International Journal of Nanomedicine最新文献

{"title":"Response to Article \"Regenerative Potential Nanomedicine of Adipocyte Stem Cell-Derived Exosomes in Senescent Skin Tissue\" [Letter].","authors":"Yingjian Tan, Yue Zeng, Rui Li","doi":"10.2147/IJN.S522282","DOIUrl":"10.2147/IJN.S522282","url":null,"abstract":"","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"2555-2556"},"PeriodicalIF":6.6,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11874987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolating Astrocyte-Derived Extracellular Vesicles From Urine.","authors":"Xin-Hui Xie, Mian-Mian Chen, Shu-Xian Xu, Junhua Mei, Qing Yang, Chao Wang, Honggang Lyu, Qian Gong, Zhongchun Liu","doi":"10.2147/IJN.S492381","DOIUrl":"https://doi.org/10.2147/IJN.S492381","url":null,"abstract":"<p><strong>Introduction: </strong>Brain-derived extracellular vesicles (BDEVs) can cross the blood-brain barrier and enter the periphery. Therefore, quantifying and analyzing peripherally circulating BDEVs offer a promising approach to directly obtain a window into central nervous system (CNS) pathobiology in vivo. Rapidly evolving CNS diseases require high-frequency sampling, but daily venipuncture of human subjects is highly invasive and usually unfeasible.</p><p><strong>Methods: </strong>To address this challenge, here we present a novel method for isolating astrocyte-derived extracellular vesicles from urine (uADEVs), combining urine concentration, ultracentrifugation to isolate total EVs, and then glutamate-aspartate transporter (GLAST) EV isolation using an anti-GLAST antibody.</p><p><strong>Results: </strong>The identity of these GLAST+EVs as uADEVs was confirmed by transmission electron microscopy, nanoparticle tracking analysis, western blotting, and assessment of astrocyte-related neurotrophins.</p><p><strong>Conclusions: </strong>Leveraging the convenience and availability of urine samples, the non-invasive uADEV approach provides a novel tool that allows high-frequency sampling to investigate rapidly evolving CNS diseases.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"2475-2484"},"PeriodicalIF":6.6,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Mesoporous Polydopamine-Coated Upconversion Nanoparticles for Dual-Enhanced Photodynamic and Photothermal Cancer Therapy.","authors":"Voradanu Visetvichaporn, Na-Young Yu, Seong-Wook Kang, Duy-Thuc Nguyen, Jun Pyo Lim, Ho Seong Jang, Dae-Duk Kim","doi":"10.2147/IJN.S503977","DOIUrl":"https://doi.org/10.2147/IJN.S503977","url":null,"abstract":"<p><strong>Background: </strong>Photodynamic therapy (PDT) is a common cancer treatment strategy that combines the use of light, a photosensitizer, and oxygen to precisely generate reactive oxygen species (ROS). However, the efficacy of this method is limited by the shallow tissue penetration of the short-wavelength lasers involved, and combination therapy with other treatments such as photothermal therapy (PTT) or radiation therapy requires additional lasers or instruments. A new dual therapy approach using a single laser could minimize the treatment procedure.</p><p><strong>Methods: </strong>Chlorin e6 (Ce6) loaded-NaYF₄:Yb,Er@NaYF₄:Yb,Nd upconversion nanoparticles@mesoporous silica@mesoporous polydopamine nanoparticles (U@MSC@MP NPs) were fabricated to achieve PDT and PTT combination cancer therapy using a single 808 nm laser. The NaYF₄:Yb,Er@NaYF₄:Yb,Nd upconversion nanoparticles (UCNPs) were coated with mesoporous silica (MS) for Ce6-loading and coated with mesoporous polydopamine (MP) as a PTT photosensitizer. The PDT and PTT effects were measured using ROS generation detection and a thermal camera, respectively; in vitro cytotoxicity studies and in vivo antitumor efficacy analysis using tumor xenograft mouse models were performed to confirm the dual effects.</p><p><strong>Results and discussion: </strong>The PDT-PTT UCNPs were successfully synthesized and emit photoluminescence spectra that can be absorbed by Ce6 to induce the PDT effect. Significant ROS generation was observed from U@MSC@MP NPs following 808 nm laser irradiation for 5 min, which corresponded to intracellular ROS detection in human colorectal adenocarcinoma HT-29 cells. The NPs significantly reduced HT-29 cell viability compared with PDT or PTT alone, demonstrating the potential of the designed UCNPs. Moreover, the in vivo antitumor efficacy analysis confirmed the dual effect with no signs of toxicity, supporting the safety and biocompatibility of the synthesized NPs.</p><p><strong>Conclusion: </strong>These findings suggest that the combination of PDT and PTT using a single laser can be achieved with UCNPs. This approach is a promising strategy for simplifying the cancer treatment procedures in clinical applications.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"2505-2519"},"PeriodicalIF":6.6,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Targeted Nanotoxin Inhibits Colorectal Cancer Growth Through Local Tumor Pyroptosis and Eosinophil Infiltration and Degranulation.","authors":"Luis Miguel Carrasco-Díaz, Alberto Gallardo, Eric Voltà-Durán, Anna C Virgili, David Páez, Antonio Villaverde, Esther Vazquez, Patricia Álamo, Ugutz Unzueta, Isolda Casanova, Ramon Mangues, Lorena Alba-Castellon","doi":"10.2147/IJN.S499192","DOIUrl":"10.2147/IJN.S499192","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC) has traditionally been treated with genotoxic chemotherapy to activate pro-apoptotic proteins to induce anticancer effects. However, cancer cells develop resistance to apoptosis, which leads to recurrence and poor prognosis. Moreover, this kind of therapy has been shown to be highly toxic to healthy tissues and, therefore, to patients. To overcome this issue, we developed a self-assembly tumor-targeted nanoparticle, T22-DITOX-H6, that incorporates the T22 peptide (a CXCR4 ligand) to selectively target cells overexpressing CXCR4, fused to the catalytic domain of diphtheria toxin, that exhibits a potent cytotoxic effect on these CXCR4+ cancer cells that exhibits potent cytotoxic effects on CXCR4-overexpressing cancer cells through the activation of pyroptosis, an immunogenic type of cell death.</p><p><strong>Methods: </strong>Colorectal CXCR4-expressing tumor cells (CT26-CXCR4+) were implanted subcutaneously into immunocompetent mice to study the effects of T22-DITOX-H6 treatment on tumor growth, cell death and innate immune cell recruitment to the tumor.</p><p><strong>Results: </strong>Here, we demonstrated that the T22-DITOX-H6 nanoparticle selectively activated pyroptosis, an immunogenic cell death that differs from apoptosis, leading to cell death in CXCR4-expressing cells, without affecting the viability of CXCR4-lacking cells. In addition, the nanoparticle administered to tumor-bearing mice induced a local antitumor effect due to the selective activation of pyroptosis in CXCR4+ targeted cancer cells. Biochemical analysis of plasma and histological analysis of non-tumor tissues revealed no differences between the groups. Remarkably, pyroptosis activation stimulates eosinophil infiltration into the tumor microenvironment, an effect recently reported to have an anti-tumorigenic function.</p><p><strong>Conclusion: </strong>These results highlight the dual role of CXCR4-targeted cytotoxic nanoparticle in eliminating cancer cells and boosting the self-immune response without compromising healthy organs.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"2445-2460"},"PeriodicalIF":6.6,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Electrospun Nanofiber Blend With Improved Mechanical and Biological Performance [Corrigendum].","authors":"","doi":"10.2147/IJN.S523937","DOIUrl":"https://doi.org/10.2147/IJN.S523937","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.2147/IJN.S175619.].</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"2369-2370"},"PeriodicalIF":6.6,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Bioreducible Nanocapsules for Folic Acid-Assisted Targeting and Effective Tumor-Specific Chemotherapy [Corrigendum].","authors":"","doi":"10.2147/IJN.S523506","DOIUrl":"https://doi.org/10.2147/IJN.S523506","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.2147/IJN.S149458.].</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"2367-2368"},"PeriodicalIF":6.6,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilizing Nanoparticles to Overcome Anti-PD-1/PD-L1 Immunotherapy Resistance in Non-Small Cell Lung cancer: A Potential Strategy.","authors":"Yuli Ge, Qiong Zhou, Fan Pan, Rui Wang","doi":"10.2147/IJN.S505539","DOIUrl":"https://doi.org/10.2147/IJN.S505539","url":null,"abstract":"<p><p>Lung cancer is the leading cause of cancer-related mortality globally, with non-small cell lung cancer (NSCLC) constituting 85% of cases. Immune checkpoint inhibitors (ICIs) represented by anti-programmed cell death protein 1 (PD-1)/ programmed cell death ligand 1 (PD-L1) have emerged as a promising frontier in cancer treatment, effectively extending the survival of patients with NSCLC. However, the efficacy of ICIs exhibits significant variability across diverse patient populations, with a substantial proportion showing poor responsiveness and acquired resistance in those initially responsive to ICIs treatments. With the advancement of nanotechnology, nanoparticles offer unique advantages in tumor immunotherapy, including high permeability and prolonged retention(EPR) effects, enhanced drug delivery and stability, and modulation of the inflammatory tumor microenvironment(TME). This review summarizes the mechanisms of resistance to ICIs in NSCLC, focusing on tumor antigens loss and defective antigen processing and presentation, failure T cell priming, impaired T cell migration and infiltration, immunosuppressive TME, and genetic mutations. Furthermore, we discuss how nanoparticles, through their intrinsic properties such as the EPR effect, active targeting effect, shielding effect, self-regulatory effect, and synergistic effect, can potentiate the efficacy of ICIs and reverse resistance. In conclusion, nanoparticles serve as a robust platform for ICIs-based NSCLC therapy, aiding in overcoming resistance challenges.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"2371-2394"},"PeriodicalIF":6.6,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances in Aptamers-Based Nanosystems for Diagnosis and Therapy of Cardiovascular Diseases: An Updated Review.","authors":"Hongqin Yu, Jie Yu, Gang Yao","doi":"10.2147/IJN.S507715","DOIUrl":"10.2147/IJN.S507715","url":null,"abstract":"<p><p>The increasing global prevalence of cardiovascular diseases highlights the urgent need for innovative diagnostic and therapeutic strategies. Aptamers, small single-stranded nucleic acid molecules with exceptional specificity and affinity for target biomolecules, have emerged as promising tools for precise diagnostics and targeted therapies. Their selective binding capabilities provide valuable insights into the molecular mechanisms underlying cardiovascular conditions. When integrated into nanosystems, aptamers enhance the delivery, bioavailability, and stability of diagnostic and therapeutic agents, addressing challenges of solubility and degradation. This integration enables more targeted drug delivery, advanced imaging techniques, and improved therapeutic interventions, ultimately improving the management of cardiovascular diseases. Recent advancements in aptamer selection methodologies, coupled with their unique three-dimensional structures, have significantly expanded their application potential in cardiovascular health. By combining aptamers with nanosystems, novel approaches to cardiovascular disease diagnosis and treatment are emerging, promising enhanced efficacy, safety, and precision. This review explores recent progress in the development and application of aptamer-based nanosystems in cardiovascular diagnostics and therapies.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"2427-2443"},"PeriodicalIF":6.6,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Cytolytic Iridium-Complexed Octaarginine Peptide Albumin Nanomedicine for Hepatocellular Carcinoma Treatment.","authors":"Xingwei Sun, Di Wang, Shiwei Chang, Liang Yin, Hao Zhang, Shuangshuang Ji, Hao Fei, Yong Jin","doi":"10.2147/IJN.S502257","DOIUrl":"https://doi.org/10.2147/IJN.S502257","url":null,"abstract":"<p><strong>Objective: </strong>Hepatocellular carcinoma is one of the most challenging malignancies and has high incidence and mortality rates worldwide. Digital subtraction angiography (DSA)-guided hepatic arterial infusion of the standard chemotherapeutic agent oxaliplatin (OXA) has the advantages of both precision and efficacy, making it an important therapeutic strategy for advanced-stage liver cancer. However, patients receiving this treatment still face severe systemic toxicity and poor tolerability of oxaliplatin.</p><p><strong>Methods: </strong>In this study, we compared oxaliplatin with novel albumin-formulated oncolytic peptide nanoparticles, Ir-cR8 (abbreviated as iPep), in the treatment of orthotopic liver cancer in a mouse model by intravenous injection and in a rabbit model via DSA-guided hepatic arterial infusion.</p><p><strong>Results: </strong>The results showed that intravenous Ir-cR8-BSA-NPs had enhanced inhibitory effects to the growth of H22 ectopic liver tumors in mice and also with reduced toxicity in animals compared to OXA treatment. Specifically, Ir-cR8-BSA-NPs-treated mice showed approximately 92% tumor growth inhibition compared to approximately 88% for OXA. In the rabbit VX2 ectopic hepatocellular carcinoma model, Ir-cR8-BSA-NPs demonstrated significantly stronger inhibition (P<0.01) of tumor size compared to OXA, as assessed by PET/CT imaging, with SUV values decreasing from 5.15±0.46 to 2.52±0.57, compared to OXA-treated group, which decreased from 5.44±0.43 to 3.90±0.24. Furthermore, Ir-cR8- BSA-NPs significantly improved stability by albumin encapsulation and reduced hemolytic toxicity (P<0.001), resulting in improved therapeutic efficacy.</p><p><strong>Conclusion: </strong>This study demonstrated the combined advantages of a novel membrane-active oncolytic peptide nanomedicine and precise drug delivery enabled by arterial infusion technology for the interventional treatment of liver cancer.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"2395-2409"},"PeriodicalIF":6.6,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Versatile Nanomaterials That Interfere with Ferroptosis in the Tumor Microenvironment.","authors":"Yurong Liu, Yunheng Liu, Xinting Li, Song Li, Xiaokang Zhang, Longqing Si, Shaojing Jiang, Jinghui Hu, Jing Chen","doi":"10.2147/IJN.S508767","DOIUrl":"https://doi.org/10.2147/IJN.S508767","url":null,"abstract":"<p><p>Ferroptosis is a type of iron-dependent programmed cell death characterized by a depletion of glutathione. Although generally less harmful to normal cells, in tumor cells, the high demand for iron ions provides conditions conducive to ferroptosis. In this review, we provide an overview of recent progress in research on the regulation of ferroptosis in tumor cells, summarizing and assessing the current state, trends, and applications of nanomaterials in the regulation of ferroptosis in tumor cells. Given the advantages of nanomaterials in terms of targeting, safety, improved drug efficacy, and reduced side effects, these materials are considered to have potential therapeutic value in modulating ferroptosis in tumor cells via different mechanisms. In this respect, we describe methods for modifying the regulation of iron ions and interfering with glutathione activity and lipid peroxidation. The development of nanomaterials that can be applied to induce or inhibit ferroptosis is anticipated to provide new therapeutic options for the treatment of a diverse range of diseases.</p>","PeriodicalId":14084,"journal":{"name":"International Journal of Nanomedicine","volume":"20 ","pages":"2461-2473"},"PeriodicalIF":6.6,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}