International Journal of Hyperthermia最新文献_第3页

Computational predictions of magnetic resonance acoustic radiation force imaging for breast cancer focused ultrasound therapy. 磁共振声辐射力成像用于乳腺癌聚焦超声治疗的计算预测。

IF 3 3区医学

International Journal of Hyperthermia Pub Date : 2025-12-01 Epub Date: 2025-01-22 DOI: 10.1080/02656736.2025.2452927

Chloe K Nelson, Michelle Kline, Allison Payne, Christopher R Dillon

{"title":"Computational predictions of magnetic resonance acoustic radiation force imaging for breast cancer focused ultrasound therapy.","authors":"Chloe K Nelson, Michelle Kline, Allison Payne, Christopher R Dillon","doi":"10.1080/02656736.2025.2452927","DOIUrl":"10.1080/02656736.2025.2452927","url":null,"abstract":"Purpose: In magnetic resonance-guided focused ultrasound (MRgFUS) breast therapies, the focal location must be characterized to guide successful treatment. Focal characterization is difficult because heterogeneous breast tissues introduce phase aberrations that blur and shift the focus and traditional guidance methods do not work in adipose tissues. The purpose of this work is to evaluate numerical simulations of MRgFUS that predict the focal location. Those simulations are compared to clinical magnetic resonance acoustic radiation force imaging (MR-ARFI) data collected during in vivo treatment of breast tumors.Methods: The focal location was evaluated before MRgFUS treatment with MR-ARFI in five patients. The hybrid angular spectrum method (HAS) was applied to simulate pressure fields which were converted to forces, then convolved with a 3D Green's function (with time-of-arrival weighting) to produce a simulation of the MR-ARFI tissue displacement.Results: The focal locations found by the simulations and the MR-ARFI measurements were on average separated by 3.7 mm (SD: 0.9 mm). Characterization of the focal zone spatial distributions had a normalized root mean squared difference of 8.1% (SD: 2.5%). The displacement magnitudes of the simulations underestimated the MR-ARFI measurements by 82% (SD: 5.6%).Conclusions: The agreement between MR-ARFI measurements and simulations demonstrates that HAS can predict the in vivo focal location in heterogeneous tissues, though accurate patient-specific properties are needed to improve predictions of tissue displacement magnitude. Tools developed in this study could be used to streamline MRgFUS treatment planning and optimization, for biomechanical property estimation, and in developing phase aberration correction techniques.","PeriodicalId":14137,"journal":{"name":"International Journal of Hyperthermia","volume":"42 1","pages":"2452927"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11902895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The clinical study of high-intensity focused ultrasound for the treatment of 160 cases of postpartum placenta increta. 高强度聚焦超声治疗 160 例产后胎盘增大的临床研究。

IF 3 3区医学

International Journal of Hyperthermia Pub Date : 2025-12-01 Epub Date: 2025-03-05 DOI: 10.1080/02656736.2025.2473386

Xiaogang Zhu, Xin Sun, Mingzhu Ye, Min Xue

{"title":"The clinical study of high-intensity focused ultrasound for the treatment of 160 cases of postpartum placenta increta.","authors":"Xiaogang Zhu, Xin Sun, Mingzhu Ye, Min Xue","doi":"10.1080/02656736.2025.2473386","DOIUrl":"https://doi.org/10.1080/02656736.2025.2473386","url":null,"abstract":"Purpose: To investigate the safety and efficacy of high-intensity focused ultrasound (HIFU) in the treatment of postpartum placenta increta and to analyze the influencing factors of intraoperative blood loss and curettage times.Methods: From January 2016 to December 2018, a retrospective analysis was conducted on 160 patients with placenta increta treated by HIFU combined with (or without) curettage in our hospital. Intraoperative blood loss and the number of curettage procedures were recorded. The clinical outcomes and the influencing factors of bleeding and the number of curettage procedures were analyzed.Results: No serious complications occurred during HIFU treatment. The median volume of blood loss during suction curettage was 20 ml (range: 5-600 ml). Blood loss was significantly higher in patients with a large placental diameter (p = 0.007). The risk of requiring multiple curettage procedures was significantly higher in patients with a large placental diameter (p = 0.023). The interval time between HIFU and suction curettage was identified as a protective factor, a longer interval was associated with fewer curettage procedures (p = 0.015).Conclusion: Based on the results of our large-sample study, HIFU appears to be safe and effective in the treatment of postpartum placenta increta. Blood loss volume is associated with the largest diameter of the placenta. The risk of requiring multiple curettage procedures is related to the largest diameter of the placenta, While the interval time between HIFU and suction curettage is a protective factor for reducing curettage times.","PeriodicalId":14137,"journal":{"name":"International Journal of Hyperthermia","volume":"42 1","pages":"2473386"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co-ablation of lung malignancies with coexisting usual interstitial pneumonia: a retrospective analysis of safety and efficacy. 肺部恶性肿瘤合并常见性间质性肺炎的联合消融：安全性和有效性的回顾性分析。

IF 3 3区医学

International Journal of Hyperthermia Pub Date : 2025-12-01 Epub Date: 2025-02-23 DOI: 10.1080/02656736.2025.2468764

Yu-Feng Wang, Xiao-Guang Li

{"title":"Co-ablation of lung malignancies with coexisting usual interstitial pneumonia: a retrospective analysis of safety and efficacy.","authors":"Yu-Feng Wang, Xiao-Guang Li","doi":"10.1080/02656736.2025.2468764","DOIUrl":"https://doi.org/10.1080/02656736.2025.2468764","url":null,"abstract":"Purpose: This retrospective study aimed to evaluate the feasibility and safety of co-ablation (Co-A) for lung malignancies in patients with usual interstitial pneumonia (UIP).Materials and methods: We retrospectively reviewed the clinical records of 1,537 consecutive patients treated for malignant lung tumors. UIP was assessed using standard-dose computed tomography (CT). Overall, 14 patients (12 men and two women; mean age ± standard deviation: 71.68 ± 7.83 years, range: 60-87 years) with UIP underwent CT-guided percutaneous Co-A. The mean tumor size was 29.14 mm (standard deviation: 12.60; range: 12-45 mm). Follow-up was performed using CT 1 and 3 months after Co-A. Complications and safety outcomes were also assessed.Results: The median follow-up duration for all patients was 3 months (range: 1-5 months). The mortality rate was 0% within 30 d of ablation. Major complications, including pneumonia and bronchopleural fistula, occurred in 14.3% (2/14) of patients. The technical success rate was 100%.Conclusion: Co-A appears to be a safe and effective treatment for lung malignancies in patients with UIP.","PeriodicalId":14137,"journal":{"name":"International Journal of Hyperthermia","volume":"42 1","pages":"2468764"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning models for prediction of NPVR ≥80% with HIFU ablation for uterine fibroids. 机器学习模型预测子宫肌瘤HIFU消融患者NPVR≥80%。

IF 3 3区医学

International Journal of Hyperthermia Pub Date : 2025-12-01 Epub Date: 2025-03-23 DOI: 10.1080/02656736.2025.2473754

Meijie Yang, Ying Chen, Xue Zhou, Renqiang Yu, Nannan Huang, Jinyun Chen

{"title":"Machine learning models for prediction of NPVR ≥80% with HIFU ablation for uterine fibroids.","authors":"Meijie Yang, Ying Chen, Xue Zhou, Renqiang Yu, Nannan Huang, Jinyun Chen","doi":"10.1080/02656736.2025.2473754","DOIUrl":"https://doi.org/10.1080/02656736.2025.2473754","url":null,"abstract":"Background: Currently high-intensity focused ultrasound (HIFU) is widely used to treat uterine fibroids (UFs). The aim of this study is to develop a machine learning model that can accurately predict the efficacy of HIFU ablation for UFs, assisting the preoperative selection of suitable patients with UFs.Methods: This study collected data from 1,000 patients with UFs who underwent ultrasound-guided high-intensity focused ultrasound. The least absolute shrinkage and selection operator (LASSO) regression was used for multidimensional feature screening. Five machine learning algorithms such as logistic regression, random forest, extreme gradient boosting (XGBoost), artificial neural network, and gradient boosting decision tree were utilized to predict ablation efficacy. The efficacy was quantified by the non-perfused volume ratio (NPVR), which was classified into two categories: NPVR <80% and NPVR ≥80%.Results: The XGBoost model proved to be the most effective, showing the highest AUC of 0.692 (95% CI: 0.622-0.762) in the testing data set. The four key predictors were T2 weighted image, the distance from ventral side of UFs to skin, platelet count, and contrast-enhanced T1 weighted image.Conclusions: The machine learning prediction model in this study showed significant potential for accurately predicting the preoperative efficacy of HIFU ablation for UFs. These insights were important for clinicians in the preoperative assessment and selection of patients, which could enhance the precision of treatment planning.","PeriodicalId":14137,"journal":{"name":"International Journal of Hyperthermia","volume":"42 1","pages":"2473754"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143692187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical study on the relationship between the incidence of complications and tumour size after thermal ablation of benign thyroid nodules. 甲状腺良性结节热消融术后并发症发生率与肿瘤大小关系的临床研究。

IF 3 3区医学

International Journal of Hyperthermia Pub Date : 2025-12-01 Epub Date: 2025-02-13 DOI: 10.1080/02656736.2025.2464205

Han-Xiao Zhao, Ying Wei, Zhen-Long Zhao, Li-Li Peng, Yan Li, Jie Wu, Shi-Liang Cao, Na Yu, Ming-An Yu

{"title":"Clinical study on the relationship between the incidence of complications and tumour size after thermal ablation of benign thyroid nodules.","authors":"Han-Xiao Zhao, Ying Wei, Zhen-Long Zhao, Li-Li Peng, Yan Li, Jie Wu, Shi-Liang Cao, Na Yu, Ming-An Yu","doi":"10.1080/02656736.2025.2464205","DOIUrl":"https://doi.org/10.1080/02656736.2025.2464205","url":null,"abstract":"Objective: The present study aimed to analyze the relationship between the incidence of complications and tumor size following thermal ablation of benign thyroid nodules (BTNs).Methods: In this retrospective study, 1198 patients who underwent thermal ablation for unifocal BTN were enrolled. Receiver Operating Characteristic analysis was performed to select the cutoff values of the maximum diameter (MD) for dividing patients into different groups or subgroups. Multivariable logistic regression was performed to identify the risk factors. Propensity score matching (PSM) was employed to control for confounding variables.Results: The overall complication rate was 3.8% (45/1198). Major complications included hoarseness (2.4%), nodule rupture (0.3%) and delayed hemorrhage (0.1%), whereas minor complications were limited to intraoperative hemorrhage (0.9%). The difference in the overall complication rate between the smaller group (< 3.15 cm) and the larger group (> 3.15 cm) was significant (1.0% vs. 6.5%, p < 0.001). In the subgroup analysis, a significant difference was observed between the 3.15-4.15 cm and > 4.15 cm subgroups (4.2% vs. 8.7%, p = 0.023); however, no significant difference was identified between the < 2.35 and 2.35-3.15 cm subgroups (0.6% vs. 1.6%, p = 0.390). Multivariable logistic regression indicated that MD and the nodule component were associated with complications. After PSM, no significant difference in complication rates was observed between MWA and RFA in either the smaller group (p = 1.000) or the larger group (p = 0.186).Conclusions: The incidence of complications in thermal ablation is greater for larger thyroid nodules, particularly for predominantly solid nodules with MDs greater than 3.15 cm.","PeriodicalId":14137,"journal":{"name":"International Journal of Hyperthermia","volume":"42 1","pages":"2464205"},"PeriodicalIF":3.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic effects of focused ultrasound on vulvar squamous intraepithelial lesions in rat. 聚焦超声对大鼠外阴鳞状上皮内病变的治疗作用

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-09-10 DOI: 10.1080/02656736.2024.2401417

Yijin Fan,Xi Wang,Yao Liu,Huajun Tang,Chengzhi Li

{"title":"Therapeutic effects of focused ultrasound on vulvar squamous intraepithelial lesions in rat.","authors":"Yijin Fan,Xi Wang,Yao Liu,Huajun Tang,Chengzhi Li","doi":"10.1080/02656736.2024.2401417","DOIUrl":"https://doi.org/10.1080/02656736.2024.2401417","url":null,"abstract":"OBJECTIVEIn this study, we established a Sprague-Dawley rat model of vulvar squamous intraepithelial lesions and investigated the impact of focused ultrasound on the expression of hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) and mutant type p53 (mtp53) in the vulvar skin of rats with low-grade squamous intraepithelial lesions (LSIL).MATERIALS AND METHODSThe vulvar skin of 60 rats was treated with dimethylbenzanthracene (DMBA) and mechanical irritation three times a week for 14 weeks. Rats with LSIL were randomly allocated into the experimental group or the control group. The experimental group was treated with focused ultrasound, while the control group received sham treatment.RESULTSAfter 14 weeks treatment of DMBA combined with mechanical irritation, LSIL were observed in 44 (73.33%) rats, and high-grade squamous intraepithelial lesions (HSIL) were observed in 14 (23.33%) rats. 90.91% (20/22) of rats showed normal pathology and 9.09% (2/22) of rats exhibited LSIL in the experimental group at four weeks after focused ultrasound treatment. 22.73% (5/22) of rats exhibited LSIL, 77.27% (17/22) of rats progressed to HSIL in the control group. Compared with the control-group rats, the levels of HIF-1α, VEGF and mtp53 were significantly decreased in experimental-group rats (p < 0.05).CONCLUSIONSThese results indicate that DMBA combined with mechanical irritation can induce vulvar squamous intraepithelial lesion in SD rats. Focused ultrasound can treat LSIL safely and effectively, prevent the progression of vulvar lesions, and improve the microenvironment of vulvar tissues by decreasing the localized expression of HIF-1α, VEGF, and mtp53 in rats.","PeriodicalId":14137,"journal":{"name":"International Journal of Hyperthermia","volume":"117 1","pages":"2401417"},"PeriodicalIF":3.1,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142213662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the therapeutic efficacy of high-intensity focused ultrasound ablation combined with different drugs in the treatment of adenomyosis 评估高强度聚焦超声消融联合不同药物治疗子宫腺肌症的疗效

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-09-09 DOI: 10.1080/02656736.2024.2384471

Yu Dai, Ling Liu, Guiyuan Yu, Yan Peng, Na Chen, Jiahong Gao, Qiuling Shi, Ping Jin

引用次数: 0

Heat shock protein-related diagnostic signature and molecular subtypes in ankylosing spondylitis: new pathogenesis insights 强直性脊柱炎的热休克蛋白相关诊断特征和分子亚型：对发病机制的新认识

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-04-28 DOI: 10.1080/02656736.2024.2336149

Geqiang Wang, Yongji Li, Jiaxing Liu, Qian Zhang, Weixin Cai, Xiaodong Li

引用次数: 0

Hyperthermia and cisplatin combination therapy promotes caspase-8 accumulation and activation to enhance apoptosis and pyroptosis in cancer cells 热疗和顺铂联合疗法可促进 Caspase-8 的积累和激活，从而增强癌细胞的凋亡和热解作用

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-04-18 DOI: 10.1080/02656736.2024.2325489

Guanghui Zi, Jin Chen, Yatu Peng, Yue Wang, Baowei Peng

引用次数: 0

Intravoxel incoherent motion (IVIM)-derived perfusion fraction mapping for the visual evaluation of MR-guided high intensity focused ultrasound (MR-HIFU) ablation of uterine fibroids 体外非相干运动（IVIM）推导的灌注分数图用于对磁共振引导下的高强度聚焦超声（MR-HIFU）消融子宫肌瘤进行可视化评估

IF 3.1 3区医学

International Journal of Hyperthermia Pub Date : 2024-04-14 DOI: 10.1080/02656736.2024.2321980

Derk J. Slotman, Lambertus W. Bartels, Ingrid M. Nijholt, Martijn Froeling, Judith A. F. Huirne, Chrit T.W Moonen, Martijn F. Boomsma

引用次数: 0