International Journal of Gynecological Pathology最新文献_第4页

Morphologic Correlations With Homologous Recombination Deficiency in High-grade Serous Carcinomas. 高级别浆液性癌中同源重组缺陷的形态学相关性

IF 1.7 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-09-01 Epub Date: 2025-01-09 DOI: 10.1097/PGP.0000000000001090

Udita Chapagain, Julia B Huecker, Lulu Sun

{"title":"Morphologic Correlations With Homologous Recombination Deficiency in High-grade Serous Carcinomas.","authors":"Udita Chapagain, Julia B Huecker, Lulu Sun","doi":"10.1097/PGP.0000000000001090","DOIUrl":"10.1097/PGP.0000000000001090","url":null,"abstract":"High-grade serous carcinomas (HGSCs) with homologous recombination deficiency (HRD) respond favorably to platinum therapy and poly ADP ribose polymerase (PARP) inhibitors. Mutations in BRCA1 and BRCA2 commonly cause HRD and have been associated with Solid, pseudoEndometrioid, and Transitional-like (SET-like) histology. Mutations in other homologous recombination repair (HRR) genes as well as epigenetic changes can also result in HRD; however, morphologic correlates have not been well-explored in these cases. We hypothesized that HGSCs with HRD, regardless of the etiology, are associated with specific morphologic features. Forty-three cases of HGSC with genomic profiling, which included HRR gene mutation analysis and HRD score, were evaluated. The morphologic patterns, degree of nuclear atypia, necrosis, mitotic index, and tumor-infiltrating lymphocytes (TILs) were determined. The results showed that HRD-high status was significantly associated with the presence of BRCA1/2 mutation, SET-like morphology, geographic necrosis, and severe nuclear atypia. Additional HRR pathway genes with oncogenic mutations identified included ATM, BRIP1, BLM, FANCC, CDK12, CHEK2, RAD51C, and RAD51D . Almost one-third of HRD-high tumors did not have mutations in any HRR pathway genes identified. In conclusion, HGSC with HRD, regardless of BRCA1/2- status, was associated with SET-like morphology and more severe nuclear atypia. Identifying and reporting these patterns of tumor morphology can prompt genomic profiling with prognostic, therapeutic, and genetic counseling implications.","PeriodicalId":14001,"journal":{"name":"International Journal of Gynecological Pathology","volume":" ","pages":"398-406"},"PeriodicalIF":1.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HPV-negative Differentiated Intraepithelial Neoplasia in the Anogenital Region Including the Cervix. 包括子宫颈在内的肛门生殖器区hpv阴性分化上皮内瘤变。

IF 1.7 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-09-01 Epub Date: 2025-07-10 DOI: 10.1097/PGP.0000000000001105

Sigrid Regauer, Olaf Reich

引用次数: 0

Papillary Thyroid Carcinoma With an STRN::ALK Fusion Arising From a Mature Ovarian Teratoma. 成熟卵巢畸胎瘤并发STRN::ALK融合的甲状腺乳头状癌。

IF 1.7 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-08-11 DOI: 10.1097/PGP.0000000000001131

Ambrus Mályi, Erika Tóth, Ildikó Vereczkey, Andrea Kohánka, Zsombor Melegh

引用次数: 0

TRPS1 Reliably Stains Benign and Malignant Lesions Arising Within Vulvar Anogenital Mammary-like Glands. TRPS1可靠地染色外阴阴部乳腺样腺内良恶性病变。

IF 1.7 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-08-08 DOI: 10.1097/PGP.0000000000001126

Alexis Heller, Malini Harigopal, Akm Juber Ahmed, Samantha StClair, Victoria Collins

{"title":"TRPS1 Reliably Stains Benign and Malignant Lesions Arising Within Vulvar Anogenital Mammary-like Glands.","authors":"Alexis Heller, Malini Harigopal, Akm Juber Ahmed, Samantha StClair, Victoria Collins","doi":"10.1097/PGP.0000000000001126","DOIUrl":"https://doi.org/10.1097/PGP.0000000000001126","url":null,"abstract":"TRPS1 is a novel immunohistochemical marker that is known to stain normal mammary epithelium and breast carcinomas (especially triple negative carcinomas). TRPS1 staining has also been reported in normal skin appendages, benign and malignant cutaneous neoplasms, and anogenital mammary-like glands (AGMLG). However, research regarding TRPS1 staining in various neoplasms derived from AGMLG is limited. Past studies have focused on two neoplasms of AGMLG-hidradenoma papilliferum (HP) and extramammary Paget disease (EMPD). We confirm the finding that TRPS1 is positive in the epithelium of HP and we report its expression in a variety of other benign and malignant lesions derived from vulvar AGMLG, including fibroepithelial lesion (FEL), lactating adenoma (LA), fibroepithelial polyp with AGMLG, and mammary-type adenocarcinoma (MAc). The majority of TRPS1 staining was diffuse and displayed strong (3+) intensity. We show that TRPS1 is significantly more sensitive than GCDFP-15 in lesions of AGMLG and is comparable to GATA3. TRPS1 was also more sensitive than mammaglobin, but the finding did not reach statistical significance. TRPS1 demonstrated diffuse staining in these lesions significantly more often than either GCDFP-15 or mammaglobin. This study was limited by its small sample size, due to the rarity of some entities such as the malignant MAc (n=3).","PeriodicalId":14001,"journal":{"name":"International Journal of Gynecological Pathology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HPV-associated Endocervical Adenocarcinoma In Situ (AIS) With an ER+/Vimentin+/CEA- immunophenotype Mimicking Tubo-endometrioid Metaplasia. 具有ER+/Vimentin+/CEA-免疫表型模拟输卵管子宫内膜样化生的hpv相关宫颈内膜腺癌原位（AIS）

IF 1.7 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-08-05 DOI: 10.1097/PGP.0000000000001129

Jin Xu, Qinyuan Li, Paul S Weisman

{"title":"HPV-associated Endocervical Adenocarcinoma In Situ (AIS) With an ER+/Vimentin+/CEA- immunophenotype Mimicking Tubo-endometrioid Metaplasia.","authors":"Jin Xu, Qinyuan Li, Paul S Weisman","doi":"10.1097/PGP.0000000000001129","DOIUrl":"https://doi.org/10.1097/PGP.0000000000001129","url":null,"abstract":"HPV-associated endocervical adenocarcinoma in situ (AIS) is typically ER-, vimentin-, and CEA+. By contrast, tubo-endometrioid metaplasia (TEM), a well-known mimicker of AIS, is typically ER+, vimentin+, and CEA-. Both AIS and TEM express p16, with block-positive expression in AIS and predominantly patchy expression in TEM; however, TEM may also exhibit p16 expression that is extensive enough that it borders on block-like expression. Here we share 2 cases of endocervical AIS that showed an endometrioid immunophenotype (ER+, vimentin+, and CEA-). The AIS in these cases also had a second population of pale p40- epithelioid cells resembling the ciliated cells of TEM; no true cilia were seen. High-risk human papillomavirus (HPV) in situ hybridization (HR-HPV ISH) testing was positive in both cases of AIS, establishing their HPV association. Despite the lack of true cilia, the morphology and immunophenotype of the AIS in these cases resulted in a very TEM-like picture. Given the aforementioned propensity of TEM to show a high degree of p16 expression, we share these cases as a reminder that an endometrioid-like immunophenotype by ER, CEA, and vimentin IHC does not unequivocally establish a benign diagnosis.","PeriodicalId":14001,"journal":{"name":"International Journal of Gynecological Pathology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145075329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent Detection of TERT Promoter Mutation in HPV-independent Cervical Squamous Cell Carcinoma: A Letter Regarding Horn et al. 不依赖hpv的宫颈鳞状细胞癌中TERT启动子突变的复发检测：关于Horn等人的一封信。

IF 1.7 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-08-01 DOI: 10.1097/PGP.0000000000001130

Ahmet Erbağci, Abdullah Aydin, İlker Nihat Ökten, Gözde Kir

引用次数: 0

From Serous Tubal Intraepithelial Carcinoma to Neuroendocrine Carcinoma: Molecular Dissection of a Rare Fallopian Tube Carcinoma. 从浆液性输卵管上皮内癌到神经内分泌癌：一例罕见输卵管癌的分子解剖。

IF 1.7 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-07-29 DOI: 10.1097/PGP.0000000000001127

Jesús Machuca-Aguado, Carmen Alfonso-Rosa, Antonio García-Escudero, Francisco Javier Rubio-Garrido, Inmaculada Trigo, Tatiana Cano-Barbadillo, W Glenn McCluggage

引用次数: 0

Origin of Endometrioid Carcinoma Adjacent to Extraovarian Endometriosis: Detailed Molecular Analyses. 毗邻卵巢外子宫内膜异位症的子宫内膜样癌的起源：详细的分子分析。

IF 1.7 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-07-29 DOI: 10.1097/PGP.0000000000001128

Tomo Yamagata, Koichi Watanabe, Koji Yamanoi, Nobuyuki Kakiuchi, Rin Mizuno, Mana Taki, Ryusuke Murakami, Ken Yamaguchi, Junzo Hamanishi, Hiroaki Itoh, Seishi Ogawa, Masaki Mandai

{"title":"Origin of Endometrioid Carcinoma Adjacent to Extraovarian Endometriosis: Detailed Molecular Analyses.","authors":"Tomo Yamagata, Koichi Watanabe, Koji Yamanoi, Nobuyuki Kakiuchi, Rin Mizuno, Mana Taki, Ryusuke Murakami, Ken Yamaguchi, Junzo Hamanishi, Hiroaki Itoh, Seishi Ogawa, Masaki Mandai","doi":"10.1097/PGP.0000000000001128","DOIUrl":"https://doi.org/10.1097/PGP.0000000000001128","url":null,"abstract":"A well-differentiated endometrioid carcinoma at the site of extra-uterine/ovarian endometriosis complicates the differentiation between an uncommon metastatic pattern from a corpus cancer and a synchronous primary tumor originating from adjacent endometriosis. Herein, we present 2 cases of well-differentiated uterine endometrial carcinoma metastasizing to the intestinal tract and uterosacral ligament, which were adjacent to surrounding endometriosis. Case 1: a well-differentiated endometrioid carcinoma was identified in the uterus and the uterosacral ligament. Genetic analysis revealed shared driver gene mutations between the uterine corpus tumor and uterosacral ligament tumor, indicating a common clonal origin. Case 2: an endometrioid carcinoma was identified in the intestinal tract, with adjacent ectopic endometriosis. Furthermore, the patient had a history of treatment for early-stage uterine well-differentiated endometrial carcinoma 7 yr prior. Genetic analysis demonstrated shared genetic alterations between the uterine corpus tumor, treated 7 yr earlier, and the intestinal tumor, strongly supporting a shared clonal origin. Although clinical and pathologic findings suggested that these tumors could originate from endometriosis, detailed genetic analysis confirmed that they shared genetic alterations with the primary uterine endometrioid carcinoma, indicating a common clonal origin in both cases. When well-differentiated adenocarcinoma is identified at an extrauterine/ovarian site adjacent to endometriosis, the tumor can be considered to be derived from the surrounding endometriosis. However, if a uterine endometrial carcinoma is present concurrently or has a history of existing, metastasis from the uterine endometrial carcinoma should be considered first, even if its clinical malignant potential is not high.","PeriodicalId":14001,"journal":{"name":"International Journal of Gynecological Pathology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Abnormal Nuclear Membranous Staining Pattern by MLH1 Immunohistochemistry in Endometrial Cancer: A Diagnostic Pitfall and Clone-dependent Artifact. 子宫内膜癌MLH1免疫组化异常核膜染色模式：诊断缺陷和克隆依赖伪影。

IF 1.7 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-07-28 DOI: 10.1097/PGP.0000000000001125

Lisha Wang, David Jou, Ruchi Patel, Grace Malvar, Katherine Germansky, Jonathan L Hecht, Monika Vyas

{"title":"Abnormal Nuclear Membranous Staining Pattern by MLH1 Immunohistochemistry in Endometrial Cancer: A Diagnostic Pitfall and Clone-dependent Artifact.","authors":"Lisha Wang, David Jou, Ruchi Patel, Grace Malvar, Katherine Germansky, Jonathan L Hecht, Monika Vyas","doi":"10.1097/PGP.0000000000001125","DOIUrl":"https://doi.org/10.1097/PGP.0000000000001125","url":null,"abstract":"Immunohistochemistry (IHC) for mismatch repair (MMR) proteins is routinely performed for endometrial cancer (EC). Loss of nuclear staining for MLH1/PMS2 triggers reflex testing for MLH1 promoter hypermethylation, while loss of MSH2/MSH6 or isolated loss of MSH6 and PMS2 prompts germline testing for Lynch syndrome. We observed an unusual nuclear membranous staining pattern of MLH1 (clone G168-15). The goal of the study was to determine its significance and highlight this IHC interpretation pitfall. A total of 52 EC cases with abnormal IHC staining patterns were identified in our database from 2017 to 2020. Of these, 41 were reported as MLH1/PMS2 deficient, and 11 as MSH2/MSH6 deficient. On review, 6/41 (14.6%) showed nuclear membranous expression of MLH1 (focal in 1 and diffuse in 5) with complete loss of PMS2 in the same foci. These foci demonstrated mucinous morphology or squamous/morular metaplasia in 3 cases. One additional consultation case showed nuclear membranous staining of MLH1 in the carcinoma and complete loss in the associated endometrial intraepithelial neoplasia, with PMS2 loss in both. Three of 7 cases were FIGO grade 1, and 4 were FIGO grade 2 to 3. MLH1 promoter hypermethylation was detected in 6/7 cases (not performed for one case). Repeat staining with ES05 clone showed complete loss of nuclear MLH1 expression in all 6 in-house cases. Nuclear membranous expression of MLH1 represents an aberrant staining pattern, observed with complete loss of PMS2 and frequently associated with MLH1 promoter hypermethylation. Failure to recognize this aberrant MLH1 expression pattern can lead to misinterpreting isolated PMS2 loss.","PeriodicalId":14001,"journal":{"name":"International Journal of Gynecological Pathology","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144784202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Uterine Mesenchymal Neoplasm With BRD8::PHF1 Fusion: Low-grade Endometrial Stromal Sarcoma or Uterine Ossifying Fibromyxoid Tumor? 子宫间质肿瘤合并BRD8::PHF1融合：低级别子宫内膜间质肉瘤还是子宫骨化纤维黏液样肿瘤？

IF 1.6 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-07-16 DOI: 10.1097/PGP.0000000000001108

Niall O'Neill, James Sampson, W Glenn McCluggage

引用次数: 0