ACS Chemical Neuroscience最新文献

{"title":"","authors":"Anjian Yang, Xinyou Lv, Hongshuang Wang* and Xiaohui Wang*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"16 15","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":3.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.5c00509","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144778975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Yoshihisa Hirota, Taiki Sato, Rina Watanabe, Kazuki Takeda, Sho Sano, Satoshi Asano, Yuki Shibahashi, Yumi Yasuda, Yuta Takagi, Yutaro Yamashita, Wu YuXin, Mikino Arakawa, Yuri Maitani, Vannessa Lawai, Kurumi Nakagawa, Natsuko Furukawa, Atsuko Takeuchi, Chisato Tode, Maya Kamao, Akimori Wada, Zainab Ngaini and Yoshitomo Suhara*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"16 15","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":3.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.5c00111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144778962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"16 15","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":3.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/cnv016i015_1967771","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144778969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Demet Ataman Sadık*, Cemre Sare Cansız, Merve Turğut, Çağdaş Dağ and Memed Duman, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"16 15","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":3.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.5c00238","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144778974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Sharif Arar*, Md. Anzarul Haque, Anas Kayed, Sheeza Khan, Nemil Bhatt, Yingxin Zhao and Rakez Kayed*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"16 15","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":3.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.5c00122","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144778949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Rana Jahani, Sathishkumar Munusamy, Haiyan Zheng, Juanhua Kong, Jun Chen, Shuo Zhou and Xiyun Guan*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"16 15","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":3.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.5c00137","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144778952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Xue Wang, Fan Jun, Cong Lin* and Xiaohui Wang*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"16 15","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":3.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.5c00418","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144778972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Peng Wu, Chao Fu, Min Chen, Fanchan Wu, Wanyou He, Qichen Luo, Hanbing Wang* and Yalan Li*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"16 15","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":3.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.5c00214","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144778976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, Synthesis and Biological Evaluation of Chromeno[3,4-b]xanthones as Multifunctional Agents for Alzheimer’s Disease","authors":"Daniela Malafaia,&nbsp;Natércia F. Brás,&nbsp;Anna Sampietro,&nbsp;Inês Quintelas,&nbsp;Pedro Ferreira,&nbsp;Lúcia Melo,&nbsp;Joana Saavedra,&nbsp;Loreto Martinez-Gonzalez,&nbsp;Marisa Pereira,&nbsp;Jessica Sarabando,&nbsp;Leo König,&nbsp;Isabel Cardoso,&nbsp;Daniela Ribeiro,&nbsp;Ana R. Soares,&nbsp;Raimon Sabaté,&nbsp;Gert Fricker,&nbsp;Ana Martinez,&nbsp;Pedro A. Fernandes,&nbsp;Artur M. S. Silva and Hélio M. T. Albuquerque*,&nbsp;","doi":"10.1021/acschemneuro.5c00425","DOIUrl":"10.1021/acschemneuro.5c00425","url":null,"abstract":"<p >Alzheimer’s disease (AD) remains a complex and unmet medical challenge, requiring innovative approaches to address its multifaceted pathology. In this study, we explored chromeno[3,4-<i>b</i>]xanthones as a novel multifunctional scaffold, synthesized via the straightforward cyclization of their precursor, (<i>E</i>)-2-styrylchromones. Compounds <b>10</b> and <b>11q</b>–<b>s</b> exhibited potent and selective cholinesterase inhibition (IC₅₀ 1.7–9.0 μM for AChE and BChE), along with significant antiamyloid activity (inhibition exceeding 50% at 50 μM). Among them, compound <b>11r</b> demonstrated the most well-balanced multifunctional profile against all four AD-relevant targets. Molecular docking studies revealed key π-stacking, hydrogen bonding, and halogen interactions, which underlie the selective binding of compound <b>11r</b> to AChE and BChE. Moreover, docking and molecular dynamics simulations showed that compound <b>11r</b> binds strongly to the L-S-shaped β-amyloid 1–42 (Aβ₄₂) fibril with a binding affinity of −11.3 kcal/mol, representing a structural barrier to Aβ₄₂ elongation. Additionally, compound <b>11r</b>, selected as the representative scaffold, effectively disrupted Aβ aggregation, as demonstrated by <i>in vitro</i> studies, transmission electron microscopy (TEM), and cellular studies. It also displayed favorable drug-like properties, including predicted blood-brain barrier (BBB) permeability and an acceptable safety profile at active doses. The calcein-AM-assay also showed that this compound is unlikely to be actively effluxed from the brain. These findings underscore the therapeutic potential of chromeno[3,4-<i>b</i>]xanthone as multifunctional agents for AD, broadening the chemical space of small-molecule exploration.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"16 16","pages":"3184–3203"},"PeriodicalIF":3.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144792939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"Wenjing Li,&nbsp;Xiaochuan Zha,&nbsp;Xiaoyu Zhang,&nbsp;Haixin Dai,&nbsp;Suyun Pu,&nbsp;Xinya Yao,&nbsp;Wenxue Hui,&nbsp;Rui Xu,&nbsp;Junyu Bao,&nbsp;Jiahao Yu,&nbsp;Yan Wei,&nbsp;Jiawen Huang,&nbsp;Na Guo,&nbsp;Ming Xu,&nbsp;Jian Zhao*,&nbsp;Bingbing Cheng* and Zonghua Luo*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"16 15","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":3.9,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.5c00476","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144778960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}