicated by grayed tissue, were smaller than those typical in other soft tissues. Posthumous MRI images of in vivo ablations showed hyperintensity. In vivo experiments illustrated the technical feasibility of creating directional microwave ablation zones in porcine vertebral body.Conclusion: Computational models and experimental studies illustrate the feasibility of controlled dMWA in bone tissue.","PeriodicalId":14137,"journal":{"name":"International Journal of Hyperthermia","volume":"41 1","pages":"2313492"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11357707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139899826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0