International Journal of Inflammation最新文献

{"title":"Ethanol Extract of Pomegranate (<i>Punica granatum</i>) Peel in Increasing the Expression of Caspase-3 in DSS-Induced Mice.","authors":"Kusmardi Kusmardi,&nbsp;Lyanna Azzahra Baihaqi,&nbsp;Ari Estuningtyas,&nbsp;Nurhuda Sahar,&nbsp;Hadi Sunaryo,&nbsp;Aryo Tedjo","doi":"10.1155/2021/4919410","DOIUrl":"https://doi.org/10.1155/2021/4919410","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC) is a malignancy derived from the glandular epithelial cells in the colon. Patients with inflammatory bowel disease (IBD) are more likely to develop CRC. Cancer proliferation is characterized by the loss of inhibition of apoptosis, which involves caspase-3 activation. This study examined the effects of the pomegranate peel extract on the expression of caspase-3 in mice crypt cells induced by dextran sodium sulfate (DSS) 2%.</p><p><strong>Methods: </strong>The experimental study was done in six groups. All treatments were done in 42 days. The groups were all induced by DSS through water drinking, except for the normal group, which was only given water. The treatments given included the pomegranate extract in two doses (240 mg and 480 mg/kg bw/day), aspirin, and ellagic acid. The specimens were then fixated and stained for the immunohistochemistry scoring for the expression of caspase-3, which was then analyzed statistically.</p><p><strong>Results: </strong>The H-scores of each treatment group were 213.23 ± 8.32 (DSS group), 243.81 ± 18.69 (normal group), 226.10 ± 12.38 (pomegranate peel extract of 240 mg/kg/d), 238.84 ± 15.81 (pomegranate peel extract of 480 mg/kg/d), 227.47 ± 12.15 (aspirin), and 224.01 ± 18.39 (ellagic acid). Statistical differences were found in one-way analysis of variance (ANOVA) and <i>post hoc</i> analysis among the DSS group, normal group, and dose 2 group (pomegranate peel extract of 480 mg/kg/day).</p><p><strong>Conclusions: </strong>The ethanol extract of pomegranate was able to induce apoptosis, which was demonstrated by the increase of caspase-3 expression.</p>","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2021 ","pages":"4919410"},"PeriodicalIF":2.0,"publicationDate":"2021-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8660243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39582100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endotoxin Triggers Tumor Initiation Events in Nontumorigenic Breast Epithelial Cells and Enhances Invasion-Related Phenotype in Pretumorigenic and Tumorigenic Breast Epithelial Cells.","authors":"Farah Yassine,&nbsp;Sabreen F Fostok,&nbsp;Nataly Naser Al Deen,&nbsp;Rabih S Talhouk","doi":"10.1155/2021/4666380","DOIUrl":"https://doi.org/10.1155/2021/4666380","url":null,"abstract":"<p><p>Inflammation is associated with the development of several cancers, including breast cancer. However, the molecular mechanisms driving breast cancer initiation or enhancement by inflammation are yet to be deciphered. Hence, we opted to investigate the role of inflammation in initiating and enhancing tumor-like phenotypes in nontumorigenic, pretumorigenic, and tumorigenic breast epithelial cells. Noncytotoxic endotoxin (ET) concentrations capable of inducing an inflammatory phenotype were determined for the different cell lines. Results showed that short-term ET exposure upregulated matrix metalloproteinase-9 (MMP-9) activity in nontumorigenic mammary epithelial cells of mouse (SCp2) and human origins (HMT-3522 S1; S1) and upregulated inflammatory mediators including nitric oxide (NO) and interleukin 1-<i>β</i> in tumorigenic human breast cells (MDA-MB-231), all in a dose-dependent manner. Long-term ET treatment, but not short-term, triggered the migration of SCp2 cells, and proliferation and migration of tumorigenic human breast cells MCF-7 and MDA-MB-231. Both short- and long-term ET exposures preferentially enhanced the invasion of pretumorigenic S1-connexin 43 knockout (Cx43-KO S1) cells compared to their nontumorigenic S1 counterparts. Moreover, both ET exposures disrupted lumen formation and apicolateral distribution of <i>β</i>-catenin in 3D cultures of S1 cells. In conclusion, ET treatment at concentrations that elicited inflammatory phenotype triggered tumor initiation events in nontumorigenic and pretumorigenic breast cells, and increased tumorigenicity of breast cancer cells. Our findings highlight the role of inflammation in enhancing migration, invasion, and loss of normal 3D morphology and suggest that such inflammatory insults can \"add injury\" to pretumorigenic and tumorigenic breast epithelial cells.</p>","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2021 ","pages":"4666380"},"PeriodicalIF":2.0,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39695021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Pathogen Type on Neonatal Sepsis Biomarkers.","authors":"Lyudmila Akhmaltdinova,&nbsp;Svetlana Kolesnichenko,&nbsp;Alyona Lavrinenko,&nbsp;Irina Kadyrova,&nbsp;Olga Avdienko,&nbsp;Lyudmila Panibratec","doi":"10.1155/2021/1009231","DOIUrl":"https://doi.org/10.1155/2021/1009231","url":null,"abstract":"<p><p>Understanding immunoregulation in newborns can help to determine the pathophysiology of neonatal sepsis and will contribute to improve the diagnosis, prognosis, and treatment and remains an urgent and unmet medical need to understand hyperinflammation or hypoinflammation associated with sepsis in newborns. This study included infants (up to 4 days old). The \"sepsis\" criteria was a positive blood culture. C-reactive protein demonstrates a strong dependence on the pathogen etiology. Therefore, its diagnostic odds ratio in Gram-positive bacteremia was 2.7 and the sensitivity was 45%, while Gram-negative was 15.0 and 81.8%, respectively. A neutrophil-lymphocyte ratio above 1 and thrombocytopenia below 50 ^<i>∗</i> 10⁹ cells/L generally do not depend on the type of pathogen and have a specificity of 95%; however, the sensitivity of these markers is low. nCD64 demonstrated good analytical performance and was equally discriminated in both Gram (+) and Gram (-) cultures. The sensitivity was 87.5-89%, and the specificity was 65%. The HLA-DR and programmed cell death protein study found that activation-deactivation processes in systemic infection is different at points of application depending on the type of pathogen: Gram-positive infections showed various ways of activation of monocytes (by reducing suppressive signals) and lymphocytes (an increase in activation signals), and Gram-negative pathogens were most commonly involved in suppressing monocytic activation. Thus, the difference in the bacteremia model can partially explain the problems with the high variability of immunologic markers in neonatal sepsis.</p>","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2021 ","pages":"1009231"},"PeriodicalIF":2.0,"publicationDate":"2021-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8626169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39673977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoarthritis Affects Mammalian Oogenesis: Effects of Collagenase-Induced Osteoarthritis on Oocyte Cytoskeleton in a Mouse Model.","authors":"Anton Ivanov Kolarov,&nbsp;Irina Valcheva Chakarova,&nbsp;Valentina Prodanova Hadzhinesheva,&nbsp;Venera Pantaleeva Nikolova,&nbsp;Stefka Metodieva Delimitreva,&nbsp;Maya Dyankova Markova,&nbsp;Ralitsa Stefanova Zhivkova","doi":"10.1155/2021/8428713","DOIUrl":"https://doi.org/10.1155/2021/8428713","url":null,"abstract":"<p><p>Known as a degenerative joint disorder of advanced age affecting predominantly females, osteoarthritis can develop in younger and actively working people because of activities involving loading and injuries of joints. Collagenase-induced osteoarthritis (CIOA) in a mouse model allowed us to investigate for the first time its effects on key cytoskeletal structures (meiotic spindles and actin distribution) of ovulated mouse oocytes. Their meiotic spindles, actin caps, and chromatin were analyzed by immunofluorescence. A total of 193 oocytes from mice with CIOA and 209 from control animals were obtained, almost all in metaphase I (M I) or metaphase II (MII). The maturation rate was lower in CIOA (26.42% M II) than in controls (55.50% M II). CIOA oocytes had significantly larger spindles (average 37 <i>μ</i>m versus 25 <i>μ</i>m in controls, <i>p</i> < 0.001), with a proportion of large spindles more than 64% in CIOA versus up to 15% in controls (<i>p</i> < 0.001). Meiotic spindles were wider in 68.35% M I and 54.90% M II of CIOA oocytes (mean 18.04 <i>μ</i>m M I and 17.34 <i>μ</i>m M II versus controls: 11.64 <i>μ</i>m M I and 12.64 <i>μ</i>m M II), and their poles were approximately two times broader (mean 6.9 <i>μ</i>m) in CIOA than in controls (3.6 <i>μ</i>m). CIOA oocytes often contained disoriented microtubules. Actin cap was visible in over 91% of controls and less than 20% of CIOA oocytes. Many CIOA oocytes without an actin cap had a nonpolarized thick peripheral actin ring (61.87% of M I and 52.94% of M II). Chromosome alignment was normal in more than 82% in both groups. In conclusion, CIOA affects the cytoskeleton of ovulated mouse oocytes-meiotic spindles are longer and wider, their poles are broader and with disorganized fibers, and the actin cap is replaced by a broad nonpolarized ring. Nevertheless, meiotic spindles were successfully formed in CIOA oocytes and, even when abnormal, allowed correct alignment of chromosomes.</p>","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2021 ","pages":"8428713"},"PeriodicalIF":2.0,"publicationDate":"2021-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39904942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Idiopathic Pulmonary Comorbidities and Mechanisms.","authors":"Maricica Pacurari,&nbsp;Amal Mitra,&nbsp;Timothy Turner","doi":"10.1155/2021/3963659","DOIUrl":"10.1155/2021/3963659","url":null,"abstract":"<p><p>Idiopathic pulmonary fibrosis (IPF) is a disease with an unknown etiology mainly characterized by a progressive decline of lung function due to the scarring of the tissue deep in the lungs. The overall survival after diagnosis remains low between 3 and 5 years. IPF is a heterogeneous disease and much progress has been made in the past decade in understanding the disease mechanisms that contributed to the development of two new drugs, pirfenidone and nintedanib, which improved the therapeutic management of the disease. The understanding of the cofactors and comorbidities of IPF also contributed to improved management of the disease outcome. In the present review, we evaluate scientific evidence which indicates IPF as a risk factor for other diseases based on the complexity of molecular and cellular mechanisms involved in the disease development and of comorbidities. We conclude from the existing literature that while much progress has been made in understating the mechanisms involved in IPF development, further studies are still necessary to fully understand IPF pathogenesis which will contribute to the identification of novel therapeutic targets for IPF management as well as other diseases for which IPF is a major risk factor.</p>","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2021 ","pages":"3963659"},"PeriodicalIF":2.0,"publicationDate":"2021-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8528608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39554091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased Levels of CD107a and Intracellular Cytokines in IL-2 Stimulated PBMCs from Endometriosis Patients.","authors":"R Muharam,&nbsp;Ririn Rahmala Febri,&nbsp;Kevin Ardito Prabowo,&nbsp;Arleni Bustami,&nbsp;Indra G Mansur","doi":"10.1155/2021/5760959","DOIUrl":"10.1155/2021/5760959","url":null,"abstract":"<p><p>It has been postulated that the immune system is impaired in individuals with endometriosis, with attention directed to natural killer (NK) cells. Specifically, it has been hypothesized that altered numbers of peripheral NK cells in blood are associated with the presence of endometriotic lesions. This study aimed to evaluate the level of the peripheral NK cell surface marker CD107a in endometriosis in the presence of IL-2 stimulation. Peripheral blood mononuclear cells (PBMCs) were obtained from 7 women with endometriosis and 7 women without endometriosis. The PBMCs were divided into two groups and either treated with recombinant IL-2 or left untreated. The cytotoxic activity of the PBMCs toward target cells (K562) was evaluated. Then, both groups were cocultured for 4 days. The expressions of CD107a, TNF-<i>α</i>, and IFN-<i>γ</i> were determined using flow cytometry analysis. There was no difference in the expression of CD107a prior to IL-2 stimulation in PBMCs from women with endometriosis compared to those from women without endometriosis. However, we observed upregulation of the expression of the surface marker CD107a after treatment in the endometriosis group. In addition, there was a significant difference in CD107a expression in the endometriosis group before versus after stimulation with IL-2 (<i>p</i> < 0.01). We also found no difference in the production of TNF-<i>α</i> and IFN-<i>γ</i> before versus after treatment with IL-2 in either groups. The levels of CD107a were significantly enhanced in peripheral blood taken from women with endometriosis after treatment with IL-2.</p>","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2021 ","pages":"5760959"},"PeriodicalIF":2.0,"publicationDate":"2021-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8490079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39491259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xanthine Oxidase-Induced Inflammatory Responses in Respiratory Epithelial Cells: A Review in Immunopathology of COVID-19.","authors":"Irandi Putra Pratomo,&nbsp;Dimas R Noor,&nbsp;Kusmardi Kusmardi,&nbsp;Andriansjah Rukmana,&nbsp;Rafika I Paramita,&nbsp;Linda Erlina,&nbsp;Fadilah Fadilah,&nbsp;Anggi Gayatri,&nbsp;Magna Fitriani,&nbsp;Tommy T H Purnomo,&nbsp;Anna Ariane,&nbsp;Rudi Heryanto,&nbsp;Aryo Tedjo","doi":"10.1155/2021/1653392","DOIUrl":"https://doi.org/10.1155/2021/1653392","url":null,"abstract":"<p><p>Xanthine oxidase (XO) is an enzyme that catalyzes the production of uric acid and superoxide radicals from purine bases: hypoxanthine and xanthine and is also expressed in respiratory epithelial cells. Uric acid, which is also considered a danger associated molecule pattern (DAMP), could trigger a series of inflammatory responses by activating the inflammasome complex path and NF-<i>κ</i>B within the endothelial cells and by inducing proinflammatory cytokine release. Concurrently, XO also converts the superoxide radicals into hydroxyl radicals that further induce inflammatory responses. These conditions will ultimately sum up a hyperinflammation condition commonly dubbed as cytokine storm syndrome (CSS). The expression of proinflammatory cytokines and neutrophil chemokines may be reduced by XO inhibitor, as observed in human respiratory syncytial virus (HRSV)-infected A549 cells. Our review emphasizes that XO may have an essential role as an anti-inflammation therapy for respiratory viral infection, including coronavirus disease 2019 (COVID-19).</p>","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2021 ","pages":"1653392"},"PeriodicalIF":2.0,"publicationDate":"2021-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8346299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39291466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase I/II Clinical Trial of Autologous Activated Platelet-Rich Plasma (aaPRP) in the Treatment of Severe Coronavirus Disease 2019 (COVID-19) Patients.","authors":"Karina Karina,&nbsp;Iis Rosliana,&nbsp;Imam Rosadi,&nbsp;Siti Sobariah,&nbsp;Louis Martin Christoffel,&nbsp;Rita Novariani,&nbsp;Siti Rosidah,&nbsp;Novy Fatkhurohman,&nbsp;Yuli Hertati,&nbsp;Nurlaela Puspitaningrum,&nbsp;Wismo Reja Subroto,&nbsp;Irsyah Afini,&nbsp;Difky Ernanda","doi":"10.1155/2021/5531873","DOIUrl":"https://doi.org/10.1155/2021/5531873","url":null,"abstract":"<p><strong>Background: </strong>The outbreak of Coronavirus Disease 2019 (COVID-19) has been increasing rapidly. This disease causes an increase in proinflammatory cytokine production that leads to cytokine storm or cytokine release syndrome (CRS). Autologous activated platelet-rich plasma (aaPRP) contains various types of growth factors and anti-inflammatory cytokines that may have the potential to suppress CRS. This study of phase I/II trial was aimed to evaluate the safety and efficacy of aaPRP to treat severe COVID-19 patients.</p><p><strong>Methods: </strong>A total of 10 severe COVID-19 patients from Koja Regional Public Hospital (Koja RPH) were admitted to the intensive care unit (ICU). All patients received aaPRP administration three times. Primary outcomes involving the duration of hospitalization, oxygen needs, time of recovery, and mortality were observed. Secondary outcomes involving C-reactive protein (CRP), neutrophil, lymphocyte, and lymphocyte-to-CRP (LCR) and neutrophil-lymphocyte ratio (NLR) were analyzed.</p><p><strong>Results: </strong>All patients were transferred to the ICU with a median duration of 9 days. All patients received oxygen at enrollment and nine of ten patients recovered from the ICU and transferred to the ward room. There was one patient who passed away in the ICU due to heart failure. The results of secondary outcomes showed that CRP value and lymphocytes counts were significantly decreased while neutrophils, LCR, and NLR were slightly increased after aaPRP administration.</p><p><strong>Conclusions: </strong>Our results of the phase I/II trial demonstrated that the use of aaPRP in severe COVID-19 patients was safe and not associated with serious adverse events, which showed that aaPRP was a promising adjunctive therapy for severe COVID-19 patients.</p>","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2021 ","pages":"5531873"},"PeriodicalIF":2.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8285191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39219625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Nondialysis Chronic Kidney Patients.","authors":"Gysllene M C Brito,&nbsp;Andrea M M Fontenele,&nbsp;Erika Cristina R L Carneiro,&nbsp;Iara Antonia L Nogueira,&nbsp;Tamires B Cavalcante,&nbsp;André A M Vale,&nbsp;Sally Cristina M Monteiro,&nbsp;Natalino Salgado Filho","doi":"10.1155/2021/6678960","DOIUrl":"10.1155/2021/6678960","url":null,"abstract":"<p><strong>Background: </strong>The Neutrophil-to-Lymphocyte Ratio (NLR) and the Platelet-to-Lymphocyte Ratio (PLR) are inflammatory biomarkers for several diseases, such as cancer and cardiovascular morbidities; however, there are currently few studies on kidney diseases. We aimed to evaluate nondialysis patients and determine the association of NLR and PLR with inflammation in these patients.</p><p><strong>Methods: </strong>A prospective cross-sectional study was conducted with 85 patients at different stages of chronic kidney disease (CKD), treated at the Kidney Disease Prevention Center of the University Hospital of the Federal University of Maranhão. This study included adult nondialysis patients diagnosed with CKD. The participants' blood samples were collected for a high-sensitivity C-reactive protein (hs-CRP) test and blood count. They were divided into two groups according to the presence or absence of inflammation based on the hs-CRP value (<0.5 mg/dL). NLR and PLR were calculated based on the absolute number of neutrophils, lymphocytes, and platelets and were compared between them and with hs-CRP. Statistical analysis was performed using the Stata software, with the Shapiro-Wilk, Mann-Whitney, Spearman's Correlation, and receiver operating characteristic curve tests. This study was approved by the local ethics committee.</p><p><strong>Results: </strong>The participants were categorized into two groups: with inflammation (<i>n</i> = 64) and without inflammation (<i>n</i> = 21). The mean age was 61.43 ± 14.63 y. The NLR and PLR values were significantly different between the groups with and without inflammation (<i>p</i>=0.045and <i>p</i>=0.004, respectively). However, only PLR showed a significant positive correlation with hs-CRP (<i>p</i>=0.015). The best cutoff point for NLR to detect inflammation was 1.98, with 76.19% sensitivity and 48.44% specificity. For PLR, it was 116.07, with 85.71% sensitivity and 51.56% specificity. There was no significant difference between the area under the NLR and PLR curve (0.71 vs. 0.64; <i>p</i>=0.186) for this population.</p><p><strong>Conclusions: </strong>This study showed that PLR was positively correlated with hs-CRP in nondialysis CKD patients and can be used to identify inflammation in this population.</p>","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2021 ","pages":"6678960"},"PeriodicalIF":2.0,"publicationDate":"2021-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39180717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extended Inflammation Parameters (EIP) as Markers of Immune System Cell Activation in Psoriasis.","authors":"Anna Kowalska-Kępczyńska,&nbsp;Mateusz Mleczko,&nbsp;Weronika Domerecka,&nbsp;Marcin Mazurek,&nbsp;Dorota Krasowska,&nbsp;Teresa Małecka-Massalska,&nbsp;Helena Donica","doi":"10.1155/2021/9216528","DOIUrl":"https://doi.org/10.1155/2021/9216528","url":null,"abstract":"<p><p>Psoriasis is an inflammatory, autoimmune disease that affects approximately 2% of the population. The inflammation in psoriasis can be systemic, so despite a predominantly cutaneous manifestation, it also affects the internal organs. The diagnosis and monitoring of the disease are based on the clinical picture. To assess the disorders of other organs, additional tests need to be performed. Recently, the examination of blood morphology has been enriched with modern haematological parameters, i.e., Extended Inflammation Parameters (EIP), which include RE-LYMPH (activated lymphocytes), AS-LYMPH (antibody-producing B lymphocytes), and NEUT-RI and NEUT-GI (activated neutrophils). In the study, higher values of new haematological parameters were observed in individuals with psoriasis than in healthy controls. A higher EIP value was noted in the group of individuals with plaque psoriasis than in the group of individuals with psoriatic arthritis. Implementation of these parameters into routine laboratory analysis will likely make it possible to estimate the severity of the inflammation and improve its assessment.</p>","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2021 ","pages":"9216528"},"PeriodicalIF":2.0,"publicationDate":"2021-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8219407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39163048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}