International journal of medicinal mushrooms最新文献_第3页

Medicinal Potential of the Giant Puffball Mushroom Calvatia gigantea (Agaricomycetes): A Review 巨型袖珍蘑菇 Calvatia gigantea（姬松茸科）的药用潜力：综述

IF 1.2 4区生物学

International journal of medicinal mushrooms Pub Date : 2024-05-01 DOI: 10.1615/intjmedmushrooms.2024054161

Małgorzata Cicha-Jeleń, Bożena Muszyńska, Katarzyna Kała, Katarzyna Sułkowska-Ziaja

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Oral administration of Ganoderma lucidum extract protects gingival tissues against proinflammatory TNF and oxidative stress in periodontitis model rats 口服灵芝提取物可保护牙周炎模型大鼠的牙龈组织免受促炎性 TNF 和氧化应激的影响

IF 1.2 4区生物学

International journal of medicinal mushrooms Pub Date : 2024-05-01 DOI: 10.1615/intjmedmushrooms.2024053946

Shahdat Hossain, Mohammad Azizur Rahman, Borhan Uddin, Taslima Nahar, Marzan Sarker, Shoriful Islam Joy

{"title":"Oral administration of Ganoderma lucidum extract protects gingival tissues against proinflammatory TNF and oxidative stress in periodontitis model rats","authors":"Shahdat Hossain, Mohammad Azizur Rahman, Borhan Uddin, Taslima Nahar, Marzan Sarker, Shoriful Islam Joy","doi":"10.1615/intjmedmushrooms.2024053946","DOIUrl":"https://doi.org/10.1615/intjmedmushrooms.2024053946","url":null,"abstract":"Ganoderma lucidum is a medicinal mushroom that has been tempting since ancient times. We investigated whether chronic oral administration of G. lucidum extract withstands the increases in levels of proinflammatory TNF and lipid peroxide (LPO), an indicator of oxidative stress, in gingival tissue of periodontitis model rats. It was also investigated if G. lucidum extract inhibits oxidative stress induced by Fenton’s reagents in whole homogenates of fresh rat gigival tissues in vitro. Prior to in vivo and in vitro experiments with rats, G. lucidum extract was quantitatively tested for its total polyphenols and/or flavonoids content and ability to scavenge 2,2-diphenyl-1-picrylhydrazyl (DPPH)-free radicals. Chronic oral administration of G. lucidum extract (300 mg/kg BW, body weight) significantly reduced TNF and LPO levels in the gingival tissue of periodontitis model rats. G. lucidum extract also inhibited oxidative stress in vitro (P<0.05), as indicated by reduced LPO levels in gingival tissue whole homogenates preincubated with G. lucidum extract. The in vitro results were thus consistent with those in vivo inhibition of lipid peroxidation, DPPH free radical-scavenging effect and the presence of total polyphenols/flavonoids in G. lucidum extract. Our results provide, at least partial evidence for the beneficial effect of G. lucidum on periodontitis, an inflammatory disease of the gums associated with oxidative stress and preceding infectious gum disease.","PeriodicalId":14025,"journal":{"name":"International journal of medicinal mushrooms","volume":"157 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140932605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The Analysis of Chemical and Medicinal Properties of Armillaria Ostoyae (Agaricomycetes) Extracts and the Presence of Heavy Metals in Dry Basidiocarps 姬松茸提取物的化学和药用特性及干基木中重金属含量的分析

IF 1.2 4区生物学

International journal of medicinal mushrooms Pub Date : 2024-05-01 DOI: 10.1615/intjmedmushrooms.2024054187

Nevena Petrovic, Tomislav Tosti, Ivana Srbljak, Ana Đurić, Zoran Simić, Marijana Kosanic

{"title":"The Analysis of Chemical and Medicinal Properties of Armillaria Ostoyae (Agaricomycetes) Extracts and the Presence of Heavy Metals in Dry Basidiocarps","authors":"Nevena Petrovic, Tomislav Tosti, Ivana Srbljak, Ana Đurić, Zoran Simić, Marijana Kosanic","doi":"10.1615/intjmedmushrooms.2024054187","DOIUrl":"https://doi.org/10.1615/intjmedmushrooms.2024054187","url":null,"abstract":"In this manuscript, we investigated the chemical and medicinal properties of methanolic and acetonic extracts of Armillaria ostoyae and the presence of heavy metals in its dry basidiocarps. The chemical content of extracts was analyzed with the HPLC-DAD-MS/MS method. According to our results, the most abundant mineral was potassium; the most abundant organic acid was malic acid; the most abundant carbohydrate was fructose, and the most abundant polyphenol was chlorogenic acid. The antimicrobial potential was evaluated using the microdilution assay, and the results ranged from 0.62 to 20 mg/mL. Antioxidant potential was studied by DPPH (IC50 of the methanolic extract was 619.67 μg/mL and of the acetonic extract was 533.65 μg/mL) and reducing power assays (the results ranged 0.025-0.078 μg/mL). Total phenolic content was presented as gallic acid equivalent (methanolic extract - 6.12 mg GAE/g; acetonic extract – 3.99 mg GAE/g). The antidiabetic potential was explored by applying the α-amylase (the results ranged from 39.62 to 44.33%) and α-glucosidase assays (the results were in the range of 0.27–2.51%). The neuroprotective activity was asserted by the acetylcholinesterase inhibition assay (the results were in the range of 3.06-6.09%). The cytotoxic potential was investigated using the microtetrazolium assay, and the IC50 values ranged from 221.96 to > 400 μg/mL. Heavy metal content of the dry basidiocarps was evaluated using the AAS method and iron was the most abundant metal. Armillaria ostoyae is a conditionally edible mushroom, which was not studied thoroughly before, thus this research will provide valuable knowledge about this species.","PeriodicalId":14025,"journal":{"name":"International journal of medicinal mushrooms","volume":"10 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141147757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Enhancing Cordycepin in Functional Porridge through Rice Varietal Fermentation with Cordyceps militaris (Ascomycetes) and Utilizing Non-Targeted Metabolomics for Process Enhancement 通过冬虫夏草（子囊菌）与水稻品种发酵及利用非靶向代谢组学改进工艺，提高功能粥中的虫草素含量

IF 1.2 4区生物学

International journal of medicinal mushrooms Pub Date : 2024-05-01 DOI: 10.1615/intjmedmushrooms.2024054150

Min-Ling Liu, Tsu-Yi Chien, Hui-Chen Lo, Tai-Hao Hsu, Shih-Chieh Lee, Shih-Ching Chao

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In vitro assessment of 4-acetyl-antrquinonol B and erinacine A in suppressing breast cancer-induced osteoclastogenesis 4-acetyl-antrquinonol B 和麦角新碱 A 在抑制乳腺癌诱导的破骨细胞生成方面的体外评估

IF 1.2 4区生物学

International journal of medicinal mushrooms Pub Date : 2024-05-01 DOI: 10.1615/intjmedmushrooms.2024053977

Yi-Ming Huang, You-Sheng Fu, Woan-Ling Chen, Hsi-Chi Lu

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The Artist's Conk Medicinal Mushroom Ganoderma applanatum (Agaricomycetes): A Mycological, Mycochemical, and Pharmacological Values: A Review 艺术家的海螺药用蘑菇灵芝（姬松茸）：真菌学、真菌化学和药理学价值：综述

IF 1.2 4区生物学

International journal of medicinal mushrooms Pub Date : 2024-05-01 DOI: 10.1615/intjmedmushrooms.2024053900

Mengtao Cheng, Liying Zhang, Jing Wang, Xiaomei Sun, Yitong Qi, Lijing Chen, chunchao han

{"title":"The Artist's Conk Medicinal Mushroom Ganoderma applanatum (Agaricomycetes): A Mycological, Mycochemical, and Pharmacological Values: A Review","authors":"Mengtao Cheng, Liying Zhang, Jing Wang, Xiaomei Sun, Yitong Qi, Lijing Chen, chunchao han","doi":"10.1615/intjmedmushrooms.2024053900","DOIUrl":"https://doi.org/10.1615/intjmedmushrooms.2024053900","url":null,"abstract":"As a commonly used Chinese herbal medicine, Ganoderma applanatum (Pers.) Pat., also known as flatling Ganoderma (Chinese name Bianlingzhi), old mother fungus (Laomujun) and old ox liver (Laoniugan), has high medicinal value. It is used as an anti-cancer drug in China and Japan. Besides, it can treat rheumatic tuberculosis and has the effect of relieving pain, clearing away heat, eliminating accumulation, stopping bleeding and eliminating phlegm. The purpose of this review is to systematically and comprehensively analyze the research progress in mycology, mycochemistry and pharmacological activities of G. applanatum, and discuss the prospect of prospective research and implementation of this medicinal material. A comprehensive literature search was performed on G. applanatum using scientific databases including Web of Science, PubMed, Google Scholar, CNKI, Elsevier. Collected data from different sources was comprehensively summarized for mycology, mycochemistry and pharmacology of G. applanatum. A total of 324 compounds were recorded, the main components of which were triterpenoids, meroterpenoids, steroids, and polysaccharides. G. applanatum and its active ingredients have a variety of pharmacological effects, including anti-tumor, liver protection, hypoglycemic, anti-fat, anti-oxidation, antibacterial and other activities. Although G. applanatum is widely used in traditional medicine and has diverse chemical constituents, more studies should be carried out in animals and humans to evaluate the cellular and molecular mechanisms involved in its biological activity.","PeriodicalId":14025,"journal":{"name":"International journal of medicinal mushrooms","volume":"11 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140941883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Mushrooms and Their Compounds with Potential Anticancer Activity: A Review 具有潜在抗癌活性的蘑菇及其化合物：综述

IF 1.2 4区生物学

International journal of medicinal mushrooms Pub Date : 2024-05-01 DOI: 10.1615/intjmedmushrooms.2024054163

Maura Téllez Téllez, Gerardo Díaz-Godínez

{"title":"Mushrooms and Their Compounds with Potential Anticancer Activity: A Review","authors":"Maura Téllez Téllez, Gerardo Díaz-Godínez","doi":"10.1615/intjmedmushrooms.2024054163","DOIUrl":"https://doi.org/10.1615/intjmedmushrooms.2024054163","url":null,"abstract":"Mushrooms produce many metabolites that show biological activity, which can be obtained from their fruiting body, mycelium or recovered from the culture broth when mushrooms are grown in submerged fermentation. Mushrooms are a source of natural pharmaceuticals, they have been reported to have potential inhibitory or preventive activity against some diseases, including different types of cancer. Cancer represents one of the main causes of death worldwide. It is worth mentioning that despite advances in pharmacological treatments, they still present side effects in patients. In this sense, the study of the use of mushrooms in complementary treatments against cancer is of great interest. Based on studies carried out in vitro and, in some cases, using animal models, it has been observed that mushrooms present preventive, corrective, and therapeutic properties against different types of cancer, by stimulating the immune system, due to their antioxidant, antimutagenic, and anti-inflammatory activities, as well as the regulation of the expression of some cellular processes, cell cycle arrest, and apoptosis, etc. Based on the above, this manuscript shows a review of scientific studies that support the anticancer activity of some mushrooms and/or their bioactive compounds.","PeriodicalId":14025,"journal":{"name":"International journal of medicinal mushrooms","volume":"35 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141147756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Size Matters: Influence of Particle Size on Antioxidant, β-Glucan and Anti-inflammatory Potential in Pleurotus floridanus 大小很重要：颗粒大小对花叶茄抗氧化、β-葡聚糖和抗炎潜力的影响

IF 1.2 4区生物学

International journal of medicinal mushrooms Pub Date : 2024-05-01 DOI: 10.1615/intjmedmushrooms.2024054164

Wei Yan Wong, Siti Marjiana Ismail, Chia Wei Phan, Yee Shin Tan

{"title":"Size Matters: Influence of Particle Size on Antioxidant, β-Glucan and Anti-inflammatory Potential in Pleurotus floridanus","authors":"Wei Yan Wong, Siti Marjiana Ismail, Chia Wei Phan, Yee Shin Tan","doi":"10.1615/intjmedmushrooms.2024054164","DOIUrl":"https://doi.org/10.1615/intjmedmushrooms.2024054164","url":null,"abstract":"Cellular damage resulting from elevated levels of free radicals can lead to persistent health issues. Pleurotus floridanus, an edible white oyster mushroom, is rich in β-glucans with potent antioxidant and anti-inflammatory properties. In this research, we examined the β-glucan content, total phenolic content, as well as antioxidant and anti-inflammatory potential of hot water extracts with varying particle sizes (<75 µm, 75-154 µm, 154-300 µm, and 300-600 µm) of both whole (WFB) and sliced (SFB) fruiting bodies of P. floridanus. The findings revealed that the β-glucan content increased as the particle size increased, though no significant differences were observed. Conversely, smaller particle sizes (<75 µm) of whole and sliced fruiting bodies of P. floridanus exhibited higher phenolic content, DPPH and ABTS scavenging activity and reducing ability compared to larger particle size (>75 µm). Out of the four samples (AW2, AW3, AS1, and AS2) with the highest antioxidant activity, selected for anti-inflammatory assays, all demonstrated the ability to reduce NO and TNF-α levels but did not enhance IL-10 expression in LPS-stimulated RAW264.7 cells. Interestingly, particle size < 75 to 300 µm did not appear to influence the anti-inflammatory activity, as no significant differences were observed among the particle sizes. Therefore, it is suggested that the particle size <300 µm of P. floridanus hot water extract could serve as a valuable source of antioxidant and anti-inflammatory compounds to counteract the harmful effects of free radicals.","PeriodicalId":14025,"journal":{"name":"International journal of medicinal mushrooms","volume":"26 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141147894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Evaluation of hepatoprotective effect of Trametes gibbosa on CCl4-induced liver injury in rats 评估西布曲霉对 CCl4 引起的大鼠肝损伤的保肝作用

IF 1.2 4区生物学

International journal of medicinal mushrooms Pub Date : 2024-05-01 DOI: 10.1615/intjmedmushrooms.2024053967

Amirhossein Sarkar, Omid Sabzevari, Seyed Esmaeil Sadat Ebrahimi, Sana Shahnazari, Reza Asadollahi Rad, Mahdi Vazirian

{"title":"Evaluation of hepatoprotective effect of Trametes gibbosa on CCl4-induced liver injury in rats","authors":"Amirhossein Sarkar, Omid Sabzevari, Seyed Esmaeil Sadat Ebrahimi, Sana Shahnazari, Reza Asadollahi Rad, Mahdi Vazirian","doi":"10.1615/intjmedmushrooms.2024053967","DOIUrl":"https://doi.org/10.1615/intjmedmushrooms.2024053967","url":null,"abstract":"Mushrooms have been used as medicine by humans for more than 5,000 years. Nowadays, some extracts and compounds obtained from medicinal mushrooms have increased a great prospect of treating many disorders by having a great role in modulation of immune system, cancer inhibiting, cardio-vascular health, antiviral, antibacterial, antioxidant and protective effects against hepatitis and diabetes.\u0000In this study, we evaluated the antioxidant effect of methanol and hot water extract of the Trametes gibbosa (Pers.) Fr. mushroom and hepatoprotective effect of the extract with the most radical scavenging potency. To assess the antioxidant properties of different extracts of the mushroom, DPPH method was used. For assessing the hepatoprotective properties, a seven-day experiment was designed and liver toxicity was induced by carbon tetrachloride (intraperitoneal/ip for seven consecutive days, 0.5 ml/kg BW). Rats were simultaneously fed with aqueous extract of the mushroom with the dose of 250, 500 and 1000 mg/kg BW and silymarin (100 mg/kg BW) as positive control. At the end of the experiment, major liver factors (e.g., AST, ALT, ALP, bilirubin) were quantified. Tissue samples were obtained for pathological examination.\u0000Aqueous extract showed more potent radical scavenging activity (IC50=414.33 µg/ml, compared to 936.92 µg/ml for methanolic extract). Indeed, hepatoprotective properties of the aqueous extract of the mushroom were comparable with those of silymarin and even showed superior protective effects in histopathological examination. It seems that with further complementary studies, T. gibbosa could be considered a potential candidate for hepatoprotection.","PeriodicalId":14025,"journal":{"name":"International journal of medicinal mushrooms","volume":"103 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140932444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Nanogel in Complete Freund’s Adjuvant-Induced Rheumatoid Arthritis (RA) Rat Model: Anti-Arthritic, Anti-Inflammatory, and Antioxidative Activity 灵芝或灵芝药用菌灵芝（姬松茸）纳米凝胶在完全弗氏佐剂诱导的类风湿性关节炎（RA）大鼠模型中的应用：抗关节炎、抗炎和抗氧化活性

IF 1.2 4区生物学

International journal of medicinal mushrooms Pub Date : 2024-05-01 DOI: 10.1615/intjmedmushrooms.2024053884

Nuniek Ina Ratnaningtyas, Fajar Husen, Nur Fitrianto

{"title":"Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Nanogel in Complete Freund’s Adjuvant-Induced Rheumatoid Arthritis (RA) Rat Model: Anti-Arthritic, Anti-Inflammatory, and Antioxidative Activity","authors":"Nuniek Ina Ratnaningtyas, Fajar Husen, Nur Fitrianto","doi":"10.1615/intjmedmushrooms.2024053884","DOIUrl":"https://doi.org/10.1615/intjmedmushrooms.2024053884","url":null,"abstract":"Lingzhi or reishi mushroom, Ganoderma lucidum, is a medicinal mushroom quite widely developed as herbal medicine because it has acted as an anticancer, antitumor, antioxidant, and anti-inflammatory. The active mycochemical compounds of G. lucidum mushrooms, such as flavonoids and polysaccharides, can suppress the release of pro-inflammatory cytokines and prevent lipid peroxidation due to oxidative stress. Rheumatoid arthritis (RA) is an autoimmune disease where the exact cause is unknown, and RA prevalence continues to increase yearly. In patients with RA, joint damage and inflammation occur. This study aims to evaluate the effectiveness of G. lucidum nanogels as anti-arthritis, anti-inflammatory, and antioxidative. The research method was a true experiment using a control group and treatment group that randomly assigned, using 24 male Wistar rats (Rattus norvegicus) induced with complete Freund's adjuvant (CFA) 0.1 mL. The rats were divided into six groups; healthy control/HCt (did not receive the treatment), negative control/NCt (induced by CFA), and positive control/PCt (given 0.012 diclofenac sodium). TG1 (given 250 mg G. lucidum nanogels), TG2 (given 500 mg G. lucidum nanogels), TG3 (given 750 mg G. lucidum nanogels). IgG, eNOS, IL-1β, COX-2, NOS, TNF-α, and IL-6 parameters were measured using ELISA, and the data obtained were analyzed by one-way ANOVA using SPSS (p < 0.05). The results showed that administering G. lucidum nanogels significantly reduced IgG, NOS, TNF-α, COX-2, IL-1β, and IL-6 and increased eNOS levels. The anti-inflammatory and antioxidative activities in suppressing pro-inflammatory cytokines and increasing eNOS levels prove that the nanogel ext","PeriodicalId":14025,"journal":{"name":"International journal of medicinal mushrooms","volume":"25 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140830217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0