International Journal of Gynecological Pathology最新文献_第10页

Napsin A Immunoreactivity in "Hobnail" Epithelium in Benign Endometrial and Endocervical Polyps. 良性子宫内膜和宫颈内膜息肉的 "蜗牛 "上皮中的 Napsin A 免疫反应。

IF 1.6 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-01-01 Epub Date: 2024-05-06 DOI: 10.1097/PGP.0000000000001037

Maysa Al-Hussaini, Karen L Talia, W Glenn McCluggage

{"title":"Napsin A Immunoreactivity in \"Hobnail\" Epithelium in Benign Endometrial and Endocervical Polyps.","authors":"Maysa Al-Hussaini, Karen L Talia, W Glenn McCluggage","doi":"10.1097/PGP.0000000000001037","DOIUrl":"10.1097/PGP.0000000000001037","url":null,"abstract":"Endometrial and endocervical polyps not uncommonly exhibit focal benign \"hobnail\" change/metaplasia within the glandular epithelium, sometimes in association with inflammation or infarction. In most cases, this is readily recognized as benign but occasionally, especially in endometrial polyps, this change prompts consideration of a premalignant or malignant lesion, including early serous or clear cell carcinoma. Herein we highlight the previously unreported phenomenon of positive staining of this hobnail epithelium with Napsin A which has the potential to exacerbate concern for clear cell carcinoma. Endometrial (n = 22) and endocervical (n = 17) polyps showing hobnail change were stained with Napsin A. Six cases were positive (4 of 22 endometrial and 2 of 17 endocervical polyps). In all cases, Napsin A positivity was confined to the hobnail epithelium. The hobnail epithelium was positive with estrogen receptor and hepatocyte nuclear factor 1- beta and exhibited wild-type immunoreactivity with p53 in all cases where these markers were performed. In addition, in 2 of 3 uterine adenosarcomas with focal hobnail change the epithelium was Napsin A positive. Pathologists should be aware that Napsin A may be expressed in benign/reactive hobnail epithelium in endometrial and endocervical polyps and should not consider positivity with this marker as a diagnostic of clear cell carcinoma.","PeriodicalId":14001,"journal":{"name":"International Journal of Gynecological Pathology","volume":" ","pages":"31-36"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141087388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stathmin is an Independent Prognostic Marker of Poor Outcome in Uterine Leiomyosarcoma. Stathmin是子宫纵膈肉瘤不良预后的独立标志物

IF 1.6 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-01-01 Epub Date: 2024-06-04 DOI: 10.1097/PGP.0000000000001030

Ben Davidson, Tone Skeie-Jensen, Arild Holth, Silke Hausladen

{"title":"Stathmin is an Independent Prognostic Marker of Poor Outcome in Uterine Leiomyosarcoma.","authors":"Ben Davidson, Tone Skeie-Jensen, Arild Holth, Silke Hausladen","doi":"10.1097/PGP.0000000000001030","DOIUrl":"10.1097/PGP.0000000000001030","url":null,"abstract":"The objective of this study was to analyze the expression and prognostic role of cancer-associated proteins in uterine leiomyosarcoma (uLMS). p53, DAXX, ATRX, HMGA2, IMP3, Stathmin, and phospho-Stathmin (p-Stathmin) protein expression by immunohistochemistry was analyzed in tissue microarrays from 244 uLMS. Expression was assessed for association with clinicopathologic parameters in 173 patients with available data. Tissue microarrays were informative in 230 cases. p53 was aberrant in 44% of tumors. DAXX, ATRX, HMGA2, IMP3, and Stathmin were expressed in 90%, 55%, 40%, 33%, and 97% uLMS, respectively. Cytoplasmic and nuclear p-Stathmin staining was seen in 77% and 68% of tumors, respectively. Stathmin expression was significantly related to higher mitotic count ( P < 0.001), a higher degree of atypia ( P = 0.006), and vascular invasion ( P = 0.016), whereas p-Stathmin expression was significantly related to advanced stage ( P < 0.001), higher mitotic count ( P < 0.001), and vascular invasion ( P = 0.001). In univariate survival analysis for 165 patients with informative tissue microarrays, aberrant p53 ( P = 0.026) and higher IMP3 ( P = 0.024), Stathmin ( P < 0.001), cytoplasmic p-Stathmin ( P < 0.001), and nuclear p-Stathmin ( P < 0.001) expression was associated with poor disease-specific survival. Clinicopathologic parameters significantly related to poor disease-specific survival were older age ( P = 0.006), extrauterine disease at diagnosis (International Federation of Gynecology and Obstetrics (FIGO) stage ≥2; P < 0.001), high mitotic count ( P = 0.02), and grade 2 to 3 atypia ( P = 0.017). In multivariate analysis, age ( P = 0.002), FIGO stage ( P < 0.001), and Stathmin expression ( P < 0.001) were independent prognosticators. Stathmin was the only prognosticator in a multivariate analysis limited to patients with FIGO stage I disease ( P = 0.013). In conclusion, Stathmin expression is strongly associated with poor survival in uLMS and may be a new prognostic marker in this malignancy.","PeriodicalId":14001,"journal":{"name":"International Journal of Gynecological Pathology","volume":" ","pages":"56-66"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141283601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LINE-1 ORF1p is a Promising Biomarker in Cervical Intraepithelial Neoplasia Degree Assessment. LINE-1 ORF1p 是宫颈上皮内瘤变程度评估中一种有前途的生物标记物。

IF 1.6 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-01-01 Epub Date: 2024-06-26 DOI: 10.1097/PGP.0000000000001035

Réka Karkas, Khaldoon Sadiq Ahmed Abdullah, László Kaizer, Ádám Ürmös, May Raya, Lilla Tiszlavicz, Tibor Pankotai, István Nagy, Lajos Mátés, Farkas Sükösd

{"title":"LINE-1 ORF1p is a Promising Biomarker in Cervical Intraepithelial Neoplasia Degree Assessment.","authors":"Réka Karkas, Khaldoon Sadiq Ahmed Abdullah, László Kaizer, Ádám Ürmös, May Raya, Lilla Tiszlavicz, Tibor Pankotai, István Nagy, Lajos Mátés, Farkas Sükösd","doi":"10.1097/PGP.0000000000001035","DOIUrl":"10.1097/PGP.0000000000001035","url":null,"abstract":"Cervical intraepithelial neoplasia (CIN) represents a spectrum of preinvasive squamous lesions within the cervical epithelium, whose identification is a diagnostic challenge due to subtle histomorphological differences among its categories. This study explores ORF1p, a nucleic acid-binding protein derived from long interspersed nuclear element-1 (LINE-1), as a potential biomarker for enhancing CIN diagnosis. A comprehensive analysis of 143 cervical specimens, encompassing CIN I (n=20), CIN II (n=46), CIN III (n=14), invasive cancer (n=32), and nondysplastic cases (normal cervical epithelia (n=24) and atrophy (n=7) were conducted. ORF1p, Ki67, and p16 expressions were evaluated using immunohistochemistry. ORF1p immunopositivity was detected in the vast majority [110/112 (98.2%)] of dysplastic and neoplastic (CIN and invasive cancer) specimens, whereas 19/24 (79.2%) of normal cervical specimens lacked ORF1p expression. The observed pattern of ORF1p expression showed a progressively increasing extent and intensity with advancing CIN grades. CIN I exhibited mild ORF1p expression in the lower one or two-thirds of the cervical epithelium [14/16 (87.5%)], whereas CIN II demonstrated moderate to strong ORF1p expression spanning the lower two-thirds [29/46 (63.0%)]. Pronounced transepithelial ORF1p immunopositivity characterized CIN III cases [13/14 (92.8%)] and cervical cancer [30/32 (93.8%)]. These findings propose ORF1p as a valuable indicator even for detecting CIN I, effectively discerning them from normal cervical tissue (p < 0.0001). Our findings underscore the potential of ORF1p as an early diagnostic marker for cervical neoplasia.","PeriodicalId":14001,"journal":{"name":"International Journal of Gynecological Pathology","volume":" ","pages":"22-30"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11627315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141450389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erythrasma of the Vulva: An Invisible Dermatosis. 外阴红斑：一种隐形皮肤病。

IF 1.6 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-01-01 Epub Date: 2024-04-09 DOI: 10.1097/PGP.0000000000001031

Soma Jobbagy, Alvaro C Laga, Jaclyn C Watkins

{"title":"Erythrasma of the Vulva: An Invisible Dermatosis.","authors":"Soma Jobbagy, Alvaro C Laga, Jaclyn C Watkins","doi":"10.1097/PGP.0000000000001031","DOIUrl":"10.1097/PGP.0000000000001031","url":null,"abstract":"Erythrasma is a prevalent superficial bacterial infection typically caused by Corynebacteria species and preferentially affecting intertriginous sites including axillary, interdigital, and inguinal skin folds. However, erythrasma of the vulva is uncommon, with only 2 cases previously reported. Although erythrasma can be diagnosed clinically using Woods lamp examination, it may not always be considered in the differential diagnosis for patients presenting with persistent vulvar pruritus. We report 12 cases of vulvar erythrasma identified by histopathology, with a review of clinical and histologic features. The mean patient age was 60.1 yr and the mean patient BMI was 30.5. Five of 12 patients presented with pruritic rash. The time from symptom onset to diagnosis was 9 mo in 1 case, >18 mo in 4 cases, and unknown in the remaining cases. The characteristic histologic features were compact orthokeratosis and mild perivascular chronic inflammation. In all 12 cases, Periodic Acid-Schiff-diastase (PAS-D) staining highlighted intracorneal filamentous rods which were not readily appreciable on H&E. After the diagnosis of erythrasma, 4 patients were treated with topical lincomycin, of whom 3 had clinical improvement in symptoms. One patient was treated with topical macrolide antibiotic and also reported improvement in symptoms. Consideration of erythrasma on the differential for patients presenting with vulvar rash and pruritus may shorten the time to diagnosis and treatment, minimize patient discomfort, and reduce the scope and cost of diagnostic testing.","PeriodicalId":14001,"journal":{"name":"International Journal of Gynecological Pathology","volume":" ","pages":"15-21"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serous Tubal Intraepithelial Carcinoma After Neoadjuvant Chemotherapy: A Report of 2 Cases. 新辅助化疗后的浆液性输卵管上皮内癌：2例报告

IF 1.6 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-01-01 Epub Date: 2024-08-22 DOI: 10.1097/PGP.0000000000001045

Iris A S Stroot, Leonie Smit, Geertruida H de Bock, Marise M Wagner, Mathilde Jalving, Léon C L T van Kempen, Joost Bart, Marian J E Mourits

{"title":"Serous Tubal Intraepithelial Carcinoma After Neoadjuvant Chemotherapy: A Report of 2 Cases.","authors":"Iris A S Stroot, Leonie Smit, Geertruida H de Bock, Marise M Wagner, Mathilde Jalving, Léon C L T van Kempen, Joost Bart, Marian J E Mourits","doi":"10.1097/PGP.0000000000001045","DOIUrl":"10.1097/PGP.0000000000001045","url":null,"abstract":"Serous tubal intraepithelial carcinoma (STIC) is regarded as the origin of most high-grade serous carcinomas (HGSC). After a diagnosis of isolated STIC, risk of developing HGSC is substantial. Since surveillance cannot detect HGSC in time to cure the disease, there is no consensus on the optimal treatment after a diagnosis of isolated STIC, but chemotherapy is considered one of the possible strategies. In this case report, we describe 2 women with advanced-stage HGSC treated with 3 cycles of neoadjuvant chemotherapy followed by interval debulking surgery. In both women, histopathological examination showed a complete histopathological tumor response, but a vital STIC was found in both cases. The 2 cases presented here indicate that STICs may not respond to chemotherapy. Further research focused on the underlying biology and chemosensitivity of STIC, as well as the effectiveness of treatment to prevent HGSC in case of isolated STIC, is needed.","PeriodicalId":14001,"journal":{"name":"International Journal of Gynecological Pathology","volume":" ","pages":"94-97"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11627307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter from the Editor. 编辑来信。

IF 1.6 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-01-01 Epub Date: 2024-12-11 DOI: 10.1097/PGP.0000000000001087

Lora Hedrick Ellenson

引用次数: 0

Mixed Gestational Trophoblastic Tumors-Challenging Clinicopathological Presentations. 混合型妊娠滋养细胞肿瘤--具有挑战性的临床病理表现。

IF 1.6 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-01-01 Epub Date: 2024-06-26 DOI: 10.1097/PGP.0000000000001044

Na Niu, Natalia Buza, Pei Hui

{"title":"Mixed Gestational Trophoblastic Tumors-Challenging Clinicopathological Presentations.","authors":"Na Niu, Natalia Buza, Pei Hui","doi":"10.1097/PGP.0000000000001044","DOIUrl":"10.1097/PGP.0000000000001044","url":null,"abstract":"Mixed gestational trophoblastic tumors are exceptionally rare and have variable clinicopathological presentations. We report 3 such tumors with different combinations of choriocarcinoma (CC), placental site trophoblastic tumor (PSTT), and epithelioid trophoblastic tumor (ETT). The patients' age ranged from 38 to 44 years. Mixed trophoblastic tumor was not considered at the initial diagnosis and all 3 tumors were proven of gestational origin by DNA genotyping. Patient #1 presented with serum human chorionic gonadotropin (hCG) of 97 mIU/mL and a 5.6-cm cervical mass that was initially interpreted as PSTT on biopsy. Hysterectomy revealed a mixed PSTT (60%) and ETT (40%) with extrauterine metastases of only the ETT component. The tumor recurred 15 months after a multiagent chemotherapy and was tested positive for programmed death-ligand 1. The patient received immune checkpoint inhibitor therapy and remained disease-free after 24 months. Patient #2 presented with vaginal bleeding and serum hCG of 46,458 mIU/mL. An endometrial biopsy was interpreted as CC. Recurrence developed in the uterus and lung after methotrexate-based chemotherapy. A mixed CC and ETT were eventually diagnosed upon consultation review. Patient #3 presented with a complete hydatidiform mole and serum hCG of 744,828 mIU/mL. Three months after methotrexate, followed by actinomycin D therapy, a uterine mass was found. Hysterectomy revealed a mixed CC and PSTT. In conclusion, the rarity, elusive presentation, and wide range of histology make the diagnosis of mixed trophoblastic tumors highly challenging. The clinical management and prognosis are dictated by each component of the tumor. CC component must be considered when the patient presents with a high serum hCG level.","PeriodicalId":14001,"journal":{"name":"International Journal of Gynecological Pathology","volume":" ","pages":"42-48"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human Papillomavirus-Associated Multiphenotypic Carcinoma: First Description of a Vulval Case. 人类乳头瘤病毒相关多型性癌：外阴病例的首次描述。

IF 1.6 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-01-01 Epub Date: 2024-04-09 DOI: 10.1097/PGP.0000000000001034

Charlotte C Currie, Darren Leaning, W Glenn McCluggage, Emma Spoor

{"title":"Human Papillomavirus-Associated Multiphenotypic Carcinoma: First Description of a Vulval Case.","authors":"Charlotte C Currie, Darren Leaning, W Glenn McCluggage, Emma Spoor","doi":"10.1097/PGP.0000000000001034","DOIUrl":"10.1097/PGP.0000000000001034","url":null,"abstract":"Human papillomavirus (HPV)-associated multiphenotypic sinonasal carcinoma is a rare and recently described epithelial neoplasm exhibiting myoepithelial differentiation and morphological overlap with salivary gland neoplasms, especially adenoid cystic carcinoma; it is commonly associated with HPV, especially type 33. It has mainly been reported in the nasal cavity and paranasal sinuses with a single case reported in the breast. Herein, we report the first vulval example in a 47-year-old patient who presented with a large craggy mass in the region of the Bartholin gland. The histologic features were of a high-grade carcinoma composed of basaloid cells arranged in sheets and nests, with occasional ductal formations, surrounded by densely hyalinised basement membrane-type material. There was diffuse block-type immunoreactivity with p16 and HPV genotyping revealed high-risk HPV type 16. In reporting this case, we highlight the propensity for \"salivary gland-type\" neoplasms to arise in the vulva, especially in the Bartholin gland, and stress that pathologists should consider salivary-type neoplasms when faced with a morphologically unusual vulval tumor.","PeriodicalId":14001,"journal":{"name":"International Journal of Gynecological Pathology","volume":" ","pages":"37-41"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140863855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Androgen Receptor Splice Variant 7 in Gynecologic Tumors. 妇科肿瘤中的新型雄激素受体剪接变异体 7

IF 1.6 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-01-01 Epub Date: 2024-05-29 DOI: 10.1097/PGP.0000000000001029

Lucy Wang, Varshini Vasudevaraja, Ivy Tran, Purvil Sukhadia, Victor E Reuter, Nadeem R Abu-Rustum, Maria M Rubinstein, Anuradha Gopalan, Dara Ross, Matija Snuderl, Sarah Chiang

{"title":"Novel Androgen Receptor Splice Variant 7 in Gynecologic Tumors.","authors":"Lucy Wang, Varshini Vasudevaraja, Ivy Tran, Purvil Sukhadia, Victor E Reuter, Nadeem R Abu-Rustum, Maria M Rubinstein, Anuradha Gopalan, Dara Ross, Matija Snuderl, Sarah Chiang","doi":"10.1097/PGP.0000000000001029","DOIUrl":"10.1097/PGP.0000000000001029","url":null,"abstract":"Androgen receptor splicing variant 7 (AR-V7) is a truncated variant of the AR mRNA that may be a predictive biomarker for AR-targeted therapy. AR-V7 has been described in prostate, breast, salivary duct, and hepatocellular carcinomas as well as mammary and extra-mammary Paget disease. We report 2 gynecologic cancers occurring in the lower uterine segment and ovary and both harboring AR-V7 by targeted RNA sequencing. The uterine tumor was an undifferentiated carcinoma consisting of epithelioid cells and focally spindled cells arranged in sheets, nests, and cords associated with brisk mitotic activity and tumor necrosis. The ovarian tumor consisted of glands with cribriform and solid architecture and uniform cytologic atypia. ER and PR were positive in the ovarian tumor and negative in the uterine tumor. Both were positive for AR and negative for HER2, GATA3, and NKX3.1. DNA methylation profiling showed epigenetic similarity of the AR-V7-positive gynecologic cancers to AR-V7-positive breast cancers rather than to prostate cancers. AR-V7 may underpin rare gynecologic carcinomas with undifferentiated histology or cribriform growth reminiscent of prostatic adenocarcinoma and breast invasive ductal carcinoma.","PeriodicalId":14001,"journal":{"name":"International Journal of Gynecological Pathology","volume":" ","pages":"88-93"},"PeriodicalIF":1.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141247990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

POLE-mutated Endometrial "Carcinosarcoma". POLE突变子宫内膜 "癌肉瘤

IF 1.6 4区医学

International Journal of Gynecological Pathology Pub Date : 2025-01-01 Epub Date: 2024-05-29 DOI: 10.1097/PGP.0000000000001039

Astrid De Boeck, Erik Nohr, Soufiane El-Hallani, Prafull Ghatage, Cheng Han Lee, Martin Köbel

引用次数: 0