International Journal of Gynecological Pathology最新文献_第3页

The Maternal-Fetal Interface Fibrin Deposition and Expression of FGL2 in the Placenta of Preeclampsia and Fetal Growth Restriction. 子痫前期胎盘中母胎界面纤维蛋白沉积和FGL2的表达与胎儿生长限制。

IF 1.7 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-09-01 Epub Date: 2025-05-16 DOI: 10.1097/PGP.0000000000001095

Qihui Chen, Donglu Li, Yushuang Zheng, Xinran Li, Lu Wang, Wangzhi Li, Zheyu Lu, Fan Wang, Lingling Zhou

{"title":"The Maternal-Fetal Interface Fibrin Deposition and Expression of FGL2 in the Placenta of Preeclampsia and Fetal Growth Restriction.","authors":"Qihui Chen, Donglu Li, Yushuang Zheng, Xinran Li, Lu Wang, Wangzhi Li, Zheyu Lu, Fan Wang, Lingling Zhou","doi":"10.1097/PGP.0000000000001095","DOIUrl":"10.1097/PGP.0000000000001095","url":null,"abstract":"We aimed to assess fibrin deposition in placentas of patients with preeclampsia (PE) with fetal growth restriction (FGR) and the relationship with fibrinogen-like protein 2 (FGL2). In this case-control study, pregnant women with PE (n=48), PE with FGR (n=44), FGR (n=43), and healthy pregnant women (n=43) at term gestation were recruited. We compared the baseline characteristics, blood coagulation parameters, and placenta characteristics. Masson's trichrome staining was used to categorize 2 types of fibrinoid. FGL2 expression was examined by immunohistochemical staining. The PE+FGR placentas showed more obvious fetal and maternal vascular malperfusion and maternal-fetal interface fibrin deposition when compared with the others. Increased fibrin-type and matrix-type fibrinoids were found in the placenta of the PE+FGR group when compared with the controls. FGL2 was localized in the junction of these 2 types of fibrinoid, as well as extravillous trophoblastic layers and decidual stromal cells. The PE+FGR group had significantly lower FGL2 expression levels. Placental vascular malperfusion with massive maternal-fetal interface fibrin deposition was found in PE with FGR. We report the characteristic colocalization of 2 types of placental fibrinoid deposition and FGL2 immunoreactivity and, therefore, help in elucidating the mechanisms in the pathology of PE with FGR.","PeriodicalId":14001,"journal":{"name":"International Journal of Gynecological Pathology","volume":" ","pages":"436-444"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12337937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sclerosis in Metastatic Uterine Tumor Resembling Ovarian Sex Cord Tumor: Diagnostic Dilemma Presented by Unusual Morphology. 类似卵巢性索瘤的转移性子宫肿瘤硬化：由异常形态呈现的诊断困境。

IF 1.7 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-09-01 Epub Date: 2025-02-21 DOI: 10.1097/PGP.0000000000001098

Li Lei, Omonigho Aisagbonhi

{"title":"Sclerosis in Metastatic Uterine Tumor Resembling Ovarian Sex Cord Tumor: Diagnostic Dilemma Presented by Unusual Morphology.","authors":"Li Lei, Omonigho Aisagbonhi","doi":"10.1097/PGP.0000000000001098","DOIUrl":"10.1097/PGP.0000000000001098","url":null,"abstract":"Uterine tumors resembling ovarian sex cord tumors (UTROSCT) are rare neoplasms that typically follow a benign course. However, metastasis occurs in rare cases and features associated with poor outcomes are only recently being described. These include: size >5 cm, at least moderate cytologic atypia, >3 mitosis per 10 high-powered fields, infiltrative borders, necrosis, GREB1 rearrangements, ESR1 rearrangements, and NCOA2/3 fusions. To our knowledge, prominent sclerosis has not been described in UTROSCT, nor has it been associated with an increased risk of metastasis. We present the case of a 51-yr-old woman with UTROSCT with corded/trabecular growth and sclerosis. The presence of sclerosis resulted in the misdiagnosis of her uterine tumor as leiomyoma and her lung metastasis as sclerosing epithelioid fibrosarcoma. The correct diagnosis of UTROSCT with lung metastasis was reached upon a morphologic comparison of the primary and metastatic tumors and the performance of a broad panel of immunohistochemical stains revealing the tumor to be CD99, CD56, ER, and inhibin positive and negative for rearrangements in 138 targeted genes, including genes commonly described as rearranged in endometrial stromal sarcomas, Ewing sarcoma and sclerosing epithelioid fibrosarcoma. The panel did not include GREB1 or ESR or NCOA3 , but NCOA1/2 rearrangements were not detected. Our case highlights the diagnostic dilemma introduced by the presence of sclerosis in UTROSCT. We suspect prominent sclerosis may be another feature predictive of malignant potential in UTROSCT.","PeriodicalId":14001,"journal":{"name":"International Journal of Gynecological Pathology","volume":" ","pages":"457-460"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12337943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of hCG Expression in Endometrial Cancer Prognosis. hCG表达在子宫内膜癌预后中的作用。

IF 1.7 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-09-01 Epub Date: 2025-01-13 DOI: 10.1097/PGP.0000000000001102

Varol Gülseren, Mehmet Dolanbay, Fulya Çağli, Mine Dağgez, Nahit Topaloğlu, Figen Öztürk, Bülent Özçelik, İbrahim Serdar Serin, Kemal Güngördük

{"title":"The Role of hCG Expression in Endometrial Cancer Prognosis.","authors":"Varol Gülseren, Mehmet Dolanbay, Fulya Çağli, Mine Dağgez, Nahit Topaloğlu, Figen Öztürk, Bülent Özçelik, İbrahim Serdar Serin, Kemal Güngördük","doi":"10.1097/PGP.0000000000001102","DOIUrl":"10.1097/PGP.0000000000001102","url":null,"abstract":"This study aims to investigate the expression pattern of human chorionic gonadotropin (hCG) in the tissue of endometrioid type endometrial cancer (EEC) using immunohistochemistry, and also to investigate the effect of hCG expression pattern on prognosis and survival in EEC. We evaluated patients who were operated between 2010 and 2020 in the obstetrics and gynecology clinic of our center due to EEC. In total, 194 women were determined to be in either the hCG-negative group (n=137) or the hCG-positive group (n=57). The detection rate of deep myometrial invasion (16.8% vs. 36.8%; P =0.002), lymphovascular space invasion (10.9% vs. 24.6%; P =0.015), and metastatic lymph node (6.7% vs. 21.8%; P = 0.003) in patients with hCG-positive staining were analyzed to be significantly higher. Five-year disease-free survival (DFS) ( P = 0.015) and overall survival (OS) ( P = 0.024) rates were found to be higher in the hCG-negative group. hCG expression was found to be an independent risk factor for recurrence, and DFS in grade I-II EEC was limited to the uterus and with superficial myometrial invasion (low risk). No independent risk factors for OS were analyzed. hCG positivity is a risk factor with poor prognostic factors in endometrial cancer. It was concluded that hCG expression in low-risk EEC is a valuable negative prognostic factor for recurrence and DFS.","PeriodicalId":14001,"journal":{"name":"International Journal of Gynecological Pathology","volume":" ","pages":"445-450"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Trichoadenoma/Trichoepithelioma/Trichoblastoma-like Lesion in the Uterine Cervix Focally Mimics an Adenoid Basal Tumor. 宫颈毛腺瘤/毛上皮瘤/毛母细胞瘤样病变局灶性模拟腺样基底瘤。

IF 1.7 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-09-01 Epub Date: 2025-02-17 DOI: 10.1097/PGP.0000000000001106

Sanika Satoskar, Timothy J Vanderkwaak, Jaroslaw Jedrych, Russell Vang, Deyin Xing

{"title":"A Trichoadenoma/Trichoepithelioma/Trichoblastoma-like Lesion in the Uterine Cervix Focally Mimics an Adenoid Basal Tumor.","authors":"Sanika Satoskar, Timothy J Vanderkwaak, Jaroslaw Jedrych, Russell Vang, Deyin Xing","doi":"10.1097/PGP.0000000000001106","DOIUrl":"10.1097/PGP.0000000000001106","url":null,"abstract":"The presence of ectodermal adnexal structures in the uterine cervix, including sebaceous glands, hair follicles, and sweat glands, has been well documented in the literature. In theory, there exists the possibility of developing cutaneous-type lesions from the ectopic ectodermal structures in this location. Here we report the first case of cervical hair follicle-derived proliferations reminiscent of trichoadenoma, trichoepithelioma, and trichoblastoma (TA/TE/TB) in a 52-year-old woman who underwent a prophylactic hysterectomy due to a germline microphthalmia-associated transcription factor ( MITF ) gene mutation. The lesion was an incidental finding in the cervix, exhibiting a spectrum of morphologic features ranging from germinative TB with basaloid cells, to TE with some degree of infundibulocystic differentiation, to well-differentiated TA. In some areas, hair follicle-like structures were associated with sebaceous glands, forming pilosebaceous units. The proliferations in the TB-like area resembled adenoid basal epithelioma/carcinoma; however, ancillary studies, particularly patchy p16 expression and non-detection of HPV, argued against this diagnosis. Similar to adenoid basal tumors, the TB-like lesion focally expressed NKX3.1, suggesting that it might be related to ectopic prostatic tissue or exhibit prostatic-lineage differentiation. While the theory of misplaced embryonal tissue, or an acquired metaplastic process, has been discussed, the histopathologic origin of these lesions remains largely unknown.","PeriodicalId":14001,"journal":{"name":"International Journal of Gynecological Pathology","volume":" ","pages":"466-470"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12350076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary Lymphoma of the Female Genital Tract: A Needle in a Haystack. 女性生殖道原发性淋巴瘤：大海捞针。

IF 1.7 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-09-01 Epub Date: 2024-12-03 DOI: 10.1097/PGP.0000000000001083

Khadiga M Ali, Gehad A Saleh, Nahla Ali, Omar Hamdy, Reham Alghandour, Amr Hossam, Rokia Masoud, Amany Hassan

{"title":"Primary Lymphoma of the Female Genital Tract: A Needle in a Haystack.","authors":"Khadiga M Ali, Gehad A Saleh, Nahla Ali, Omar Hamdy, Reham Alghandour, Amr Hossam, Rokia Masoud, Amany Hassan","doi":"10.1097/PGP.0000000000001083","DOIUrl":"10.1097/PGP.0000000000001083","url":null,"abstract":"Primary lymphoma of the female genital tract (PLFGT) is a rare entity with nonspecific symptoms. Its prognosis relies on accurate and quick diagnosis and therapy despite the lack of standardized management guidelines. This study aimed to explore the clinicopathologic and radiologic characteristics; and differential diagnoses of women with lymphoma of the female genital tract (FGT) treated at the same institution. A retrospective study was conducted on 22 cases diagnosed with lymphoma of their FGT during the study period from June 2016 and December 2023. Medical records and radiologic, pathologic, management, and survival data were collected. The mean age was 49.45 yr, and the mean follow-up duration was 48 mo. Only 15 cases were diagnosed with PLFGT, while the remaining 7 cases were secondary to the disease. The ovary was the predominant site (9 cases), and diffuse large B-cell lymphoma was the main histologic subtype (90.9%). Eleven (50%) patients underwent surgery. PLFGT demonstrated a more favorable outcome (60% achieved complete remission). Treatment strategies and Ann Arbor staging were significantly correlated with overall survival. To avoid misdiagnosis, it is essential to include lymphoma in the differential diagnosis of histologically difficult gynecologic neoplasms. Increasing awareness about this rare entity and providing a preoperative diagnosis is paramount to avoid unnecessary gynecologic surgery.","PeriodicalId":14001,"journal":{"name":"International Journal of Gynecological Pathology","volume":" ","pages":"419-429"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First Case of Ovarian Metastases From a Primary Retroperitoneal Mucinous Carcinoma Associated With Teratoma, With KRAS and ERBB3 Mutations: Case Report and Literature Review. 合并KRAS和ERBB3突变的原发性腹膜后黏液癌伴畸胎瘤的卵巢转移一例：病例报告和文献回顾。

IF 1.7 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-09-01 Epub Date: 2025-01-28 DOI: 10.1097/PGP.0000000000001073

Jennifer Fallas, Isabelle Salmon, Calliope Maris, María Gómez Galdón, Nicky D'Haene, Jean-Christophe Noël, Xavier Catteau

{"title":"First Case of Ovarian Metastases From a Primary Retroperitoneal Mucinous Carcinoma Associated With Teratoma, With KRAS and ERBB3 Mutations: Case Report and Literature Review.","authors":"Jennifer Fallas, Isabelle Salmon, Calliope Maris, María Gómez Galdón, Nicky D'Haene, Jean-Christophe Noël, Xavier Catteau","doi":"10.1097/PGP.0000000000001073","DOIUrl":"10.1097/PGP.0000000000001073","url":null,"abstract":"Primary retroperitoneal mucinous carcinomas (PRMCa) are exceedingly rare and poorly understood neoplasms, with <80 cases documented in the medical literature and molecular profiling hardly ever performed. Recent theories suggest that PRMCa might develop from mature cystic teratomas or Brenner tumors, mirroring their ovarian counterparts. However, only 2 cases of primary retroperitoneal mucinous tumors associated with teratoma have been reported in the literature to support this idea. In this paper, we detail an exceptional case: a 66-yr-old woman with ovarian metastases stemming from a PRMCa that originated in a mature cystic teratoma. The patient initially presented with a long-standing cystic mass in the retroperitoneum, diagnosed as a mucinous carcinoma after surgical removal. Following initial resection, the patient experienced rapid metastatic progression requiring aggressive treatment. Interestingly, the later ovarian metastases exhibited the full spectrum of architectural complexity observed in the initial lesion. This \"maturation phenomenon,\" frequently observed in ovarian metastases of mucinous tumors, remains enigmatic. Molecular analysis revealed a KRAS mutation along with an ERBB3 mutation, making it the first instance of ERBB3 mutation being documented in this specific entity. This case underscores the importance of thorough data collection and continued research to improve our understanding of these rare tumors.","PeriodicalId":14001,"journal":{"name":"International Journal of Gynecological Pathology","volume":" ","pages":"461-465"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12337904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphologic Characteristics Seen in High-grade Serous Ovarian Carcinoma Metastases in Postneoadjuvant Chemotherapy Resections. 新辅助化疗切除后高级别浆液性卵巢癌转移的形态学特征。

IF 1.7 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-09-01 Epub Date: 2024-12-03 DOI: 10.1097/PGP.0000000000001084

Marcos Lepe, Emily Mejia, Yifan Bu, Jonathan L Hecht

引用次数: 0

The Morphologic and Molecular Heterogeneity of Fumarate Hydratase-deficient Leiomyomas: Integrative Molecular Profiling of Uterine Smooth Muscle Tumors With Histologic Feature Correlation. 富马酸水合酶缺乏的平滑肌瘤的形态和分子异质性：子宫平滑肌肿瘤的综合分子特征与组织学特征的相关性。

IF 1.7 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-09-01 Epub Date: 2025-01-13 DOI: 10.1097/PGP.0000000000001101

Julianne M Szczepanski, David B Chapel, Tao Huang, Trinh Pham, Rahul Mannan, Rohit Mehra, Andrew P Sciallis, Scott Tomlins, Stephanie L Skala, Aaron M Udager

{"title":"The Morphologic and Molecular Heterogeneity of Fumarate Hydratase-deficient Leiomyomas: Integrative Molecular Profiling of Uterine Smooth Muscle Tumors With Histologic Feature Correlation.","authors":"Julianne M Szczepanski, David B Chapel, Tao Huang, Trinh Pham, Rahul Mannan, Rohit Mehra, Andrew P Sciallis, Scott Tomlins, Stephanie L Skala, Aaron M Udager","doi":"10.1097/PGP.0000000000001101","DOIUrl":"10.1097/PGP.0000000000001101","url":null,"abstract":"The morphologic features of uterine smooth muscle tumors (USMTs) are subject to interobserver variability and are complicated by consideration of features of fumarate hydratase deficiency (FHd) and other morphologic subtypes, with difficult cases occasionally diagnosed as smooth muscle tumor of uncertain malignant potential (STUMP). We compare immunohistochemical findings and detailed morphologic analysis of 45 USMTs by 4 fellowship-trained gynecologic pathologists with comprehensive molecular analysis, focusing on FHd leiomyomas (n=15), compared to a variety of other USMTs with overlapping morphologic features, including 9 STUMPs, 8 usual-type leiomyomas (ULM), 11 apoplectic leiomyomas, and 2 leiomyomas with bizarre nuclei (LMBN). FHd leiomyomas, defined by immunohistochemical (IHC) loss of FH and/or 2SC accumulation, showed FH mutations and/or FH copy loss in all cases, with concurrent TP53 mutations in 2 tumors. Severe and/or symplastic-type cytologic atypia was seen more often in FHd leiomyomas with only FH copy loss (6/8, and 2/2 with concurrent TP53 mutations) compared to those with FH mutations (2/7) and typically showed increased genomic instability. This subset of FHd tumors often showed morphologic overlap with STUMPs and LMBN, but all cases of FHd tumors showed 2SC accumulation and/or FH loss by IHC. In conclusion, we highlight the importance of investigating USMTs with severe and/or symplastic-type cytologic atypia with FH and 2SC IHC, as many of these tumors are FH-deficient via focal deep deletion (2-copy loss) of the FH locus. In addition, we report the presence of concurrent TP53 mutations in FHd tumors with more severe cytologic atypia; further data about clinical outcomes for these tumors are needed.","PeriodicalId":14001,"journal":{"name":"International Journal of Gynecological Pathology","volume":" ","pages":"385-397"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Female Adnexal Tumor of Probable Wolffian Origin (FATWO): An Unusual Case With Development of Peritoneal Lesions After 3 Decades. 女性附件肿瘤可能起源于沃尔夫犬（FATWO）：一个不寻常的病例，30年后发展为腹膜病变。

IF 1.7 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-09-01 Epub Date: 2025-01-15 DOI: 10.1097/PGP.0000000000001103

Manisha Goel, Elin Rønne, Ellen Veronika Vesterfjell, Guro Aune, Jennifer A Bennett

引用次数: 0

Entirely Exophytic HPV-associated Endocervical Adenocarcinoma: A Rare But Potentially Aggressive Neoplastic Phenomenon. 完全外生性hpv相关的宫颈内膜腺癌：一种罕见但潜在侵袭性的肿瘤现象。

IF 1.7 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-09-01 Epub Date: 2024-12-03 DOI: 10.1097/PGP.0000000000001082

Roman E Zyla, Karen L Talia, Anjelica Hodgson

{"title":"Entirely Exophytic HPV-associated Endocervical Adenocarcinoma: A Rare But Potentially Aggressive Neoplastic Phenomenon.","authors":"Roman E Zyla, Karen L Talia, Anjelica Hodgson","doi":"10.1097/PGP.0000000000001082","DOIUrl":"10.1097/PGP.0000000000001082","url":null,"abstract":"A subset of human papillomavirus (HPV)-associated endocervical adenocarcinoma (EA) displays exclusively exophytic growth, with or without a classic villoglandular appearance. Given that increased depth and extent of destructive stromal invasion are associated with poorer prognosis for HPV-associated EA, it is believed that exclusively exophytic tumors are associated with a relatively indolent clinical course. There is, however, a paucity of data regarding the behavior of these neoplasms. We assembled a cohort of 73 patients with entirely resected cervix-confined HPV-associated EA treated with primary operative therapy. The tumors were classified based on architecture and presence/extent of stromal invasion, and histopathologic parameters, including the International Federation of Gynecology and Obstetrics (FIGO) 2018 substage and lymphovascular invasion (LVI). Clinical outcomes including local recurrence, metastasis, and death were evaluated. Of 73 tumors, 4 (6%) demonstrated exclusively exophytic growth (0.4-2.2 cm in maximal dimension). All lacked LVI as well as nodal involvement. None of the 4 patients with exclusively exophytic tumors received adjuvant therapy. Two of the 4 (50%), however, experienced recurrence and both patients eventually died of causes related to EA. Of the remaining 69 cases with a component of nonexophytic growth, <6% of patients experienced tumor recurrence. Our study has found that, in at least a subset of cases, exclusively exophytic HPV-associated EA is associated with adverse outcomes. Additional studies are needed to substantiate these findings and to identify additional features (pathologic, molecular, etc.) that may aid in identifying those patients who could benefit from more aggressive treatment.","PeriodicalId":14001,"journal":{"name":"International Journal of Gynecological Pathology","volume":" ","pages":"412-418"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0