International Journal of Implant Dentistry最新文献

{"title":"Clinical accuracy assessment of a dynamic navigation system and surgical guide using an oral appliance-secured patient tracker targeting anterior teeth.","authors":"Manabu Okubo, Koudai Nagata, Yurie Okuhama, Kana Wakamori, Hayato Tsuruoka, Kurumi Saito, Ryota Fumimoto, Hiromasa Kawana, Shinji Kuroda","doi":"10.1186/s40729-025-00627-5","DOIUrl":"10.1186/s40729-025-00627-5","url":null,"abstract":"<p><strong>Purpose: </strong>Dynamic navigation systems and surgical guides have been reported to be equally accurate. However, the accuracy of dynamic navigation systems is affected by the movement of the patient tracker fixed to the tooth. We hypothesized that fixing the patient tracker to the oral appliance could improve accuracy. Therefore, this study aimed to compare accuracy between a dynamic navigation system with a patient tracker fixed to an oral appliance and a surgical guide.</p><p><strong>Methods: </strong>This observational study was conducted on patients who had undergone complete implant treatment at Kanagawa Dental University from 2020 to September 2024. Fifty implant bodies were placed in 42 patients with anterior tooth defects in both the dynamic navigation and surgical guide groups (25 implants each). DTX Studio™ (Nobel Biocare AG, Kloten, Switzerland) was used to overlay planning data on postoperative Digital Imaging and Communications in Medicine data to calculate entry point, apex point, and angular deviation accuracy.</p><p><strong>Results: </strong>The entry point, apex point, and angular deviation values were 0.99 ± 0.33 mm, 0.97 ± 0.43 mm, and 2.64 ± 0.87° in the dynamic navigation group and 1.33 ± 0.26 mm, 1.38 ± 0.3 mm, and 3.42 ± 1.03° in the surgical guide group, respectively, differing significantly at all measurement sites (P < 0.01).</p><p><strong>Conclusions: </strong>The fixation of the X-clip to the oral appliance improved intra-oral stability and inhibited intraoperative movement of the X-clip, resulting in high accuracy. These results suggest that dynamic navigation by oral appliance fixation is more accurate than surgical guides.</p>","PeriodicalId":14076,"journal":{"name":"International Journal of Implant Dentistry","volume":"11 1","pages":"38"},"PeriodicalIF":3.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of an infectious complication appearing in a transcanine implant: a case report.","authors":"Maxime Delarue, Pierre Klienkoff, Mélanie Le Ven, Fabien Bornert","doi":"10.1186/s40729-025-00626-6","DOIUrl":"10.1186/s40729-025-00626-6","url":null,"abstract":"<p><strong>Background: </strong>Maxillary canine impaction is the second most common dental eruption anomaly, affecting approximately 0.2-3% of individuals, with a higher incidence in females. This condition often results in complications such as the misalignment of adjacent teeth, root resorption, and the development of cystic lesions. In some cases, abstention is recommended for impacted canine is kept with the lacteal tooth held on the dental arch. But in the longer term an implant therapy is nevertheless indicated.</p><p><strong>Case presentation: </strong>A 42-year-old man presented with persistent swelling and pain in the maxillary region associated with a transcanine implant placed one year ago by his dental practitioner. Imaging assessment showed the implant's apex inserted into the impacted canine which presented a crown and root resorption and was associated to a radiolucency around. In order to preserve implant and reduce morbidity related to a full extraction of the tooth, a coronectomy was performed allowing inflammatory surrounding tissues curettage.</p><p><strong>Discussion: </strong>This case shows an infectious complication of a transcanine implant and demonstrates an approach for managing these complications while preserving this implant. The coronectomy is a less invasive technique that reduces potential surgical complications and supports healing. A 2-year follow-up revealed complete bone reossification reinforcing the effectiveness of this method in similar clinical scenarios.</p><p><strong>Conclusion: </strong>This case suggests that coronectomy may be a viable option for managing impacted canines in proximity to implants when complete extraction poses a high risk of complications. However, given the limited number of reported cases and the absence of long-term data, this approach should be considered with caution. Further studies are necessary to better define the indications, long-term outcomes, and potential risks of this technique.</p>","PeriodicalId":14076,"journal":{"name":"International Journal of Implant Dentistry","volume":"11 1","pages":"37"},"PeriodicalIF":3.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and radiographic evaluation for two crestal sinus lift techniques: osteotome versus osseodensification. a systematic review and meta-analysis.","authors":"Carlos Manuel Cobo-Vázquez, Sonia García-Rodríguez, María Eugenia Colmenares-Otero, Luis Miguel Sáez-Alcaide, Jorge Cortés-Bretón-Brinkmann, Cristina Madrigal Martínez-Pereda, Cristina Meniz-Garcia","doi":"10.1186/s40729-025-00615-9","DOIUrl":"10.1186/s40729-025-00615-9","url":null,"abstract":"<p><strong>Purpose: </strong>Maxillary sinus floor elevation is a safe and effective surgical technique for achieving vertical bone height, performed through either a lateral or crestal approach. The latter includes both the osteotome technique and osseodensification. The aim of this systematic review was to compare the outcomes of the classic crestal sinus lift technique and the osseodensification sinus lift approach in terms of the bone gain, marginal bone loss, survival rate, follow-up time and complications.</p><p><strong>Methods: </strong>This review was performed following PRISMA guidelines. An electronic search was conducted across three databases: (1) The National Library of Medicine (MEDLINE/PubMed); (2) SCOPUS; and (3) Cochrane Central Register of Controlled Trials (CENTRAL). The Newcastle-Ottawa Quality Assessment Scale and the Cochrane Collaboration tool for evaluating risk of bias. A meta-analysis for random effects was carried out for implant survival, residual bone height and bone gain.</p><p><strong>Results: </strong>Thirteen studies were included, ten studies performed the osteotome (OST) approach and three performed the osseodensification (OD) approach, with a total of 519 sites treated. The residual bone height was 5.94 and 5.00 mm for OD and OST, respectively. For bone gain, similar results were found for both groups, being 3.37 mm for OD and 3.18 mm for OST. For both groups, the most used diameter and length of the implant was 4 and 10 mm, respectively, and the implant survival rates ranged from 94.1% to 100%. OST technique reflected a complication rate of 14.32%, compared to the OD technique, which showed a complication rate of 2.78%.</p><p><strong>Conclusions: </strong>It can be concluded that the maxillary sinus lift by osseodesinfication approach is a safe, predictable and successful technique compared to the osteotome approach, with similar outcomes regarding bone gain which is an important parameter for implant placement.</p>","PeriodicalId":14076,"journal":{"name":"International Journal of Implant Dentistry","volume":"11 1","pages":"36"},"PeriodicalIF":3.1,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144077996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Freehand vs. computer-aided implant surgery: a systematic review and meta-analysis-part 1: accuracy of planned and placed implant position.","authors":"Joscha G Werny, Katharina Frank, Shengchi Fan, Keyvan Sagheb, Bilal Al-Nawas, Clement T Narh, Eik Schiegnitz","doi":"10.1186/s40729-025-00622-w","DOIUrl":"https://doi.org/10.1186/s40729-025-00622-w","url":null,"abstract":"<p><strong>Objectives: </strong>This systematic review aimed to investigate and compare the accuracy of free-hand and computer-aided implant surgery (CAIS) approaches in dental implant placement.</p><p><strong>Material and methods: </strong>The PICO question as follows: In patients receiving dental implants, does computer-aided implant surgery superior in accuracy compared to non-computer-aided implant surgery? The primary outcome was angular deviation between the planned and placed position of the implant. An electronic search was made to identify all relevant studies reporting the accuracy of CAIS approaches and freehand for dental implant placement. The data were extracted in the descriptive description, and a meta-analysis of single means was performed to estimate the deviations for each variable using a random-effects model.</p><p><strong>Results: </strong>Out of 1609 initial articles, 55 were selected for data extraction. The mean value of angular, entry, and apex deviations were 7.46°, 1.56 mm, and 2.22 mm for freehand, 5.94°, 1.13 mm, and 1.43 mm for pilot drill-sCAIS, 2.57°, 0.72 mm, 0.88 mm for fully guided-sCAIS (fg-sCAIS), and 3.67°, 1.01 mm, and 1.36 for dynamic CAIS (dCAIS), respectively. Significant differences were found between the freehand and CAIS approaches (p < 0.04). Fg-sCAIS was significantly more accurate than dCAIS systems at the entry (p < 0.001).</p><p><strong>Conclusions: </strong>Compared to the freehand approach, both sCAIS and dCAIS improve implant placement accuracy, with angular deviations ranging from 2° to 6°. Detailed planning is crucial for CAIS, particularly for fg-sCAIS, which demonstrated the highest accuracy than others. As apex deviations of 1 to 2 mm have been observed in CAIS approaches, a 2-mm safety margin should be implemented to minimize surgical risks.</p>","PeriodicalId":14076,"journal":{"name":"International Journal of Implant Dentistry","volume":"11 1","pages":"35"},"PeriodicalIF":3.1,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraction of teeth 11 and 21 due to gemination and space closure with skeletal anchorage in a patient with class III tendency: a case report.","authors":"Yoana Zinovieva, Moataz Bayadse, Julia Heider, Christina Erbe, Ambili Mundethu","doi":"10.1186/s40729-025-00606-w","DOIUrl":"https://doi.org/10.1186/s40729-025-00606-w","url":null,"abstract":"&lt;p&gt;&lt;p&gt;Tooth gemination is a dental phenomenon in which a single tooth bud attempts to divide into two, resulting in the formation of a structure that appears as two teeth but originates from the same follicle. This partial separation is often indicated clinically by a groove or depression that suggests the presence of two distinct teeth (Rajeswari M, Ananthalakshmi R. 2011. Gemination-case report and review. Indian Journal of Multidisciplinary Dentistry). The distinction between gemination and fusion plays an important role in treatment planning. If the number of teeth is one less, the tooth is fused and not geminated. In addition, it is assumed in the literature that geminated teeth have a single root canal and fused teeth have two separate root canals (Mahendra et al. in Case Rep Dent. 2014:425343, 2014;Duncan and Helpin in Oral Surg Oral Med Oral Pathol 64:82-87, 1987). The gemination of teeth is relatively rare and occurs mainly in the frontal region of the upper jaw. The prevalence of unilateral tooth gemination in the primary dentition is between 0.01 and 0.04% and in the permanent dentition: 0.05% (Duncan and Helpin in Oral Surg Oral Med Oral Pathol 64:82-87, 1987). Gemination management often requires a multidisciplinary approach and involves several steps ( Rajeswari M, Ananthalakshmi R. 2011. Gemination-case report and review. Indian Journal of Multidisciplinary Dentistry). The orthodontist will then take a thorough medical, dental and family history and perform clinical and radiographic examinations to confirm the diagnosis. Treatment options would include reshaping and restoring teeth with appropriate materials, performing root canal treatment followed by reduction of the mesiodistal width and crown restoration, extraction if the tooth is not suitable for root canal treatment followed by orthodontic space closure or fixed or removable prosthesis if required, transplantation of supernumerary teeth to replace the missing tooth. This case report presents a patient with gemination of teeth 11, 21 and progressive Class III growth tendency. In this case, the malformed anterior teeth were extracted and the gap was closed using skeletal anchorage. Patients with missing central incisors often require a complex interdisciplinary treatment, whether a prosthetic tooth-supported restoration of the missing anterior tooth, single implant, or orthodontic space closure are chosen. Ideally, each alternative should fulfill individual aesthetic concerns, functional requirements, and periodontal tissue health, not only at the end of treatment but also in the long term (Marco in Sem Orthodont 26:1, 2020; Rosa M, Zachrisson BU. Integrating space closure and esthetic dentistry in patients with missing maxillary lateral incisors. J Clin Orthod. 2007; 41(9); Czochrowska ,E.M.,Skaare,A.B.,Stevnik A, Zachrisson, B.U. Outcome of orthodontic space closure with a missing maxillary central incisor;) If gap closure is chosen, it is important to select the correct ort","PeriodicalId":14076,"journal":{"name":"International Journal of Implant Dentistry","volume":"11 1","pages":"34"},"PeriodicalIF":3.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective clinical study to evaluate the success and survival of two-piece zirconia implants: a single-center study. 12-month results.","authors":"Marie-Elise Jennes, Insa Herklotz, Margarita Bessonova, Jeremias Hey, Florian Beuer","doi":"10.1186/s40729-025-00621-x","DOIUrl":"https://doi.org/10.1186/s40729-025-00621-x","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the survival and success rates of a novel two-piece zirconia implant system restored with screw-retained glass-ceramic crowns over 12 months, including assessment of bone levels, soft tissue parameters, and patient-reported outcome measures.</p><p><strong>Methods: </strong>Twenty-four patients received single two-piece zirconia implants (CERALOG^® Hexalobe) in healed sites. After a 6-month healing period, implants received provisional screw-retained crowns on PEKK temporary abutments, followed by definitive lithium disilicate crowns (IPS e.max Press) on PEKK abutments. Clinical and radiographic examinations were performed at implant placement, re-entry, definitive loading, and 12-month follow-up, along with patient-reported outcome measures.</p><p><strong>Results: </strong>The implant survival rate at 12 months was 60.9%. Nine implants were lost: two due to lack of osseointegration at re-entry, four due to mobility after loading, and three due to fractures in the coronal third after loading. Surviving implants showed stable soft tissue parameters with mean probing pocket depths of 2.7 ± 0.7 mm at 12 months. The mean distance from implant shoulder to first bone contact decreased from 1.9 ± 0.6 mm at loading to 1.4 ± 0.6 mm at 12 months. Patients with surviving implants reported high satisfaction scores (4.8 ± 0.4) for function and aesthetics.</p><p><strong>Conclusions: </strong>The two-piece zirconia implant system with screw-retained restorations showed unsatisfactory survival rates. The combination of ceramic implants with screw-retained prosthetic restorations may have contributed to the higher failure rates observed. As a pilot study with a relatively small sample size, these findings should be confirmed by larger multicenter studies to validate these preliminary results.</p>","PeriodicalId":14076,"journal":{"name":"International Journal of Implant Dentistry","volume":"11 1","pages":"33"},"PeriodicalIF":3.1,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retention forces in mini-dental-implant retained mandibular overdentures: 10-year outcomes of a non-comparative longitudinal observational study.","authors":"Hristina Bukvic, Nicole Schenk, Sebastian Hinz, Martin Schimmel, Norbert Enkling, Samir Abou-Ayash","doi":"10.1186/s40729-025-00620-y","DOIUrl":"https://doi.org/10.1186/s40729-025-00620-y","url":null,"abstract":"<p><strong>Purpose: </strong>To report the evaluation of in vivo retention forces after replacement of O-rings in one-piece mini dental implants (MDIs), retaining mandibular implant overdentures (IODs) with ball/O-ring attachments during 10 years assessed.</p><p><strong>Methods: </strong>Twenty patients received new complete dentures, which were converted into IODs through stabilization with four MDIs (Condent GmbH; diameter: 1.8 mm) placed in the interforaminal region. Retention forces were measured at the male and female parts at baseline, 5, and 10 years using a validated strain gauge. Fourteen patients completed the 10-year follow-up.</p><p><strong>Results: </strong>After 10 years, a minor but significant reduction in retention force was observed in the male part of the implant at position 44. In contrast, neither the male part at the other implant positions nor the female part at any position showed a significant decrease in retention force compared to baseline. After replacement of the O-ring inserts, baseline values could be restored and no significant changes in retention forces were observed at the 10-year follow-up. No difference in anterior and posterior implants could be determined.</p><p><strong>Conclusions: </strong>Initial retention forces of mandibular IODs supported by four MDIs can be reestablished by replacing the O-rings with pristine ones after 10 years, with stable retention forces at both the male and female parts throughout the functional period, with no discernible differences between anterior and posterior implants.</p>","PeriodicalId":14076,"journal":{"name":"International Journal of Implant Dentistry","volume":"11 1","pages":"32"},"PeriodicalIF":3.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alveolar ridge augmentation in Oral and Maxillofacial Surgery: a study on current practices, patient management and innovations in Germany.","authors":"Andreas Pabst, Jörg Wiegner, Matthias Schneider, Nils Weyer, Alexander Bartella, Max Heiland, Philipp Becker, Alexander-N Zeller","doi":"10.1186/s40729-025-00619-5","DOIUrl":"https://doi.org/10.1186/s40729-025-00619-5","url":null,"abstract":"<p><strong>Introduction: </strong>This study identifies current practices, patient management concepts and innovations in alveolar ridge augmentation (ARA) in Oral and Maxillofacial Surgery (OMFS) in Germany.</p><p><strong>Material and methods: </strong>A survey with a dynamic online questionnaire with up to 40 questions was designed to collect general and specific data on ARA, such as case numbers, imaging, surgical techniques, (bio-)materials, and case management in OMFS. After internal and external validation, 1863 OMF surgeons within the German Association for Oral and Maxillofacial Surgery (DGMKG) were invited via email to participate. Data management was anonymized and descriptively.</p><p><strong>Results: </strong>324 OMF surgeons participated in the study (response rate 17.39%). Most participants (60.8%) work in private practices without inpatient care. 62.03% of participants insert > 200 implants, and 28.70% perform > 200 ARA annually. About 30.86% also provide implant-based prosthetic restorations. Cone-beam computed tomography (CBCT) is the imaging method most preferred by 87.74% of participants. The most common ARA techniques are external and internal sinus lift (SL) and bone block augmentation (97.31%, 90.57%, and 73.4%, respectively). Intraoral harvested autogenous bone grafts (ABG) are most commonly used for ARA (96.63%). The oblique line is the participants' preferred donor site for ABG (93.27%). ABG and xenogeneic bone substitutes are the most frequently used graft combinations (72.73%). Platelet-rich fibrin (PRF) is used by 58.59% of participants for ARA, mostly in SL procedures (76.44%). PRF is the most common substitute used to biofunctionalize biomaterials (48.16%). Oral antibiotics are used by 86.40% pre-/intraoperatively and by 88.97% postoperatively for ARA. Most participants believe the surgical technique (94.49%) and the surgeon's experience (92.28%) are the most critical factors for ARA success. 46.32% of participants aim to perform ARA within the skeletal envelope.</p><p><strong>Conclusion: </strong>The findings highlight current practices, patient management, and innovations in ARA in OMFS in Germany. They show standard practices and numerous variations in several aspects.</p><p><strong>Clinical relevance: </strong>Surgical technique, experience, patient health and compliance are relevant ARA success factors. This underlies the importance of extended surgical training and careful patient selection.</p>","PeriodicalId":14076,"journal":{"name":"International Journal of Implant Dentistry","volume":"11 1","pages":"31"},"PeriodicalIF":3.1,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatially distributed and interconnected porous architectures for dental implants.","authors":"Rana Dabaja, W Benton Swanson, Sun-Yung Bak, Gustavo Mendonca, Yuji Mishina, Mihaela Banu","doi":"10.1186/s40729-025-00618-6","DOIUrl":"10.1186/s40729-025-00618-6","url":null,"abstract":"<p><strong>Purpose: </strong>Patients with pre-existing medical conditions that impair bone integrity face challenges in dental implant success due to compromised osseointegration. This study evaluates three titanium interconnected porous architectures: the TPMS solid gyroid, TPMS sheet gyroid, and Voronoi stochastic lattice. We aim to assess manufacturability, design controllability, and cellular interactions to identify an optimal architecture that enhances cellular behavior with the potential to strengthen bone-to-implant contact.</p><p><strong>Methods: </strong>Three porous architectures were designed and compared: the two variants of the uniform, periodic triply periodic minimal surface (TPMS) gyroid, and the random, non-uniform Voronoi stochastic lattice. The porous constructs were fabricated using selective laser melting (SLM) and evaluated using microcomputed tomography (microCT) for porosity, manufacturability, and permeability. In vitro experiments used primary bone marrow stromal cells (BMSCs) isolated from 8-week-old wild type C57BL6/J mice. These cells were seeded onto the SLM-fabricated porous architectures and evaluated for adhesion using scanning electron microscopy (SEM) and RNA extraction. Cell trajectory was profiled using fluorescent confocal microscopy.</p><p><strong>Results: </strong>Selective laser melting (SLM) successfully fabricated all three porous architectures, with the TPMS solid gyroid exhibiting the highest manufacturing resolution, controllability, and the most uniform pore distribution. Computational fluid dynamics (CFD) analysis showed that its permeability outperformed both the TPMS sheet gyroid and stochastic Voronoi architectures. In vitro cell culturing demonstrated superior cell behavior in the TPMS solid gyroid scaffold. RNA quantification after 72 h of culture showed that cells are most adherent to the TPMS solid gyroid, demonstrating a 4-fold increase in RNA quantity compared to the fully dense (control). Additionally, cell trajectory analysis indicated enhanced cell infiltration and cellularization within the pore channels for the TPMS solid gyroid architecture.</p><p><strong>Conclusion: </strong>This research demonstrates that inducing an interconnected porous architecture into a titanium construct enhances cellular behavior compared to a traditional dense implant. The TPMS solid gyroid architecture showed superior manufacturability, making it a promising solution to improve dental implant success in patients with compromised bone integrity.</p>","PeriodicalId":14076,"journal":{"name":"International Journal of Implant Dentistry","volume":"11 1","pages":"30"},"PeriodicalIF":3.1,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11977072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aggregatibacter actinomycetemcomitans induces biofilm formation of Streptococcus sanguinis on titanium implants.","authors":"Andrea Schubert, Jana Marisa Friebel, Oskar Bunz, Christoph Sasse, Ralf Bürgers, Torsten Wassmann","doi":"10.1186/s40729-025-00616-8","DOIUrl":"10.1186/s40729-025-00616-8","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to investigate the distinct behaviors of single-species and dual-species biofilms formed by Streptococcus sanguinis and Aggregatibacter actinomycetemcomitans on different titanium and implant surfaces. Four types of surfaces were examined: two clinically used implant surfaces, a super-polished surface and a sand-blasted surface of grade 4 titanium.</p><p><strong>Methods: </strong>Specimens were incubated with single- and dual-species biofilms for 24 h. Biofilm formation was determined based on the amount of total DNA extracted from the bacteria. In order to specifically determine the biofilm formation of Streptococcus sanguinis, qPCR experiments were carried out. Staining followed by fluorescence microscopy was employed to verify the efficiency of the washing steps.</p><p><strong>Results: </strong>Biofilm formation by single- and dual-species cultures was observed on all tested implant surfaces. However, a clear influence of surface characteristics on biofilm formation could not be conclusively demonstrated. Mixed cultures of S. sanguinis and A. actinomycetemcomitans (AAC) exhibited increased biofilm formation through the enhanced DNA amount of S. sanguinis. In contrast, this effect was not observed in dual-species cultures of Staphylococcus epidermidis and S. sanguinis.</p><p><strong>Conclusion: </strong>AAC promotes biofilm formation of S. sanguinis, highlighting the significant role of AAC in enhancing biofilm development. Conversely, a definitive conclusion regarding the correlation between titanium implant surface roughness and biofilm formation was not possible. However, our results suggest a tendency that dual-species biofilm formation may be influenced by surface structure.</p>","PeriodicalId":14076,"journal":{"name":"International Journal of Implant Dentistry","volume":"11 1","pages":"29"},"PeriodicalIF":3.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11968620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}