International journal of medicinal mushrooms最新文献

{"title":"“Hypsizygus marmoreus (Agaricomycetes) – the Beech Mushroom Cultivation and His Outstanding Health-Promoting Properties: A Review”","authors":"Katarzyna Kała, Jan Lazur, Joanna Karnafał, Wojciech Pająk, Katarzyna Sułkowska-Ziaja, Bozena Muszynska","doi":"10.1615/intjmedmushrooms.2023052257","DOIUrl":"https://doi.org/10.1615/intjmedmushrooms.2023052257","url":null,"abstract":"Currently, in many Asian and European countries, a group of mushrooms has been distinguished, which, due to their medicinal and/or dietary properties, are referred to as medicinal mushrooms. Hypsizygus marmoreus (Peck) is a species of the family Lyophyllaceae and phylum Basidiomycota known as shimeji and Bunapi shimeji referring to two different varieties of H. marmoreus, the first being the brown variety, and the second the white variety. H. marmoreus is a species valued for its proven nutritional and healing properties. In the scientific literature available so far, mainly from Asian countries, it is possible to find research on the therapeutic effect of H. marmoreus. Biologically active substances, their presence, and in particular, their level in this species have not been the subject of extensive research. The aim of the present review is to describe and summarize the dietary and therapeutic potential of this increasingly popular species among consumers in European countries. Because H. marmoreus is a species with known dietary and health-promoting properties, this species of wood fungi could be commonly obtained from cultivation in European countries.","PeriodicalId":14025,"journal":{"name":"International journal of medicinal mushrooms","volume":"11 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139071686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical compounds, bioactivities, and potential applications of the genus Suillus: a review","authors":"Jinxiu Zhang, Hanyu Zhao, Lan Yao, Jian Zhao, Moxin Zhang, Li-An Wang, Jianhua Lv","doi":"10.1615/intjmedmushrooms.2023051919","DOIUrl":"https://doi.org/10.1615/intjmedmushrooms.2023051919","url":null,"abstract":"The genus Suillus, also known as “Song mo,” falls under the order Boletales and consists of various higher fungi. It establishes mycorrhizae primarily with pine trees and has a good taste and medicinal values. Herein, we reviewed the chemical compounds present in the genus Suillus, including polysaccharides, steroids, phenols, polyprenyl phenol derivatives, fatty acids, organic acids, and amino acids, and their reported bioactivities and potential applications. This review aims to promote the utilization of the resources belonging to the genus Suillus and serves as a theoretical basis for their future studies and clinical applications.","PeriodicalId":14025,"journal":{"name":"International journal of medicinal mushrooms","volume":"51 2","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138519196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Different Carbon Sources on Antioxidant Properties of Exopolysaccharides Produced by Scleroderma areolatum (Agaricomycetes)","authors":"Gaolei Xi, Changtong Lu, Yihong Wu, Zhifei Chen, Kejing Xu, Xuewei Jia, Zhiwei Zhao, Chun-Ping Xu, Qiuling Wang","doi":"10.1615/intjmedmushrooms.2023052044","DOIUrl":"https://doi.org/10.1615/intjmedmushrooms.2023052044","url":null,"abstract":"Five kinds of exopolysaccharides (EPS) were obtained by fermentation of Scleroderma areolatum Ehrenb. with sucrose, glucose, maltose, lactose, and fructose as carbon sources. Antioxidant abilities of the obtained EPSs were evaluated by inhibiting AAPH, HO·, and glutathione (GS·) induced oxidation of DNA and quenching 2,2’-azinobis (3-ethylbenzothiazoline-6-sulfonate) cationic radical (ABTS·) and galvinoxyl radicals. The effects of carbon sources on the antioxidant properties of EPSs could be examined. The results showed that five EPSs can effectively inhibit radicals induced oxidation of DNA, and the thiobarbituric acid reactive substances (TBARS) percentages were 44.7%-80.8%, 52.3%-77.5%, and 44.7%-73.3% in inhibiting AAPH, HO·, and GS· induced oxidation of DNA, respectively. All five EPSs could scavenge ABTS·and Galvinoxyl·, and exhibit superior activity in scavenging free radicals. Antioxidant abilities of EPS with fructose as carbon source were highest among five EPS.","PeriodicalId":14025,"journal":{"name":"International journal of medicinal mushrooms","volume":"151 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138741369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Purification and Biochemical Characterization of novel galectin from black poplar mushroom Cyclocybe cylindracea (Agaricomycetes) Strain MEST42 Grown in Algeria","authors":"TOUMI Mohammed Esseddik, KEBAILI Fethi Farouk, REBAI Redouane, DERARDJA Imene, TOUMI Mouaad, GAGLIO Salvatore Calogero, PERDUCA Massimiliano, NECIB Youcef","doi":"10.1615/intjmedmushrooms.2023051925","DOIUrl":"https://doi.org/10.1615/intjmedmushrooms.2023051925","url":null,"abstract":"In the present study, a new galectin designated Cyclocybe cylindracea lectin (CCL) was extracted from the fruiting bodies of the wild black popular mushroom C. cylindracea grown in Algeria. The protein was isolated using sepharose 4B as affinity chromatography matrix, and galactose as elutant. The purified galectin was composed of two subunits of 17.873 kDa each, with a total molecular mass of 35.6 kDa. Its agglutinant activity was impeded by galactose and its derivatives, as well as melibiose. Lactose showed the highest affinity, with a minimal inhibitory concentration of 0.0781 mM. CCL was sensitive to extreme pH conditions, and its binding function decreased when incubated with 10 mM EDTA, and it could be restored by metallic cations such as Ca2+, Mg2+, and Zn2+. CCL agglutinated human red blood cells, without any discernible specificity. Circular dichroism spectra demonstrated that its secondary structure contained β-sheet as dominant fold. In addition, bioinformatics investigation on their peptide fingerprint obtained after MALDI-TOF/TOF ionization using mascot software confirmed that CCL was not like any previous purified lectin from mushroom: instead, it possessed an amino acid composition with high similarity to that of the putative urea carboxylase of Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) with 44% of similarity score.","PeriodicalId":14025,"journal":{"name":"International journal of medicinal mushrooms","volume":"22 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138519195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ganoderic Acid A: A Potential Natural Neuroprotective Agent for Neurological Disorders: A Review","authors":"Feifei Ma, Jing Wang, Wenming Jiang, Jiahao Luo, Rui Yang, Liying Zhang, chunchao han","doi":"10.1615/intjmedmushrooms.2023051918","DOIUrl":"https://doi.org/10.1615/intjmedmushrooms.2023051918","url":null,"abstract":"Ganoderic acid A (GAA) is one of the major triterpenoids in Ganoderma lucidum (GL). Accumulating evidence has indicated that GAA demonstrates multiple pharmacological effects and exhibits treatment potential for various neurological disorders. Here, the effects and mechanisms of GAA in the treatment of neurological disorders were evaluated and discussed through previous research results. By summarizing previous research results, we found that GAA may play a neuroprotective role through various mechanisms: anti-inflammatory, anti-oxidative stress, anti-apoptosis, protection of nerve cells, and regulation of nerve growth factor. Therefore, GAA is a promising natural neuroprotective agent and this review would contribute to the future development of GAA as a novel clinical candidate drug for treating neurological diseases.","PeriodicalId":14025,"journal":{"name":"International journal of medicinal mushrooms","volume":"15 10","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138519209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Submerged Culture of Edible and Medicinal Mushroom Mycelia and Their Applications in Food Products: A Review","authors":"Yuan Zou, Wanting Xv, Qianwang Zheng, Zhiwei Ye, Tao Wei, Liqiong Guo, Junfang Lin","doi":"10.1615/intjmedmushrooms.2023052039","DOIUrl":"https://doi.org/10.1615/intjmedmushrooms.2023052039","url":null,"abstract":"Edible mushrooms have rich nutrition (e.g., proteins, dietary fibers, polysaccharides) and they can be potential sources of important ingredients in food processing. However, the cultivation of mushroom fruiting bodies needs a relatively long time period and they can be easily polluted during the growth process. At the same time, a lot of labor and larger planting area are also required. As we all known, submerged fermentation is a good way to produce edible mushroom mycelia with less environmental pollution and small footprint, which are also rich in nutrition and bioactive components that are used as dietary supplements or health care products in food industry. Therefore, it can be considered that the replacement of edible mushroom fruiting bodies with edible mushroom mycelia produced through submerged fermentation have great application potential in food production. At present, most of the researches about edible mushroom mycelia focus on the production of bioactive metabolites in fermentation liquid, but there are few reports concentrate on their applications in food. This paper reviews the research progress of submerged culture of edible mushroom mycelia and their applications in food products for attracting more attention of human beings.","PeriodicalId":14025,"journal":{"name":"International journal of medicinal mushrooms","volume":"33 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138632162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANTIMICROBIAL ACTIVITY OF THREE ITALIAN STRAINS OF MORCHELLA ESCULENTA (ASCOMYCOTA, PEZIZALES)","authors":"Susanna Badalyan, Susanna Badalyan, Narine Gharibyan, Alessandra Zambonelli","doi":"10.1615/intjmedmushrooms.2023051956","DOIUrl":"https://doi.org/10.1615/intjmedmushrooms.2023051956","url":null,"abstract":"Three genetically identified and morphologically characterized strains (MesAQ2-C, MesAQ6–2 and MesFI2-3) of the culinary-medicinal ascomycete mushroom Morchella esculenta (L.) Pers. collected in central-north Italy have been studied for their antifungal and antibacterial activities. The obtained data showed that mycelium of M. esculenta possess variable antimicrobial activity against four test fungi (Chrysosporium keratinophilum, Microsporum gypseum, Trichophyton terrestre, Penicillium griseofulvum), as well as one Gram positive (Staphylococcus aureus) and three Gram negative (Escherichia coli, Salmonella typhimurium, Pseudomonas aeruginosa) test bacteria potentially pathogenic for humans and animals. Up to 20.4% of inhibition of the average mycelial growth rate (GRavr) of test fungi in dual culture experiment was detected. The samples of cultural liquid (CL) and mycelial extract (ME) obtained by static cultivation of M. esculenta strains showed up to 13.9 and 23.0% of GRavr inhibition of test fungi, respectively. Similarly, the inhibition of the bacterial colonies by CL and ME samples was 34.1 and 32.3%, respectively in comparison with the control with streptomycin indicating almost equal secretion of both intra- and extracellular antimicrobial compounds by M. esculenta mycelium. As a producer of antimicrobial compounds among tested M. esculenta strains, MesAQ2-C was the most effective. It may be considered for further myco-pharmacological research to develop mushroom-based antimicrobial biotech products with biomedical significance.","PeriodicalId":14025,"journal":{"name":"International journal of medicinal mushrooms","volume":"6 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138558311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicinal Potential of the Insoluble Extracted Fibers Isolated from the Fomes fomentarius (Agaricomycetes) Fruiting Bodies: A Review.","authors":"Liudmila Kalitukha,&nbsp;Alvaro Galiano,&nbsp;Francisco Harrison","doi":"10.1615/IntJMedMushrooms.2022047222","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2022047222","url":null,"abstract":"<p><p>The tough, hoof-shaped fruiting bodies of the tinder conk mushroom, Fomes fomentarius (L.) Fr. (Polyporaceae, Agaricomycetes), were traditionally used all over the world as tinder to start fire, for ritual purposes, to make artworks like clothing, frames, ornaments, and also to cure various human diseases (wounds, gastro-intestinal disorders, liver-related problems, inflammations, various cancers, etc.). The first wave of scientific interest in F. fomentarius in Europe dates back to the early 1970s with the discovery of the red-brown pigments of the F. fomentarius external layer. Since then, a number of research papers and reviews have mentioned the history of use, taxonomy, composition and medicinal properties of some F. fomentarius preparations, e.g., soluble extracts and their fractions, isolated cell walls, mycelia and compounds purified from the culture broth. The present review is focused on the composition and benefits of the water-insoluble cell walls obtained from the F. fomentarius fruiting bodies. Isolated cell walls of the tinder mushroom reveal a fibrous hollow structure with an average diameter of 3-5 μm and a wall thickness of 0.2-1.5 μm. Naturally, the fibers are composed of 25-38% glucans, with a majority of β-glucans, around 30% polyphenols, 6% chitin and less than 2% hemicellulose. The percentage of the main structural compounds can vary either slightly or considerably, depending on the extraction conditions. According to in vitro, in vivo, ex vivo as well as clinical studies, F. fomentarius fibers can modulate the immune system, contribute to intestinal health, accelerate wound healing, absorb heavy metals, organic dyes and radionuclides, normalize kidney and liver function, and provide antibacterial, antiviral, antifungal, anxiolytic, anti-inflammatory and analgesic effects. Multiple action of the insoluble cell walls purified from the F. fomentarius fruiting bodies is particularly effective in the treatment of chronic, recurring, complicated multifactorial diseases. It is certainly worth exploring the medicinal potential and the practical application of these preparations further.</p>","PeriodicalId":14025,"journal":{"name":"International journal of medicinal mushrooms","volume":"25 3","pages":"21-35"},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9257108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical Components Analyzed by UPLC-QTOF-MS and In Vitro Antitumor Effects of the Chestnut Mushroom Pholiota adiposa (Agaricomycetes).","authors":"Xiaoyan Wang,&nbsp;Yan Liu,&nbsp;Fanli Kong,&nbsp;Gang Li","doi":"10.1615/IntJMedMushrooms.2023047786","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2023047786","url":null,"abstract":"<p><p>We investigated the chemical constituents and anti-tumor activity of cultivated Pholiota adiposa in vitro using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry. HepG-2, A549, HeLa, and MCF-7 cells, which are 4 kinds of human cancer cell lines, were cultured in vitro, treated with different concentrations of the ethanol extract of Ph. adiposa (EPA), and cytotoxicity was determined using the cell counting kit-8 assay. Flow cytometry was used to analyze the apoptosis of HepG-2 cells via annexin V-fluorescein isothiocyanate/propidium iodide double staining. Expression levels of apoptosis-associated proteins were determined via Western blotting analysis. Thirty-five components were consistent with those recorded in the chemical composition database, with sterols, fatty acids, and polysaccharide compounds accounting for a relatively high proportion. EPA showed the strongest cytotoxicity against HepG-2 cells, increasing the apoptosis rate up to 23.71 ± 1.59% at a concentration of 50 μg/mL. Ph. adiposa has various functional chemical constituents and potential anti-tumor applications. We found that the functional constituents exerted anti-tumor activity by inducing apoptosis. Furthermore, the expression levels of BCL-2-associated X were increased, whereas those of BCL-2 were decreased in cells after treatment with EPA. These results suggest that EPA induces HepG-2 cell apoptosis via a caspase-mediated pathway.</p>","PeriodicalId":14025,"journal":{"name":"International journal of medicinal mushrooms","volume":"25 4","pages":"43-53"},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9421628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical Constituents from Mycelia of Lepista sordida (Agaricomycetes) and Their ABTS Radical Scavenging Activity.","authors":"Wenting Hu,&nbsp;Yongchuan Li,&nbsp;Yudie He,&nbsp;Qingfeng Meng,&nbsp;Jianhua Ju,&nbsp;Shaobin Fu","doi":"10.1615/IntJMedMushrooms.2023048194","DOIUrl":"https://doi.org/10.1615/IntJMedMushrooms.2023048194","url":null,"abstract":"<p><p>Lepista sordida is an edible mushroom possessing high nutritional value and high medicinal value. The artificial cultivation technology of L. sordida made a breakthrough and has been popularized in Yunnan, Guizhou, Sichuan province with good economic benefits. The secondary metabolites were investigated from ethyl EtOAc (acetate extract) of solid cultures of L. sordida. Silica gel column chromatography, semi-preparation HPLC, recrystallization, and medium pressure column chromatography were applied to obtain 15 compounds. Nine compounds were first isolated from genus Lepista and 11 compounds were first isolated from species L. sordida. Moreover, compounds 13 and 14 exhibited strong scavenging activity of ABTS.</p>","PeriodicalId":14025,"journal":{"name":"International journal of medicinal mushrooms","volume":"25 6","pages":"31-39"},"PeriodicalIF":1.2,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9901983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}