ACS Chemical Neuroscience最新文献

{"title":"SERS-Encoded Nanoprobes Based on Silver-Coated Gold Nanorods for Cell Sorting","authors":"Kang Qi, Qiaowei Zhuang, Qingsong Zhou, Danying Lin, Liwei Liu, Junle Qu, Rui Hu","doi":"10.1002/smll.202405061","DOIUrl":"https://doi.org/10.1002/smll.202405061","url":null,"abstract":"Optically-encoded probes have great potential for applications in the fields of biosensing and imaging. By employing specific encoding methods, these probes enable the detection of multiple target molecules and high-resolution imaging within the same sample. Among the various encoding methods, surface-enhanced Raman scattering (SERS) spectral encoding stands out due to its extremely narrow linewidth. Compared to fluorescence spectral encoding, SERS encoding significantly reduces crosstalk between adjacent peaks, thereby achieving a larger encoding capacity and enabling multi-channel parallel analysis. This article presents the design and construction of two novel sets of SERS-encoded probes based on noble metal core–shell nanostructures. Two different encoding strategies are successfully applied to encode the SERS spectra of the probes: 1D encoding based on the wavenumber of characteristic peaks in the SERS spectrum, and 2D encoding combining both wavenumber and intensity of characteristic peaks in the SERS spectrum. In addition, this study also demonstrates the potential application of 1D encoded probes in cell sorting. These studies verify the feasibility of applying these two encoding methods to SERS core–shell probes and provide new insights into the construction of optically encoded probes.","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"72 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142599900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiological and pathological roles of the transcriptional kinases CDK12 and CDK13 in the central nervous system","authors":"Consuelo Pitolli, Alberto Marini, Claudio Sette, Vittoria Pagliarini","doi":"10.1038/s41418-024-01413-3","DOIUrl":"https://doi.org/10.1038/s41418-024-01413-3","url":null,"abstract":"<p>The cyclin-dependent kinases 12 (CDK12) and 13 (CDK13) govern several steps of gene expression, including transcription, RNA processing and translation. The main target of CDK12/13 is the serine 2 residue of the carboxy-terminal domain of RNA polymerase II (RNAPII), thus influencing the directionality, elongation rate and processivity of the enzyme. The CDK12/13-dependent regulation of RNAPII activity influences the expression of selected target genes with important functional roles in the proliferation and viability of all eukaryotic cells. Neuronal cells are particularly affected by the loss of CDK12/13, as result of the high dependency of neuronal genes on RNAPII processivity for their expression. Deregulation of CDK12/13 activity strongly affects brain physiology by influencing the stemness potential and differentiation properties of neuronal precursor cells. Moreover, mounting evidence also suggest the involvement of CDK12/13 in brain tumours. Herein, we discuss the functional role(s) of CDK12 and CDK13 in gene expression regulation and highlight similarities and differences between these highly homologous kinases, with particular attention to their impact on brain physiology and pathology. Lastly, we provide an overview of CDK12/13 inhibitors and of their efficacy in brain tumours and other neoplastic diseases.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"22 1","pages":""},"PeriodicalIF":12.4,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142600989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precise fabrication and superior combustion properties of n-B pomegranate microspheres based on a new dissolution-dispersion-coating method","authors":"Yushu Xiong, Baoxuan Li, Yinghong Wang, Linlin Liu, Jie Huang, Suhang Chen, Fengqi Zhao, Kangzhen Xu","doi":"10.1016/j.cej.2024.157624","DOIUrl":"https://doi.org/10.1016/j.cej.2024.157624","url":null,"abstract":"To enhance the reactivity and combustion efficacy of boron powders, a new dissolution-dispersion-coating (DDC) method of fabricating nano-boron (n-B) pomegranate microspheres were developed. Metal nanoparticles were uniformly encapsulated within n-B microspheres, which varied in size from 2 to 500 μm. The spheroidization mechanism of microsphere structure was investigated. Subsequently, the ignition and combustion performance of the prepared pomegranate microspheres were evaluated by combustion tests at 0.2 and 0.5 MPa, respectively. The results demonstrated that the n-B microspheres of F5 (75 wt% n-B@17 wt% NC@8 wt% n-Ti) exhibited superior performances, achieving the largest flame area, minimal ignition delay time and combustion time. The combustion thermal value and combustion residue analysis indicated that the content of available boron in the F5 microspheres exceeded 72.6 % and the combustion was complete. This study provides a novel approach to enhance the ignition and combustion efficiency of n-B powders.","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"72 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142601457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upcycling CO2 and bio-derived furan into degradable plastic monomer via coupling of photocatalysis and thermocatalysis","authors":"Qi Liu, Chengyang Li, Tingting Wang, Peng Sun, Jia Wang, Yongjie Xi, Guang Gao, Mengnan Nie, Li Huang, Guofeng Wang, Zelun Zhao, Zhiwei Huang, Fuwei Li","doi":"10.1016/j.cej.2024.157519","DOIUrl":"https://doi.org/10.1016/j.cej.2024.157519","url":null,"abstract":"Coupling of CO₂ with biomass-derived molecules into degradable plastic monomer provides a promising strategy to address the increasing problems of carbon recycle and carbon neutrality. Herein, we develop a sustainable route to produce 6-hydroxycaproate (6-HMC) by coupling photocatalytic carboxylation of biomass-derived furfuryl alcohol with CO₂ to 2-furanacetic acid (FA), and the thermocatalytic hydrogenolysis of methyl 2-tetrahydrofuranyl acetate (MTFA) derived from FA, wherein Pd/CeO₂ exhibit the highest productivity of 6-HMC (505 mmol_6-HMC mmol^-1_metal h⁻¹), much higher than its counterparts of precious- and non-precious-metal catalysts. Moreover, Pd/CeO₂ also presents good stability for 6 recycles without remarkable decrease in 6-HMC yield. Systematic experiments and computational studies suggest that higher concentration of oxygen vacancies and strong metal-support interactions account for enhanced catalytic performance of Pd/CeO₂. The work employs CO₂ and lignocellulosic-derived platform molecule as feedstocks to produce valuable degradable plastic monomer, providing a promising route to access pure-CO₂ originated high-carbon oxygen-containing compounds.","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"42 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142599574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interface-Engineered CuxO@Bi2MoO6 Heterojunctions to Inhibit Piezoelectric Screening Effect and Promote Double-Nanozyme Catalysis for Antibacterial Treatment","authors":"Guiyuan Zhang, Sumei He, Junwu Wei, Pan Ran, Huan Zheng, Long He, Xiaohong Li","doi":"10.1002/smll.202407281","DOIUrl":"https://doi.org/10.1002/smll.202407281","url":null,"abstract":"Sonodynamic therapy is confronted with the low acoustic efficiency of sonosensitizers, and nanozymes are accompanied by intrinsic low catalytic activity. Herein, to increase the piezopotential of N-type piezoelectric semiconductors, the P-N heterojunction is designed to inhibit the piezoelectric screening effect (PSE) and increase electron utilization efficiency to enhance nanozyme activity. P-type Cu_xO nanoparticles are in situ grown on N-type piezoelectric Bi₂MoO₆ (BMO) nanoflakes (NFs) to construct heterostructured Cu_xO@BMO by interface engineering. Cu_xO deposition leads to lattice distortion of BMO NFs to improve piezoelectric response, and the strong interface electric field (IEF) suppresses PSE and increases piezopotential. The nonlocal piezopotential, local IEF, and glutathione (GSH) inoculation enhances electron−hole separation and increases peroxidase (POD)-like activity of BMO and GSH oxidase (GSHOx)-like activity of Cu_xO with high selectivity. The heterojunction formation causes the transfer and rearrangement of interface electrons, and the increased piezopotential accelerates electron transfer at interfaces with bacteria, thus increasing the production of reactive oxidative species and interfering with adenosine triphosphate synthesis. The heterostructured nanozymes produce abundant intracellular ·OH and achieve 4log magnitude reductions in viable bacteria and effective biofilm dispersion. This study elucidates integral mechanisms of nanozyme and acoustic catalysis and opens up a new way to synergize high piezopotential and nanozyme-catalyzed therapy.","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"36 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142601551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AMn2O4 (A = Ni, Co, Cu) oxygen carrier chemical looping reforming of benzene: Migration pathways of reactive oxygen species by experimental and DFT investigations","authors":"Heng Chen, Junguang Meng, Zhiyuan Liu, Xinye Wang, Yuan Sun, Changsheng Bu, Jubing Zhang, Changqi Liu, Xi Cao, Hao Xie","doi":"10.1016/j.cej.2024.157609","DOIUrl":"https://doi.org/10.1016/j.cej.2024.157609","url":null,"abstract":"Chemical looping reforming (CLR) provides a novel solution for clean and efficient utilization of biomass tar. The versatility of oxygen carrier (OC) is essential for improving reforming efficiency. The properties of Mn-based spinel OCs (AMn₂O₄, A = Ni, Co, Cu) were investigated in the CLR process using benzene as a tar model compound. Detailed characterization and experimental results demonstrate the excellent structural stability of Mn-based spinel. The NiMn₂O₄ showed the most prominent reforming effect on benzene with the highest conversion of 95.77 % at 850 °C, S/C = 1.0, and WHSV = 3.0 h⁻¹. After 40 cycles, NiMn₂O₄ and CoMn₂O₄ maintained significant catalytic activity for benzene reforming, achieving conversions of 92.96 % and 90.07 %, respectively, in the final cycle. Density functional theory (DFT) calculations demonstrate that the addition of H₂O increases the activity of NiMn₂O₄. Compared to benzene adsorption alone, the adsorption energy decreased from −2.20 eV to −2.54 eV after the addition of H₂O. The migration path of NiMn₂O₄ (100) reactive oxygen species in the presence or absence of H₂O is directly demonstrated. In the absence of H₂O, the activation energy barrier for direct oxidation of C₆H₅* by NiMn₂O₄ lattice oxygen is dominant (0.98 eV), but OH* produced by dissociation of H₂O exhibits high activity, and oxidation of C₆H₅* to produce the key intermediate product C₆H₅O* has an activation energy barrier of only 0.35 eV. In addition, H₂O has a predominant role in the replenishment of oxygen vacancies. The elucidation of the oxygen migration mechanism provides new guidance for the design of efficient OCs for catalytic oxidation.","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"18 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142599553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-Reconstructed Amorphous CoOx/NiCoB Heterostructure Catalysts for Enhanced HER Performance","authors":"Bowen Lu, Wei Wang, Jian Huang, Haohao Gao, Suhui Chen, Haiwei Xu, Zile Hua, Jianlin Shi","doi":"10.1002/smll.202408571","DOIUrl":"https://doi.org/10.1002/smll.202408571","url":null,"abstract":"Amorphous electrocatalysts exhibit potentials as precursors for triggering the in situ reconstruction to generate the real catalytic active species toward electrochemical processes. In this work, a new kind of amorphous Ni-Co-B alloy pre-catalysts for hydrogen evolution reaction (HER) is reported, which is obtained via a facile electroless plating strategy on the nickel foam (NF). Interestingly, X-ray photoelectron spectroscopy, X-ray absorption spectroscopy and morphological characterizations identify the in situ reconstruction process during HER accompanied by the preferential leaching of surface B species and the formation of amorphous CoO_x nanosheet arrays as the real active sites. Benefiting from the synergistic effect between the surface CoO_x layer and the inner unaltered NiCoB phase, the resultant CoO_x/NiCoB heterostructure catalyst achieves a low overpotential of 209 mV at the elevated current density of 500 mA cm⁻² and maintains stability for 300 h without significant attenuation. Theoretical calculation reveals the electron reconfiguration at the interfaces between the newly formed CoO_x and inner NiCoB phases, which is favorable for the stabilization of reconstructed active oxide layers at the reductive potentials for catalyzing HER. Moreover, the CoO_x/NiCoB heterostructure optimizes hydrogen adsorption free energies, thereby enhancing HER catalytic activity.","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"25 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142599902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Turning properties of Ni/Al2O3 catalyst to improve catalytic ammonia decomposition for green hydrogen production: pH does matter!","authors":"Quoc Cuong Do, Youngmin Kim, Geo Jong Kim, Younghwan Im, Thien An Le, Gye Hong Kim, Kyoung Chul Ko, Ho-Jeong Chae","doi":"10.1016/j.cej.2024.157605","DOIUrl":"https://doi.org/10.1016/j.cej.2024.157605","url":null,"abstract":"In this study, the influence of solution pH (6.0–12.5) of the cation–anion double hydrolysis (CADH) method in the formation of Ni/Al₂O₃ catalyst and its catalytic performance for green hydrogen production NH₃ decomposition was studied for the first time. The physicochemical properties of the prepared catalysts were systematically characterized by various analysis techniques. The results indicated that pH conditions significantly influenced both the structural properties and catalytic activity of the derived Ni/Al₂O₃ catalysts. The better catalytic activity for NH₃ decomposition over catalysts prepared under high pH conditions (pH ≥ 10.0) is mainly due to the appropriate synergic effect of the interaction between Ni and Al₂O₃ support, large active Ni surface area, and suitable porosity, particle size, and basicity of the catalyst. The correlation analysis and density functional theory (DFT) calculations confirm that the percentage of surface metallic Ni plays a crucial role in controlling the catalytic activity of Ni/Al₂O₃ catalysts. The 40Ni/Al₂O₃ catalyst (Ni = 40 wt%) could achieve over 94.5 % NH₃ conversion under the harsh reaction conditions of 600 °C and NH₃ WHSV of 54000 mL/g_cat./h, and that stably maintained for 200 h without any obvious deactivation. Overall, our work not only highlights the critical role of pH conditions in the CADH solution for cost-effective Ni/Al₂O₃ catalyst preparation but also proposes a promising strategy for developing a highly active, stable, and Ru-free catalyst for practical hydrogen production via NH₃ decomposition.","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"31 1","pages":""},"PeriodicalIF":15.1,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142601494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific topological structure associated with dementia via latent space estimation","authors":"Selena Wang, Yiting Wang, Frederick H. Xu, Xinyuan Tian, Carolyn A. Fredericks, Li Shen, Yize Zhao","doi":"10.1002/alz.14266","DOIUrl":"https://doi.org/10.1002/alz.14266","url":null,"abstract":"We investigate sex-specific topological structures associated with typical Alzheimer's disease (AD) dementia using a novel state-of-the-art latent space estimation technique.","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"7 1","pages":""},"PeriodicalIF":14.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142599914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Cancer Vaccines with Radionuclide Imaging","authors":"Sixuan Cheng, Xingru Long, Yongxue Zhang, Xiaoli Lan, Dawei Jiang","doi":"10.1002/smll.202406950","DOIUrl":"https://doi.org/10.1002/smll.202406950","url":null,"abstract":"Cancer vaccines are emerged as a beacon of hope in the fight against cancer. However, the lack of effective methods to directly observe their in vivo behavior and monitor therapeutic responses hinders their translation into clinical settings. Radionuclide imaging allows for non-invasive and real-time visualization of vaccine biodistribution and immunological response, offering valuable insights into the effectiveness of cancer vaccines and aiding in patient stratification. In this review, the latest advances and potential applications of radionuclide imaging in cancer vaccines are discussed, with a specific focus on strategies for visualizing the spatiotemporal distribution of vaccines in vivo and monitoring treatment efficacy. The challenges and considerations for implementing these techniques in clinical practice are also highlighted, aiming to inform and guide future research in this field.","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"23 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142599932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}