International Journal of Artificial Organs最新文献_第7页

Design and evaluation of mechanical strength of multi-material polymeric implants for mandibular reconstruction. 设计和评估用于下颌骨重建的多材料聚合物植入物的机械强度。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2024-09-01 Epub Date: 2024-07-27 DOI: 10.1177/03913988241261817

Kalaithendral K, S Karuppudaiyan, Sandipan Roy

{"title":"Design and evaluation of mechanical strength of multi-material polymeric implants for mandibular reconstruction.","authors":"Kalaithendral K, S Karuppudaiyan, Sandipan Roy","doi":"10.1177/03913988241261817","DOIUrl":"10.1177/03913988241261817","url":null,"abstract":"Reconstruction of mandible implants to address segmental abnormalities is still a challenging task, both in vitro and in vivo. The mechanical strength of the materials used is a critical factor that determines how well bone is regenerated. The reconstruction technique of mandibular abnormalities widely uses polymeric implants. It is critical to evaluate the mechanical resilience under different load cases, including axial, combined, and flexural loading conditions. This study developed implants for mandibular defects using a combination of four materials: polylactic acid (PLA), polyethylene terephthalate glycol (PETG), thermoplastic polyurethane (TPU), and polycaprolactone (PCL), with the aim of mimicking the inherent characteristics of cortical and cancellous bone structures and evaluating their mechanical properties to support bone Osseo integration. The eleven of these combinations of structures result below the micro strain threshold level of <3000 µε, and the five combinations of the structures result in micro strain above the threshold value. The intact bone study results show that the stress under axial, combined, and flexural loading conditions is 27.6, 38.9, and 64.9 MPa, respectively. This study's stress results are lower than those from the intact bone study. The study found that the combinations of PLA and TPU material were most preferred for the cortical and cancellous bone regions of polymeric implants. These materials are also compatible with 3D printing. The results of this study can be used to find multi-material combinations that are strong and flexible.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"698-706"},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A special issue of our journal from the yESAO. yESAO 的特刊。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2024-08-01 Epub Date: 2024-10-03 DOI: 10.1177/03913988241288365

Andrea Remuzzi

引用次数: 0

Dialysis nanocomposite membranes based on carbon nanoforms inhibiting blood plasma protein adsorption. 基于碳纳米形式的透析纳米复合膜可抑制血浆蛋白吸附。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2024-08-01 Epub Date: 2024-08-22 DOI: 10.1177/03913988241269440

Dominika Wójtowicz, Roksana Kurpanik, Dominika Nguyen Ngoc, Joanna Wessley-Szponder, Ewa Stodolak-Zych

{"title":"Dialysis nanocomposite membranes based on carbon nanoforms inhibiting blood plasma protein adsorption.","authors":"Dominika Wójtowicz, Roksana Kurpanik, Dominika Nguyen Ngoc, Joanna Wessley-Szponder, Ewa Stodolak-Zych","doi":"10.1177/03913988241269440","DOIUrl":"10.1177/03913988241269440","url":null,"abstract":"Background: Protein adsorption on medical devices in contact with blood is a significant issue during renal replacement therapy. Main forces determining fouling are the electrostatic interactions between membrane and charged protein, but the dialysis membrane surface charges can be adjusted by modifying the polymer matrix to decrease the blood plasma protein adsorption.Methods: In this study, polysulfone membranes (PSU) were modified by incorporation of carbon nanoparticles such as: multiwall carbon nanotubes (2 wt.% MWCNT), graphene oxide (1 wt.% GO), and graphite (5 wt.% GR) during manufacturing process (nonsolvent-induced phase separation, NIPS). The PSU flat sheet membrane was the reference sample.Results: Observed morphology of nanocomposite membranes was similar (SEM imaging); all of them had finger-like pore structure with unimodal distribution of pore size and similar skin-to-support ratio (1:3). The carbon nanoadditives also influenced the surface wettability: hydrophobicity and surface free energy of membranes increased (polar components of energy were reduced, while the dispersive components were increased).Conclusion: The surface charge of nanocomposite membranes increased, when the polymer matrix has been modified with CNT or GR. This significantly affects the adsorption of proteins such as chicken (CSA) and bovine serum albumin (BSA) and reduces blood clotting on the membrane.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"582-589"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Graphene-enhanced PCL electrospun nanofiber scaffolds for cardiac tissue engineering. 用于心脏组织工程的石墨烯增强 PCL 电纺纳米纤维支架。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2024-08-01 Epub Date: 2024-08-08 DOI: 10.1177/03913988241266088

Ana M Muñoz-Gonzalez, Sara Leal-Marin, Dianney Clavijo-Grimaldo, Birgit Glasmacher

{"title":"Graphene-enhanced PCL electrospun nanofiber scaffolds for cardiac tissue engineering.","authors":"Ana M Muñoz-Gonzalez, Sara Leal-Marin, Dianney Clavijo-Grimaldo, Birgit Glasmacher","doi":"10.1177/03913988241266088","DOIUrl":"10.1177/03913988241266088","url":null,"abstract":"Cardiovascular diseases, particularly myocardial infarction, have significant healthcare challenges due to the limited regenerative capacity of injured heart tissue. Cardiac tissue engineering (CTE) offers a promising approach to repairing myocardial damage using biomaterials that mimic the heart's extracellular matrix. This study investigates the potential of graphene nanopowder (Gnp)-enhanced polycaprolactone (PCL) scaffolds fabricated via electrospinning to improve the properties necessary for effective cardiac repair. This work aimed to analyze scaffolds with varying graphene concentrations (0.5%, 1%, 1.5%, and 2% by weight) to determine their morphological, chemical, mechanical, and biocompatibility characteristics. The results presented that incorporating graphene improves PCL scaffolds' mechanical properties and cellular interactions. The optimal concentration of 1% graphene significantly enhanced mechanical properties and biocompatibility, promoting cell adhesion and proliferation. These findings suggest that Gnp-enhanced PCL scaffolds at this concentration can serve as a potent substrate for CTE providing insights into designing more effective biomaterials for myocardial restoration.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"633-641"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of titanium surface roughness on a nanoscale on the zeta potential and platelet adhesion. 纳米级钛表面粗糙度对 zeta 电位和血小板附着力的影响

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2024-08-01 Epub Date: 2024-08-21 DOI: 10.1177/03913988241268000

Isabell Esslinger, Michael Lommel, Florian Kießlich, Ulrich Kertzscher, Tim Bierewirtz

{"title":"Influence of titanium surface roughness on a nanoscale on the zeta potential and platelet adhesion.","authors":"Isabell Esslinger, Michael Lommel, Florian Kießlich, Ulrich Kertzscher, Tim Bierewirtz","doi":"10.1177/03913988241268000","DOIUrl":"10.1177/03913988241268000","url":null,"abstract":"Thromboembolic complications still arise on blood contacting surfaces. Surface charge and topography influence the subsequent deposition of proteins and platelets, potentially leading to thrombi. Research showed a correlation of surface charge and nanoscale roughness, and a negative surface charge as well as a smooth surface finish are associated with lower thrombogenicity. The aim of this study was to compare the platelet adhesion on titanium with different nanoscale roughnesses and to examine if those roughness variations caused a change in surface charge. Titanium samples were polished and roughened to four different nanoscale roughness levels. Platelet adhesion (covered surface area (CSA), N = 8) was tested in flow chambers with human whole blood using fluorescence imaging. ζ-potential was measured over a broad range of pH-values and interpolated to obtain the ζ-potential for pHBlood (7.4). Platelet adhesion tests were evaluated in terms of p-values and the Wilcoxon test effect size and the trend of the ζ-potential at pHBlood and the CSA was compared. Ra-values ranged between 35 (polished) and 156 nm. Regarding platelet adhesion, the polished sample showed the lowest mean CSA with a medium or strong effect size compared to the roughened samples. The interpolated ζ-potentials for pHBlood follow a similar trend as the CSA, with the lowest ζ-potential measured for the polished surface. These findings suggest that the decreasing ζ-potential due to lower nanoscale roughness might be an additional explanation for the improved hemocompatibility besides the smoother topography.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"618-623"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of high-frequency mechanical stimuli on flow related vascular cell biology. 高频机械刺激对流动相关血管细胞生物学的影响。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2024-08-01 Epub Date: 2024-08-21 DOI: 10.1177/03913988241268105

Elena Carrara, Luca Soliveri, Sofia Poloni, Michela Bozzetto, Chiara Emma Campiglio

{"title":"Effects of high-frequency mechanical stimuli on flow related vascular cell biology.","authors":"Elena Carrara, Luca Soliveri, Sofia Poloni, Michela Bozzetto, Chiara Emma Campiglio","doi":"10.1177/03913988241268105","DOIUrl":"10.1177/03913988241268105","url":null,"abstract":"Mechanical forces related to blood pressure and flow patterns play a crucial role in vascular homeostasis. Perturbations in vascular stresses and strain resulting from changes in hemodynamic may occur in pathological conditions, leading to vascular dysfunction as well as in vascular prosthesis, arteriovenous shunt for hemodialysis and in mechanical circulation support. Turbulent-like blood flows can induce high-frequency vibrations of the vessel wall, and this stimulus has recently gained attention as potential contributors to vascular pathologies, such as development of intimal hyperplasia in arteriovenous fistula for hemodialysis. However, the biological response of vascular cells to this stimulus remains incompletely understood. This review provides an analysis of the existing literature concerning the impact of high-frequency stimuli on vascular cell morphology, function, and gene expression. Morphological and functional investigations reveal that vascular cells stimulated at frequencies higher than the normal heart rate exhibit alterations in cell shape, alignment, and proliferation, potentially leading to vessel remodeling. Furthermore, vibrations modulate endothelial and smooth muscle cells gene expression, affecting pathways related to inflammation, oxidative stress, and muscle hypertrophy. Understanding the effects of high-frequency vibrations on vascular cells is essential for unraveling the mechanisms underlying vascular diseases and identifying potential therapeutic targets. Nevertheless, there are still gaps in our understanding of the molecular pathways governing these cellular responses. Further research is necessary to elucidate these mechanisms and their therapeutic implications for vascular diseases.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"590-601"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11487902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of hydroxyapatite and honeycomb micro-structure in bone tissue engineering using electrospun beads-on-string fibers. 使用电纺串珠纤维的骨组织工程中羟基磷灰石和蜂窝状微结构的比较。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2024-08-01 Epub Date: 2024-08-21 DOI: 10.1177/03913988241268033

Nicolas Rivoallan, Marc Mueller, Timothée Baudequin, Pascale Vigneron, Anne Hébraud, Rachid Jellali, Quentin Dermigny, Anne Le Goff, Guy Schlatter, Birgit Glasmacher, Cécile Legallais

{"title":"Comparison of hydroxyapatite and honeycomb micro-structure in bone tissue engineering using electrospun beads-on-string fibers.","authors":"Nicolas Rivoallan, Marc Mueller, Timothée Baudequin, Pascale Vigneron, Anne Hébraud, Rachid Jellali, Quentin Dermigny, Anne Le Goff, Guy Schlatter, Birgit Glasmacher, Cécile Legallais","doi":"10.1177/03913988241268033","DOIUrl":"10.1177/03913988241268033","url":null,"abstract":"Thick honeycomb-like electrospun scaffold with nanoparticles of hydroxyapatite (nHA) recently demonstrated its potential to promote proliferation and differentiation of a murine embryonic cell line (C3H10T1/2) to osteoblasts. In order to distinguish the respective effects of the structure and the composition on cell differentiation, beads-on-string fibers were used to manufacture thick honeycomb-like scaffolds without nHA. Mechanical and biological impacts of those beads-on string fibers were evaluated. Uniaxial tensile test showed that beads-on-string fibers decreased the Young Modulus and maximal stress but kept them appropriate for tissue engineering. C3H10T1/2 were seeded and cultured for 6 days on the scaffolds without any growth factors. Viability assays revealed the biocompatibility of the beads-on-string scaffolds, with adequate cells-materials interactions observed by confocal microscopy. Alkaline phosphatase staining was performed at day 6 in order to compare the early differentiation of cells to bone fate. The measure of stained area and intensity confirmed the beneficial effect of both honeycomb structure and nHA, independently. Finally, we showed that honeycomb-like electrospun scaffolds could be relevant candidates for promoting bone fate to cells in the absence of nHA. It offers an easier and faster manufacture process, in particular in bone-interface tissue engineering, permitting to avoid the dispersion of nHA and their interaction with the other cells.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"642-649"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of haemolysis models for a positive-displacement total artificial heart. 评估正位移全人工心脏的溶血模型。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2024-08-01 Epub Date: 2024-09-19 DOI: 10.1177/03913988241267797

Joseph Bornoff, Shaikh Faisal Zaman, Azad Najar, Thomas Finocchiaro, Ina Laura Perkins, Andrew N Cookson, Katharine H Fraser

{"title":"Assessment of haemolysis models for a positive-displacement total artificial heart.","authors":"Joseph Bornoff, Shaikh Faisal Zaman, Azad Najar, Thomas Finocchiaro, Ina Laura Perkins, Andrew N Cookson, Katharine H Fraser","doi":"10.1177/03913988241267797","DOIUrl":"10.1177/03913988241267797","url":null,"abstract":"The assessment and reduction of haemolysis within mechanical circulatory support (MCS) remains a concern with regard to device safety and regulatory approval. Numerical methods for predicting haemolysis have typically been applied to rotary MCS devices and the extent to which these methods apply to positive-displacement MCS is unclear. The aim of this study was to evaluate the suitability of these methods for assessing haemolysis in positive-displacement blood pumps. Eulerian scalar-transport and Lagrangian particle-tracking approaches derived from the shear-based power-law relationship were used to calculate haemolysis in a computational fluid dynamics model of the Realheart total artificial heart. A range of power-law constants and their effect on simulated haemolysis were also investigated. Both Eulerian and Lagrangian methods identified the same key mechanism of haemolysis: leakage flow through the bileaflet valves. Whilst the magnitude of haemolysis varied with different power-law constants, the method of haemolysis generation remained consistent. The Eulerian method was more robust and reliable at identifying sites of haemolysis generation, as it was able to capture the persistent leakage flow throughout the entire pumping cycle. This study paves the way for different positive-displacement MCS devices to be compared across different operating conditions, enabling the optimisation of these pumps for improved patient outcomes.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"570-581"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Purified granulocytes in extracorporeal cell therapy: A multifaceted approach to combat sepsis-induced immunoparalysis. 体外细胞疗法中的纯化粒细胞：抗脓毒症诱导的免疫麻痹的多重方法。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2024-08-01 Epub Date: 2024-07-23 DOI: 10.1177/03913988241262901

Gerd Klinkmann, Sophie Brabandt, Marlene Möller, Thomas Wild, Benjamin Heskamp, Jens-Christian Schewe, Martin Sauer, Jens Altrichter, Steffen Mitzner

{"title":"Purified granulocytes in extracorporeal cell therapy: A multifaceted approach to combat sepsis-induced immunoparalysis.","authors":"Gerd Klinkmann, Sophie Brabandt, Marlene Möller, Thomas Wild, Benjamin Heskamp, Jens-Christian Schewe, Martin Sauer, Jens Altrichter, Steffen Mitzner","doi":"10.1177/03913988241262901","DOIUrl":"10.1177/03913988241262901","url":null,"abstract":"Background: Immune cell dysfunction plays a central role in sepsis-induced immunoparalysis. Targeted treatment using healthy donor immune cell transfusions, particularly granulocyte concentrates (GC) potentially induces tissue damage. Initial trials using GC in an extracorporeal immune cell perfusion system provided evidence for beneficial effects with fewer side effects, by separating patient and donor immune cell compartments. A multicenter clinical trial is exploring feasibility and effects of a 6-h treatment (NCT06143137). This ex vivo study examines technical feasibility and cellular effects of an extended treatment interval up to 24 h.Methods: Standard GC were purified to increase the potential storage time and subsequently implemented in the extracorporeal immune cell perfusion system. Parameters assessed included cell viability, phagocytosis activity, oxidative burst, cytokine release, and metabolic parameters of purified. GC during an extended circulation time of up to 24 h.Results: After storage of 72 h granulocytes were viable throughout the study period and exhibited preserved functionality and metabolic activity. The findings highlight a time-dependent nature of cytokine release by neutrophils in the extracorporeal circuit, as cytokine secretion patterns showed IL-8 peaking within 6 h, while MCP-1, IL-6, IL-1β, and TNF-α increased after 24 h of circulation.Conclusion: Purified GC remain functional after 72 h of storage and additional 24 h in the circulating treatment model. Cytokine secretion patterns revealed a significant increase, especially between 10 and 24 h of treatment. Extending treatment time holds promise for enhancing immune response against sepsis-induced immunoparalysis. These findings provide valuable insights for optimizing immune-targeted therapeutic interventions.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"602-617"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141748146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic VAD simulations: Performing accurate simulations of ventricular assist devices in interaction with the cardiovascular system. 动态 VAD 模拟：对与心血管系统相互作用的心室辅助装置进行精确模拟。

IF 1.4 4区医学

International Journal of Artificial Organs Pub Date : 2024-08-01 Epub Date: 2024-09-05 DOI: 10.1177/03913988241268067

Vincenz Crone, Mario Hahne, Finn Knüppel, Frank-Hendrik Wurm, Benjamin Torner

{"title":"Dynamic VAD simulations: Performing accurate simulations of ventricular assist devices in interaction with the cardiovascular system.","authors":"Vincenz Crone, Mario Hahne, Finn Knüppel, Frank-Hendrik Wurm, Benjamin Torner","doi":"10.1177/03913988241268067","DOIUrl":"10.1177/03913988241268067","url":null,"abstract":"Medical advancements, particularly in ventricular assist devices (VADs), have notably advanced heart failure (HF) treatment, improving patient outcomes. However, challenges such as adverse events (strokes, bleeding and thrombosis) persist. Computational fluid dynamics (CFD) simulations are instrumental in understanding VAD flow dynamics and the associated flow-induced adverse events resulting from non-physiological flow conditions in the VAD.This study aims to validate critical CFD simulation parameters for accurate VAD simulations interacting with the cardiovascular system, building upon the groundwork laid by Hahne et al. A bidirectional coupling technique was used to model dynamic (pulsatile) flow conditions of the VAD CFD interacting with the cardiovascular system. Mesh size, time steps and simulation method (URANS, LES) were systematically varied to evaluate their impact on the dynamic pump performance (dynamic <math><mrow><mi>H</mi><mo>-</mo><mi>Q</mi></mrow></math> curve) of the HeartMate 3, aiming to find the optimal simulation configuration for accurately reproduce the dynamic <math><mrow><mi>H</mi><mo>-</mo><mi>Q</mi></mrow></math> curve. The new Overlapping Ratio (OR) method was developed and applied to quantify dynamic <math><mrow><mi>H</mi><mo>-</mo><mi>Q</mi></mrow></math> curves.In particular, mesh and time step sizes were found to have the greatest influence on the calculated pump performance. Therefore, small time steps and large mesh sizes are recommended to obtain accurate dynamic <math><mrow><mi>H</mi><mo>-</mo><mi>Q</mi></mrow></math> curves. On the other hand, the influence of the simulation method was not significant in this study. This study contributes to advancing VAD simulations, ultimately enhancing clinical efficacy and patient outcomes.","PeriodicalId":13932,"journal":{"name":"International Journal of Artificial Organs","volume":" ","pages":"624-632"},"PeriodicalIF":1.4,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11656629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0