灵芝酸A:一种治疗神经系统疾病的潜在天然神经保护剂

IF 1.4 4区生物学 Q4 MYCOLOGY

International journal of medicinal mushrooms Pub Date : 2023-12-01 DOI:10.1615/intjmedmushrooms.2023051918

Feifei Ma, Jing Wang, Wenming Jiang, Jiahao Luo, Rui Yang, Liying Zhang, chunchao han

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引用次数: 0

摘要

灵芝酸A (GAA)是灵芝中主要的三萜类化合物之一。越来越多的证据表明，GAA具有多种药理作用，并具有治疗各种神经系统疾病的潜力。本文结合前人的研究成果，对GAA治疗神经系统疾病的作用和机制进行评价和探讨。综合以往研究结果，我们发现GAA可能通过抗炎、抗氧化应激、抗凋亡、保护神经细胞、调节神经生长因子等多种机制发挥神经保护作用。因此，GAA是一种很有前景的天然神经保护剂，本文的综述将有助于GAA作为治疗神经系统疾病的新型临床候选药物的进一步开发。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Ganoderic Acid A: A Potential Natural Neuroprotective Agent for Neurological Disorders: A Review

Ganoderic acid A (GAA) is one of the major triterpenoids in Ganoderma lucidum (GL). Accumulating evidence has indicated that GAA demonstrates multiple pharmacological effects and exhibits treatment potential for various neurological disorders. Here, the effects and mechanisms of GAA in the treatment of neurological disorders were evaluated and discussed through previous research results. By summarizing previous research results, we found that GAA may play a neuroprotective role through various mechanisms: anti-inflammatory, anti-oxidative stress, anti-apoptosis, protection of nerve cells, and regulation of nerve growth factor. Therefore, GAA is a promising natural neuroprotective agent and this review would contribute to the future development of GAA as a novel clinical candidate drug for treating neurological diseases.

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来源期刊

International journal of medicinal mushrooms 医学-药学

CiteScore

2.60

自引率

16.70%

发文量

审稿时长

6-12 weeks

期刊介绍： The rapid growth of interest in medicinal mushrooms research is matched by the large number of disparate groups that currently publish in a wide range of publications. The International Journal of Medicinal Mushrooms is the one source of information that will draw together all aspects of this exciting and expanding field - a source that will keep you up to date with the latest issues and practice. The International Journal of Medicinal Mushrooms published original research articles and critical reviews on a broad range of subjects pertaining to medicinal mushrooms, including systematics, nomenclature, taxonomy, morphology, medicinal value, biotechnology, and much more.