Bio-monitoring of endocrine disrupting chemicals in human serum: insights from a study in Central India.

Abstract

In recent years, the health impacts of phthalates and bisphenol-A (BPA) have garnered significant research attention due to their widespread use in consumer products and identification as endocrine disrupting chemicals (EDCs). Human exposure occurs through various pathways, including dietary intake, inhalation of dust, and dermal contact. This study initially aimed to analyze serum samples from 200 participants in Jabalpur city (Central India); however, samples from 173 individuals were ultimately analyzed to assess the occurrence, concentration patterns, and gender-related differences of six phthalates and BPA. Serum samples were collected, processed, and analyzed for EDC content using gas chromatography coupled with mass spectrometry. The findings highlighted differences in detection frequencies among genders and residential areas, shaped by environmental exposure variability, lifestyle variations, and gender-specific metabolic disparities. All the targeted analytes were detected with diethyl phthalate (DEP) having the highest mean concentration of 13.74 ± 6.2 ng/ml, followed by di(2-ethylhexyl) phthalate (DEHP) with mean value of 13.69 ± 99.82 ng/ml in human serum. Studies have linked DEP exposure endocrine disruption and reproductive abnormalities. Subsequent research endeavors should prioritize elucidating EDC sources, pathways, and health impacts, facilitating evidence-based policies to mitigate risks and ensure a healthier future.