{"title":"Associations of phenols, parabens, and phthalates with biological aging: stratified analyses by chronological age and lifestyle in NHANES 2005-2010.","authors":"Han Ma, Jinyue Li, Hanping Ma","doi":"10.1080/09603123.2025.2451626","DOIUrl":"https://doi.org/10.1080/09603123.2025.2451626","url":null,"abstract":"<p><p>Humans are widely exposed to phenols, parabens, and phthalates with health risks, while the effects of these chemicals on biological aging remain unclear. Among 3,441 adults in the National Health and Nutrition Examination Survey 2005-2010, phenol, paraben, and phthalate concentrations were measured and phenotypic age acceleration (PhenoAgeAccel) was calculated. Linear regression and weighted quantile sum (WQS) regression were used to evaluate the associations of single and mixed chemicals with PhenoAgeAccel. Stratified analyses by chronological age and lifestyle were also performed. Individual phthalates were positively associated with PhenoAgeAccel. The WQS model found the positive relationship between mixed chemicals with PhenoAgeAccel (<i>β</i> = 0.175, 95%CI: 0.001, 0.349). The adverse impacts of phenols and phthalates on biological aging were stronger in older participants with significant interactions. Adherence to healthier lifestyle might partly reduce the positive relationships of phenols and phthalates with biological aging, especially among older adults, which is expected to be a viable intervention in the future.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-17"},"PeriodicalIF":2.2,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Disposal practices, risk perceptions, and quantification of potential active pharmaceutical ingredients (APIs) from used human medicine in Upper Citarum River Basin.","authors":"Anindrya Nastiti, Rosetyati Retno Utami, Shafiya Qonita Ramadhina, Nabila Fathonah, Gunawan Pratama Yoga, Herto Dwi Ariesyady, Siska Widya Dewi Kusumah, Hidayat","doi":"10.1080/09603123.2024.2445162","DOIUrl":"https://doi.org/10.1080/09603123.2024.2445162","url":null,"abstract":"<p><p>This paper highlights potential active pharmaceutical ingredients (APIs) generations from improper disposal of medicines and captures the perceptions of key stakeholders - households and pharmaceutical actors in Upper Citarum River Basin (UCRB). Most pharmaceutical waste is disposed of with household waste, suggesting landfills are the most significant APIs contamination sources. We highlight the complex relationship between knowledge, risk perception, and behavioural intentions, stressing the relevance of risk perception as a mediator when studying how knowledge affects behaviour. Age and income are suggested to moderate risk perception and behavioural intention. There is a heavy use of over-the-counter and prescription drugs in UCRB, especially Paracetamol (426.1 tons/year) and Amoxicillin (343.7 tons/year). Measured herbal APIs highlight the cultural significance and dependence on traditional medicine. We suggest examining the influence of affect on perception and behaviour in safe medicine disposal and the environmental and health risk impact of APIs in the water systems.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-18"},"PeriodicalIF":2.2,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Air pollution and breast cancer risk: a Mendelian randomization study.","authors":"Kangdi Cao, Jinkun Wang, Wei Hou","doi":"10.1080/09603123.2025.2451622","DOIUrl":"https://doi.org/10.1080/09603123.2025.2451622","url":null,"abstract":"<p><p>Previous research yields inconsistent findings on the association between air pollution and breast cancer risk, with no definitive causal relationship established. To address this, we conducted a two-sample Mendelian randomization study on data from the IEU open GWAS databases and the Breast Cancer Association Consortium to explore the potential link between air pollution (including PM<sub>2.5</sub>, PM<sub>2.5</sub> absorbance, PM<sub>2.5-10</sub>, PM<sub>10</sub>, NO<sub>2</sub>, and NO<sub>x</sub>) and breast cancer risk. We found that PM<sub>10</sub> (odds ratio (OR) = 1.39, 95% CI: 1.07-1.80, <i>p</i> = 0.013) and NO<sub>x</sub> (OR = 1.67, 95% CI: 1.16-2.41, <i>p</i> = 0.006) were significantly associated with elevated breast cancer risk. Furthermore, PM<sub>2.5</sub> (OR = 2.10, 95% CI: 1.09-4.03, <i>p</i> = 0.027) and NO<sub>x</sub> (OR = 3.08, 95% CI: 1.24-7.64, <i>p</i> = 0.015) were significantly associated with an elevated risk of luminal B/HER2-negative-like cancer. Results were stable in sensitivity analyses. This suggested that controlling air pollution could potentially reduce breast cancer risk.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-11"},"PeriodicalIF":2.2,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anan S Jarab, Walid Al-Qerem, Shrouq Abu Heshmeh, Yazid N Al Hamarneh, Tareq Mukattash, Eman Alefishat
{"title":"Drug repurposing for sustainable antimicrobial use: exploring pharmacists' awareness, attitudes, facilitators and barriers.","authors":"Anan S Jarab, Walid Al-Qerem, Shrouq Abu Heshmeh, Yazid N Al Hamarneh, Tareq Mukattash, Eman Alefishat","doi":"10.1080/09603123.2025.2451623","DOIUrl":"https://doi.org/10.1080/09603123.2025.2451623","url":null,"abstract":"<p><p>This study utilized a validated questionnaire that aimed to assess pharmacists' awareness and attitude towards drug repurposing for antimicrobial use. Despite the reasonable awareness, pharmacists reported unfavourable attitudes. Pharmacists with a B.Pharm. or Pharm.D. degree reported less awareness than pharmacists with a master's or PhD degree. In contrast, pharmacists who dispensed fewer than 10 prescriptions or 10-29 prescriptions had significantly higher awareness than those who dispensed 30 prescriptions daily or more. Pharmacists who had 1-5 years of experience and those who dispensed less than 10 prescriptions daily had significantly lower attitude scores than their counterpats. The most reported facilitator was the reduced risk of antimicrobial resistance, while the most reported barrier was patient safety. Pharmacists' perception of drug repurposing for antimicrobial needs to improve via implementing educational sessions that highlight the impact of drug repurposing on supporting the fight against antimicrobial resistance and promoting a more sustainable and resilient healthcare system.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-11"},"PeriodicalIF":2.2,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Parastoo Baharvand, Patrick Amoatey, Yusef Omidi Khaniabadi, Pierre Sicard, Hasan Raja Naqvi, Rajab Rashidi
{"title":"Short-term exposure to PM<sub>2.5</sub> pollution in Iran and related burden diseases.","authors":"Parastoo Baharvand, Patrick Amoatey, Yusef Omidi Khaniabadi, Pierre Sicard, Hasan Raja Naqvi, Rajab Rashidi","doi":"10.1080/09603123.2025.2449969","DOIUrl":"https://doi.org/10.1080/09603123.2025.2449969","url":null,"abstract":"<p><p>The objective of this study was to estimate the health effects attributed to PM<sub>2.5</sub> exposure in southwest of Iran. In order to estimate HA-CVD, HA-RD, LC-M, I-As in children, RAD, and WDL, the exposure-response function method was used. The annual mean of PM<sub>2.5</sub> regularly exceeded 5.26-8.5 times from 2021 annual limit value established by the WHO. The dominance of PM<sub>2.5</sub> in PM<sub>2.5</sub>/PM<sub>10</sub> ratio decreased -34.6% from 2015 to 2020. The results showed that the risks of HA-CVD (- 51. 9), HA-RD (- 68.7%), LC-M (- 43.6%), I-As (- 52.1%), RAD (- 56.8%), and WDL (- 58.7%) declined per 10<sup>5</sup> inhabitants between 2018 and 2020 . Reducing the particulate emissions from industries and road traffic led to lower exposure to PM<sub>2.5</sub>, which will be effective in decrease of mortality rate.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-13"},"PeriodicalIF":2.2,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142948503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jun Zhang, Hongxia Yang, Lu Li, Shuqiong Hu, Yongqing Liu, Suyan Li, Li Wu, Tao He
{"title":"Genetic evidence supports the causal effects of exposure to ambient air pollution on autoimmune eye diseases.","authors":"Jun Zhang, Hongxia Yang, Lu Li, Shuqiong Hu, Yongqing Liu, Suyan Li, Li Wu, Tao He","doi":"10.1080/09603123.2025.2449968","DOIUrl":"https://doi.org/10.1080/09603123.2025.2449968","url":null,"abstract":"<p><p>Previous observational studies have reported inconsistent associations between air pollution and autoimmune eye diseases (AEDs). The primary objective of this Mendelian randomization (MR) study was to investigate the causal link of air pollution with AEDs risk. The instrumental variables were selected based on genome-wide association study data. Univariable and multivariable MR analyses were conducted to disentangle the causality of air pollutants with AEDs. The estimates of univariable MR analysis revealed a suggestively causal link between NO2 or NOx exposure and diabetic retinopathy (OR=1.29, 95% CI=1.05-1.58, P=0.015; OR=1.33, 95% CI=1.05-1.69, P=0.019, respectively). A suggestive association was observed between PM2.5 exposure and age-related macular degeneration (OR=1.46, 95% CI=1.09-1.97, P=0.013). In addition, multivariable MR indicated that the observed association was remained consistent and robust. Rigorous sensitivity analyses confirmed the robustness and consistency of these findings. Our study firstly provided the genetic evidence linking air pollution, specially NO2, NOx and PM2.5, to AEDs susceptibility.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-14"},"PeriodicalIF":2.2,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of individual and work factors on the heat-related consequences among power plant workers in a hot region.","authors":"Alireza Dehdashti, Farin Fatemi, Niloofar Poureghtedar","doi":"10.1080/09603123.2024.2346559","DOIUrl":"10.1080/09603123.2024.2346559","url":null,"abstract":"<p><p>Prolonged exposure to hot environments increases the probability of heat load that may cause occupational heat strain to workers. This study investigates the impact of individual and work-related factors on the heat-related consequences among power plant workers in a hot region. This cross-sectional study was conducted in 2020. The collecting data tool was a validated self-reported 26 item questionnaire and completed in 534 individuals. We used logistic regression, Adjusted odds ratio (AOR) and maximum likelihood evaluations for data analysis. The findings indicated that age, work environment, physical work demands and drinking fluids during work hours are significant with heat exposure perception, heat-related symptoms, and work performance (P-value<0.05). Further, the male workers aged 40-49 are more prone to heat-related symptoms (AOR 1.34, 95% CI 1.18-2.13). The importance of addressing heat stress in occupational settings is necessary and informing strategies to help workers adapt to heat in hot workplaces.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"116-128"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140897650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effect of TikTok use on internet addiction of college students in Somalia: a cross-sectional study.","authors":"Elif Gezginci Akpinar, Hasan Huseyin Eker","doi":"10.1080/09603123.2024.2448488","DOIUrl":"https://doi.org/10.1080/09603123.2024.2448488","url":null,"abstract":"<p><p>This study aimed to assess the effect of TikTok use on the internet addiction of college students in Somalia. This cross-sectional study was conducted with 210 students at the faculty of health sciences of a university in Mogadishu, Somalia. The data were obtained with the Individual Information Form and Young Internet Addiction Test-Short Form. The students' internet addiction average score was 31.93±7.14. A positive, very weak, significant correlation was determined between the students' daily time spent on TikTok and internet addiction (r=.190, p=.006). Internet addiction scores of students having a TikTok account and using the TikTok application were found to be significantly higher than students not having (p=.027) and not using the application (p=.032). This study shows that most students had a TikTok account and actively used this application, and their internet addiction level was moderate. The students having a TikTok account and using the application had higher internet addiction.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-11"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A bidirectional Mendelian randomization analysis between COVID-19 and cardiac arrest.","authors":"Xisha Tang, Huijia Zhuang, Hai Yu","doi":"10.1080/09603123.2024.2365304","DOIUrl":"10.1080/09603123.2024.2365304","url":null,"abstract":"<p><p>Epidemiological studies link COVID-19 to increased cardiac arrest (CA) risk, but causality remains unclear due to potential confounding factors in observational studies . We conducted a Mendelian randomization (MR) analysis using genome-wide association study (GWAS) data, employing COVID-19-associated single nucleotide polymorphisms (SNPs) with significance values smaller than 5 × 10⁻⁸. We calculated inverse-variance weighted (IVW) MR estimates and performed sensitivity analyses using MR methods robust to horizontal pleiotropy. Additionally, a reverse MR analysis was conducted using CA-associated SNPs with significance values smaller than 1 × 10⁻⁵. Results indicated that infected COVID-19 (OR = 1.12, 95% CI = 0.47-2.67, <i>p</i> = 0.79), hospitalized COVID-19 (OR = 1.02, 95% CI = 0.70-1.49, <i>p</i> = 0.920), and severe respiratory COVID-19 (OR = 0.99, 95% CI = 0.81-1.21, <i>p</i> = 0.945) did not causally influence CA risk. Reverse MR analysis also did not support a causal effect of CA on COVID-19. Thus, associations in observational studies may stem from shared biological factors or environmental confounding.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"233-244"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141305874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effect of eating motivation on adherence to the Mediterranean diet, glycemia and lipid profile in individuals with type 2 diabetes.","authors":"Gülin Öztürk Özkan, Büşra Çeteoğlu, Beyza Temiz, Hüsna Dursun, Melike Karaçam, Mehmet Sarğın","doi":"10.1080/09603123.2024.2438122","DOIUrl":"10.1080/09603123.2024.2438122","url":null,"abstract":"<p><p>The aim of this study was to investigate the effect of eating motivation on Mediterranean diet adherence, glycemia and lipid profile in individuals with type 2 diabetes. A questionnaire consisting of general information, eating motivation scale and Mediterranean diet adherence scale was applied to 400 individuals with diabetes. Height, weight, plasma glucose, total cholesterol, triglycerides, low density lipoprotein and high density lipoprotein values were measured. Environmental and political, health, commercial and marketing, economic and affordability motivations are effective in individuals with diabetes. Emotional motivation and social motivation were positively correlated with body mass index, HbA1C, total cholesterol, triglyceride and low density lipoprotein levels. Health motivation increased the likelihood of having glucose levels below 130 mg/dl. Individuals with diabetes were influenced by eating motivations and these motivations were associated with adherence to the Mediterranean diet and glycemia. Eating motivation may be effective in the management of type 2 diabetes.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"257-268"},"PeriodicalIF":2.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}