Design of chemical synthesis of trioxan derivatives in respect of artemisinin as anti malarial drug

Abstract

Trioxane is a six membered heterocyclic ring system with Carbon, Hydrogen and Oxygen where the oxygen is hetero atoms. Trioxane has total three oxygen atom in its ring. It can be the alternate of Artemisinin that shows anti malarial activity. Substituting trioxane can be prepared by various substitutions perhaps in the minimum requirement to show biological activities similar to Artemisinin. Artemisinin is a Chinese herb that has been used in the treatment of fevers for over 1,000 years. The chemical composision of Artemisinin is known and structurally it also has heterocyclic ring comprising the oxygen. So, Author proposed the findings of possibility of synthesis of trioxane in respect of Artemisinin as trioxane derivatives through different complex pathways. This paper focus on different strategies followed for the convenient synthesis of trioxane derivatives.