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International Journal of Environmental Health Research最新文献

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Antioxidants from Rubus idaeus leaves: LC-MS/MS chemical profiling, in vitro antiglycation, α-glucosidase and α-amylase inhibitory activities. 茜草叶中的抗氧化剂：LC-MS/MS 化学分析、体外抗糖化、α-葡萄糖苷酶和α-淀粉酶抑制活性。
IF 3.2 4区 医学
International Journal of Environmental Health Research Pub Date : 2024-09-18 DOI: 10.1080/09603123.2024.2404248
El Asri Sara,Ben Mrid Reda,Zouaoui Zakia,Chibuye Bitwell,Ennoury Abdelhamid,Kabach Imad,Nhiri Mohamed,Chibi Fatiha
{"title":"Antioxidants from Rubus idaeus leaves: LC-MS/MS chemical profiling, in vitro antiglycation, α-glucosidase and α-amylase inhibitory activities.","authors":"El Asri Sara,Ben Mrid Reda,Zouaoui Zakia,Chibuye Bitwell,Ennoury Abdelhamid,Kabach Imad,Nhiri Mohamed,Chibi Fatiha","doi":"10.1080/09603123.2024.2404248","DOIUrl":"https://doi.org/10.1080/09603123.2024.2404248","url":null,"abstract":"The present study evaluated a range of biological activities of Rubus idaeus leaves, often considered as by-products, in relation to hyperglycemia. The antiglycation potential of this plant has not been previously reported. In this research, the methanolic leaf extract of R. idaeus was assessed for its antioxidant, enzyme inhibitory and antiglycation activities. The bioactive compounds present in the extract were screened using LC-MS/MS. Enzyme inhibitory activities were tested on α-glucosidase and α-amylase, and the antiglycation effect was investigated using BSA-fructose model. The methanolic extract showed a high polyphenolic contents (176.26 ± 2.26 mg GAE/g) and important IC50 values for DPPH (34.79 ± 2.40 µg/mL) and ABTS radical scavenging activities (49.75 ± 2.47 µg/mL). In addition, the plant leaf extract significantly inhibited hyperglycemia-related enzymes in a dose-dependent manner and demonstrated a reduction in fluorescent AGEs, fructosamine, and dicarbonyl compounds. Therefore, R. idaeus cv Maravilla could be an effective source of therapeutics for improving the healthcare outcomes of diabetic patients.","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect and interaction of PINK1 genetic polymorphisms and environmental factors on blood pressure in COEs-exposed workers. PINK1 基因多态性和环境因素对接触 COE 的工人血压的影响和相互作用。
IF 3.2 4区 医学
International Journal of Environmental Health Research Pub Date : 2024-09-18 DOI: 10.1080/09603123.2024.2403685
Jing Sun,Yang Chen,Xiangkai Zhao,Zeming Niu,Zhiguang Gu,Zhaofan Yan,Wei Wang
{"title":"Effect and interaction of PINK1 genetic polymorphisms and environmental factors on blood pressure in COEs-exposed workers.","authors":"Jing Sun,Yang Chen,Xiangkai Zhao,Zeming Niu,Zhiguang Gu,Zhaofan Yan,Wei Wang","doi":"10.1080/09603123.2024.2403685","DOIUrl":"https://doi.org/10.1080/09603123.2024.2403685","url":null,"abstract":"Coke oven emissions (COEs) contain a variety of polycyclic aromatic hydrocarbons (PAHs), which can cause damage to the human cardiovascular system. In addition, myocardial mitochondria are susceptible to damage in hypertensive patients. However, it is not clear whether genetic variation, in single nucleotide polymorphisms (SNPs) in PINK1 affects COEs exposure-induced abnormal blood pressure. We surveyed and tested 518 workers exposed to COEs and statistically analyzed them with SPSS 21.0 software. SBP was greater in the high-exposure group than in the low-exposure group. Generalized linear model analysis showed that the interaction of PINK1 rs3738136 (GA+AA) and COEs had an effect on SBP [β(95%CI) = -6.537(-12.072, -1.002), p = 0.021] and DBP [β(95%CI) = -4.811(-8.567, -1.056), p = 0.012]. This study is the first to identify the role of PINK1 rs3738136 in COE- induced abnormal blood pressure, and to prove that the abnormal blood pressure of workers is the result of environmental and genetic factors.","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A new perspective on essential tremor: the potential etiologic role of Toxoplasma gondii and Toxocara spp 本质性震颤的新视角：弓形虫和弓形虫的潜在致病作用
IF 3.2 4区 医学
International Journal of Environmental Health Research Pub Date : 2024-09-17 DOI: 10.1080/09603123.2024.2404480
Tuncay Celik, Erman Altunisik, Turkan Mutlu Yar, Tuba Gul, Yeliz Kasko Arici, Ulku Karaman
{"title":"A new perspective on essential tremor: the potential etiologic role of Toxoplasma gondii and Toxocara spp","authors":"Tuncay Celik, Erman Altunisik, Turkan Mutlu Yar, Tuba Gul, Yeliz Kasko Arici, Ulku Karaman","doi":"10.1080/09603123.2024.2404480","DOIUrl":"https://doi.org/10.1080/09603123.2024.2404480","url":null,"abstract":"Our aim was to examine the relationship between Toxoplasma gondii (T. gondii) and Toxocara infection and patients with essential tremor (ET). This study comprised a total of 174 participants, consi...","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of environmental factors with breast cancer incidence among African American women in Memphis, Tennessee 环境因素与田纳西州孟菲斯市非裔美国妇女乳腺癌发病率的关系
IF 3.2 4区 医学
International Journal of Environmental Health Research Pub Date : 2024-09-13 DOI: 10.1080/09603123.2024.2400702
Namuun Batbaatar, Alana Smith, Chunrong Jia, Abu Mohd Naser, Xichen Mou, Gregory Vidal, Athena Starlard-Davenport
{"title":"Association of environmental factors with breast cancer incidence among African American women in Memphis, Tennessee","authors":"Namuun Batbaatar, Alana Smith, Chunrong Jia, Abu Mohd Naser, Xichen Mou, Gregory Vidal, Athena Starlard-Davenport","doi":"10.1080/09603123.2024.2400702","DOIUrl":"https://doi.org/10.1080/09603123.2024.2400702","url":null,"abstract":"African American (AA) women confront distinct disparities in breast cancer rates, and the impact of their living environment is unclear. This study aimed to examine the association between breast c...","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142267960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The ratio of concentration of organic carbon and elemental carbon bound to particulate matter in ambient air: a global systematic review and meta-analysis. 环境空气中与颗粒物结合的有机碳和元素碳的浓度比：全球系统回顾和荟萃分析。
IF 3.2 4区 医学
International Journal of Environmental Health Research Pub Date : 2024-09-10 DOI: 10.1080/09603123.2024.2399207
Yadolah Fakhri,Mansour Sarafraz,Allahbakhsh Javid,Mahboobeh Moradi,Fereshteh Mehri,Rasul Nasiri,Sepideh Saadatmandsepideh
{"title":"The ratio of concentration of organic carbon and elemental carbon bound to particulate matter in ambient air: a global systematic review and meta-analysis.","authors":"Yadolah Fakhri,Mansour Sarafraz,Allahbakhsh Javid,Mahboobeh Moradi,Fereshteh Mehri,Rasul Nasiri,Sepideh Saadatmandsepideh","doi":"10.1080/09603123.2024.2399207","DOIUrl":"https://doi.org/10.1080/09603123.2024.2399207","url":null,"abstract":"Four hundred and sixty-six references with 625 data reports were included in our study. The high frequency of ratio OC/EC for PM0.1 was observed in 3.92-5.93; PM1 in 1.08-3.08; PM2.5, 2.08-4.08; PM10 in 2.70-4.70 and TSP in 2.66-4.66. The rank order of areas based on the pooled concentration of OC bound to PM2.5 was traffic (17.893 µg/m3) > industrial (10.58 µg/m3) > urban (7.696 µg/m3) > rural (4.08 µg/m3). The rank order of areas based on the pooled (mean) concentration of EC in PM2.5 was traffic (17.893 µg/m3) > industrial (2.65 µg/m3) > Urban (1.48 µg/m3) > rural (1.06 µg/m3). The pooled concentrations of OC and EC bound to PM2.5 in traffic areas were higher than in other areas. Therefore, it is recommended that monitoring and effectively reducing concentration plans are carried out, especially in traffic areas.","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142207184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disinfection byproducts in US drinking water and cancer mortality. 美国饮用水中的消毒副产物与癌症死亡率。
IF 3.2 4区 医学
International Journal of Environmental Health Research Pub Date : 2024-09-10 DOI: 10.1080/09603123.2024.2400701
Angelico Mendy
{"title":"Disinfection byproducts in US drinking water and cancer mortality.","authors":"Angelico Mendy","doi":"10.1080/09603123.2024.2400701","DOIUrl":"https://doi.org/10.1080/09603123.2024.2400701","url":null,"abstract":"Trihalomethanes, the main drinking water disinfection byproducts, may be carcinogenic and are regulated to amaximum total trihalomethanes (TTHM) of 80 µg/l in the US. We aimed to determine whether total and individual trihalomethanes in drinking water across the US are associated with higher cancer mortality in 6,260 adult participants to the National Health and Nutrition Examination Surveys from 1999 to 2008 followed for mortality until 2019 (median: 14.4 years). At baseline, the geometric mean (standard error) of TTHM in drinking water was 9.61 (0.85) µg/l. During follow-up, 873 deaths occurred, including 207 from cancer. In Cox proportional hazards regression adjusted for relevant covariates, drinking water TTHM (HR: 1.45, 95% CI: 1.16-1.82), chloroform (HR: 1.35, 95% CI: 1.12-1.64), and bromodichloromethane (HR: 1.30, 95% CI: 1.05-1.59) were associated with 30% to 45% higher cancer mortality. Therefore, drinking water trihalomethanes, especially chloroform and bromodichloromethane maybe risk factors for cancer mortality.","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142207183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acrylamide exposure, sex hormones, and pubertal status in Japanese adolescents. 日本青少年接触丙烯酰胺的情况、性激素和青春期状况。
IF 3.2 4区 医学
International Journal of Environmental Health Research Pub Date : 2024-09-10 DOI: 10.1080/09603123.2024.2401578
Chisato Nagata,Keiko Wada,Michiyo Yamakawa,Masaaki Sugino,Tomoka Mori,Jun Ueyama,Yoshio Sumoto
{"title":"Acrylamide exposure, sex hormones, and pubertal status in Japanese adolescents.","authors":"Chisato Nagata,Keiko Wada,Michiyo Yamakawa,Masaaki Sugino,Tomoka Mori,Jun Ueyama,Yoshio Sumoto","doi":"10.1080/09603123.2024.2401578","DOIUrl":"https://doi.org/10.1080/09603123.2024.2401578","url":null,"abstract":"Acrylamide may affect sex hormone levels and the timing of sexual maturation. The present study cross-sectionally examined interrelationship between the urinary metabolite of acrylamide exposure, serum sex hormone levels, and pubertal status in 408 Japanese adolescents aged 13-14 years. Their caregivers completed a questionnaire concerning the health status of their children, including pubertal maturation, and the lifestyles of children and parents. Pubertal status was queried by the Pubertal Development Scale. A major metabolite of acrylamide, N-acetyl-S-(2-carbamoylethyl)-cysteine (AAMA) in first-void urine samples. In male students, urinary AAMA was significantly inversely associated with testosterone, puberty stage, and facial hair growth after controlling for covariates. Serum testosterone and DHEAS were significantly positively associated with puberty stage. In female students, urinary AAMA was not associated with puberty stage, the indices, or any measured hormones. The data suggest that exposure to acrylamide may impact the pubertal development of boys through the effects on testosterone level.","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142207182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dose assessment from exposure to uranium and radon in groundwater in Safi province, Morocco. 摩洛哥萨菲省地下水铀和氡暴露剂量评估。
IF 3.2 4区 医学
International Journal of Environmental Health Research Pub Date : 2024-09-09 DOI: 10.1080/09603123.2024.2400274
Bouchra Samyh,Abdellatif Nachab,Meryame Jabbade,Abdel-Mjid Nourreddine
{"title":"Dose assessment from exposure to uranium and radon in groundwater in Safi province, Morocco.","authors":"Bouchra Samyh,Abdellatif Nachab,Meryame Jabbade,Abdel-Mjid Nourreddine","doi":"10.1080/09603123.2024.2400274","DOIUrl":"https://doi.org/10.1080/09603123.2024.2400274","url":null,"abstract":"In this study we evaluate the uranium and radon concentrations in groundwater from the Province of Safi. The samples were collected from 58 wells across five communes and analyzed using the LR-115 type II detector. Results indicate that uranium concentrations ranged from the Limit of Detection (LLD) to 3.73 µg/l, with a mean of 0.72 µg/l, well below the World Health Organization's safe limit of 30 µg/l. Radon levels varied from LLD to 2.39 Bq/l, with an average of 0.60 Bq/l, also below the United States Environmental Protection Agency's limit of 11 Bq/l. The estimated total annual effective dose due to uranium and radon ranged from 3.47 to 18.84 µSv/y, with an average of 7.54 µSv/y, which is significantly lower than the European Commission's recommended limit of 100 µSv/y. This investigation represents the first study of uranium and radon levels in groundwater in the Province of Safi, providing valuable data for future research and public health.","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":null,"pages":null},"PeriodicalIF":3.2,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142207185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Family cleaning behaviors and air treatment equipment significantly affect associations of indoor damp indicators with childhood pneumonia among preschoolers. 家庭清洁行为和空气处理设备对学龄前儿童室内潮湿指标与儿童肺炎的相关性有显著影响。
IF 2.2 4区 医学
International Journal of Environmental Health Research Pub Date : 2024-09-05 DOI: 10.1080/09603123.2024.2398092
Wei Liu, Jing Chang, Nan Zhang, Wangjin Lai, Wenjie Li, Wenming Shi, Jian Wang, Jianhua Wei, Jiao Cai
{"title":"Family cleaning behaviors and air treatment equipment significantly affect associations of indoor damp indicators with childhood pneumonia among preschoolers.","authors":"Wei Liu, Jing Chang, Nan Zhang, Wangjin Lai, Wenjie Li, Wenming Shi, Jian Wang, Jianhua Wei, Jiao Cai","doi":"10.1080/09603123.2024.2398092","DOIUrl":"https://doi.org/10.1080/09603123.2024.2398092","url":null,"abstract":"<p><p>In this study, based on a cross-sectional study among 9597 preschoolers in Shandong of China, we quantitatively evaluated influences of lifestyle behaviors and air treatment equipment on indoor damp exposures and thus on risks of childhood pneumonia. In the two-level multivariate logistic regression analyses, childhood pneumonia was significantly associated with parent-reported damp clothing/bedding and visible mold spots or damp stains. These associations were weaker among preschoolers from families who frequently opened the child's bedroom windows, frequently cleaned the child's bedroom, and frequently exposed beddings to sunshine (references: not frequently), as well as among preschoolers without usage of air humidifier and air conditioner and with usage of air purifier. Our results indicate that frequently keeping household ventilation and cleanness, and exposing beddings to sunshine, as well using air purifier could decrease the effects of household damp-related exposures on childhood pneumonia, but using air humidifier and air conditioner could increase the effects.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histone deacetylase inhibitory properties of metabolites from leaves of Quercus pontica K. Koch and its metabolites. Quercus pontica K. Koch叶片及其代谢物的组蛋白去乙酰化酶抑制特性。
IF 2.2 4区 医学
International Journal of Environmental Health Research Pub Date : 2024-09-05 DOI: 10.1080/09603123.2024.2399210
Gülin Renda, Sezer Sevgi, Michal Šoral, Gamze Bora-Akoğlu, Suat Sari, Özge Çetin, Pelin Zobaroğlu-Özer, Didem Şöhretoğlu
{"title":"Histone deacetylase inhibitory properties of metabolites from leaves of <i>Quercus pontica</i> K. Koch and its metabolites.","authors":"Gülin Renda, Sezer Sevgi, Michal Šoral, Gamze Bora-Akoğlu, Suat Sari, Özge Çetin, Pelin Zobaroğlu-Özer, Didem Şöhretoğlu","doi":"10.1080/09603123.2024.2399210","DOIUrl":"https://doi.org/10.1080/09603123.2024.2399210","url":null,"abstract":"<p><p>The infusions prepared from some <i>Quercus</i> L. species are used in folk medicine for medicinal purposes and consumed as tea. <i>Quercus pontica</i> K. Koch was selected in this study, for which no phytochemical isolation studies have been performed so far. Quercetin 3-<i>O</i>- β-D-glucopyranoside, kaempferol 3-<i>O</i>-(6\"\"-<i>O</i>-galloyl)-β-D-glucopyranoside, kaempferol 3-<i>O</i>-β-D-glucopyranoside, kaempferol 3-<i>O</i>-(6\"'-coumaroyl-β-D-glucopyranoside, phlorizin, rosmarinic acid, and catechin were isolated from the titled plant for the first time. Some polyphenolic compounds have been shown to inhibit histone deacetylase (HDAC) enzymes. However, there is no study on the any activities of <i>Quercus</i> species in the literature. In this study, we demonstrated that the extract has <i>in vitro</i> pan-HDAC inhibition activity. Through a virtual screening study, the compounds were found to inhibit HDAC7 more strongly than the other HDAC isoforms; therefore, the HDAC7 inhibition activities were studied <i>in vitro</i>. Kaempferol 3-<i>O-β</i>-D-glucopyranoside and kaempferol 3-<i>O</i>-(6'\"-coumaroyl-<i>β</i>-D-glucopyranoside) showed the best anti-HDAC7 activity with 37% and 41% inhibition at 500 μM.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":null,"pages":null},"PeriodicalIF":2.2,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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