Fractional exhaled nitric oxide (FeNO) in Chinese children and its association with respiratory symptoms and home environment.

IF 2.2 4区医学 Q3 ENVIRONMENTAL SCIENCES

International Journal of Environmental Health Research Pub Date : 2025-05-15 DOI:10.1080/09603123.2025.2506137

Yuexia Sun, Justice Mlambo, Yuxuan Zhao, Dan Norbӓck, Samali Ayoma Marasinghe, Jing Hou, Pan Wang, Qingnan Zhang, Jan Sundell

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引用次数: 0

Abstract

The association between home environments and fractional exhaled nitric oxide (FeNO) has been insufficiently investigated. We measured FeNO levels in children aged 4-8 years (N = 105) in Tianjin, China, and examined their association with respiratory symptoms and various indoor environmental parameters, namely house dust mite allergens and phthalates in dust, dampness, environmental tobacco smoke (ETS) and furry pets (dogs/cats) in the home. FeNO levels were significantly higher in children with diagnosed asthma (p < 0.001) and pneumonia (p = 0.03). Exposure to Diisononyl phthalate (DiNP) - a new phthalate replacing the commonly used Di(2-ethylhexyl) phthalate (DEHP) - was significantly associated with increased FeNO in children (p = 0.01). In conclusion, diagnosed asthma and pneumonia were associated with increased FeNO levels in children. Exposure to DiNP may contribute to airway inflammation, as indicated by its association with increased FeNO levels. These findings underscore the importance of closely monitoring emerging contaminants to better understand their potential impacts on respiratory health.

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中国儿童呼出一氧化氮分数（FeNO）及其与呼吸道症状和家庭环境的关系

家庭环境与分数呼出一氧化氮（FeNO）之间的关系尚未得到充分的研究。我们测量了中国天津4-8岁儿童（N = 105）的FeNO水平，并研究了其与呼吸道症状和各种室内环境参数（即灰尘、潮湿、环境烟草烟雾（ETS）和家中毛茸茸的宠物（狗/猫）中的尘螨过敏原和邻苯二甲酸盐）的关系。诊断为哮喘的儿童FeNO水平显著升高（p p = 0.03）。暴露于邻苯二甲酸二异壬酯（DiNP）——一种取代常用邻苯二甲酸二（2-乙基己基）酯（DEHP）的新型邻苯二甲酸酯——与儿童FeNO增加显著相关（p = 0.01）。总之，诊断为哮喘和肺炎的儿童与FeNO水平升高有关。暴露于DiNP可能导致气道炎症，这与FeNO水平升高有关。这些发现强调了密切监测新出现的污染物以更好地了解它们对呼吸健康的潜在影响的重要性。

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来源期刊

International Journal of Environmental Health Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.70

自引率

3.10%

发文量

134

审稿时长

>12 weeks

期刊介绍： International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.