International Journal of Geriatric Psychiatry最新文献

{"title":"Meaningful Moments of Connection: How People Affected by Dementia and Their Carers Living at Home Understand, Interpret and Experience Everyday Aesthetics","authors":"Sarah Fox,&nbsp;James Thompson,&nbsp;John Keady","doi":"10.1002/gps.70136","DOIUrl":"https://doi.org/10.1002/gps.70136","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study considers how people affected by dementia living in their own homes understand and interpret everyday aesthetics and what relevance this holds in their everyday lives.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Nine households, comprising ten family carers and seven people living with dementia, shared their self-identified meaningful moments of connection reflective of their personal understanding and interpretation of everyday aesthetics. Data collection involved a range of creative and self-initiated approaches, including scrapbooking, photography, and elicitation interviews. Data were analysed using reflective thematic analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Six discrete but interlinked themes were identified, namely: (1) Connection with others; (2) Connection with materiality; (3) Connection with self-image; (4) Connection with pride and societal value; (5) Connection with enjoyable activities; and (6) Connection with the lived environment, that revealed how people affected by dementia self-identify everyday aesthetic experiences in their daily lives.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>Our findings show these self-identified experiences span multiple physical and psychological domains of everyday life, each of which acts to support the personhood and identity of the person living with dementia. We suggest that development of a new model of care based on everyday aesthetic needs and informed by people affected by dementia, might bridge the gap between theory and practice in person-centred care. Going forward, developing care practices and support systems which focus on identifying and fulfilling the aesthetic needs of people living with dementia may offer a novel way to enhancing independence and personal well-being.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gps.70136","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inequalities in Dementia Care and Research.","authors":"Pinar Soysal, Andrea Slachevski, Yaohua Chen","doi":"10.1002/gps.70143","DOIUrl":"https://doi.org/10.1002/gps.70143","url":null,"abstract":"","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":"e70143"},"PeriodicalIF":2.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “The Influence of a Dementia Diagnosis on Clinical Decision-Making in Dysphagia Management”","authors":"","doi":"10.1002/gps.70133","DOIUrl":"https://doi.org/10.1002/gps.70133","url":null,"abstract":"<p>Table 3 should have the following labels for the columns and rows:</p><p>We apologize for this error.</p>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gps.70133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Health Literacy and Depressive Symptoms With the Mediation Role of Family Health and Perceived Social Support in Older Adults: A Nationwide Cross-Sectional Study in China.","authors":"Shiying Cai, Zijie Zhuang, Weiming Lu, Yifei Wang, Zhiyuan Tian, Jie Ren, Jue Li, Jiaxin Chen, Guangbo Luo, Bin Lin, Xiali Yang","doi":"10.1002/gps.70134","DOIUrl":"https://doi.org/10.1002/gps.70134","url":null,"abstract":"<p><strong>Objectives: </strong>There was a lack of in-depth understanding of the relationship between health literacy and depressive symptoms, and it was also unclear whether family health and perceived social support mediated this relationship and were negatively associated with the presence of depressive symptoms in older adults. This study aimed to explore the relationship between health literacy and depressive symptoms among older adults, while assessing the mediating roles of family health and perceived social support.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in China in 2021, involving 1147 participants aged 60 and older recruited using a nationwide multistage random sampling method. Ordered logistic regression and generalized additive models were employed to examine the association between health literacy and depressive symptoms, and the mediating effects of family health and perceived social support were assessed using mediation analysis with non-parametric bootstrapping. The Karlson-Holm-Breen (KHB) method was used to evaluate combined indirect associations, and subgroup mediation analyses were performed for \"young-old\" (65-74 years) and \"old-old\" (≥ 75 years) participants.</p><p><strong>Results: </strong>Higher health literacy was associated with a lower likelihood of depressive symptoms (OR = 0.98, 95% CI: 0.97-0.99). Mediation analysis showed that the total indirect effect was thus estimated at -0.01, and the total effect of health literacy on depressive symptoms was approximately -0.03. The negative association between health literacy and depressive symptoms, as well as the mediating role of family health, remained significant in both the 65-74 and ≥ 75 age groups. However, the mediating effect of perceived social support was significant only in the 65-74 age group.</p><p><strong>Conclusions: </strong>Health literacy is negatively associated with depressive symptoms in Chinese older adults and could be considered as a focus for intervention strategies. Enhancing health literacy may improve family health and perceived social support, and potentially lower depressive symptoms.</p>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":"e70134"},"PeriodicalIF":2.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose-Response Association of Handgrip Strength With Alzheimer's Disease: A Longitudinal Study Involving 85,979 Adults","authors":"Rodrigo Núñez-Cortés,&nbsp;Joaquín Calatayud,&nbsp;Sergio Calonge-Pascual,&nbsp;Lars Louis Andersen,&nbsp;Rúni Bláfoss,&nbsp;José Francisco López-Gil,&nbsp;Rubén López-Bueno","doi":"10.1002/gps.70137","DOIUrl":"https://doi.org/10.1002/gps.70137","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the dose-response relationship between handgrip strength and incidence of Alzheimer's disease (AD) in middle-aged and older adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Longitudinal study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Patients and Methods</h3>\u0000 \u0000 <p>A longitudinal study was conducted in people over 50 years old in 27 European countries and Israel. Data were collected from waves 1, 2, 4, 5, 6, 7 and 8 of the Survey of Health, Ageing and Retirement in Europe (SHARE) between February 2004 and January 2021. Handgrip strength was measured with a hand dynamometer. AD was self-reported based on previous diagnosis. Dose-response associations were assessed by restricted cubic splines.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 85,979 (55.8% female) participants were followed for a median of 9.3 years. Over this time, 3324 (3.9%) developed AD. In the adjusted model, for participants &lt; 65 years, those in the middle third of handgrip strength showed a lower risk of AD compared to the lower third (HR = 0.63, 95% CI: 0.47–0.84), as well as participants in the upper third (HR = 0.63, 95% CI: 0.47–0.85). The spline model determined that the minimum and optimal doses of handgrip strength for a significant reduction in the risk of AD for those aged &lt; 65 years were 54 kg (HR = 0.99; 95% CI: 0.08–0.99) and 56 kg (HR = 0.27; 95% CI: 0.08–0.91), respectively. Among those aged ≥ 65 years, the minimum and optimal doses were 31 kg (HR = 0.69; 95% CI: 0.48–0.99) and 49 kg (HR = 0.57; 95% CI: 0.43–0.76), respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Higher levels of handgrip strength showed a lower risk of developing AD, among adults aged 50 years and over. However, the dose-response relationship is limited to specific ranges according to age group. We identified a range between 54 and 56 kg years and a range between 31 and 49 kg as suitable to prevent AD in adults aged 50–64 and ≥ 65 years, respectively. Routine assessment of hand grip strength can help healthcare professionals identify people at increased risk of AD. Strength-based interventions could provide a practical strategy to support cognitive health and reduce the risk of dementia in clinical practice.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gps.70137","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Plasma p-tau181 With Age, Adjusted for Kidney Function and Sociodemographic Factors","authors":"Jemma Hazan,&nbsp;Kathy Y. Liu,&nbsp;Henrik Zetterberg,&nbsp;Nick Fox,&nbsp;Robert Howard,&nbsp;with ADNI","doi":"10.1002/gps.70138","DOIUrl":"https://doi.org/10.1002/gps.70138","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Plasma phosphorylated tau (p-tau) levels, such as p-tau181, are elevated in Alzheimer's disease compared to cognitively unimpaired individuals. They represent potential candidate blood biomarkers for use in memory services where CSF examinations are not available. However, the effect of age on plasma p-tau levels remains undetermined. Limited studies have investigated the association between age and plasma p-tau thus far, and fewer still have differentiated levels by brain amyloid pathology. Characterising these associations and determining if this is influenced by sociodemographic factors or medical comorbidities is important for establishing blood biomarker reference ranges.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Using ADNI data, we analysed 860 observations (581 participants; age range: 55–95 years; 56.0% male; 93.6% White). Linear mixed models (LMMs) estimated fixed effects of age, creatinine, baseline BMI, sex, ethnicity, and group (Control vs. AD) on plasma p-tau181 concentration, with a random intercept for participant ID. Separate LMMs assessed covariate effects and interactions with group status.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Analysis of ADNI data revealed a significant positive association between p-tau181 levels, group status, and creatinine in the fully adjusted LLM. Group status may have obscured the total effect of age on p-tau181, as its removal from the model resulted in a significant age effect. Single-variable models showed the positive association between either age, or creatinine and p-tau181 levels did not differ between control and AD groups. There was a significant negative association between BMI and plasma p-tau, which was stronger in AD versus control groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study provides insights into the factors that may influence plasma p-tau181 levels. These findings underscore the need to account for clinical and demographic factors when interpreting p-tau181. Future research should validate these associations in diverse populations and explore underlying mechanisms.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 8","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gps.70138","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144725626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time to Diagnosis in Dementia: A Systematic Review With Meta-Analysis","authors":"Olubunmi Kusoro,&nbsp;Moïse Roche,&nbsp;Rafael Del-Pino-Casado,&nbsp;Phuong Leung,&nbsp;Vasiliki Orgeta","doi":"10.1002/gps.70129","DOIUrl":"https://doi.org/10.1002/gps.70129","url":null,"abstract":"<p>Timely dementia diagnosis is a global priority, reflected in most national and regional policies and plans. Nevertheless, there are currently no robust estimates of the average time to diagnosis (TTD) and factors influencing diagnostic intervals. This article presents the first systematic review of quantitative studies on TTD in dementia and the factors associated with its duration. We systematically searched EMBASE, Psych INFO, MEDLINE, and CINAHL databases for relevant studies published up to December 2024. We defined TTD as the interval between symptom onset (rated by family carers or patients using interviews or medical records) to final diagnosis. Risk of bias was assessed using the Reporting studies on time to diagnosis tool. We included 13 studies reporting data on 30,257 participants, with age at onset ranging between 54 and 93 years. Meta-analysis pooling 10 studies showed that average mean TTD across all types of dementia was 3.5 years [confidence interval (CI): 2.7–4.3; moderate quality evidence]. Analyses of six studies showed that TTD in young onset dementia was 4.1 years (CI: 3.4–4.9; moderate quality evidence). Although the factors influencing TTD were inconsistent, a younger age at onset and having frontotemporal dementia were consistently associated with a longer interval to diagnosis. TTD in dementia remains long, and specific healthcare strategies are urgently needed to improve it. Increasing the evidence base and developing interventions to reduce TTD should be a future research priority. Specialist services are likely to be key in improving TTD in young-onset dementia.</p>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 7","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gps.70129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144714851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Moderating Role of Dementia-Related Fear in the Relationship Between Perceived Cognitive Decline and Motivation for Dementia Risk Reduction Behaviors in Community-Dwelling Middle-Aged and Older Adults","authors":"Rose Lin,&nbsp;Sara Laureen Bartels,&nbsp;Ladislav Batalik,&nbsp;Jing Jing Su","doi":"10.1002/gps.70130","DOIUrl":"https://doi.org/10.1002/gps.70130","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>With the increasing incidence of dementia, lifestyle interventions are key for long-term risk reduction. Understanding the psychological factors affecting lifestyle change motivation is crucial to developing effective policy strategies for dementia risk reduction. This study explores the moderating role of dementia-related fear on the relationship between perceived cognitive decline and engagement in dementia risk reduction behaviors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A cross-sectional study was conducted among 200 Chinese community-dwelling middle-aged and older adults. Hierarchical regression and simple slope analysis were used to assess the moderating effect of dementia-related fear on the relationship between perceived cognitive decline and motivation to engage in dementia risk reduction behaviors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A significant correlation was found between perceived cognitive decline and increased motivation to engage in dementia risk reduction behaviors (<i>r</i> = 0.44). Dementia-related fear acted as a significant moderator; motivation was positively associated with low to moderate levels of fear, whereas this association diminished and became non-significant at higher levels of fear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The findings suggest that while lower levels of dementia-related fear may be linked to increased motivation for engaging in risk reduction behaviors, elevated levels of fear do not appear to support such engagement. Rather than emphasizing the negative impacts of dementia, public health strategies should empower individuals with actionable messages to engage in dementia risk reduction behaviors.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 7","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Cost-Effectiveness of an Intervention to Preserve Independence in People With Dementia (Vs. No Intervention): A Decision-Analytic (Markov) Model Analysis","authors":"Luke Paterson,&nbsp;Rachel A. Elliott,&nbsp;Fofi Constantinidou,&nbsp;Renaud David,&nbsp;Piers Dawes,&nbsp;Eric Frison,&nbsp;Mark Hann,&nbsp;Hannah Hussain,&nbsp;Iracema Leroi,&nbsp;Antonis M. Politis,&nbsp;Chryssoula Thodi,&nbsp;Elizabeth M. Camacho,&nbsp;SENSE-Cog Study Team","doi":"10.1002/gps.70132","DOIUrl":"https://doi.org/10.1002/gps.70132","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Interventions that enable people with dementia to retain some independence in activities of daily living (ADL) may delay transitions into residential care and offset sharp reductions in quality of life (QoL). The aim of this study was to estimate how effective a hypothetical intervention needs to be at preserving independence in home-dwelling people with dementia, to be cost-effective.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A decision-analytic model was constructed to compare costs and outcomes of a cohort of people with dementia in the United Kingdom and European Union over a 10-year period. At model entry, the cohort was distributed across low, moderate, or high levels of dependence. The impact of a hypothetical intervention that preserves independence was evaluated by reducing the proportion of people entering the model with moderate and high dependence. The model included costs for the intervention and health and social care resource use. Secondary analysis included estimated costs of informal care. Health benefit was measured as quality-adjusted life-years (QALYs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The cost of the intervention was £570/person. At this cost, an intervention that resulted in 7.5% of the sample entering the model in a lower level of dependence (compared with no intervention) was likely to be cost-effective (£8690/QALY). An intervention costing £250/person would only need a 2.5% effect and one costing £1000/person would need to have a 10% effect to be potentially cost-effective. Including informal care costs increased the size of the effect required for the intervention to be cost-effective because more of the care provided at lower levels of dependence is informal.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Preserving independence in people with dementia may be a cost-effective way to help them live well for longer. Our results provide a guide on costs and required effects for those developing interventions to preserve independence in people with dementia.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 7","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gps.70132","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Criminal Trajectories Across the Dementia Timeline—A Nationwide Finnish Register Study","authors":"Milena Ginters,&nbsp;Tiina Talaslahti,&nbsp;Hannu Kautiainen,&nbsp;Risto Vataja,&nbsp;Anniina Palm,&nbsp;Henrik Elonheimo,&nbsp;Jaana Suvisaari,&nbsp;Nina Lindberg,&nbsp;Hannu Koponen","doi":"10.1002/gps.70131","DOIUrl":"https://doi.org/10.1002/gps.70131","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objectives&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The aim of this longitudinal register study was to examine the crime counts, crime incidence and timing of criminal activity in relation to the diagnosis of Alzheimer's disease (AD), frontotemporal dementia (FTD) and Lewy body dementias (LBD). The objective was to analyse the associated risk factors and risk relations among the offender categories.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We collected register data from Finnish nationwide registers (Finnish Care Register for Health Care and Finnish National Police Register) between 1998 and 2015. Mortality statistics were collected until the end of 2018 (Statistics Finland). Our study included a total of 92,189 patients, of whom 80,540 had AD, 1059 had FTD, and 10,590 had LBD. We examined the crimes committed by the study population before and after diagnosis. In the follow-up, we primarily focussed on the 4-year period and secondarily on the 10-year period after diagnosis. First, we measured the post-diagnostic crime rates in patients who had committed crimes before diagnosis and in those who had not; we also calculated the incidence rate ratio (IRR) of post-diagnosis crimes in these groups. Second, we calculated the cumulative incidence of first post-diagnoses crimes and investigated the risk of the first post-diagnoses crime by calculating the adjusted subhazard ratio (sHR) in pre-diagnosis offenders and non-offenders.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Most of the study population did not exhibit criminal behaviour before or after diagnosis. However, individuals who had engaged in criminal behaviour before diagnosis also showed a higher incidence of criminal activity in the 4-year period after diagnosis compared to patients with no criminal history prior to diagnosis. They also showed a steep increase in the cumulative incidence of the first post-diagnosis crime, particularly in the first 2 years after diagnosis. The age- and sex-adjusted sHR for the occurrence of the first post-diagnosis crime was 4.42 (95% confidence interval: 3.83–5.11) in AD, 4.36 (2.15–8.83) in FTD and 4.87 (3.88–6.12) in LBD in pre-diagnosis offenders versus non-offenders.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Individuals with a history of criminal behaviour before diagnosis of a neurocognitive disorder showed higher rates and a higher risk of future criminal activity. The cumulative incidence rose steeply during the first 2 years after diagnosis and after more gradually. Criminal activity closer to the time of diagnosis, especially 1 year prior, was the ","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 7","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gps.70131","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144646899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}