Human Papillomavirus-Associated Multiphenotypic Carcinoma: First Description of a Vulval Case.

IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY
Charlotte C Currie, Darren Leaning, W Glenn McCluggage, Emma Spoor
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引用次数: 0

Abstract

Human papillomavirus (HPV)-associated multiphenotypic sinonasal carcinoma is a rare and recently described epithelial neoplasm exhibiting myoepithelial differentiation and morphological overlap with salivary gland neoplasms, especially adenoid cystic carcinoma; it is commonly associated with HPV, especially type 33. It has mainly been reported in the nasal cavity and paranasal sinuses with a single case reported in the breast. Herein, we report the first vulval example in a 47-year-old patient who presented with a large craggy mass in the region of the Bartholin gland. The histologic features were of a high-grade carcinoma composed of basaloid cells arranged in sheets and nests, with occasional ductal formations, surrounded by densely hyalinised basement membrane-type material. There was diffuse block-type immunoreactivity with p16 and HPV genotyping revealed high-risk HPV type 16. In reporting this case, we highlight the propensity for "salivary gland-type" neoplasms to arise in the vulva, especially in the Bartholin gland, and stress that pathologists should consider salivary-type neoplasms when faced with a morphologically unusual vulval tumor.

人类乳头瘤病毒相关多型性癌:外阴病例的首次描述。
人乳头状瘤病毒(HPV)相关多型鼻窦癌是一种罕见的上皮性肿瘤,最近才被描述出来,表现为肌上皮分化,形态上与唾液腺肿瘤重叠,尤其是腺样囊性癌;它通常与人乳头状瘤病毒(尤其是 33 型)相关。它主要发生在鼻腔和副鼻窦,乳房也有一例报道。在此,我们报告了第一例外阴癌,患者 47 岁,巴氏腺区域有一个巨大的峭壁状肿块。组织学特征为高级别癌,由成片和成巢排列的类基底细胞组成,偶有导管形成,周围为致密透明的基底膜样物质。p16呈弥漫块状免疫反应,HPV基因分型显示为高危HPV16型。在报告该病例时,我们强调了 "唾液腺型 "肿瘤在外阴,尤其是巴氏腺中出现的倾向,并强调病理学家在遇到形态异常的外阴肿瘤时应考虑唾液腺型肿瘤。
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来源期刊
CiteScore
3.90
自引率
12.50%
发文量
154
审稿时长
6-12 weeks
期刊介绍: International Journal of Gynecological Pathology is the official journal of the International Society of Gynecological Pathologists (ISGyP), and provides complete and timely coverage of advances in the understanding and management of gynecological disease. Emphasis is placed on investigations in the field of anatomic pathology. Articles devoted to experimental or animal pathology clearly relevant to an understanding of human disease are published, as are pathological and clinicopathological studies and individual case reports that offer new insights.
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