International Journal of Dentistry最新文献

{"title":"Assessment of the Antimicrobial Properties of Mesoporous Zinc Oxide Nanoparticles Against <i>Streptococcus mutans</i>: An In Vitro Investigation.","authors":"Zahra Jowkar, Shima Askarzadeh, Seyed Ahmadreza Hamidi, Zahra Fattah, Ali Moaddeli","doi":"10.1155/ijod/4438269","DOIUrl":"10.1155/ijod/4438269","url":null,"abstract":"<p><p><b>Background:</b> This study focused on synthesizing and characterizing mesoporous zinc oxide nanoparticles (ZnO NPs) while evaluating their antibacterial effectiveness against <i>Streptococcus mutans</i>. Their antimicrobial properties were compared to conventional ZnO NPs using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests. <b>Methods:</b> Mesoporous ZnO NPs were produced and analyzed for structural properties. Their antibacterial potential was assessed through MIC and MBC determinations, along with inhibition zone measurements. The test groups included calcined and noncalcined mesoporous ZnO NP solutions (10 mg/mL), standard ZnO NP solution (10 mg/mL), normal saline, and chlorhexidine (CHX) solution (2 mg/mL). <b>Results:</b> All ZnO NP solutions exhibited an MIC of 5 mg/mL, with lower concentrations (2.5 mg/mL and below) showing no inhibition against <i>S. mutans</i>. The MIC for CHX (2 mg/mL) was found to be 0.156 mg/mL. MBC values matched MIC results for all NP solutions (5 mg/mL), whereas CHX had an MBC of 0.312 mg/mL. Among the tested solutions, the calcined mesoporous ZnO NP solution produced the largest inhibition zone (19 ± 0.02 mm), followed by the noncalcined version (17.2 ± 0.03 mm). CHX (14.9 ± 0.02 mm) and ZnO NP solution (15.2 ± 0.13 mm) showed similar inhibitory effects. <b>Conclusion:</b> The study suggests that mesoporous ZnO NP solution possesses strong antibacterial properties against <i>S. mutans</i>, offering a promising alternative to CHX, which is widely used in dental disinfection. These findings highlight the potential application of mesoporous ZnO NPs in various dental procedures, including endodontics, restorative treatments, and periodontal therapy.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2025 ","pages":"4438269"},"PeriodicalIF":1.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Genetic Polymorphisms of <i>IL33</i> and <i>IL1RL1</i> Genes on the Immunopathogenesis of Periodontitis.","authors":"Aléia Harumi Uchibaba Yamanaka, Josiane Bazzo de Alencar, Victor Hugo de Souza, Joana Maiara Valentini Zacarias, Larissa Danielle Bahls-Pinto, Cléverson O Silva, Ana Maria Sell, Quirino Alves de Lima Neto","doi":"10.1155/ijod/7599713","DOIUrl":"https://doi.org/10.1155/ijod/7599713","url":null,"abstract":"<p><p>Periodontitis (PD) is an inflammatory disease that affects the protective and supporting tissues of teeth. Mutations in cytokines and their receptors may influence the immunopathogenesis of PD, but the role of interleukin-33 (IL-33) and IL1RL1 is not clear. Thus, this study aimed to analyze the polymorphisms in <i>IL33</i> (rs1929992 and rs7025417) and <i>IL1RL1</i> (rs11685424 and rs3821204) genes and the IL-33 serum levels in PD patients. A case-control study was performed with 186 PD patients and 189 controls. Genotyping was performed by polymerase chain reaction using sequence-specific primer (PCR-SSP) technique. Serum levels of IL-33 were determined using the immunoenzymatic method. Statistical analyses were performed using SNPStats and OpenEpi. <i>p</i> > 0.05 was considered statistically significant. The <i>IL33</i> rs7025417 C/C genotype was a risk factor for PD in nonsmokers (<i>p</i>=0.0015) regardless of smoking status and gender. In the general population, the <i>IL1RL1</i> rs3821204 G/G genotype was protective for PD (<i>p</i>=0.006), regardless of gender. Nevertheless, the IL-33 serum levels were increased in patients compared to controls (<i>p</i> < 0.0001); however, no difference was observed among PD patients. The polymorphisms <i>IL33</i> rs7025417 and <i>IL1RL1</i> rs3821204 were associated with risk and protection, respectively, and the production of IL-33 was higher in PD patients than in controls, independent of the extent or severity of the disease.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2025 ","pages":"7599713"},"PeriodicalIF":1.9,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12064316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment Strategies for Peri-Implant Mucositis: The Final Stop for Preventing Peri-Implantitis.","authors":"Rafael Pereira, Hamoun Sabri, Paolo Nava, Abdusalam Alrmali, Hom-Lay Wang","doi":"10.1155/ijod/6901156","DOIUrl":"https://doi.org/10.1155/ijod/6901156","url":null,"abstract":"<p><p><b>Objectives:</b> This article aims to provide a comprehensive overview of peri-implant mucositis, covering its etiology, risk factors, clinical features, diagnosis, and available treatment modalities. <b>Methods:</b> A comprehensive electronic and manual search was performed on electronic databases. Studies with focus on peri-implant mucositis were included and reviewed comprehensively. Based on the latest evidence, decisional workflows and clinical recommendations were proposed. <b>Results:</b> The review highlights the multifactorial etiology of peri-implant mucositis, primarily driven by bacterial biofilm accumulation. Key risk factors identified include poor oral hygiene, smoking, uncontrolled diabetes, and local factors such as implant surface characteristics and prosthesis design. Diagnostic criteria are based on the presence of clinical signs (inflammation, redness, swelling, and bleeding on probing (BoP)) and the absence of radiographic bone changes. Nonsurgical treatments, including mechanical debridement and photodynamic therapy (PDT), have shown effectiveness in managing the condition. However, the efficacy of adjunctive therapies remains inconclusive. Regular maintenance and optimal oral hygiene are critical in preventing and managing peri-implant mucositis. <b>Conclusion:</b> Peri-implant mucositis remains a prevalent condition in implant dentistry, with nonsurgical treatment strategies showing promising outcomes in disease management. Further research is needed to establish the long-term effectiveness of adjunctive therapies and optimize preventive strategies for maintaining peri-implant health.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2025 ","pages":"6901156"},"PeriodicalIF":1.9,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flexural Strength and Stress Analysis of CAD-CAM Milled Glass Fiber Post and Core.","authors":"Sergio Eduardo Ramos Dos Santos, Klíssia Romero Felizardo, Ricardo Danil Guiraldo, Sandrine Bittencourt Berger, Murilo Baena Lopes","doi":"10.1155/ijod/6298753","DOIUrl":"https://doi.org/10.1155/ijod/6298753","url":null,"abstract":"<p><p>Intraradicular posts have the potential to induce mechanical stresses within the root structure during masticatory activities, hence contributing to fatigue and ultimately resulting in the fracture of the remaining dental structure. The objective of this work was to compare the stress pattern generated on the root by a computer-aided design and computer-aided manufacturing (CAD-CAM) milled fiberglass post under occlusal load in a photoelastic simulation and to compare its flexural strength (FS) to other types of posts. A total of 15 simulated roots, produced from photoelastic resins, were created using human canine teeth. These specimens were then separated into three distinct groups: Fiber post conventional, which consisted of fiberglass posts; fiber post customizable, which involved prefabricated fiberglass posts anatomized with composite resin; and fiber post CAD-CAM, which utilized CAD-CAM milled fiberglass posts. Following the application of Relyx ARC cement, the posts underwent photoelastic testing using a polariscope and FS testing using a universal testing machine. The data were submitted to analysis of variance (ANOVA) and Tukey's test at 5% significance level. It was found that the stress was significantly greater (<i>p</i> < 0.05) for the customizable post (246.5 MPa ± 218.7) in comparison to both the conventional (135.8 MPa ± 99.3) and CAD-CAM (136.5 MPa ± 68.4) posts; the latter group exhibited the lowest flexural values (50.8 MPa ± 7.9), which were significantly different from both the conventional group (123.0 MPa ± 26.9) and the customized group (230.3 MPa ± 18.9), which also differed from each other. The modulus of elasticity showed statistical differences (<i>p</i>  < 0.05) among the three different methods: CAD-CAM (0.50 GPa ± 0.06), conventional (1.75 GPa ± 0.13), and custom (3.46 GPa ± 0.19). The FS and elasticity modulus of customized posts were significantly higher than those of CAD-CAM, that exhibited the lowest values. Intermediate values were demonstrated by conventional posts. In comparison, to the customized post, the stress study revealed that conventional and CAD-CAM posts had a lower stress in the apical area and a lower general root stress value; but the cervical stress from CAD-CAM posts were practically twice of conventional and customized posts.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2025 ","pages":"6298753"},"PeriodicalIF":1.9,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12049247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital Occlusion Tracking by T-Scan Novus System in Bruxism Patients Treated With 3D Printed Occlusal Splints.","authors":"Dobromira Shopova","doi":"10.1155/ijod/8842498","DOIUrl":"https://doi.org/10.1155/ijod/8842498","url":null,"abstract":"<p><p><b>Background:</b> Bruxism is a chronic pathological condition with significant clinical implications, necessitating meticulous monitoring for comprehensive treatment. The primary aim of this study was to conduct a digital measurement-based comparative analysis of occlusal alterations in occlusal splints over a 3-month period. <b>Methods:</b> This investigation involved 32 patients with natural dentition, fixed dental restorations, implant treatments, and a minimum of second molars. Intraoral scanning was executed using the 3DISK OVO imaging system. Digital models generated from these scans were employed to design occlusal splints using the 3Shape design software in conjunction with its splint studio module. The splints were subsequently fabricated using 3D printing technology and a biocompatible resin, Ortho Rigid (Nextdent). The assessment of occlusion was carried out using the T-Scan Novus system (Tekscan, 2018) and subjected to analysis with licensed software version 10.0.40 (T-Scan 10). Student's <i>t</i>-test for independent samples and a paired-sample <i>t</i>-test were used to detect the statistically significant difference in the distribution of occlusal force. <b>Results:</b> Initial digital occlusal measurements revealed statistically significant disparities in two specific regions between male and female subjects-the right first molar (<i>t</i>(31) = 2.04, <i>p</i> < 0.05) and left second molar (<i>t</i>(31) = 1.95, <i>p</i> < 0.05). Following a 3-month follow-up, significant differences in occlusal splint wear were discerned among male subjects (<i>p</i> < 0.01), whereas such differences were not observed among female subjects (<i>p</i> > 0.01). <b>Conclusion:</b> The digital design of occlusal splints facilitates the development of uniform contact areas across the entire occlusal surface. Nonetheless, the examination with T-Scan Novus unveiled that uniformity in contact area does not necessarily correspond to uniformity in force distribution.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2025 ","pages":"8842498"},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the Cytoprotective Effect of <i>Morus alba L</i>. Fruits as a Means of Transporting the Avulsed Teeth.","authors":"Mihaela Chirilă, Ioana Suciu, Ecaterina Ionescu, Ionela Daniela Popescu, Eleonora Codorean, Elena Codrici, Lucian Chirilă, Oana Amza, Bogdan Dimitriu, Cornelia Nichita","doi":"10.1155/ijod/6661398","DOIUrl":"https://doi.org/10.1155/ijod/6661398","url":null,"abstract":"<p><p>This study aims to test the cytoprotective effect of <i>Morus alba</i> L. fruit extracts on cell viability and its suitability as a transport medium for avulsed teeth. <b>Materials and Methods</b>. Two <i>Morus alba</i> L. fruit extracts were synthesized, E1 and E2. The E1 extract was composed of fresh mulberry fruits, whereas the E2 extract was made from dehydrated fruits. The cytoprotective effect of the E1 and E2 extracts was determined using MTS testing over 5000 and 10,000 cells, after a 48 h incubation period, and sampling times of 1 h and 3 h. The concentrations tested were 50 μg/mL (E1A and E2A), 150 μg/mL (E1B and E2B), and 250 μg/mL (E1C and E2C). The data was analyzed using the one-way analysis of variance (ANOVA) test (<i>p</i> < 0.05) and post hoc LSD (least significant difference) analysis (<i>p</i> < 0.1). <b>Results.</b> The post hoc LSD analysis based on the concentration of the E1 extract showed statistically differences (<i>p</i> < 0.1), and for the E2 extract, the results were highly significant (<i>p</i> = 0.011). As a function of concentration between the populations, there are significant differences between E1A and E1B (<i>p</i> = 0.071) and between E1B and E1C (<i>p</i> = 0.084), and statistically insignificant differences between E1A and E1C (<i>p</i> = 0.919). Significant differences were also detected between the E2A and E2B extracts (<i>p</i> = 0.047) and between E2B and E2C (<i>p</i> = 0.004). <b>Conclusions</b>. Analyzing the preliminary results of our study, we can conclude that the <i>M. alba</i> L. extract can be considered a potential transport medium for avulsed teeth.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2025 ","pages":"6661398"},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Assessment of the Fenestration, Dehiscence Frequency and Facial Bone Thickness in the Maxillary Anterior Region of Smokers Versus Non-Smokers: A Cross-Sectional Study.","authors":"Ferena Sayar, Amirhossein Farahmand, Bahar Ebrahimi Kordasiabi, Ladan Hafezi, Mahsa Soleimani","doi":"10.1155/ijod/9783707","DOIUrl":"https://doi.org/10.1155/ijod/9783707","url":null,"abstract":"<p><p><b>Aim:</b> To investigate the presence of fenestration and dehiscence. In addition, the thickness of the facial bone in the anterior region of the maxillary anterior teeth was measured using C.B.C.T. scans in both smokers and non-smokers. <b>Materials and Methods:</b> The study used 300 C.B.C.T. Scans of patients with intact maxillary anterior teeth to assess the presence of bone defects in the fenestration and dehiscence areas. In addition, the thickness of the facial bone in the anterior region of the maxilla was measured in both smokers and non-smokers. <b>Results:</b> The study included 300 participants free of systemic or periodontal diseases. The subjects were divided into smokers (49.33%) and non-smokers (50.66%). The results showed that female smokers most frequently had fenestrations in the right premolar and left canine areas, with a majority rate of 1.57%. However, dehiscence was most common in male smokers, with the left premolar area being the most common with a frequency of 3.43%. <b>Conclusion:</b> The study found that smoking reduced the thickness of the labial bone in the anterior maxillary regions. In addition, female smokers had a higher frequency of fenestrations in the right premolar and left canine regions, and on average, smoking patients had the highest rate of dehiscence in the left premolar-maxillary region.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2025 ","pages":"9783707"},"PeriodicalIF":1.9,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12033065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Masticatory Efficiency of Thermoplastic Versus Conventional Acrylic Resin Mandibular Implant Overdenture With Bar/Clip Attachment.","authors":"Hamada Z Mahross Atia, Ehab M Atito, Mamdouh M Mansour, Mohamed S Osman, Wesam E Badr, Mohamed A Quassem","doi":"10.1155/ijod/4212059","DOIUrl":"https://doi.org/10.1155/ijod/4212059","url":null,"abstract":"<p><p><b>Objectives:</b> To evaluate the effects of different base materials of mandibular implant-supported overdenture with bar/clip attachment on masticatory efficiency. <b>Materials and Methods:</b> Twenty-four edentulous patients were selected to place two interforaminal mandibular implants with custom-made cast bars to retain overdentures made from two different base materials and divided into two groups: Group I was the patients with heat-cured acrylic resin overdentures, and Group II was the patients with thermoplastic base overdentures. Masticatory efficiency was tested using three food categories (carrots, bananas, and apples) and measured by four parameters. One-way analysis of variance (ANOVA) with a post hoc Tukey test was used at the chosen probability level <i>p</i> < 0.05. <b>Results:</b> Group II was more efficient than Group I with the carrots as the difference was statistically significant for two parameters: the number of chewing strokes until the mouth was free of food with <i>p</i>=0.018 and the number of swallows it takes for the mouth to be empty of food <i>p</i> ≤ 0.001. With apples, the significance was related to two parameters: how many chews there were before the first swallow <i>p</i>=0.053 and the number of swallows until the mouth was empty of food <i>p</i> ≤ 0.001. With bananas, the significance is related to two parameters, the number of swallows until the mouth was free of food with <i>p</i> ≤ 0.001 and the time in seconds until the mouth was free from food <i>p</i>=0.037. <b>Conclusions:</b> The overdentures made with the thermoplastic base material and supported with bar/clip attachments were more masticatory efficient than patients whose overdentures were made of the traditional acrylic resin. <b>Trial Registration:</b> This clinical study presentation has been registered and publicly figured at clinical trial.gov PRS for protocol registration and results system under ID NCT05877092 University and conducted following the CONSORT checklist.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2025 ","pages":"4212059"},"PeriodicalIF":1.9,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluoride Content, Availability, and Stability in a Propolis-Based Dentifrice.","authors":"Mara Assef Leitão Lotif, Lidia Audrey Rocha Valadas, Peter Bottenberg, Aldo Squassi, Thereza Cristina Farias Botelho Dantas, Vanara Florêncio Passos, Edilson Martins Rodrigues Neto, Mary Anne Medeiros Bandeira, Marta Maria de França Fonteles","doi":"10.1155/ijod/3414733","DOIUrl":"https://doi.org/10.1155/ijod/3414733","url":null,"abstract":"<p><p><b>Purpose:</b> This study aims to verify the stability of different types of fluoride in a dentifrice containing Brazilian red propolis (BRP). <b>Methods:</b> The dentifrice formulation was developed with calcium carbonate (CaCO₃) and sodium monofluorophosphate (MFP) (patent INPI BR1020170110974). Nominal fluoride content was 1500 μg/g. Batches of five lots were selected and analyzed for 2 consecutive years (fresh, with 12 and 24 months). Dentifrices from each tube were analyzed in duplicate using an ion-specific electrode (ISE). The concentrations of fluoride (total fluoride [TF], total soluble fluoride [TSF], and ionizable fluoride [IF]) were determined, and the results were expressed in ppm F (μgF/g). <b>Results:</b> After 12 months of aging, the samples showed TF concentration ranging from 1198.9 ± 26.9 to 1443.6 ± 33.4 ppm F, TSF ranging from 869.6 ± 105.5 to 965.8 ± 149.8 ppm F, and IF ranging from 223.5 ± 14.8 to 269.7 ± 10.1 ppm F. After 24 months of aging, the samples showed TF concentration ranging from 763.5 ± 73.2 to 1083.1 ± 32.4 ppm F, TSF ranging from 552.3 ± 39.9 to 758.4 ± 141.1 ppm F, and IF ranging from 102.2 ± 4.0 to 174.7 ± 4.9 ppm F. <b>Conclusion:</b> Soluble fluoride remained relatively stable until 12 months of aging; however, at 24 months of aging, the concentration reduced.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2025 ","pages":"3414733"},"PeriodicalIF":1.9,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive Pilot Analysis of Oral Hypofunction Among Swiss Adults.","authors":"Murali Srinivasan, Lisa Takeshita, Cláudio Rodrigues Leles, Dusit Nantanapiboon, Manabu Kanazawa, Koichiro Matsuo","doi":"10.1155/ijod/8852345","DOIUrl":"https://doi.org/10.1155/ijod/8852345","url":null,"abstract":"<p><p><b>Objectives:</b> This study aimed to explore the effects of age and sex on oral function, specifically focusing on the prevalence of oral hypofunction (OHF) in different age groups. <b>Materials and Methods:</b> A total of 126 healthy adults, evenly distributed across six age groups (20-29, 30-39, 40-49, 50-59, 60-69, and 70+ years), participated, with an equal number of men and women in each group. OHF was assessed using seven key oral function parameters: oral hygiene, oral dryness, occlusal force, oral diadochokinesis (ODK), tongue pressure, masticatory function, and swallowing function. Body mass index (BMI) and hand grip strength (HGS) were also measured. Data analysis included descriptive statistics, bivariate comparisons with effect size(ES) calculation, and exploratory factor analysis to identify underlying domains affecting oral function (<i>p</i> < 0.05). <b>Results:</b> Older age groups exhibited a marked decline in occlusal force (<i>p</i> < 0.001), ODK (<i>p</i> < 0.001), tongue pressure (<i>p</i>=0.002), and masticatory function (<i>p</i> < 0.001), with moderate to large ESs. Factor analysis revealed three domains: chewing-related, tongue-related, and oral status. The chewing-related and tongue-related domains were impacted by age (<i>p</i> < 0.001), while the oral status domain showed no significant age-related changes (<i>p</i>=0.135). Additionally, the prevalence of OHF increased with age, with older participants showing a higher number of failed oral function tests. No significant differences in oral function were observed between sexes. <b>Conclusion:</b> The findings suggest an influence of age in oral function, particularly in chewing and tongue-related activities, contributing to increased OHF in older adults. These results highlight the importance of early detection and targeted interventions to maintain oral health and function in the aging population, with a focus on preserving chewing and tongue-related capabilities. The oral status domain, however, did not correlate with age, suggesting other factors might be involved in its deterioration.</p>","PeriodicalId":13947,"journal":{"name":"International Journal of Dentistry","volume":"2025 ","pages":"8852345"},"PeriodicalIF":1.9,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12006710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}