{"title":"Clarifying clinical impact and methodological considerations in the comparison of OPAL and ALBUNIQUE systems.","authors":"Teruhiko Imamura","doi":"10.1177/03913988261461134","DOIUrl":"10.1177/03913988261461134","url":null,"abstract":"","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"507-508"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aleksandra Canevska Taneska, Lada Trajceska, Zvezdana Petronijevik, Marija Janeku Kartalova, Golubinka Boshevska, Nikola Gjorgjievski, Gjulshen Selim
{"title":"Aggravated sepsis, acute kidney injury, and microbiological resistance: Four year's pre-post COVID-19 outcome study.","authors":"Aleksandra Canevska Taneska, Lada Trajceska, Zvezdana Petronijevik, Marija Janeku Kartalova, Golubinka Boshevska, Nikola Gjorgjievski, Gjulshen Selim","doi":"10.1177/03913988261446104","DOIUrl":"10.1177/03913988261446104","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of our study was to compare the prevalence, etiology, and outcomes of sepsis and associated AKI in pre- and post-COVID-19 pandemic.</p><p><strong>Methods: </strong>We conducted a retrospective observational analysis in 144 patients with sepsis and AKI, in two periods of time, 2 years before and after COVID-19 pandemic, with 2 years' washout period.</p><p><strong>Results: </strong>The comparative analysis between the two periods demonstrated more severe forms of sepsis with septic shock dominating in the post pandemic period (5 (10%) vs 23 (25%), <i>p</i> = 0.037). According AKI staging we found AKI stage 3 more frequently present after pandemic and more patients needed dialysis in the post COVID-19 pandemic (35 (70%) vs 79 (84%), <i>p</i> = 0.04; 31 (62%) vs 78 (54%), <i>p</i> = 0.02; 16 (32%) vs 51% (54%), <i>p</i> = 0.018), respectively. Patients in post COVID-19 era survived less longer (22.66 ± 11.32 vs 17.132 ± 12.66, <i>p</i> = 0.021) with almost doubled risk for mortality HR: 1.977; 95% CI (1.127 ± 3.469), <i>p</i> = 0.018. Regarding causative agents' there was similar distribution in both periods, but the multiple antibiotic resistance index (MAR) was significantly higher in the post COVID-19 period for <i>Staphylococcus</i> coagulase negative (0.48 vs 0.62, <i>p</i> = 0.001).</p><p><strong>Conclusion: </strong>Sepsis and associated AKI occurrence, morbidity and mortality are significantly higher in the post COVID-19 pandemic and the increased MAR of the germs can be one of the main reason for it.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"511-519"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The effect of diabetes technology use satisfaction on insulin therapy self-management in adults with type 1 diabetes.","authors":"Dilek Yildirim, Deniz Aras","doi":"10.1177/03913988261469882","DOIUrl":"https://doi.org/10.1177/03913988261469882","url":null,"abstract":"<p><strong>Background: </strong>Type 1 diabetes is a lifelong chronic disease that requires a high level of daily self-management skills. Although diabetes technologies that have become widespread in recent years facilitate glycemic monitoring, the effect of satisfaction with these technologies on insulin therapy self-management has not been sufficiently clarified.</p><p><strong>Methods: </strong>This descriptive and correlational study was conducted with 154 individuals diagnosed with type 1 diabetes. Data were collected using a Participant Information Form, the Diabetes Technology Questionnaire, and the Insulin Therapy Self-Management Scale. Descriptive statistics, correlation analysis, and multiple linear regression analysis were used to evaluate the relationships and predictors of insulin therapy self-management.</p><p><strong>Results: </strong>The mean age of the participants was 31.7 ± 11.8 years, the mean HbA1c level was 8.81% ± 2.09%. The mean total score of the Diabetes Technology Questionnaire was 70.597 ± 17.768, while the mean total score of the Insulin Therapy Self-Management Scale was 96.642 ± 17.839. Correlation analysis revealed a negative and significant relationship between the total score of the Diabetes Technology Questionnaire and the total score of insulin therapy self-management (<i>r</i> = -0.326, <i>p</i> < 0.001). According to the multiple regression analysis, the model was significant (<i>F</i> = 10.750, <i>p</i> < 0.001) and explained 26.6% of the variance. The total score of the Diabetes Technology Questionnaire (β = -0.380, <i>p</i> < 0.001) and HbA1c level (β = -0.291, <i>p</i> < 0.001) were significant predictors of insulin therapy self-management.</p><p><strong>Conclusions: </strong>The findings of this study indicate that as satisfaction with diabetes technology use increases, the level of insulin therapy self-management decreases among individuals with type 1 diabetes, and poor glycemic control negatively affects self-management.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988261469882"},"PeriodicalIF":1.6,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148630197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bleeding phenotypes associated with P2Y12 inhibitor therapy in venoarterial extracorporeal membrane oxygenation.","authors":"Nabeel Sami, Monica Prario, Iosif Gulkarov, Monika Tukacs, Yoshifumi Naka, Ankur Srivastava, Berhane Worku","doi":"10.1177/03913988261465314","DOIUrl":"https://doi.org/10.1177/03913988261465314","url":null,"abstract":"<p><strong>Background: </strong>Many patients requiring VA-ECMO for acute coronary syndromes receive P2Y12 inhibitor therapy to prevent stent thrombosis, yet existing literature reports only composite bleeding rates without stratification by anatomic site. Whether P2Y12 inhibitor use produces distinct bleeding patterns compared to standard heparin anticoagulation remains underexplored.</p><p><strong>Methods: </strong>Retrospective analysis of adult VA-ECMO patients at NewYork-Presbyterian Hospital (April 2011-January 2025). Patients receiving P2Y12 inhibitors plus heparin (<i>n</i> = 36) were compared to those receiving standard heparin alone (<i>n</i> = 129). Postcardiotomy patients were excluded. Primary outcomes were site-specific bleeding complications. Multivariate logistic regression adjusted for baseline differences in illness severity.</p><p><strong>Results: </strong>P2Y12 patients were older (63.0 vs 50.7 years, <i>p</i> < 0.001), had higher rates of cardiac arrest (83.3% vs 55.0%, <i>p</i> = 0.002), and elevated lactate (10.2 vs 7.1 mmol/L, <i>p</i> = 0.004). P2Y12 inhibitor use was associated with increased airway hemorrhage (19.4% vs 7.0%, <i>p</i> = 0.049) and reduced weaning success (44.4% vs 66.7%, <i>p</i> = 0.015). On multivariate analysis adjusting for illness severity, P2Y12 inhibitor use was not associated with bleeding complications or mortality, whereas lactate was an independent predictor of mortality (OR 1.11 per mmol/L, 95% CI 1.02-1.20, <i>p</i> = 0.020).</p><p><strong>Conclusions: </strong>Although not independently associated with bleeding complications, P2Y12 inhibitor therapy in VA-ECMO patients identifies a high-risk population with elevated airway hemorrhage. These findings support enhanced mucosal surveillance and individualized anticoagulation strategies in this vulnerable population.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"3913988261465314"},"PeriodicalIF":1.6,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148497370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Simulating physiological blood maintenance: A dialysis-integrated in vitro flow loop for realistic hemocompatibility evaluation of devices.","authors":"Tansu Gölcez, Demet Kul, Elif Uğurel, İrem Günaydın, Özlem Yalçın, Kerem Pekkan, Yahya Yıldız","doi":"10.1177/03913988261445012","DOIUrl":"10.1177/03913988261445012","url":null,"abstract":"<p><p>Conventional blood flow-loop systems, employing animal or rarely fresh human blood, used in in vitro testing of blood-contact devices fail to simulate the actual physiological conditions. This study aims to develop a metabolically sustainable blood flow loop system to be used in cardiovascular device testing, by integrating nutrition, oxygenation, and dialysis modules. Two flow loop systems with human blood were compared: (1) control circuit with oxygenation and (2) experimental circuit with the addition of nutrition, oxygenation, and dialysis modules. Blood was circulated for 12 and 48 h, and hemolysis (NIH, pfHb, bilirubin, haptoglobin), blood gases (pH, glucose, lactate), inflammation (IL-8, TNF-α, C3a), coagulation (fibrinogen, TAT), platelet/endothelial activation (β-TG, vWF), and ferritin levels were measured over time. While pH decrease, lactate increase, and inflammatory/coagulation markers increased in the control group, these parameters were stable or decreased in the dialysis group. NIH was 77%-81% lower in dialysis, and vWF decreased 55%-73% in dialysis while increasing in control (<i>p</i> < 0.05). The improved flow loop system reduced hemolysis, inflammation, and coagulation by maintaining the metabolic balance and biochemical integrity of blood during long-term circulation. This approach has the potential to improve in vitro testing of blood-contacting medical devices.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"431-442"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Athanasios Tsiouris, Seth T Lirette, Lampros Papadimitriou
{"title":"Increased risk of stroke after heart transplant in patients bridged with prolonged Impella 5.5 support.","authors":"Athanasios Tsiouris, Seth T Lirette, Lampros Papadimitriou","doi":"10.1177/03913988261448204","DOIUrl":"10.1177/03913988261448204","url":null,"abstract":"<p><strong>Background: </strong>Recent data have suggested an increased risk of stroke with the utilization of Impella 5.5 (Abiomed, Danvers, MA, USA) devices for bridging Status 2 heart transplant patients. The purpose of our study was to investigate the relationship between the duration of Impella 5.5 support and the incidence of stroke after heart transplant.</p><p><strong>Methods: </strong>An analysis of the UNOS database was performed on heart transplant recipients that were bridged with an Impella 5.5 from January 2022 to March 2025. Patients were divided into two cohorts according to duration of support (<30 and >30 days). A propensity score matched adjustment model was used to ascertain stroke probabilities across analyzed groups.</p><p><strong>Results: </strong>A total of 1580 patients that received an Impella 5.5 as a bridge to heart transplant were identified, of which 1186 (75%) were supported for <30 days and 394 (25%) >30 days. Age, male sex, previous cardiac surgery, higher BMI and functional status at listing were significant factors for the occurrence of stroke in both groups (<30 and >30 days). Propensity score matched stroke rate in the <30-day cohort was 3.5% and in the >30-day group was 6.2% (<i>p</i> = 0.043). In patients with post-transplant stroke, pre-transplant history of stroke was present in 22.4% of patients supported <30 days and 19% of patients on Impella for >30 days.</p><p><strong>Conclusions: </strong>Prolonged duration of support, in excess of 30 days, with an Impella 5.5 is associated with a significantly higher risk of stroke after heart transplantation.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"473-478"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148198851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aysun Kazak Salti, Hasret Topali, Osman Oğulcan Türkmen
{"title":"Determinants of sleep quality and fatigue in patients undergoing hemodialysis.","authors":"Aysun Kazak Salti, Hasret Topali, Osman Oğulcan Türkmen","doi":"10.1177/03913988261456929","DOIUrl":"10.1177/03913988261456929","url":null,"abstract":"<p><strong>Aim: </strong>This research aimed to evaluate sleep quality and fatigue among individuals undergoing hemodialysis and to explore the determinants affecting these variables.</p><p><strong>Methods: </strong>This observational investigation was carried out among 78 who were regularly receiving hemodialysis therapy. The research was carried out between May and October 2025 in three different public hospitals among individuals undergoing hemodialysis treatment. Data were gathered using the Patient Information Form (PIF), the Fatigue Severity Scale (FSS), and the Pittsburgh Sleep Quality Index (PSQI).</p><p><strong>Results: </strong>The mean score of the hemodialysis patients on the FSS is 4.97 ± 1.11, and the mean PSQI value is 7.76 ± 3.64. A moderately positive and statistically noteworthy relation was observed between the PSQI and FSS scores. Additionally, a low negative meaningful correlation was seen between ferritin levels and the FSS scores, as well as between calcium levels and the PSQI scores. The use of medications related to chronic disease and the PSQI scores were identified as significant predictors of the FSS scores.</p><p><strong>Conclusion: </strong>Fatigue and sleep quality in individuals receiving hemodialysis treatment are related to each other, as well as to biochemical balance and treatment adherence.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"448-454"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical efficacy of anticoagulants in patients with uremic cerebral hemorrhage receiving continuous renal replacement therapy.","authors":"Zhenhua Li, Kun Liu","doi":"10.1177/03913988251318901","DOIUrl":"10.1177/03913988251318901","url":null,"abstract":"<p><strong>Objective: </strong>Hemodialysis can significantly prolong the survival of uremia patients, but uremia and long-term hemodialysis can also cause complications. This study aimed to compare the clinical efficacy between the menostat mesylate and sodium citrate as anticoagulants in patients receiving CRRT.</p><p><strong>Methods: </strong>The clinical data of 80 patients with uremic cerebral hemorrhage in our hospital from January 2020 to October 2022 were collected and randomly divided into observation (nelostat anticoagulation, <i>n</i> = 40) and control (citrate and sodium anticoagulation, <i>n</i> = 40) groups. Physiological parameters, CRRT filter life, coagulation function index, activated whole blood coagulation time (ACT), anticoagulation efficiency rate, and incidence of adverse reactions were compared between the two groups.</p><p><strong>Results: </strong>The physiological index, coagulation function index, ACT value, and anticoagulation efficiency were higher in the observation group than in the control group (<i>p</i> < 0.05). The observation group also demonstrated a longer CRRT filter life and lower incidence of adverse reactions than those in the control group (both <i>p</i> < 0.5).</p><p><strong>Conclusion: </strong>Naphlimostat mesylate demonstrated a good anticoagulant effect and was safe for use in CRRT.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"443-447"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148155768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Antithrombin and 20% albumin as treatment of oxygenator high pressures excursion during cardiopulmonary bypass in cardiac surgery: A case report.","authors":"Raffaele Mandarano, Silvia Pedevilla, Flavia Annese, Luca Pessetti, Enrico Squiccimarro, Stefano Romagnoli, Sergio Bevilacqua","doi":"10.1177/03913988261450135","DOIUrl":"10.1177/03913988261450135","url":null,"abstract":"<p><p>High-pressure excursions (HPE) during cardiopulmonary bypass (CPB) are rare but potentially life-threatening events linked to coagulation activation, inflammation. Known risk factors include male sex, large body surface area (BSA), elevated hematocrit (Htc), prior stroke and urgent surgery. Recommended management follows a stepwise approach involving haemodilution, heparin and antithrombin (AT), albumin or epoprostenol depending on Htc and pressure thresholds. We report a 69-year-old man undergoing urgent complex cardiac surgery who developed rising pre-oxygenator pressures 10 min after CPB initiation. Despite initial haemodilution and AT, pressures improved only partially. Administration of 100 mL of 20% albumin led to rapid normalization of pre-oxygenator and delta pressures, allowing safe continuation of CPB. The postoperative course was uneventful. Subsequent review of the oxygenator transmembrane resistance (R) showed a progressive decline following the administration of AT and albumin. This case suggests that AT, administered alongside albumin, may reduce blood viscosity and improve oxygenator performance. Further research is needed to clarify mechanisms and standardize management of HPE during CPB.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"468-472"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative study of slotted and slotless BLDC motors for blood pump applications.","authors":"Chuang Xiang, Liang Wang","doi":"10.1177/03913988261455775","DOIUrl":"10.1177/03913988261455775","url":null,"abstract":"<p><p>In order to match physiological characteristics, the application of pulsating rotational speed in blood pumps has become popular. This places greater demands on the motor of the blood pump, necessitating low power, rapid response and compact dimensions, among other considerations. In consideration of the characteristics inherent to the slotless BLDC motor, this paper proposes the implementation of a slotless stator as a replacement for the slotted stator in a magnetic-hydrodynamic double levitated axial blood pump. Initially, the slotless stator was conceived in accordance with the theory of slotless motors, incorporating helical windings and meeting the drive capacity requirements of the blood pump. The torque exerted on the rotor of the slotted stator motor and slotless stator motor was then compared through the application of the finite element method. An experimental system was constructed for the purpose of measuring the difference in performance between the two motor types. The attributes, the speed characteristics, the power and the temperature of the stators of the two motors were detected. The findings indicate that the slotless motor exhibits a reduced size, diminished speed fluctuations, expedited speed response, yet concomitantly exhibits almost double the power consumption and a more substantial temperature increase in comparison with the slotted motor.</p>","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"455-467"},"PeriodicalIF":1.6,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148264458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}