International Journal of Nanomedicine最新文献

{"title":"MSC-Derived Extracellular Vesicles: Roles and Molecular Mechanisms for Tissue Repair.","authors":"Tingting Wu, Yajing Liu, Shuman Wang, Chen Shi","doi":"10.2147/IJN.S525394","DOIUrl":"10.2147/IJN.S525394","url":null,"abstract":"<p><p>Mesenchymal stem cells (MSCs) are pluripotent stem cells that have great potential in the field of regenerative medicine. Extracellular vesicles that derived from MSCs inherit the bioactive molecules, including lipids, proteins, nucleic acids, from the donate cells. With similar biological functions as MSCs, MSC-EVs show lower toxicity, better biocompatibility, stability, and less immune rejection. Therefore, MSC-EVs are emerging as a cell-free alternative therapy for MSC-based cell therapy. Here, we reviewed the characteristics of different subtype of MSC-EVs, the functional molecules in MSC-EVs for tissue repair, the potential applications of MSC-EVs for different tissue injuries in recent three years, and the clinical progress as well as the existing challenges in MSC-EV based therapy. This review would provide some insights for the future researches and clinical translation of MSC-EVs in regenerative medicine.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"7953-7974"},"PeriodicalIF":6.6,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12191179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144496156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring the Antibacterial Activity of the Green Synthesized ZnO Nanoparticles on the Negative and Positive Gram Bacteria Mimicking Oral Environment by Using a Quartz Tuning Fork (QTF) Micromechanical Sensor.","authors":"Khalid A Al-Hamad, Ashwaq Asiri, Ali M Alqahtani, Saud Alotaibi, Abdullah Almalki","doi":"10.2147/IJN.S480164","DOIUrl":"10.2147/IJN.S480164","url":null,"abstract":"<p><strong>Introduction: </strong>Green-synthesized nanoparticles show promise as anti-biofilm and antibacterial agents in medical applications, including dental implants and oral devices. However, conventional antibacterial testing methods are laborious and lack sensitivity. Quartz tuning fork (QTF)-based biosensors offer a compelling alternative due to their high sensitivity, compact size, and cost-effectiveness. This study evaluates a QTF biosensor for quantifying the antibacterial activity of green-synthesized ZnO nanoparticles against negative and positive Gram bacteria.</p><p><strong>Methods: </strong>The antibacterial activity of ZnO nanoparticles was tested in a simulated oral environment against <i>Staphylococcus aureus</i> (gram-positive) and <i>Escherichia coli</i> (gram-negative) using a QTF biosensor. Changes in resonance frequency and quality factor were measured to assess bacterial growth inhibition. Experiments were conducted with varying ZnO concentrations (eg, 1 mm) to correlate sensor responses with antibacterial effects.</p><p><strong>Results: </strong>The QTF biosensor detected significant antibacterial activity as resonance frequency decreased by 5.69 ± 3.81 hz (<i>S. aureus</i>) and 30.57 ± 4.01 hz (<i>E. coli</i>) in 1 mm ZnO. Quality factor declined by 31.75 ± 7.55 for <i>E. coli</i> but remained stable for <i>S. aureus</i>. Higher bacterial concentrations (lower ZnO doses) increased damping effects, reducing the quality factor. <i>S. aureus</i> exhibited greater sensitivity to ZnO nanoparticles than <i>E. coli</i>.</p><p><strong>Discussion: </strong>The QTF biosensor successfully quantified the antibacterial effects of green-synthesized ZnO nanoparticles, demonstrating its potential as a rapid, sensitive alternative to traditional methods. The differential responses of <i>S. aureus</i> and <i>E. coli</i> suggest species-specific interactions with ZnO, warranting further study. This approach could streamline the development of biocompatible, antibacterial medical materials.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"7975-7985"},"PeriodicalIF":6.6,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in Functionalized Nanoparticles for Osteoporosis Treatment.","authors":"Rong Cai, Yuanyuan Jiang, Haiyan Sun, Fengyi Du, Like Zhu, Jialing Tao, Long Xiao, Zhirong Wang, Haiwei Shi","doi":"10.2147/IJN.S519945","DOIUrl":"10.2147/IJN.S519945","url":null,"abstract":"<p><p>Osteoporosis (OP) represents a significant global health burden, characterized by reduced bone density and an increased risk of fractures due to imbalances in bone remodeling processes. Traditional therapeutic strategies, while mitigating symptoms, often lack the precision to address the multifactorial nature of OP effectively. In recent years, functionalized nanoparticles have emerged as a versatile platform, offering enhanced drug delivery, targeted therapy, and the potential for theranostic applications in OP treatment. This review examines the various types and architectures of functionalized nanoparticles, emphasizing their unique capabilities in targeting bone tissue and modulating bone metabolism. By focusing on their roles in inflammation modulation, oxidative stress reduction, and promoting bone regeneration, we discuss the mechanisms by which these nanoparticles offer multifunctional, synergistic effects. Additionally, we address the challenges in achieving controlled drug release, biocompatibility, and effective bone tissue penetration, proposing future directions that integrate emerging nanotechnologies, biomechanics, and regenerative medicine approaches to optimize therapeutic outcomes. This comprehensive review provides a foundation for the future development of functionalized nanoparticle therapies, positioning them as promising tools for advanced, personalized OP treatment.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"7869-7891"},"PeriodicalIF":6.6,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12186752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Baicalin Liposome-Based Temperature-Sensitive Hydrogel for Treating Ultraviolet-Induced Skin Damage.","authors":"Xing Liu, Wenlin Shu, Qingrui Zhong, Anqi Zeng, Yong Zeng, Huan Gu, Ping Chen, Xiaofang Li","doi":"10.2147/IJN.S516572","DOIUrl":"10.2147/IJN.S516572","url":null,"abstract":"<p><strong>Purpose: </strong>Prolonged exposure of the skin to ultraviolet (UV) rays from sunlight causes oxidative damage to skin cells, and prolonged exposure to UV can lead to severe sunburn and skin aging, which may increase the risk of skin cancer. Numerous natural products have been used to treat UV-induced skin damage. Baicalin (BA) has excellent antioxidant properties; however, its poor solubility hinders its direct application. Therefore, suitable formulations for dermal administration must be developed.</p><p><strong>Methods: </strong>We designed a temperature-sensitive gel drug delivery system based on baicalin liposome (BA-LP), which was first constructed using lecithin loaded with insoluble BA. Subsequently, an injectable hydrogel (BA-LG) with temperature-sensitive properties was constructed using BA-LP and chitosan (CS) with β-glycerophosphate tetrahydrate (β-GP) as a crosslinking agent.</p><p><strong>Results: </strong>BA-LP had homogeneous particle size, high EE, and good stability. BA-LG could be gelled within 2 min at 37 °C and had good spreading, adhesion, and injectability properties. The in vitro release results showed that BA-LG had a significantly slower release effect, with a cumulative release of 60% at 24 h. The effects of BA-LG on skin keratinocyte HaCaT cells were evaluated using the CCK8 method and transwell co-culture, and the results showed good cell activity and a high survival rate, indicating that the hydrogel has good biosafety. In the UVB-induced skin injury mouse model, BA-LG showed significant effects by increasing superoxide dismutase (SOD) activity, decreasing malondialdehyde (MDA) damage, and inhibiting the expression of inflammatory factors IL-6, PGE2, and TNF-α, and demonstrated a superior therapeutic effect. The analysis of histopathological sections of the skin stained with H&E and Masson revealed results consistent with those observed on the mice.</p><p><strong>Conclusion: </strong>In summary, our results suggest that BA-LG, a temperature-sensitive gel based on baicalin liposomes, has good therapeutic efficacy and potential applications in the treatment of UVB-induced skin damage.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"7935-7951"},"PeriodicalIF":6.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12184705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innervated Biomaterials for Improved Cutaneous Wound Healing: A Review of Recent Advancements and Future Prospects.","authors":"BoYang Zhang, KaiYue Zhang, QiuYue Liu, JiaLin Zhang, WenTao Chen, JieTing Tang, Chuang Wang, ZhenZhao Guo","doi":"10.2147/IJN.S524182","DOIUrl":"10.2147/IJN.S524182","url":null,"abstract":"<p><p>Cutaneous wound healing remains a significant clinical challenge, particularly for chronic and large-scale injuries, where functional recovery-especially sensory reinnervation-is often inadequate. Recent advances highlight the pivotal role of innervation in regulating tissue repair through neuropeptide signaling, immunomodulation, and angiogenesis. Despite progress in biomaterial-based therapies, most existing solutions focus on structural repair while neglecting neural regeneration, leading to suboptimal functional outcomes. This review explores emerging biomaterial strategies that integrate neuroregenerative capabilities with wound healing properties, including electroconductive scaffolds for bioelectric stimulation, neurotrophic factor-releasing matrices, and bioengineered constructs. We critically evaluate their mechanisms in promoting axonal regrowth, macrophage polarization, and vascular network formation, while addressing challenges in long-term functional integration. This review outlines the mechanisms of wound healing, existing treatments, and the vital role of nerves in the healing process. It also highlights materials that promote skin neuralization in cutaneous wound healing, aiming to inspire further research into these materials and the underlying mechanisms involved. By bridging the gap between neural and cutaneous regeneration, this work provides a roadmap for developing next-generation wound therapies that restore both structural integrity and sensory function. Future directions emphasize the need for standardized neuroregenerative assessment criteria and clinically translatable designs.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"7829-7849"},"PeriodicalIF":6.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12184695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smart Thrombosis Care: The Rise of Closed-Loop Diagnosis-to-Treatment Nano Systems.","authors":"Jiong Wu, Yuanyuan Zhang, Wu Chen, Tianjiao Hao, Chuanjiang Ran, Yuanyuan Zhou, Yan Shen, Wei You, Tao Wang","doi":"10.2147/IJN.S530884","DOIUrl":"10.2147/IJN.S530884","url":null,"abstract":"<p><p>Thrombosis continues to be a leading cause of morbidity and mortality worldwide, presenting complex pathophysiological challenges that complicate effective diagnosis and treatment. A holistic approach to thrombosis management, incorporating integrated diagnostic and therapeutic systems, is essential for improving patient outcomes. This review explores the emerging concept of closed-loop diagnosis-to-treatment nanosystems in thrombosis care, with a focus on integrating advanced technologies. Specifically, we examine the targeting of critical components involved in thrombosis, including platelets, coagulation factors, endothelial cells, the fibrinolytic system, and the immune system. Techniques such as platelet aggregation assays, coagulation function tests, biomarker detection, and nanotechnology-based therapies are discussed. Moreover, the application of these integrated systems is reviewed in both the acute and chronic phases of thrombosis, covering conditions such as acute coronary syndrome, acute pulmonary embolism, chronic deep vein thrombosis, and post-surgical thrombosis prevention. Finally, the review highlights potential future developments in integrated thrombosis care, with an emphasis on personalized treatment strategies and the role of emerging technologies in enhancing clinical outcomes. These insights underscore the transformative potential of closed-loop nano-systems in achieving more precise, timely, and effective thrombosis management.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"7851-7868"},"PeriodicalIF":6.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12184709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial and Antitumor Application of Carbon Dots Based on Natural Products for Photodynamic/Photothermal Effects.","authors":"María P Romero, Karina J Lagos, Coralia Fabiola Cuadrado, Cristina C Garzón-Romero, Mateo A Salazar, Guillermo Solorzano, Jules A Gardener, Myriam A González, Miryan Rivera","doi":"10.2147/IJN.S507574","DOIUrl":"10.2147/IJN.S507574","url":null,"abstract":"<p><strong>Introduction: </strong>This work presents an easy one-pot synthesis to prepare carbon dots (CDs) from natural products, and their successful application as photosensitizers (PS) and photothermal agents (PA) to combat bacteria and cancerous cells. Despite some differences may appear in the natural extracts due to the obtaining process, it was possible to obtain antibacterial/antitumor photoactivated nanomedicine from common carbon sources as annatto, cinnamon and curcumin.</p><p><strong>Methods: </strong>Water dispersions of <i>Bixa Orellana L</i>. (annatto), <i>Cinnamomum verum J. Presl</i> (cinnamon), <i>Curcuma longa L</i>. (turmeric or curcumin), and sucrose were used as precursors to prepare CDs1, CDs2, CDs3, and CDs4, correspondingly. The microwave-assisted route was selected to synthesize CDs since it is a simple-timesaving procedure that allows harnessing eco-friendly precursors. The shape, size, and chemical composition of CDs were determined by transmission electron microscopy (TEM), dynamic light scattering (DLS), Fourier-transform infrared (FTIR) and Raman spectroscopies, respectively. In addition, photodynamic, photothermal, luminescence, cytotoxicity, antimicrobial and antitumor analyses were carried out and assessed.</p><p><strong>Results and discussion: </strong>This research synthesized irregular shaped CDs, in the range of 2.3 to 3.7 nm, from natural sources. Regarding, their photodynamic and photothermal properties, it was demonstrated that after irradiation CDs generated ¹O₂ species and the temperature can raise in the range to 40-50 °C, respectively. The antimicrobial capacity of the CDs was tested against microorganism <i>methicillin-resistant S. aureus</i> (<i>MRSA</i>) and <i>Extended-Spectrum β-Lactamase</i> (<i>ESBL</i>)-<i>producing E. coli</i>. CDs1, CDs2, and CDs3 showed excellent antibacterial effects since complete inhibitions were observed after irradiation with blue light (450 nm; 40 mW·cm^-2). In addition, the positive antitumor effect was also evidenced against T47D cells. Therefore, it has been demonstrated that the CDs synthesized from green carbon sources such as annatto, cinnamon and curcumin have potential applications as antibacterial and antitumor nanomaterials.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"7893-7914"},"PeriodicalIF":6.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12184703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Daidzein-Decorated Gold Nanoparticles as a Novel Antimicrobial Strategy Against Carbapenem-Resistant Enterobacteriaceae.","authors":"Juan Pan, Jia Zhang, Panjie Hu, Zhuocheng Yao, Xiaotuan Zhang, Tieli Zhou, Mo Shen","doi":"10.2147/IJN.S515798","DOIUrl":"10.2147/IJN.S515798","url":null,"abstract":"<p><strong>Introduction: </strong>Bacterial resistance to carbapenems is on the rise, and the failure of common antimicrobials poses a serious challenge in treating infections caused by drug-resistant strains. In this scenario, nanomaterials have received widespread attention in medicine.</p><p><strong>Methods: </strong>In this study, the activity of daidzein-decorated gold nanoparticles (Daidzein_Au NPs) against carbapenem-resistant Enterobacteriaceae (CRE) strains was validated via in vivo and in vitro experiments, such as the microdilution broth method, growth curves, time-killing assays, and an abdominal infection model in mice. The potential mechanisms involved were examined using fluorescence quantification of N-phenyl-1-naphthylamine, propidium iodide, and reactive oxygen species (ROS) levels and transcriptomic analysis.</p><p><strong>Results: </strong>Face-centered cubic Daidzein_Au NPs with an average size of 25.78 nm and a negative surface charge were successfully synthesized. The minimum inhibitory concentration (MIC) of Daidzein_Au NPs against the tested CRE strains was 8-16 μg/mL, and they exerted a good antimicrobial effect during the dynamic killing process. In vivo experiments showed that Daidzein_Au NPs can significantly enhance the survival rate (100%) and reduce the colony load of ascites in mice (<i>P</i> < 0.05). Furthermore, Daidzein_Au NPs destroyed the permeability of bacterial cell membranes, increased the production of ROS (<i>P</i> < 0.05), and affected the metabolism of CRE strains to play a role in killing.</p><p><strong>Conclusion: </strong>Daidzein_Au NPs exhibit excellent antibacterial activity and are expected to become a promising solution to the threats posed by CRE strains.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"7811-7827"},"PeriodicalIF":6.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12184690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RGD-Functionalized Ginsenoside Rg3 Liposomes for Alleviating Oxidative Stress and Choroidal Neovascularization in Age-Related Macular Degeneration.","authors":"Jie Zhou, Dengminghong Zhao, Shaotian Niu, Weiwei Meng, Zhoujiang Chen, Hanmei Li, Ya Liu, Liang Zou, Wei Li","doi":"10.2147/IJN.S520756","DOIUrl":"10.2147/IJN.S520756","url":null,"abstract":"<p><strong>Background and aim: </strong>Age-related macular degeneration (AMD) is a leading cause of vision loss owing to choroidal neovascularization (CNV) and retinal vascular abnormalities. Current anti-VEGF therapies often exhibit limited efficacy in approximately 50% of patients owing to the complex pathological microenvironment, including elevated reactive oxygen species (ROS) levels. This study aimed to develop a multitargeted therapeutic strategy for AMD by leveraging the antioxidant and anti-angiogenic properties of ginsenoside Rg3 (Rg3).</p><p><strong>Methods: </strong>RGD-Rg3@Lips was formulated to encapsulate Rg3 and modified with (Arginine-Glycine-Aspartic Acid, RGD) peptides for targeted delivery. In vitro studies have evaluated the cellular internalization, anti-angiogenic effects, and suppression of oxidative stress and inflammation in ARPE-19 cells. In vivo efficacy was assessed using a laser-induced AMD mouse model, in which an intravitreal injection of RGD-Rg3@Lips was administered. Mechanistic studies have focused on the hypoxia-inducible factor 1-α, (HIF-1α) / vascular endothelial growth factor, (VEGF) signaling pathway and the expression of inflammatory cytokines.</p><p><strong>Results: </strong>RGD-Rg3@Lips demonstrated superior cellular internalization and anti-angiogenic efficacy compared to Rg3@Lips and free Rg3 in vitro, significantly reducing oxidative stress and inflammation. In vivo, RGD-Rg3@Lips markedly reduced CNV formation and vascular leakage in an AMD mouse model. Mechanistically, RGD-Rg3@Lips attenuated oxidative stress, inhibited the HIF-1α/VEGF pathway, and downregulated key inflammatory cytokines including tumor necrosis factor α (TNF-α) and VEGF. RGD modification significantly improved the targeting of CNV lesions, enhancing therapeutic efficacy by specifically binding to vascular surface integrin receptors compared to non-modified liposomes and free Rg3.</p><p><strong>Conclusion: </strong>This study highlights the potential of RGD-Rg3@Lips as a novel multitargeted therapeutic strategy for wet AMD. By combining the antioxidant and antiangiogenic properties of Rg3 with targeted drug delivery, RGD-Rg3@Lips offers a promising approach to address the limitations of current AMD therapies. These findings underscore the value of natural-product-based nanomedicine for the treatment of complex ocular diseases.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"7915-7933"},"PeriodicalIF":6.6,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12184786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Oxaliplatin with 5-Fluorouracil for Effective Chemotherapy Against Gastric Cancer in Animal Model.","authors":"Jiannan Ren, Menglin Song, Dongbing Ding, Tianyun Lan, Yiquan Li, Rongpu Liang, Shengxin Huang, Guangchun Jiang, Jiarong You, Jianming Yang, Chi Chen, Weiyi Luan, Bekhzod Abdullaev, He Huang, Yang Zhao, Bo Wei","doi":"10.2147/IJN.S520603","DOIUrl":"10.2147/IJN.S520603","url":null,"abstract":"<p><strong>Introduction: </strong>Oxaliplatin (OXA) and 5-fluorouracil (5-Fu) are standard chemotherapy agents used to treat advanced gastric cancer (GC). However, their clinical efficacy is often limited by systemic toxicity, poor tumor selectivity, and suboptimal therapeutic outcomes when administered as monotherapy. These limitations underscore the need for innovative approaches to improve chemotherapy sensitivity and treatment efficacy.</p><p><strong>Methods: </strong>We developed a glucose-responsive, RGD peptide-functionalized biporous silica nanocarrier (R-BSN). This system integrates hollow glucose oxidase (hGOx)-modified micelles onto hollow mesoporous silica nanoparticles functionalized with RGD peptides, enabling targeted, sustained drug release and inducing a starvation effect in tumor cells.</p><p><strong>Results: </strong>The glucose-triggered biporous release strategy significantly prolongs the drug release profile, ensuring sustained chemotherapy delivery while simultaneously depleting intratumoral glucose to enhance therapeutic efficacy. This strategy not only increases chemotherapy potency but also exacerbates oxidative stress in tumor cells, leading to the induction of immunogenic cell death (ICD). Furthermore, R-BSN exhibits robust anti-tumor activity in both subcutaneous tumor models and peritoneal metastasis models, supporting its potential for multi-pathway tumor eradication.</p><p><strong>Conclusion: </strong>The glucose-triggered biporous silica nanocarrier offers a promising strategy to enhance chemotherapy outcomes in advanced gastric cancer, integrating sustained drug release, starvation therapy, and amplification of oxidative stress. This approach holds significant potential for clinical translation in gastric cancer treatment.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"7763-7780"},"PeriodicalIF":6.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12182064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}