International Journal of Environmental Health Research最新文献_第2页

Fractional exhaled nitric oxide (FeNO) in Chinese children and its association with respiratory symptoms and home environment. 中国儿童呼出一氧化氮分数（FeNO）及其与呼吸道症状和家庭环境的关系

IF 2.2 4区医学

International Journal of Environmental Health Research Pub Date : 2025-05-15 DOI: 10.1080/09603123.2025.2506137

Yuexia Sun, Justice Mlambo, Yuxuan Zhao, Dan Norbӓck, Samali Ayoma Marasinghe, Jing Hou, Pan Wang, Qingnan Zhang, Jan Sundell

{"title":"Fractional exhaled nitric oxide (FeNO) in Chinese children and its association with respiratory symptoms and home environment.","authors":"Yuexia Sun, Justice Mlambo, Yuxuan Zhao, Dan Norbӓck, Samali Ayoma Marasinghe, Jing Hou, Pan Wang, Qingnan Zhang, Jan Sundell","doi":"10.1080/09603123.2025.2506137","DOIUrl":"https://doi.org/10.1080/09603123.2025.2506137","url":null,"abstract":"The association between home environments and fractional exhaled nitric oxide (FeNO) has been insufficiently investigated. We measured FeNO levels in children aged 4-8 years (N = 105) in Tianjin, China, and examined their association with respiratory symptoms and various indoor environmental parameters, namely house dust mite allergens and phthalates in dust, dampness, environmental tobacco smoke (ETS) and furry pets (dogs/cats) in the home. FeNO levels were significantly higher in children with diagnosed asthma (p < 0.001) and pneumonia (p = 0.03). Exposure to Diisononyl phthalate (DiNP) - a new phthalate replacing the commonly used Di(2-ethylhexyl) phthalate (DEHP) - was significantly associated with increased FeNO in children (p = 0.01). In conclusion, diagnosed asthma and pneumonia were associated with increased FeNO levels in children. Exposure to DiNP may contribute to airway inflammation, as indicated by its association with increased FeNO levels. These findings underscore the importance of closely monitoring emerging contaminants to better understand their potential impacts on respiratory health.","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-8"},"PeriodicalIF":2.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review of polybrominated diphenyl ethers contamination in environmental compartments of recycling and landfill/dumping facilities: developed vs. developing regions perspective. 回收和填埋/倾倒设施环境隔间中多溴联苯醚污染的综述：发达地区与发展中地区的对比。

IF 2.2 4区医学

International Journal of Environmental Health Research Pub Date : 2025-05-15 DOI: 10.1080/09603123.2025.2506139

Sidra Shakil, Yumna Sadef, Naeem Akhtar Abbasi

{"title":"Review of polybrominated diphenyl ethers contamination in environmental compartments of recycling and landfill/dumping facilities: developed vs. developing regions perspective.","authors":"Sidra Shakil, Yumna Sadef, Naeem Akhtar Abbasi","doi":"10.1080/09603123.2025.2506139","DOIUrl":"https://doi.org/10.1080/09603123.2025.2506139","url":null,"abstract":"Electronic devices are considered major sources of polybrominated diphenyl ethers (PBDEs), a group of brominated flame retardants (BFRs) used to mitigate or prevent fire hazards. Despite bans on PBDEs due to their toxicity and persistence in the environment, recycling centers and dumping sites remain active sources of these chemicals from the disposal of older e-waste products that contain them. This review examines historical and current PBDE concentrations in various environmental compartments at recycling centers and landfill/dumping sites, focusing on e-waste in developed and developing regions. It also identifies factors influencing PBDE emission, dispersion, deposition, accumulation, and degradation. Owing to their lipophilic properties, PBDEs preferentially accumulate in solid environmental matrices, with recycling centers exhibiting markedly higher concentrations than landfill/dumping sites. Although water and leachates also contain PBDEs, the presence of organic matter in leachates enhances leaching, resulting in concentrations higher than in pure water yet still lower than in solid matrices. This paper further intends to address the knowledge gaps and aid researchers in designing risk assessment and environmental monitoring studies. In conclusion, developed regions must reduce processing costs and expand recycling capacity, while developing regions need to invest in sustainable e-waste management infrastructure and enforce stricter regulations.","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-15"},"PeriodicalIF":2.2,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Community Knowledge, Attitudes and Practices Towards Greywater Management in Rural Malaysia. 探索社区知识，态度和实践在马来西亚农村对灰水管理。

IF 2.2 4区医学

International Journal of Environmental Health Research Pub Date : 2025-05-14 DOI: 10.1080/09603123.2025.2506134

Norzarifah Md Azmi, Nur Afiqah Fuzi, Nurul Aeimanina Noriadi, Emy Nurelyssa Norihan, Nur Najwa Atiqah Syaharidan, Murni Amirra Mohd Aminuddin, Siti Rohana Mohd Yatim, Tengku Nilam Baizura Tengku Ibrahim

{"title":"Exploring Community Knowledge, Attitudes and Practices Towards Greywater Management in Rural Malaysia.","authors":"Norzarifah Md Azmi, Nur Afiqah Fuzi, Nurul Aeimanina Noriadi, Emy Nurelyssa Norihan, Nur Najwa Atiqah Syaharidan, Murni Amirra Mohd Aminuddin, Siti Rohana Mohd Yatim, Tengku Nilam Baizura Tengku Ibrahim","doi":"10.1080/09603123.2025.2506134","DOIUrl":"https://doi.org/10.1080/09603123.2025.2506134","url":null,"abstract":"In Malaysia, 43%-70% of household wastewater is greywater, with characteristics influenced by lifestyle, fixtures, and weather. It is often discharged untreated, posing environmental and health risks. This study assessed the knowledge, attitudes, practices, and key factors influencing greywater management among rural residents in Perak, Malaysia. A community-based cross-sectional survey was conducted from March to April 2023, involving 121 participants selected via the Linear Time Function sampling method. Data were analyzed using a structured questionnaire and Chi-square analysis, revealing a significant association between knowledge and attitudes toward greywater management, with higher awareness linked to more positive perceptions and willingness to adopt proper practices (p < 0.001). Additionally, individuals with better knowledge were more likely to engage in systematic greywater disposal methods, such as using septic tanks instead of direct discharge (p = 0.006). The findings provide valuable insights for policymakers and stakeholders in designing community-driven greywater management strategies that enhance public awareness, improve infrastructure, and support sustainable water resource management. Further research is recommended to investigate the underlying factors influencing community attitudes and behaviors toward greywater management, particularly the socio-cultural, economic, and perceptual barriers that contribute to the knowledge-to-practice gap in rural areas.","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-16"},"PeriodicalIF":2.2,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improvement of photocatalytic and photo-disinfection of wastewater using natural photosensitizer: stinging nettle (Urtica dioica) leaves extract. 天然光敏剂刺荨麻叶提取物对废水光催化和光消毒的改进。

IF 2.2 4区医学

International Journal of Environmental Health Research Pub Date : 2025-05-12 DOI: 10.1080/09603123.2025.2487647

Myriam Ben Said, Dhekra Trabelsi, Asma Chekir-Jlizi, Nadra Bel-Haj-Amor, Moncef Chouebi, Latifa Bousselmi

{"title":"Improvement of photocatalytic and photo-disinfection of wastewater using natural photosensitizer: stinging nettle (Urtica dioica) leaves extract.","authors":"Myriam Ben Said, Dhekra Trabelsi, Asma Chekir-Jlizi, Nadra Bel-Haj-Amor, Moncef Chouebi, Latifa Bousselmi","doi":"10.1080/09603123.2025.2487647","DOIUrl":"https://doi.org/10.1080/09603123.2025.2487647","url":null,"abstract":"This study focuses on the improvement of photocatalytic treatment using natural photosensitizer extracted from nettle (Urtica dioica) leaves. The nettle aqueous extract (NAE) have shown antimicrobial activity against pathogenic bacteria. In addition, it contains molecules that can absorb in ultraviolet (UV) and visible region. This property was used to enhance nanobiocide activity of titanium dioxide nanoparticles (TiO2-NPs). For solar application, this NP has the limit to absorb in UV region. To monitor the impact of NAE on different photodisinfection treatments, the quencher coefficients of bacterial cutivability (Qn), and bacterial viability (Qp) were determined. The exploration of bacterial viability was done basing on the determination of phage amplification rate in relation with post-treated bacteria. Results showed a relative retention of bacterial viability compared to bacterial cultivability after photocatalytic treatment. In addition, there is an increase in quencher coefficients even without sun light illumination. The photoincitation of photcatalytic complex allowed the reduction of 99.99% of bacterial cultivability and 99.9% of bacterial viability. These results could open a new horizon to valorize the potential use natural extracts to enhance tertiary wastewater performance, and to contribute in the establishment of reliable green water disinfection process.","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-14"},"PeriodicalIF":2.2,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental bioprinting in forensic pathology: applications in DNA preservation and forensic identification. 环境生物打印在法医病理学：在DNA保存和法医鉴定中的应用。

IF 2.2 4区医学

International Journal of Environmental Health Research Pub Date : 2025-05-12 DOI: 10.1080/09603123.2025.2504610

Phoka C Rathebe, Mota X Kholopo

{"title":"Environmental bioprinting in forensic pathology: applications in DNA preservation and forensic identification.","authors":"Phoka C Rathebe, Mota X Kholopo","doi":"10.1080/09603123.2025.2504610","DOIUrl":"https://doi.org/10.1080/09603123.2025.2504610","url":null,"abstract":"Bioprinting is an advanced technology that enables the fabrication of complex three-dimensional (3D) biological structures by layering bio-inks embedded with cells to replicate natural tissues. Environmental bioprinting, an emerging field at the intersection of biotechnology and forensic science, presents new possibilities for forensic pathology by recreating biological tissues under specific environmental conditions. This narrative review explores how environmental bioprinting can enhance forensic investigations by generating tissue models that mimic real-world environmental influences such as temperature fluctuations, chemical exposure, and decomposition processes. Special attention is given to the resilience of dental pulp DNA, which remains intact under extreme environmental conditions, making it a crucial element in forensic identification. The review also examines how early childhood diet and dental structures contribute to forensic profiling by providing insights into an individual's nutritional background and regional influences. By leveraging bioprinting technology, forensic scientists can improve the accuracy of tissue reconstruction, DNA preservation, and forensic biometrics, especially in challenging cases involving mass disasters and unidentified mortal remains. This narrative review synthesizes existing literature on environmental bioprinting's forensic applications, emphasizing its potential to revolutionize forensic pathology by offering a controlled, replicable model for biological tissue analysis.","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-13"},"PeriodicalIF":2.2,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating PAH exposure and occupational health in petrochemical sector: a focus on POL depot workers. 石化行业多环芳烃暴露与职业健康评价：以POL仓库工人为重点。

IF 2.2 4区医学

International Journal of Environmental Health Research Pub Date : 2025-05-12 DOI: 10.1080/09603123.2025.2502631

Aman Ullah, Audil Rashid, Shu Tao, Maria Rafique, Aniqa Batool, Mazhar Qayyum, Atif Kamal

{"title":"Evaluating PAH exposure and occupational health in petrochemical sector: a focus on POL depot workers.","authors":"Aman Ullah, Audil Rashid, Shu Tao, Maria Rafique, Aniqa Batool, Mazhar Qayyum, Atif Kamal","doi":"10.1080/09603123.2025.2502631","DOIUrl":"https://doi.org/10.1080/09603123.2025.2502631","url":null,"abstract":"This investigation delineates occupational health concerns related to petroleum products handling at Petroleum Oil and Lubricant (POL) depots. The cohort included 117 workers from depots in Sihala, Risalpur and Lahore, alongside 69 controls. A strong correlation was found between specific job-related tasks, such as direct fuel handling, equipment maintenance, and tanker offloading, and urinary Polycyclic Aromatic Hydrocarbon (PAH) metabolites in exposed workers. Labourers and firemen displayed significantly higher (p < 0.01) urinary 1-hydroxypyrene (6.9 ± 1.7 and 5.8 ± 2.2 ng g-1 creatinine) concentration than watchmen (2.2 ± 1.2 ng g-1 creatinine) and controls (0.79 ± 0.3 ng g-1 creatinine). Logistic regression analysis linked exposure to increased likelihood of anxiety (OR = 4.6, 95% CI = 1.85-11.7), post-meal acidity (OR = 2.1, 95% CI = 1.05-4.5), dermal lesions (OR = 3.4, 95% CI = 1.8-6.4), and abdominal pain (OR = 1.9, 95% CI = 1.02-3.5). Principal component analysis (PCA) identified a collective impact of escalating serum pyrene and benzo[a]pyrene (B[a]P), and job type on insomnia, thoracic discomfort, fatigue, and headache. Gastrointestinal symptoms correlated strongly with urinary 1-hydroxypyrene and 9-hydroxyphenanthrene while urinary 2/3-OH-Flu was associated with dermatological and neurasthenic symptoms. Cigarette smoking and a sedentary lifestyle further worsened health outcomes. In conclusion, robust measures are needed to reduce PAH exposure and mitigate its neuro-metabolic and psychological impacts on the health of petrochemical workers.","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-13"},"PeriodicalIF":2.2,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of air pollution and green space with endometriosis among women undergoing assisted reproductive technology: a cross-sectional study in Anhui, China. 在中国安徽进行辅助生殖技术的妇女中，空气污染和绿地与子宫内膜异位症的关系：一项横断面研究。

IF 2.2 4区医学

International Journal of Environmental Health Research Pub Date : 2025-05-12 DOI: 10.1080/09603123.2025.2504611

Yongzhen Peng, Chunyan Wang, Lanlan Fang, Guosheng Wang, Cong Ma, Xu Zhang, Xuyang Chen, Jianpin Ni, Yubo Ma, Guoqi Cai, Huifen Xiang, Faming Pan

{"title":"Association of air pollution and green space with endometriosis among women undergoing assisted reproductive technology: a cross-sectional study in Anhui, China.","authors":"Yongzhen Peng, Chunyan Wang, Lanlan Fang, Guosheng Wang, Cong Ma, Xu Zhang, Xuyang Chen, Jianpin Ni, Yubo Ma, Guoqi Cai, Huifen Xiang, Faming Pan","doi":"10.1080/09603123.2025.2504611","DOIUrl":"https://doi.org/10.1080/09603123.2025.2504611","url":null,"abstract":"Air pollution has reproductive toxicity, while green space could lessen such harmful consequences. However, the current research on the link between air pollution/green space, and endometriosis remains scarce. Therefore, we investigated the separate and interactive relationships between air pollution, green space and endometriosis-related infertility. We collected data on 20,981 women from a large assisted reproductive center in Anhui, China, of whom 1,201 were diagnosed with endometriosis-related infertility. air pollution (PM2.5, PM10, NO2, CO, and SO2) and Green space (quantified using the normalized difference vegetation index [NDVI]) were evaluated using spatiotemporal models developed from satellite data. We employed multivariable logistic regression to calculate adjusted odds ratios (aOR) with 95% confidence intervals (CI). Per interquartile range (IQR) increase in exposure was associated with elevated odds of endometriosis prevalence for PM2.5 (aOR = 1.20, 95%CI:1.11-1.30), PM10 (1.17, 1.08-1.27), SO2 (1.12, 1.02-1.24), NO2 (1.18, 1.08-1.38), and CO (1.12, 1.05-1.19). Conversely, each IQR increase in NDVI500 m showed protective effects (0.72, 0.63-0.83). Notably, an additive antagonistic effect was observed between NDVI500 m and CO. Our findings indicated that air pollution could potentially increase the risk of endometriosis, while green space is its protective factor. Besides, green space might attenuate the negative impact of air pollution on endometriosis.","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-13"},"PeriodicalIF":2.2,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exposure to greenness modifies the association between extreme temperature events and ischemic stroke recurrence in Tianjin, China. 在中国天津，暴露于绿色环境改变了极端温度事件与缺血性脑卒中复发之间的关系。

IF 2.2 4区医学

International Journal of Environmental Health Research Pub Date : 2025-05-09 DOI: 10.1080/09603123.2025.2502634

Jingwei Zhang, Yuming Wang, Junyi Hu, Qiang Zeng

{"title":"Exposure to greenness modifies the association between extreme temperature events and ischemic stroke recurrence in Tianjin, China.","authors":"Jingwei Zhang, Yuming Wang, Junyi Hu, Qiang Zeng","doi":"10.1080/09603123.2025.2502634","DOIUrl":"https://doi.org/10.1080/09603123.2025.2502634","url":null,"abstract":"Few studies have found an association between extreme temperature events and an increased risk of recurrent ischemic stroke (IS). We examined associations between extreme temperature events (heat waves, cold spells) and recurrent IS risk in Tianjin, China (2019-2020), using a time-stratified case-crossover design, while evaluating greenness's moderating role. Significant heat wave effects peaked at lag 8, with severe intensity events increasing IS recurrence risk by 39.8% (OR = 1.398, 95% CI:1.032-1.894). Cold spell impacts peaked at lag 3, with moderate intensity cold spells elevating risk by 20.3% (OR = 1.203, 95% CI: 1.052-1.377) and severe intensity cold spells elevating risk by 98.2% (OR = 1.982, 95% CI: 1.407-2.791). Greenness modified these associations: low-greenness areas strengthened heat wave effects(lag9:OR = 2.309,95%CI:1.024-5.209) but weakened cold spell impacts(OR = 1.557,95%CI:1.037-2.340), whereas high-greenness areas attenuated heat wave links(lag8:OR = 1.402,95%CI:1.022-1.924) and nullified cold spell associations. Age and sex disparities emerged - younger individuals and males showed higher susceptibility to heat waves, while older individuals and males were more vulnerable to cold spells. The findings highlight greenness as a potential modifier of extreme temperature events-related IS recurrence risks and underscore demographic-specific vulnerabilities.","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-12"},"PeriodicalIF":2.2,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurobehavioral toxicity of cypermethrin in association with oxidative, inflammatory and neurotrophic changes in the hippocampus of rats. 氯氰菊酯的神经行为毒性与大鼠海马的氧化、炎症和神经营养改变有关。

IF 2.2 4区医学

International Journal of Environmental Health Research Pub Date : 2025-05-08 DOI: 10.1080/09603123.2025.2503472

Marjaneh Tavakkoli, Masoomeh Dadkhah, Hakimeh Saadati, Salva Afshari, Sara Mostafalou

{"title":"Neurobehavioral toxicity of cypermethrin in association with oxidative, inflammatory and neurotrophic changes in the hippocampus of rats.","authors":"Marjaneh Tavakkoli, Masoomeh Dadkhah, Hakimeh Saadati, Salva Afshari, Sara Mostafalou","doi":"10.1080/09603123.2025.2503472","DOIUrl":"https://doi.org/10.1080/09603123.2025.2503472","url":null,"abstract":"Pyrethroid pesticides can induce neurotoxicity in target and non-target organisms. We examined the effects of sub-chronic exposure to cypermethrin on anxiety-like behaviors, memory function and molecular changes in the hippocampus of rats. Twenty-four male Wistar rats (weighing 200-250 g) were randomly divided into three groups (n = 8) and received orally corn oil, cypermethrin 2 and cypermethrin 4 mg/kg/day, for 30 days. The elevated plus maze (EPM), open field maze (OFM) and novel object recognition memory (NORM) tests were conducted. At the end, brain derived neurotrophic factor (BDNF), glycogen synthase kinase-3 β (GSK-3β), cholinesterase activity, oxidative stress markers and inflammatory mediators were evaluated in the hippocampus. The results of OFM and EPM indicated higher level of anxiety and motor activity alterations in the cypermethrin treated rats. NORM test revealed impairment of cognitive memory and decreased discrimination ratio in cypermethrin treated rats. Cypermethrin decreased BDNF and increased GSK-3β, oxidative stress and mRNA expression of IL-1β and TNF-α and NF-κB in the hippocampus. The activity of cholinesterase enzyme was not changed. Cypermethrin can impair learning and memory along with provoking oxidative stress and inflammation, and dysregulation of BDNF and GSK-3β pathway may be involved in neurocognitive and neurobehavioral disorders due to long-time exposures.","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-12"},"PeriodicalIF":2.2,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bio-monitoring of endocrine disrupting chemicals in human serum: insights from a study in Central India. 人血清中内分泌干扰化学物质的生物监测：来自印度中部研究的见解。

IF 2.2 4区医学

International Journal of Environmental Health Research Pub Date : 2025-05-08 DOI: 10.1080/09603123.2025.2502636

Poonam Sharma, Namrata Pal, Samradhi Singh, Raj Ojha, Manoj Kumawat, Swasti Shubham, Vinod Verma, Rajnarayan R Tiwari, Devojit Kumar Sarma, Manoj Kumar

{"title":"Bio-monitoring of endocrine disrupting chemicals in human serum: insights from a study in Central India.","authors":"Poonam Sharma, Namrata Pal, Samradhi Singh, Raj Ojha, Manoj Kumawat, Swasti Shubham, Vinod Verma, Rajnarayan R Tiwari, Devojit Kumar Sarma, Manoj Kumar","doi":"10.1080/09603123.2025.2502636","DOIUrl":"https://doi.org/10.1080/09603123.2025.2502636","url":null,"abstract":"In recent years, the health impacts of phthalates and bisphenol-A (BPA) have garnered significant research attention due to their widespread use in consumer products and identification as endocrine disrupting chemicals (EDCs). Human exposure occurs through various pathways, including dietary intake, inhalation of dust, and dermal contact. This study initially aimed to analyze serum samples from 200 participants in Jabalpur city (Central India); however, samples from 173 individuals were ultimately analyzed to assess the occurrence, concentration patterns, and gender-related differences of six phthalates and BPA. Serum samples were collected, processed, and analyzed for EDC content using gas chromatography coupled with mass spectrometry. The findings highlighted differences in detection frequencies among genders and residential areas, shaped by environmental exposure variability, lifestyle variations, and gender-specific metabolic disparities. All the targeted analytes were detected with diethyl phthalate (DEP) having the highest mean concentration of 13.74 ± 6.2 ng/ml, followed by di(2-ethylhexyl) phthalate (DEHP) with mean value of 13.69 ± 99.82 ng/ml in human serum. Studies have linked DEP exposure endocrine disruption and reproductive abnormalities. Subsequent research endeavors should prioritize elucidating EDC sources, pathways, and health impacts, facilitating evidence-based policies to mitigate risks and ensure a healthier future.","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-13"},"PeriodicalIF":2.2,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0