International Journal of Nanomedicine最新文献

{"title":"The Current Status, Hotspots, and Development Trends of Nanoemulsions: A Comprehensive Bibliometric Review.","authors":"Guojun Sun, Liying Wang, Zuojun Dong, Yanxiao Zhang, Yan Yang, Miao Hu, Hui Fang","doi":"10.2147/IJN.S502490","DOIUrl":"https://doi.org/10.2147/IJN.S502490","url":null,"abstract":"<p><p>Nanoemulsions, which are characterized by their nanometer-scale droplets, have gained significant attention in different fields, such as medicine, food, cosmetics, and agriculture, because of their unique properties. With an increasing number of countries engaging in research on nanoemulsions, interest in their properties, preparation methods, and applications has increased. Hence, tracing the relevant research on nanoemulsions published in the past ten years on a global scale, by conducting data mining and visualization analysis on a sufficiently large text dataset through bibliometrics, sorting out and summarizing certain indicators, the development history, research status and research hotspots in the field of nanoemulsions can be clearly revealed, providing reference value and significance for subsequent research. This bibliometric review examines the research landscape of nanoemulsions from 2013-2023 via the SCI-E and SSCI databases, providing insights into the current status, hotspots, and future trends of this field. To offer a comprehensive overview, this analysis includes publication counts, author keywords, institutional contributions, research areas, prolific authors, highly cited papers and hot research papers. The findings reveal that China led in nanoemulsions research, followed by USA, India, and Brazil, with the University of Massachusetts emerging as a key player with the highest average number of citations per article (ACPP) and h-index. Food Chemistry, Pharmaceutics, and the Journal of Drug Delivery Science and Technology are among the top journals publishing in this area. Chemistry, pharmacology, and pharmacy emerged as the primary research domains, with McClements DJ as the most prolific and influential author. In keyword analysis, essential oil nanoemulsions are currently the main preparation direction, and various characteristics of nanoemulsions, such as their bioavailability, stability, biocompatibility, and antioxidant and antibacterial properties, have also been studied extensively. Research hotspots are focused mostly on the development of new applications and technologies for nanoemulsions.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"2937-2968"},"PeriodicalIF":6.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Anti-Inflammatory and Antibacterial Properties of Photo-Thermal Hydrogel as Dual Functional Platform for Management of Periodontitis.","authors":"Zhisong Mai, Yuying Mai, Xianxian Huang, Shipeng Ning, Hongbing Liao","doi":"10.2147/IJN.S508864","DOIUrl":"10.2147/IJN.S508864","url":null,"abstract":"<p><strong>Background: </strong>Periodontitis, one of the most common oral diseases caused by bacterial infection which affects gums, periodontal ligament and alveolar bone, is a leading cause of tooth loss in adults. Current clinical treatments, such as scaling or antibiotics, often result in incomplete biofilm removal or can contribute to drug resistance.</p><p><strong>Methods: </strong>To address these limitations, a nanozyme comprising platinum, copper, and selenium was developed, which was then incorporated into a thermoresponsive hydrogel.</p><p><strong>Results: </strong>When applied to periodontal pockets and exposed to 808 nm laser irradiation, the hydrogel became soft, dissolving to release the nanozyme. This nanozyme demonstrated superoxide dismutase (SOD)-like and catalase (CAT)-like activity, reducing excess reactive oxygen species (ROS) while displaying strong antibacterial and anti-inflammatory effects.</p><p><strong>Conclusion: </strong>This photothermal nanozyme hydrogel showed excellent biocompatibility and has the potential to overcome the challenges of current periodontitis treatments.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"2923-2934"},"PeriodicalIF":6.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Microbubbles Combined with ICG-Loaded Liposomes for Synergistic Mild-Photothermal and Ferroptosis-Enhanced Photodynamic Therapy of Melanoma.","authors":"Kaifen Xiong, Guanghong Luo, Wei Zeng, Guanxi Wen, Chong Wang, Aijia Ding, Min Qi, Yingying Liu, Jianglin Zhang","doi":"10.2147/IJN.S503753","DOIUrl":"https://doi.org/10.2147/IJN.S503753","url":null,"abstract":"<p><strong>Background: </strong>Melanoma poses a significant threat to human health due to the lack of effective treatment options. Previous studies have demonstrated that the combination of photothermal therapy (PTT) and photodynamic therapy (PDT) can enhance therapeutic efficacy. However, conventional PTT/PDT combination strategies face various challenges, including complex preparation processes, potential damage to healthy tissues, and insufficient generation of reactive oxygen species (ROS). This study aims to design a rational and efficient PTT/PDT therapeutic strategy for melanoma and to explore its underlying mechanisms.</p><p><strong>Methods: </strong>We first synthesized two target materials, indocyanine green-targeted liposomes (ICG-Lips) and magnetic microbubbles (MMBs), using the thin-film hydration method, followed by characterization and performance evaluation of both materials. Subsequently, we evaluated the synergistic therapeutic effects and underlying mechanisms of ICG-Lips combined with MMBs in melanoma treatment through in vitro experiments using cellular models and in vivo experiments using animal models.</p><p><strong>Results: </strong>Herein, we developed a multifunctional system comprising ICG-Lips and MMBs. ICG-Lips enhance targeted delivery through specific binding to the S100B protein on melanoma cells, while MMBs, via ultrasound (US)-induced cavitation effects, shorten the uptake time of ICG-Lips by melanoma cells and improve uptake efficiency. Furthermore, the combination of ICG-Lips and MMBs induces significant reactive oxygen species (ROS) generation. Under 808 nm laser irradiation, the accumulation of ICG-Lips in melanoma cells achieves mild photothermal therapy (mPTT) and PDT effects. The elevated temperature and excessive ROS generated during these processes result in glutathione (GSH) depletion, ultimately triggering ferroptosis. The occurrence of ferroptosis further amplifies PDT efficacy, creating a synergistic effect that effectively suppresses melanoma growth. Additionally, the combined therapeutic strategy of ICG-Lips and MMBs demonstrates excellent biosafety.</p><p><strong>Conclusion: </strong>In summary, this study presents a novel and straightforward strategy that integrates mPTT, PDT, and ferroptosis synergistically to combat melanoma, thereby laying a solid foundation for improving melanoma treatment outcomes.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"2901-2921"},"PeriodicalIF":6.6,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11908402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pluronic-Based Micelle Encapsulation Potentiates Myricetin-Induced Cytotoxicity in Human Glioblastoma Cells [Retraction].","authors":"","doi":"10.2147/IJN.S526853","DOIUrl":"https://doi.org/10.2147/IJN.S526853","url":null,"abstract":"<p><p>[This retracts the article DOI: 10.2147/IJN.S114302.].</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"2935-2936"},"PeriodicalIF":6.6,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Nanomedicine Through Electron Microscopy: Insights Into Nanoparticle Cellular Interactions and Biomedical Applications.","authors":"Sultan Akhtar, Fatimah Zuhair","doi":"10.2147/IJN.S500978","DOIUrl":"10.2147/IJN.S500978","url":null,"abstract":"<p><p>Nanomedicine has revolutionized cancer treatment by the development of nanoparticles (NPs) that offer targeted therapeutic delivery and reduced side effects. NPs research in nanomedicine significantly focuses on understanding their cellular interactions and intracellular mechanisms. A precise understanding of nanoparticle interactions at the subcellular level is crucial for their effective application in cancer therapy. Electron microscopy has proven essential, offering high-resolution insights into nanoparticle behavior within biological systems. This article reviews the role of electron microscopy in elucidating the cellular uptake and intracellular interactions of NPs. Transmission electron microscopy (TEM) provides imaging capabilities, such as cryo three-dimensional tomography, which offer in-depth insights into nanoparticle localization, endocytosis pathways, and subcellular interactions, while high resolution-TEM is primarily used for studying the atomic structure of isolated NPs rather than nanoparticles within cells or tissues. On the other hand, scanning electron microscopy (SEM) is ideal for examining larger surface areas and provides a broader perspective on the morphology and topography of the samples. The review highlights the advantages of electron microscopy in visualizing nanoparticle interactions with cellular structures and tracking their mechanisms of action. It also addresses the challenges associated with electron microscopy characterization, such as tedious sample preparation, static imaging limitations, and a restricted field of view. By examining various nanoparticle uptake pathways, and cellular destination of NPs with examples, the article emphasizes the importance of these pathways to optimize nanoparticle design and enhance therapeutic efficacy. This review underscores the need for continued advancement in electron microscopy techniques to improve the effectiveness of nanomedicine and address existing challenges. In summary, electron microscopy is a key tool for advancing our understanding of nanoparticle behavior in biological contexts, aiding in the design and optimization of nanomedicines by providing insights into nanoparticle cellular dynamics, uptake mechanisms, and therapeutic applications.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"2847-2878"},"PeriodicalIF":6.6,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11899938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomes Attenuates Experimental Periodontitis in Mice Partly by Delivering miRNAs.","authors":"Ke Li, Xiaoli Gu, Yanan Zhu, Ning Guan, Jinlei Wang, Linyuan Wang","doi":"10.2147/IJN.S502192","DOIUrl":"10.2147/IJN.S502192","url":null,"abstract":"<p><strong>Introduction: </strong>Periodontitis is the most common non-communicable disease in humans. The main challenge in the treatment of periodontitis is to effectively control periodontal inflammation and promote tissue repair. Human umbilical cord mesenchymal stem cells-derived exosomes (hucMSCs-exo) have been reported to modulate inflammatory responses and promote tissue repairment mainly through miRNAs in several diseases. However, the effect of hucMSCs-exo on periodontitis remains unknown. In this study, we hypothesized that hucMSCs-exo could inhibit bone destruction in periodontitis mice.</p><p><strong>Methods: </strong>In this study, we constructed and characterized the exo@H drug delivery platform. Lipopolysaccharide was used to construct an inflammatory microenvironment in vitro to detect MC3T3-E1 cells proliferation and bone regeneration capacity. Ligation induced to construct an experimental periodontitis mouse model. The distance of the cement-enamel junction (CEJ) to the alveolar bone crest (ABC) was measured for bone resorption evaluation. Hematoxylin-eosin (H&E) staining and Tartrate resistant acid phosphatase (TRAP) staining were used to observe periodontal tissue changes. MicroRNA (miRNA) sequencing was used to detect differential genes and for bioinformatics analysis. Real-time quantitative polymerase chain reaction (qRT-PCR). WB assay and dual luciferase assay were used to further validate the screened differentially expressed miRNAs and the targeted binding relationship with the corresponding target genes.</p><p><strong>Results: </strong>We found that lyophilized hucMSCs-exo promoted the proliferation and osteogenic differentiation of MC3T3-E1 cells, and showed more significant proliferative and osteogenic differentiation abilities in combination with the hydrogel (<i>P</i> < 0.05). Using periodontitis mice, bone resorption evaluation revealed a significant reduction in alveolar bone resorption in the exo@H group compared to the hydrogel group (<i>P</i> < 0.01), and exo@H was able to reduce the inflammatory response of periodontal tissues and the number of osteoclasts on the surface of the alveolar bone compared to the hydrogel group. Moreover, 59 miRNAs were upregulated, such as let-7f-5p and miR-203-3p, which positively targeted IL-13 and Nit2, respectively.</p><p><strong>Discussion: </strong>These results suggest that exo@H provides protection against periodontitis partly by delivering miRNAs to periodontal tissue. Our results confirm the feasibility of the exo@H delivery platform we constructed and the effectiveness of its use for periodontitis treatment, and this study provides a promising approach for the treatment of periodontitis via miRNA.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"2879-2899"},"PeriodicalIF":6.6,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11900796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of Metal-Based Nanoparticle Composite Formulations and Their Application in Wound Dressings.","authors":"Menglei Wang, Yawen Luo, Qianwen Yang, Jiawen Chen, Meixin Feng, Yingmei Tang, Wantong Xiao, Ziyi Tang, Yue Zheng, Li Li","doi":"10.2147/IJN.S508036","DOIUrl":"10.2147/IJN.S508036","url":null,"abstract":"<p><p>Metal-based nanoparticles (MNPs) have great potential for applications in wound healing and tissue engineering, and due to their unique structures, high bioactivities, and excellent designability characteristics, an increasing number of studies have been devoted to modifying these species to generate novel composites with desirable optical, electrical, and magnetic properties. However, few systematic and detailed reviews have been performed relating to the modification approaches available for MNPs and their resulting composites. In this review, a comprehensive summary is performed regarding the optimized modification formulations of MNPs for application in wound dressings, and the techniques used to prepare composite wound dressings are discussed. In addition, the safety profiles of the novel nanocomposite formulations and the limitations of the reported systems are evaluated. More importantly, a number of solution strategies are proposed to address these limitations. Overall, this review provides new ideas for the design of MNPs to facilitate their application in the field of skin tissue repair, and also looks into the future direction of MNPs in the biomedical field.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"2813-2846"},"PeriodicalIF":6.6,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomimetic Self-Oxygenated Immunoliposome for Cancer-Targeted Photodynamic Immunotherapy.","authors":"Yucheng Tang, Tiantian Tang, Yongjiang Li, Junyong Wu, Xinyi Liu, Daxiong Xiang, Xiongbin Hu","doi":"10.2147/IJN.S508696","DOIUrl":"10.2147/IJN.S508696","url":null,"abstract":"<p><strong>Objective: </strong>Photodynamic therapy (PDT) is a promising strategy with significant clinical application potential for tumor treatment. However, the tumor hypoxia and limited efficacy against tumor metastasis present significant limitations in the clinical application of PDT. To alleviate tumor hypoxia for PDT against tumor growth and metastasis, we developed a self-oxygenated immunoliposome by encapsulating the catalase (CAT) within the liposome cavity and loading the photosensitizer chlorin e6 (Ce6) and immunoadjuvant MPLA in the lipid bilayer of the immunoliposome (CAT@LP-Ce6-A). Subsequently, we fused it with the cancer cell membrane (CCM) to create the hybrid immunoliposome (CAT@LP-CCM-Ce6-A). The in vitro and in vivo anti-cancer efficacy of CAT@LP-CCM-Ce6-A-based photodynamic immunotherapy (PDIT) was evaluated.</p><p><strong>Methods: </strong>CAT@LP-CCM-Ce6-A were characterized by size, zeta potential, transmission electron microscopy (TEM), Coomassie bright blue staining, UV spectrophotometer, and standard Goth's method. Cellular uptake, cell viability, reactive oxygen species (¹O₂) generation, calreticulin exposure, and ability to promote BMDCs maturation of CAT@LP-CCM-Ce6-A were evaluated in vitro. Biodistribution, anti-cancer therapeutic efficacy, and in vivo safety of CAT@LP-CCM-Ce6-A were investigated in orthotopic triple-negative breast cancer (TNBC) lung metastasis mouse models.</p><p><strong>Results: </strong>CAT@LP-CCM-Ce6-A was successfully developed via the thin film hydration and co-extrusion method. The loading capacity of Ce6 and CAT was 4.7 ± 0.9% and 8.5 ± 0.9% respectively. CAT@LP-CCM-Ce6-A exhibited improved cellular uptake efficiency and cytotoxicity under laser irradiation against TNBC. Furthermore, CAT@LP-CCM-Ce6-A possessed enhanced anti-enzymatic degradation ability and promotion of DC maturation. In TNBC-bearing mice, CAT@LP-CCM-Ce6-A-based PDIT demonstrated remarkable therapeutic effect and antitumor immunity while maintaining minimal systemic toxicity.</p><p><strong>Conclusion: </strong>CAT@LP-CCM-Ce6-A could be employed as an innovative approach for self-oxygenated photodynamic immunotherapy against cancer.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"2743-2759"},"PeriodicalIF":6.6,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanism of Antioxidant Activity of Selenium Nanoparticles Obtained by Green and Chemical Synthesis.","authors":"Anna Grudniak, Julia Folcik, Jakub Szmytke, Aleksandra Sentkowska","doi":"10.2147/IJN.S507712","DOIUrl":"10.2147/IJN.S507712","url":null,"abstract":"<p><strong>Background: </strong>Selenium nanoparticles (SeNPs) show high therapeutic potential. SeNPs obtained by green synthesis methods, using commonly available plants, are an attractive alternative to nanoparticles obtained by classical, chemical methods. The green synthesis process uses environmentally friendly reagents, which offer an eco-friendly advantage. Clarifying their mechanism of action is key to their safe use.</p><p><strong>Methods: </strong>The study used SeNPs obtained using extracts of sage, hops, blackberry, raspberry, and lemon balm, without the use of additional stabilizers, and nanoparticles chemically obtained with ascorbic acid and gallic acid, stabilized with polyvinyl alcohol. The study was carried out on a model strain of Escherichia coli. In the study, the activities of the key enzymes catalase (CAT), superoxide dismutase (SOD), and the response of bacterial cells to osmotic shock were determined.</p><p><strong>Results: </strong>One of the key mechanisms of action of SeNPs is related to the formation of ROS in bacterial cells. The SeNPs tested showed strong inhibition of CAT, an enzyme crucial for bacterial cells that is involved in the removal of hydrogen peroxide. The tested SeNPs also had an effect on reducing the activity of superoxide dismutase (SOD), which is also involved in the removal of reactive oxygen species from cells. Green SeNPs were also shown to be involved in the cellular response to osmotic shock, confirming their pleiotropic mechanism of action in bacterial cells.</p><p><strong>Conclusion: </strong>NPs synthesized via green methods exhibit antibacterial activity against E. coli. The green synthesis process employs environmentally friendly reagents, offering a pro-ecological advantage. Notably, these nanoparticles are strongly stabilized by the post-reaction mixture, eliminating the need for toxic stabilizers. Their antimicrobial mechanism involves ROS generation, catalase (CAT) inhibition, and reduced SOD activity, affecting ROS defense and by disrupting the cellular response to osmotic shock.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"2797-2811"},"PeriodicalIF":6.6,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Triple-Negative Breast Cancer Therapy via Ultrasound-Enhanced Piezocatalysis for Targeted Chemodrug Release.","authors":"Qingwen Xue, Ningning He, Yuxiu Gao, Xuehui Zhang, Shuao Li, Fang Chen, Chunping Ning, Xiaoyu Wu, Jingtong Yao, Ziheng Zhang, Shangyong Li, Cheng Zhao","doi":"10.2147/IJN.S505526","DOIUrl":"10.2147/IJN.S505526","url":null,"abstract":"<p><strong>Introduction: </strong>Triple-negative breast cancer (TNBC) is known for its high malignancy, limited clinical treatment options, and poor chemotherapy outcomes. Although some advancements have been made using nanotechnology-based chemotherapy for TNBC treatment, the controlled and on-demand release of chemotherapeutic drugs at the tumor site remains a challenge.</p><p><strong>Methods: </strong>We manufactured DOX/BaTiO₃@cRGD-Lip (DBRL) nanoparticles as an ultrasound (US)-controlled release platform targeting the delivery of Doxorubicin (DOX) for TNBC treatment. The nanoparticles incorporate DSPE-Se-Se-PEG-NH₂ as the liposomal membrane for ROS responsiveness, cRGD peptide for TNBC cell selectivity, and polyethylene glycol for minimized phagocytic cell absorption.</p><p><strong>Results: </strong>The DBRL+US group achieved significant tumor inhibition (70.27% compared to control group, p < 0.001), while maintaining excellent biocompatibility with over 90% cell viability in normal cells. The selective cytotoxicity was evidenced by a 55.70% cell death rate in 4T1 cancer cells under US activation. DBRL showed enhanced tumor accumulation with peak fluorescence intensity of (1.01 ± 0.33)×10⁹ at 12 hours post-injection.</p><p><strong>Conclusion: </strong>This targeted nanocomposite material paves a new prospect for future precise piezoelectric catalytic therapy for the treatment of TNBC.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"2779-2796"},"PeriodicalIF":6.6,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11892375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143597087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}