4-acetyl-antrquinonol B 和麦角新碱 A 在抑制乳腺癌诱导的破骨细胞生成方面的体外评估

IF 1.4 4区生物学 Q4 MYCOLOGY

International journal of medicinal mushrooms Pub Date : 2024-05-01 DOI:10.1615/intjmedmushrooms.2024053977

Yi-Ming Huang, You-Sheng Fu, Woan-Ling Chen, Hsi-Chi Lu

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引用次数: 0

摘要

由于破骨细胞的活性，转移性乳腺癌的骨转移通常会导致溶骨性病变，从而促进骨质破坏和肿瘤进展。然而，它们对乳腺癌骨转移治疗的影响仍不清楚。我们的研究旨在探讨 4-AAQB 或 Erinacine A 对乳腺癌骨转移的影响。研究评估了 4-AAQB 和 Erinacine A 对乳腺癌诱导的破骨细胞生成、乳腺癌迁移、转移细胞因子（TGF-β）和标志物（MMP-9）的产生以及潜在的 MAPK 信号转导的影响。结果发现，4-AAQB和Erinacine A能有效抑制乳腺癌诱导的破骨细胞生成和迁移，并通过Erk或JNK信号转导减少TGF-β和MMP-9的产生，特别是在乳腺癌细胞或乳腺癌细胞诱导的破骨细胞中。

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In vitro assessment of 4-acetyl-antrquinonol B and erinacine A in suppressing breast cancer-induced osteoclastogenesis

Bone metastasis in metastatic breast cancer commonly results in osteolytic lesions due to osteoclast activity, promoting bone destruction and tumor progression. The bioactive fungal isolates, 4-Acetyl-antroquinonol B (4-AAQB) and Erinacine A, have diverse pharmacological and biological activities. However, their effects on breast cancer bone metastasis treatment remain unclear. Our study aimed to examine the impact of 4-AAQB or Erinacine A on breast cancer metastases in bone. The effects of 4-AAQB and Erinacine A on breast cancer-induced osteoclastogenesis, breast cancer migration, production of prometastatic cytokine (TGF-β) and marker (MMP-9), as well as potential MAPK signaling transductions were assessed. The results revealed that 4-AAQB and Erinacine A effectively suppressed breast cancer-induced osteoclastogenesis and migration, and reduced TGF-β and MMP-9 production via Erk or JNK signaling transductions, specifically in breast cancer cells or in breast cancer cells-induced osteoclasts.

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来源期刊

International journal of medicinal mushrooms 医学-药学

CiteScore

2.60

自引率

16.70%

发文量

审稿时长

6-12 weeks

期刊介绍： The rapid growth of interest in medicinal mushrooms research is matched by the large number of disparate groups that currently publish in a wide range of publications. The International Journal of Medicinal Mushrooms is the one source of information that will draw together all aspects of this exciting and expanding field - a source that will keep you up to date with the latest issues and practice. The International Journal of Medicinal Mushrooms published original research articles and critical reviews on a broad range of subjects pertaining to medicinal mushrooms, including systematics, nomenclature, taxonomy, morphology, medicinal value, biotechnology, and much more.