International journal of molecular medicine最新文献

{"title":"Emerging role of small RNAs in inflammatory bowel disease and associated colorectal cancer (Review).","authors":"Wei Qiu, Francis Atim Akanyibah, Yuxuan Xia, Dickson Kofi Wiredu Ocansey, Fei Mao, Yuelan Liang","doi":"10.3892/ijmm.2024.5474","DOIUrl":"https://doi.org/10.3892/ijmm.2024.5474","url":null,"abstract":"<p><p>Inflammatory bowel diseases (IBDs), which encompasses Crohn's disease and ulcerative colitis, is a chronic inflammatory condition associated with an increased risk of colorectal cancer (CRC). Small RNAs have been linked to various illnesses, including IBD and CRC. These small RNAs also serve as potential biomarkers for these diseases, offering a cutting‑edge approach to investigating possible treatments. To date, treatments involving oral nucleic acid usage are still unachievable due to the instability of medications in the gastrointestinal tract (GIT), their lack of ability to effectively target disease tissues and their notable adverse effects. However, nanoparticle or exosome delivery systems of nucleic acid medications effectively target disease tissues by overcoming the instability of the GIT, resulting in an effective outcome. In the present review, the biogenesis of small RNAs (tRNA‑derived small RNA, microRNA, small nucleolar RNA and p‑element‑induced wimpy testis‑interacting RNA), their roles in the pathogenesis of IBD and CRC as well as their application as possible diagnostic and prognostic biomarkers in IBD and CRC are discussed.</p>","PeriodicalId":14086,"journal":{"name":"International journal of molecular medicine","volume":"55 2","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Retracted] MicroRNA‑204 inhibits the proliferation, migration and invasion of human lung cancer cells by targeting PCNA‑1 and inhibits tumor growth <i>in vivo</i>.","authors":"Ping Li, Qingan Wang, Haining Wang","doi":"10.3892/ijmm.2024.5469","DOIUrl":"https://doi.org/10.3892/ijmm.2024.5469","url":null,"abstract":"<p><p>Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the histological data shown in Fig. 7E were strikingly similar to data appearing in different form in an article written by different authors at different research institutes that had already been published in the journal <i>International Journal of Molecular Sciences</i>. In view of the fact that the abovementioned data had already apparently been published prior to its submission to <i>International Journal of Molecular Medicine</i>, the Editor has decided that this paper should be retracted from the Journal. The authors were asked for an explanation to account for these concerns, but the Editorial Office did not receive a satisfactory reply. The Editor apologizes to the readership for any inconvenience caused. [International Journal of Molecular Medicine 43: 1149‑1156, 2019; DOI: 10.3892/ijmm.2018.4044].</p>","PeriodicalId":14086,"journal":{"name":"International journal of molecular medicine","volume":"55 2","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D affects antiphospholipid syndrome by regulating T cells (Review).","authors":"Rongxiu Huo, Yanting Yang, Chengcheng Wei, Xiaocong Huo, Danli Meng, Yang Yang, Yijia Huang, Rongjun Huang, Jinying Lin, Xinxiang Huang","doi":"10.3892/ijmm.2024.5471","DOIUrl":"10.3892/ijmm.2024.5471","url":null,"abstract":"<p><p>Antiphospholipid syndrome (APS) is an autoimmune disease characterized by arterial and/or venous thrombosis, pathological pregnancies and persistent antiphospholipid antibodies. The occurrence and development of APS are complex and associated with immune disorders, with its prognosis remaining uncertain. Owing to its pathogenesis, anticoagulation therapy is the primary treatment for patients with APS. In recent years, with increased attention on APS, research on its treatment strategies has flourished, and preclinical and clinical relevance studies are being conducted to re‑evaluate the mechanism of action of existing drugs and to develop new drugs. Recent evidence suggests that vitamin D (VD) may help improve immune disorders in patients with APS by regulating the balance between immune cells. In this review, the potential mechanistic role of VD in APS protection was discussed, highlighting the potential effects of VD as a promising adjuvant treatment option for APS.</p>","PeriodicalId":14086,"journal":{"name":"International journal of molecular medicine","volume":"55 2","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of psychological stress on ovarian function: Insights, mechanisms and intervention strategies (Review).","authors":"Yu Hu, Wuyang Wang, Wenqing Ma, Wenwen Wang, Wu Ren, Shixuan Wang, Fangfang Fu, Yan Li","doi":"10.3892/ijmm.2024.5475","DOIUrl":"https://doi.org/10.3892/ijmm.2024.5475","url":null,"abstract":"<p><p>Mental stress may lead to ovarian dysfunction. Psychological stress disrupts ovarian function, leading to adverse <i>in vitro</i> fertilization outcomes, premature ovarian insufficiency and decreased ovarian reserve. Furthermore, psychological stress caused by decreased ovarian function and infertility can exacerbate the mental burden. In animals, psychological stress leads to ovarian insufficiency, resulting in irregular estrous cycles and decreased ovarian reserve. The present study summarizes effects of psychogenic stress on ovarian function and the underlying mechanisms, highlighting involvement of the hypothalamic‑pituitary‑adrenal, sympathetic‑adrenal‑medullary and hypothalamic‑pituitary‑ovarian axes, as well as the neuroendocrine‑metabolic network. Moreover, the present review outlines psychological intervention and metabolic strategies for improving ovarian function, offering potential new approaches for treating ovarian hypofunction. The present study aims to clarify understanding of psychological stress‑induced ovarian dysfunction and propose alternative intervention strategies for ovarian dysfunction and infertility.</p>","PeriodicalId":14086,"journal":{"name":"International journal of molecular medicine","volume":"55 2","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Corrigendum] Spicatoside A in red <i>Liriope platyphylla</i> displays a laxative effect in a constipation rat model via regulating mAChRs and ER stress signaling.","authors":"Ji Eun Kim, Jun Go, Hee Seob Lee, Jin Tae Hong, Dae Youn Hwang","doi":"10.3892/ijmm.2024.5462","DOIUrl":"10.3892/ijmm.2024.5462","url":null,"abstract":"<p><p>Following the publication of the above article, an interested reader drew to the Editor's attention that various of the histological structural images shown in Fig. 5 on p. 190 were strikingly similar to data that were featured in Fig. 1A of a previous paper by the same research group that appeared in the Journal <i>Laboratory Animal Research</i>. On re‑examining their original data, the authors confirmed that an error occurred during the paper submission/production process, and that Fig. 5 did not appear in the above article as the authors had intended. The correct version of Fig. 5, containing the data that the authors intended for inclusion in this article, is shown on the next page. Also shown is a corrected version of Table II corresponding to the replacement version of Fig. 5, containing data that are derived from an analysis of the data shown in this figure. Furthermore, the replacement of the images in Fig. 5, and the revisions of the data made in Table II, also dictate that the following changes are needed to be made in the main text of the paper (all associated with Results section on p. 191, '<i>Recovery effect of EtRLP on histological alterations of the transverse colon</i>' subsection): The sentences in lines 9‑14 of this section should now read as following (changes from the original text are highlighted in <b>bold</b>): 'Following Lop+EtRLP or Lop+Bisac treatments, the villus length increased by <b>270‑290%</b> relative to the Lop+Vehicle‑treated group (Fig. 5 and Table II). Furthermore, the alterations in <b>muscle thickness</b> were similar to those in villus length, although crypt layer thickness only increased by <b>145‑150%</b> relative to the <b>Lop+Vehicle‑treated group</b> (Fig. 5 and Table II)'. Note that the errors made during the assembly of Fig. 5 and Table II did not grossly affect the overall conclusions reported in the paper. All the authors agree with the publication of this corrigendum, and are grateful to the Editor of <i>International Journal of Molecular Medicine</i> for allowing them the opportunity to publish this. They also apologize to the readership for any inconvenience caused. [International Journal of Molecular Medicine 43: 185‑198, 2019; DOI: 10.3892/ijmm.2018.3960].</p>","PeriodicalId":14086,"journal":{"name":"International journal of molecular medicine","volume":"55 2","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical updates of B‑cell maturation antigen‑targeted therapy in multiple myeloma (MM) and relapsed/refractory MM (Review).","authors":"Rui Xing, Meidan Wang, Liqun Wang, Mingyue Pan, Yixi Wang, Hongwei Zhou","doi":"10.3892/ijmm.2024.5468","DOIUrl":"10.3892/ijmm.2024.5468","url":null,"abstract":"<p><p>Despite significant progress in managing multiple myeloma (MM) in recent years, certain patients still have a short duration of therapeutic response, often relapsing within 18 months. These patients typically have high‑risk genetic mutations and may show little to no response to current treatments, highlighting the need for further exploration of optimal therapeutic targets for MM. B‑cell maturation antigen (BCMA), highly expressed in mature B lymphocytes and plasma cells and upregulated in MM, is a promising therapeutic target. Various BCMA‑targeted strategies, including antibody‑drug conjugates, bispecific T‑cell engagers and chimeric antigen receptor T‑cell therapy, are under clinical evaluation to optimize efficacy and safety. This review summarizes the latest clinical updates on these strategies, highlights their effectiveness in MM and relapsed/refractory MM and provides future perspectives and recommendations for overcoming current challenges.</p>","PeriodicalId":14086,"journal":{"name":"International journal of molecular medicine","volume":"55 2","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expansion of B10 cells <i>in vitro</i>: Pathways, techniques and applications in transplantation (Review).","authors":"Dayue Zhao, Guoli Huai, Yuan Yuan, Yuanyuan Cui, Yinglin Yuan, Gaoping Zhao","doi":"10.3892/ijmm.2024.5470","DOIUrl":"10.3892/ijmm.2024.5470","url":null,"abstract":"<p><p>Cellular immunotherapy represents a pivotal treatment modality in clinical practice. Regulatory B cells (Bregs), a key subset of B lymphocytes, hold promise in the management of autoimmune diseases, cancer and transplantation immunity. The expansion of Bregs for cell therapy is a promising strategy to alleviate inflammation and promote immune tolerance. Achieving immune tolerance relies on balance between regulatory and effector cells. One primary objective of cellular therapy is to shift this balance towards Bregs, fostering a more tolerant immune microenvironment. The adoptive transfer of Bregs not only increases their quantity but also modulates the number and function of other immune cells. Maximizing <i>in vitro</i> expansion of Bregs and enhancing their regulatory functions are key focuses in transplant immunology. However, the precise mechanisms underlying the <i>in vitro</i> expansion of IL‑10‑secreting B cells (B10) remain inadequately understood. The present review aims to provide a comprehensive overview of the signaling pathways involved in B10 activation and expansion, as well as to highlight the techniques for <i>in vitro</i> amplification and development of adoptive B10 therapy in transplantation, which aims to advance the field of cellular therapy targeting Bregs.</p>","PeriodicalId":14086,"journal":{"name":"International journal of molecular medicine","volume":"55 2","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repositioning of aripiprazole, an anti‑psychotic drug, to sensitize the chemotherapy of pancreatic cancer.","authors":"Ye Jin Cho, Beom Seok Han, Soyeon Ko, Min Seok Park, Yun Ji Lee, Sang Eun Kim, Pureunchowon Lee, Han Gyeol Go, Shinyoung Park, Hyunho Lee, Sohee Kim, Eun-Ran Park, Kyung Hee Jung, Soon-Sun Hong","doi":"10.3892/ijmm.2024.5458","DOIUrl":"10.3892/ijmm.2024.5458","url":null,"abstract":"<p><p>Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with limited therapeutic options. Cisplatin is a primary chemotherapeutic agent utilized in combination with other drugs or radiotherapy for PDAC treatment. However, the severe side effects of cisplatin often necessitate discontinuation of therapy and drug resistance in tumor cells poses significant clinical challenges. Therefore, the development of effective therapeutic strategies is imperative. The present study investigated whether repositioning of the antipsychotic drug aripiprazole could sensitize the anticancer activity of cisplatin in pancreatic cancer at doses calculated by the combination index. The findings indicated that aripiprazole combined with cisplatin to suppress pancreatic cancer cell growth. Notably, the combination notably increased the expression of apoptosis markers, including cleaved caspase‑3, compared with cisplatin alone. Additionally, this combination effectively decreased XIAP and MCL‑1 expression via mitochondrial membrane potential change as revealed by JC‑1 assay, thereby inducing apoptosis. Furthermore, in fluid shear stress assay, the combination of aripiprazole and cisplatin notably inhibited cell adhesion and tumor spheroid formation. Mechanistically, phospho‑kinase array profiles showed that the enhanced anticancer efficacy of the combination treatment could be attributed to the inhibition of STAT3 signaling, which led to a significant reduction in tumor growth in a pancreatic cancer animal model. The results showed that the repositioning of aripiprazole inhibits cancer cell growth by blocking the STAT3 signaling pathway and effectively enhancing cisplatin‑induced apoptosis, thereby suggesting that the combination of aripiprazole and cisplatin may be a potent chemotherapeutic strategy for the treatment of pancreatic cancer.</p>","PeriodicalId":14086,"journal":{"name":"International journal of molecular medicine","volume":"55 1","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11573310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Retracted] miR‑92a‑3p promotes the proliferation, migration and invasion of esophageal squamous cell cancer by regulating PTEN.","authors":"Xin Li, Shuilong Guo, Li Min, Qingdong Guo, Shutian Zhang","doi":"10.3892/ijmm.2024.5453","DOIUrl":"10.3892/ijmm.2024.5453","url":null,"abstract":"<p><p>Following the publication of this paper, a concerned reader drew to the Editor's attention that it appeared as if the authors had calculated the apoptotic rates erroneously. The authors were asked to provide an explanation to account for the concerns raised by the interested reader; however, they did not respond to this request submitted by the Editorial Office. Therefore, owing to the lack of responsiveness on the part of the authors, the Editor of <i>International Journal of Molecular Medicine</i> has decided that this paper should be retracted from the journal. The Editor would like to apologize to the readership for any inconvenience caused. [International Journal of Molecular Medicine 44: 973‑981, 2019; DOI: 10.3892/ijmm.2019.4258].</p>","PeriodicalId":14086,"journal":{"name":"International journal of molecular medicine","volume":"55 1","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11573319/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quercetin ameliorates senescence and promotes osteogenesis of BMSCs by suppressing the repetitive element‑triggered RNA sensing pathway.","authors":"Yutong Sun, Chunyang Wang, Liling Wen, Zihang Ling, Juan Xia, Bin Cheng, Jianmin Peng","doi":"10.3892/ijmm.2024.5445","DOIUrl":"10.3892/ijmm.2024.5445","url":null,"abstract":"<p><p>Cell senescence impedes the self‑renewal and osteogenic capacity of bone marrow mesenchymal stem cells (BMSCs), thus limiting their application in tissue regeneration. The present study aimed to elucidate the role and mechanism of repetitive element (RE) activation in BMSC senescence and osteogenesis, as well as the intervention effect of quercetin. In an H2O2‑induced BMSC senescence model, quercetin treatment alleviated senescence as shown by a decrease in senescence‑associated β‑galactosidase (SA‑β‑gal)‑positive cell ratio, increased colony formation ability and decreased mRNA expression of p21 and senescence‑associated secretory phenotype genes. DNA damage response marker γ‑H2AX increased in senescent BMSCs, while expression of epigenetic markers methylation histone H3 Lys9, heterochromatin protein 1α and heterochromatin‑related nuclear membrane protein lamina‑associated polypeptide 2 decreased. Quercetin rescued these alterations, indicating its ability to ameliorate senescence by stabilizing heterochromatin structure where REs are primarily suppressed. Transcriptional activation of REs accompanied by accumulation of cytoplasmic double‑stranded (ds)RNA, as well as triggering of the RNA sensor retinoic acid‑inducible gene I (RIG‑I) receptor pathway in H2O2‑induced senescent BMSCs were shown. Similarly, quercetin treatment inhibited these responses. Additionally, RIG‑I knockdown led to a decreased number of SA‑β‑gal‑positive cells, confirming its functional impact on senescence. Induction of senescence or administration of dsRNA analogue significantly hindered the osteogenic capacity of BMSCs, while quercetin treatment or RIG‑I knockdown reversed the decline in osteogenic function. The findings of the current study demonstrated that quercetin inhibited the activation of REs and the RIG‑I RNA sensing pathway via epigenetic regulation, thereby alleviating the senescence of BMSCs and promoting osteogenesis.</p>","PeriodicalId":14086,"journal":{"name":"International journal of molecular medicine","volume":"55 1","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11537266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}