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ACS Chemical Neuroscience最新文献

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IF 4.1 3区 医学
ACS Chemical Neuroscience Pub Date : 2025-06-18
Kalpana Pandya, Krishnashish Roul, Avanish Tripathi, Sateesh Belemkar, Anshuman Sinha, Meryem Erol and Devendra Kumar*, 
{"title":"","authors":"Kalpana Pandya, Krishnashish Roul, Avanish Tripathi, Sateesh Belemkar, Anshuman Sinha, Meryem Erol and Devendra Kumar*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"16 12","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.1,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.5c00207","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144422848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 4.1 3区 医学
ACS Chemical Neuroscience Pub Date : 2025-06-18
Hashini R. Eheliyagoda,  and , H. Peter Lu*, 
{"title":"","authors":"Hashini R. Eheliyagoda,  and , H. Peter Lu*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"16 12","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.1,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.5c00088","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144422850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 4.1 3区 医学
ACS Chemical Neuroscience Pub Date : 2025-06-18
Anna Czopek*, Jakub Jończyk, Monika Fryc, Daria Kluzik and Agnieszka Zagórska*, 
{"title":"","authors":"Anna Czopek*, Jakub Jończyk, Monika Fryc, Daria Kluzik and Agnieszka Zagórska*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"16 12","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.1,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.5c00152","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144422841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 4.1 3区 医学
ACS Chemical Neuroscience Pub Date : 2025-06-18
Barbara Mordyl, Katarzyna Szafrańska, Joanna Sniecikowska, Jakub Jonczyk, Bartłomiej Bieńko, Maria Mateos-Jimenez, Bartosz Wojdyła, Beata Gryzło, Monika Głuch-Lutwin, Agata Siwek, Tadeusz Karcz, Karolina Słoczyńska, Elżbieta Pękala, Alicja Zakrzewska-Sito, Pawel Mierzejewski, Marcin Kołaczkowski and Monika Marcinkowska*, 
{"title":"","authors":"Barbara Mordyl, Katarzyna Szafrańska, Joanna Sniecikowska, Jakub Jonczyk, Bartłomiej Bieńko, Maria Mateos-Jimenez, Bartosz Wojdyła, Beata Gryzło, Monika Głuch-Lutwin, Agata Siwek, Tadeusz Karcz, Karolina Słoczyńska, Elżbieta Pękala, Alicja Zakrzewska-Sito, Pawel Mierzejewski, Marcin Kołaczkowski and Monika Marcinkowska*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"16 12","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.1,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.5c00098","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144422842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting GABAergic Hypofunction Associated with Schizophrenia: Identification of α1β2γ2GABA-A Receptor Ligands with Neuroprotective and Antipsychotic Properties. 靶向与精神分裂症相关的gaba能功能减退：具有神经保护和抗精神病特性的α1β2γ 2gaba受体配体的鉴定
IF 4.1 3区 医学
ACS Chemical Neuroscience Pub Date : 2025-06-18 Epub Date: 2025-06-06 DOI: 10.1021/acschemneuro.5c00098
Barbara Mordyl, Katarzyna Szafrańska, Joanna Sniecikowska, Jakub Jonczyk, Bartłomiej Bieńko, Maria Mateos-Jimenez, Bartosz Wojdyła, Beata Gryzło, Monika Głuch-Lutwin, Agata Siwek, Tadeusz Karcz, Karolina Słoczyńska, Elżbieta Pękala, Alicja Zakrzewska-Sito, Pawel Mierzejewski, Marcin Kołaczkowski, Monika Marcinkowska
{"title":"Targeting GABAergic Hypofunction Associated with Schizophrenia: Identification of α1β2γ2GABA-A Receptor Ligands with Neuroprotective and Antipsychotic Properties.","authors":"Barbara Mordyl, Katarzyna Szafrańska, Joanna Sniecikowska, Jakub Jonczyk, Bartłomiej Bieńko, Maria Mateos-Jimenez, Bartosz Wojdyła, Beata Gryzło, Monika Głuch-Lutwin, Agata Siwek, Tadeusz Karcz, Karolina Słoczyńska, Elżbieta Pękala, Alicja Zakrzewska-Sito, Pawel Mierzejewski, Marcin Kołaczkowski, Monika Marcinkowska","doi":"10.1021/acschemneuro.5c00098","DOIUrl":"10.1021/acschemneuro.5c00098","url":null,"abstract":"<p><p>Clinical evidence has demonstrated significant hypofunction of GABAergic neurotransmission in patients with schizophrenia, likely contributing to the onset of psychotic symptoms. These symptoms can be alleviated by α1β2γ2GABA-A receptor ligands, which have previously shown antipsychotic activity. Building on this foundation, we synthesized and characterized various derivatives of 2-phenylimidazo[1,2-<i>a</i>]-pyridine containing cyclic amine moieties at the amide backbone to identify potent ligands and expand the chemical space of α1β2γ2GABA-A receptor ligands. The synthesized compounds exhibited <i>K</i><sub>i</sub> values ranging from 25.0 to 7822.5 nM and positive allosteric properties at α1β2γ2GABA-A receptors. Selected compounds exhibited promising cellular permeability properties, high metabolic stability, and neuroprotective activity. A representative derivative of this series elicited antipsychotic-like properties, reversing amphetamine- and MK-801-induced hyperlocomotion without inducing sedative effects. Our findings indicate that α1β2γ2GABA-A ligands represent a promising strategy for the identification of potential antipsychotic agents with an original mechanism of action.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":" ","pages":"2277-2294"},"PeriodicalIF":4.1,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12186843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 4.1 3区 医学
ACS Chemical Neuroscience Pub Date : 2025-06-18
Yaqiong Li, Junkui Shang, Huiwen Zhang, Yaru Lu, Ying Zhao, Yadan Wang, Xi Yan* and Jiewen Zhang*, 
{"title":"","authors":"Yaqiong Li,&nbsp;Junkui Shang,&nbsp;Huiwen Zhang,&nbsp;Yaru Lu,&nbsp;Ying Zhao,&nbsp;Yadan Wang,&nbsp;Xi Yan* and Jiewen Zhang*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"16 12","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.1,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.4c00826","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144422852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 4.1 3区 医学
ACS Chemical Neuroscience Pub Date : 2025-06-18
Yilin Wu, Chujun Duan, Niqi Shan, Yuling Wang, Shanshou Liu, Linxiao Wang, Yangmengjie Jing, Hanyin Fan, Jinyue Yang, Yuan Zhang, Lin Liu* and Ran Zhuang*, 
{"title":"","authors":"Yilin Wu,&nbsp;Chujun Duan,&nbsp;Niqi Shan,&nbsp;Yuling Wang,&nbsp;Shanshou Liu,&nbsp;Linxiao Wang,&nbsp;Yangmengjie Jing,&nbsp;Hanyin Fan,&nbsp;Jinyue Yang,&nbsp;Yuan Zhang,&nbsp;Lin Liu* and Ran Zhuang*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"16 12","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.1,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.5c00271","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144422845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 4.1 3区 医学
ACS Chemical Neuroscience Pub Date : 2025-06-18
Alexander Shimkevich*, 
{"title":"","authors":"Alexander Shimkevich*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"16 12","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.1,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acschemneuro.4c00859","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144422849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 4.1 3区 医学
ACS Chemical Neuroscience Pub Date : 2025-06-18
{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":"16 12","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":4.1,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/cnv016i012_1948817","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144422851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Classic Psychedelics in Pain Modulation: Mechanisms, Clinical Evidence, and Future Perspectives. 经典致幻剂在疼痛调节中的作用：机制、临床证据和未来展望。
IF 4.1 3区 医学
ACS Chemical Neuroscience Pub Date : 2025-06-18 Epub Date: 2025-06-06 DOI: 10.1021/acschemneuro.5c00152
Anna Czopek, Jakub Jończyk, Monika Fryc, Daria Kluzik, Agnieszka Zagórska
{"title":"Classic Psychedelics in Pain Modulation: Mechanisms, Clinical Evidence, and Future Perspectives.","authors":"Anna Czopek, Jakub Jończyk, Monika Fryc, Daria Kluzik, Agnieszka Zagórska","doi":"10.1021/acschemneuro.5c00152","DOIUrl":"10.1021/acschemneuro.5c00152","url":null,"abstract":"<p><p>Millions worldwide suffer from chronic pain, a complex condition often accompanied by depression and anxiety, highlighting the urgent need for innovative treatments. Classic psychedelics, including psilocybin, lysergic acid diethylamide (LSD), and <i>N</i>,<i>N</i>-dimethyltryptamine (DMT), primarily act on serotonin 5-HT<sub>2A</sub> receptors and have emerged as potential modulators of pain perception and mood regulation. These substances may offer an alternative to conventional analgesics, such as opioids and nonsteroidal anti-inflammatory drugs (NSAIDs), by influencing neuroplasticity, descending pain modulation pathways, and inflammatory processes. Evidence from case studies, preclinical research, and early phase clinical trials suggests that psychedelics may alleviate pain in conditions such as cluster headaches, migraines, fibromyalgia, and chronic pain syndromes. However, the exact mechanisms underlying their analgesic properties are yet to be fully understood. While psychedelics show promise in reshaping pain management strategies, rigorous randomized controlled trials are needed to establish their safety, efficacy, and optimal dosing. This review highlights the therapeutic potential of psychedelics for chronic pain and emphasizes the necessity of further research to validate their role in modern pain medicine.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":" ","pages":"2163-2177"},"PeriodicalIF":4.1,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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