International Journal of Pharmaceutical Chemistry and Analysis最新文献_第6页

Formulation development and evaluation of novel herbal toothpaste from natural source 新型天然草药牙膏的配方开发与评价

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2022-04-15 DOI: 10.18231/j.ijpca.2022.003

K. Senthilkumar, S. Venkateswaran, A. Vasanthan, P. Chiranjeevi, N. Mohamed, S. Dinesh, K.L.S. Neshkumar.

引用次数: 2

Method stability indicating method development and validation for emtricitabina by UV spectroscopic and RP-HPLC methods 方法稳定性表明了恩曲他滨的方法开发和紫外光谱和反相高效液相色谱法的验证

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2022-04-15 DOI: 10.18231/j.ijpca.2022.002

Ashwini V. Shelke, Pooja Surwae, Atul R. Bendale, Laxmikany Borse, A. Jadhav

引用次数: 1

Quantitative estimation of sitagliptin and dapagliflozin propanediol monohydrate in synthetic mixture using 1 order derivative spectroscopy simultaneous spectrophotometric analysis 合成混合物中西格列汀和达格列净丙二醇一水合物的一阶导数光谱同时分光光度定量分析

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2022-04-15 DOI: 10.18231/j.ijpca.2022.005

S. Jani, Rashmi Shukla, Pinak Patel, Binny Mehta, Krunal Detholia

{"title":"Quantitative estimation of sitagliptin and dapagliflozin propanediol monohydrate in synthetic mixture using 1 order derivative spectroscopy simultaneous spectrophotometric analysis","authors":"S. Jani, Rashmi Shukla, Pinak Patel, Binny Mehta, Krunal Detholia","doi":"10.18231/j.ijpca.2022.005","DOIUrl":"https://doi.org/10.18231/j.ijpca.2022.005","url":null,"abstract":"Current research paper describes highly specific and reproducible 1 order derivative spectroscopic method for quantitative analysis of Sitagliptin which is a DPP4 inhibitors and Dapagliflozin which is SGLT2 inhibitors from its synthetic mixture. Both drugs are from Anti Diabetics class. Present analytical method was developed on Shimadzu double beam spectrophotometer equipped with UV probe 2.42 as software using methyl alcohol as solvent. Quantification of Sitagliptin was carried out at zero cross over point of Dapagliflozin that is 275 nm and for Dapagliflozin, it was achieved at 232 nm which is zero cross over point of Sitagliptin. Method shows linear response in the range of 25-125 µg/mL of Sitagliptin and 2.5-12.5 µg/mL of Dapagliflozin. Method was found to be accurate with recovery between 99.3 – 100.1 % for Sitagliptin and 98.2 – 100.7 % for Dapagliflozin. The developed method was validated as per ICH Q2 R1 guidelines and was successfully applied for quantitative analysis of synthetic mixture of Sitagliptin and Dapagliflozin.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74285580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Design, synthesis and anticancer activity studies of some novel 1,2,4 triazole pyridine derivatives 新型1,2,4三唑吡啶衍生物的设计、合成及抗癌活性研究

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2022-04-15 DOI: 10.18231/j.ijpca.2022.009

A. Chakraborty, N. Patel, Sarita Karole, Kavita R. Loksh

{"title":"Design, synthesis and anticancer activity studies of some novel 1,2,4 triazole pyridine derivatives","authors":"A. Chakraborty, N. Patel, Sarita Karole, Kavita R. Loksh","doi":"10.18231/j.ijpca.2022.009","DOIUrl":"https://doi.org/10.18231/j.ijpca.2022.009","url":null,"abstract":"The development of new anticancer agents is one of the most pressing research areas in medicinal chemistry and medicine. The importance of triazole and pyridine rings as scaffolds present in a wide range of therapeutic agents has been well reported and has driven the synthesis of a large number of novel anticancer agents. The presence of these heterocyclic furnishes extensive synthetic possibilities due to the presence of several reaction sites. Prompted by these data we designed, synthesized and evaluated a series of novel 1, 2, 4-triazole-pyridine hybrid derivatives as potential anticancer agents. To design and synthesize series of novel 1, 2, 4-triazole-pyridine hybrid derivatives as potential anticancer agents Derivatives were synthesized by the reaction of nicotinohydrazide with carbon disulfide to yield potassium-3-pyridyl-dithiocarbazate (I). This was further cyclized with ammonia solution to yield 5-mercapto-substituted 1, 2, 4-triazole-pyridine hybrid (II). This was finally reacted with different substituted benzyl derivatives to produce 1, 2, 4-triazole-pyridine hybrid derivatives (III). The purity of the derivatives was confirmed by thin-layer chromatography and melting point. Structure of these derivatives was set up by determining its infrared spectroscopy, nuclear magnetic resonance spectroscopy and mass spectroscopy. Further, the synthesized 1, 2, 4 triazole pyridine derivatives were tested for their in vitro anticancer activities against murine melanoma (B16F10) using the MTT reduction assay method. The cell viability study of synthesized compounds concludes that all compounds have moderate to potent anticancer activities against cancer cell lines. Compounds TP1-TP7 have IC in the range of 41.12μM to 61.11μM and the highest activity was observed for compound TP6 against murine melanoma (B16F10) cell line.Thepresent research may pave a way for the development of 1, 2, 4-triazole-pyridine as novel anticancer agents with good efficacy and lesser adverse effects.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79459787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medicinal mushroom: What should we know? 药菇:我们应该知道些什么?

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2022-04-15 DOI: 10.18231/j.ijpca.2022.001

Waill Ahmed Elkhateeb, Ghoson Mosbah Daba

引用次数: 2

Design of chemical synthesis of trioxan derivatives in respect of artemisinin as anti malarial drug 抗疟疾药物青蒿素三氧嘧啶衍生物的化学合成设计

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2022-04-15 DOI: 10.18231/j.ijpca.2022.004

Gautam Girendra Kumar

引用次数: 0

Development and validation of stability-indicating RP-HPLC method for the estimation of azoxystrobin in its formulations 稳定性指示反相高效液相色谱法测定偶氮嘧菌酯制剂含量的建立与验证

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2022-04-15 DOI: 10.18231/j.ijpca.2022.007

N. Venkatasubba Naidu, G. Rahul, B. Ramachandra

{"title":"Development and validation of stability-indicating RP-HPLC method for the estimation of azoxystrobin in its formulations","authors":"N. Venkatasubba Naidu, G. Rahul, B. Ramachandra","doi":"10.18231/j.ijpca.2022.007","DOIUrl":"https://doi.org/10.18231/j.ijpca.2022.007","url":null,"abstract":"The current work established and validated a simple, selective, precise, and accurate HighPerformance Liquid Chromatographic technique (HPLC) for the analysis of Azoxystrobin in its formulations. The mobile phase is made up of a combination of mobile phases comprising Acetonitrile and water in proportion, 80:20 (v/v). At a run duration of 15 minutes, this was found to yield a sharp peak of Azoxystrobin. Azoxystrobin was analysed using HPLC at a wavelength of 255 nm at a flow rate of 1.0 mL/min. The calibration curve's linear regression analysis results revealed a satisfactory linear connection with a regression coefficient of 0.999 in the concentration range of 50% to 150 %. The linear regression equation was y = 2025x +123.2.The proposed approach was used to analyse Azoxystrobin with a high degree of precision and accuracy.The method was validated for precision, accuracy, specificity, ruggedness and robustness. This method is useful for the quantification of Azoxystrobin because of its precision, accuracy, short retention duration, sensitivity, and mobile phase composition.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72956544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extraction and characterization of antimicrobial pigment from marine bacteria and testing of antimicrobial activity against penicillin resistant 海洋细菌抗菌色素的提取、鉴定及对青霉素耐药的抗菌活性试验

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2022-04-15 DOI: 10.18231/j.ijpca.2022.008

C. Soundhari, K. B. Haripriya

引用次数: 0

Quantitative estimation of molnupiravir by UV- Spectrophotometric method 紫外分光光度法定量测定莫那匹拉韦的含量

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2022-04-15 DOI: 10.18231/j.ijpca.2022.006

P. Jain, Manali Bhamare, S. Surana

{"title":"Quantitative estimation of molnupiravir by UV- Spectrophotometric method","authors":"P. Jain, Manali Bhamare, S. Surana","doi":"10.18231/j.ijpca.2022.006","DOIUrl":"https://doi.org/10.18231/j.ijpca.2022.006","url":null,"abstract":"A simple, rapid, accurate and economical UV-spectrophotometric method has been developed for estimation of Molnupiravir from bulk and pharmaceutical formulation. The λ of Molnupiravir in Distilled water was found to be 235 nm. The is for zero order of drug and for Zero order AUC. The AUC of the drug was found to be in the range of 228.00 – 243.40 nm. The drug follows linearity in the concentration range 5-30 µg/ml with correlation coefficient value 0.999. The proposed method was applied to pharmaceutical formulation and % amount of drug estimated 99.99was found in good agreement with the label claim. The accuracy of the method was checked by recovery experiment performed at three different levels i.e., 80%, 100% and 120 % w/w. The % recovery was found to be in the range 98.15%– 99.97% for method A and 98.85% — 99.56% for method B. The low values of % R.S.D. are indicative of the accuracy and reproducibility of the method. The precision of the method was studied as an intra-day, inter-day variations and repeatability. The % R.S.D. value less than 2 indicate that the method is precise. Ruggedness of the proposed method was studied with the help of two analysts. The above method was a rapid and cost-effective quality-control tool for routine analysis of Molnupiravir in bulk and in pharmaceutical dosage form.","PeriodicalId":13889,"journal":{"name":"International Journal of Pharmaceutical Chemistry and Analysis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82328245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Antibiotic drug resistance TB in India 印度的抗生素耐药性结核病

International Journal of Pharmaceutical Chemistry and Analysis Pub Date : 2022-01-15 DOI: 10.18231/j.ijpca.2021.028

Chiragkumar J. Gohil, Priyanka R. Patel, Jignakumari J. Gohil

引用次数: 1