International Journal of ChemTech Research最新文献_第5页

Use of Microbial Insecticides in Control Stem Borer(Hexamithodera semivelutina Hell.) on Clove Plant(Eugenia aromatica O.K.) 微生物杀虫剂防治丁香茎螟虫的研究

International Journal of ChemTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijctr.2019.130303

D. Tarore, J. Manueke, B. Assa, J. Mamahit

引用次数: 0

Design, Synthesis and In Vitro Biological Evaluation OfN-(2-Aminophenyl)-3-Quinolin-4-yl -Prop-2-enamideDerivatives As Novel Colon Anticancer Agents 新型结肠癌抗癌药物n-(2-氨基苯基)-3-喹啉-4-基-丙二烯酰胺衍生物的设计、合成及体外生物学评价

International Journal of ChemTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijctr.2019.130310

Sunita S. Gagare, V. Choudhari, Ashish Jain

{"title":"Design, Synthesis and In Vitro Biological Evaluation Of\u0000N-(2-Aminophenyl)-3-Quinolin-4-yl -Prop-2-enamide\u0000Derivatives As Novel Colon Anticancer Agents","authors":"Sunita S. Gagare, V. Choudhari, Ashish Jain","doi":"10.20902/ijctr.2019.130310","DOIUrl":"https://doi.org/10.20902/ijctr.2019.130310","url":null,"abstract":"Acetylation and deacetylation of histone proteins is regulated through two enzymes; acetylation is mediated through histone acetyl transferase (HAT) whereas deacetylation is mediated through histone deacetylase (HDAC). Histone deacetylase removes acetyl group of lysine residue on histone proteinthis makes negatively charged histone able to bind with DNA containing positive centers. In this way DNA remain in compact form with histone proteins. Therefore the transcription or replication enzymes and cofactors not able to bind such compact DNA structure. Histone deacetylase inhibition results into inhibition of various transcription activities which may get accelerated during cancer development. The aim of proposed study is to develop effective isoform selective Histone deacetylase inhibitor. Synthesis of N-(2-Aminophenyl)-3-Quinolin-4-yl-Prop-2-Enamide derivatives from isatin and its derivatives was achieved. Synthesis was carried out in two steps with good yield. 21 Compounds were synthesized and found to be effective with IC50s in between 3.694 - 38.4µmol in human HCT-116, COLO 205 and COLO 320 DM colon cancer cells in vitro. For the cytotoxicity activity study MTT assay method was adopted. Docking studies were performed initially with HDAC8 enzyme using V-life MDS software for synthesized compounds and had selected best fit molecules for synthesis. The synthesized molecules are effective as colon anticancer agents.","PeriodicalId":13853,"journal":{"name":"International Journal of ChemTech Research","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76489008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental Investigation of Mechanical Behavior in 3DPrinted PLA Triply Periodic Minimal Surface Structure forOrthopedics 骨科用3d打印聚乳酸三周期最小表面结构力学行为实验研究

International Journal of ChemTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijctr.2019.130122

N. Nandakumar, T. Raja

引用次数: 0

The Effect of Tetrahydrofuran on Transesterification of PalmOil Using Modified Clay Catalystinto Biodiesel 四氢呋喃对改性粘土催化棕榈油酯交换制生物柴油的影响

International Journal of ChemTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijctr.2019.130116

Ilham Salim, Alex A. Lepa

{"title":"The Effect of Tetrahydrofuran on Transesterification of Palm\u0000Oil Using Modified Clay Catalystinto Biodiesel","authors":"Ilham Salim, Alex A. Lepa","doi":"10.20902/ijctr.2019.130116","DOIUrl":"https://doi.org/10.20902/ijctr.2019.130116","url":null,"abstract":"Transesterification of palm oil into biodiesel has been done using modified clay catalyst.The modified clay catalyst was synthesized by destructing the clay with 8M HCl solution, then fusion by NaOH pellet (NaOH/clayratio = 0.8), followed by treating with AlCl3.6H2O, CTAB and distilled water.Then the mixture was regulated to pH of 11.5. Next, the mixture was then poured into a reactor for hydrothermal process at 140 o C for 48 h. The results of the dealumination of clay was characterized byX-ray Fluorescence and the synthesized zeolite was characterized using surface area analyzer and X-Ray Diffraction. The transesterification of palm oil (PO) process was carried out in the variation of temperatures of 55 and 65 o C.Ratio of catalyst :PO : methanol was 1.0 : 20.0 : 13.3and reaction time was 6h. The liquid product was analyzed using Gas Chromatography Mass Spectrometer. The resulted showed that the dealumination of clay had Si content of 34.77 % and Al of 5.67 %. The modified clay (MC) had surface area of 5.5685 m 2 /g, pore volume of 0.0126 cm 3 /g, and pore diameter of 8.871 nm. The results of measurements with XRD produced a different form of chromatogram and type of mineral. The main mineral was gismondine.In this research, the transesterification reaction of PO at a temperature of 55 °Cusing MC catalyst without THF resulted methyl esters (biodiesel)of 41.5 wt%. Furthermore, after adding THFwith ratio of methanol : THF of 1 : 1 and the same treatment, the resulting methyl ester (biodiesel) was the same phase (a one-phase) and methyl esters (biodiesel) product was more than 100 wt%..","PeriodicalId":13853,"journal":{"name":"International Journal of ChemTech Research","volume":"16 1","pages":"132-141"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83700649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of RNA Secondary Structure at IVS1 Mutation ofBeta Globin Gene β -珠蛋白基因IVS1突变的RNA二级结构预测

International Journal of ChemTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijctr.2019.130131

N. Sumantri, D. R. Wijayanti

{"title":"Prediction of RNA Secondary Structure at IVS1 Mutation of\u0000Beta Globin Gene","authors":"N. Sumantri, D. R. Wijayanti","doi":"10.20902/ijctr.2019.130131","DOIUrl":"https://doi.org/10.20902/ijctr.2019.130131","url":null,"abstract":"Background: Beta globin gene is responsible for producing beta globin chains that stabilize the structure and function of hemoglobin. This gene expression is controlled by complex interactions of transcriptions factors and its regulatory elements in a specific manner. Disturbed beta globin genes may result in hemoglobinopathies, mainly sickle cell disease and beta thalassemia. It seems interesting that several mutations occurring in intronic region results in severe symptoms to beta thalassemia patients, such an IVS1nt5 G>C. This research aimed to analyze RNA structural alteration effected by intronic mutation of beta thalassemia. Methods: The most prevalent mutation of beta thalassemia in Indonesia was obtained from Ithanet. The RNA secondary structure of IVS1nt5 G>C and beta globin gen (HBB) wildtype were performed by RNAStructure, along with probknot prediction. Results: The result showed that intronic mutation caused conformational change in beta globin secondary structure, either for max expect or base pairing probability approach. The mutant had bigger and more loops that diminished the protein stability. Thus, the structure might undergo dysfunction. Conclusion: The comprehensive structural-functional significance of these findings needs further study.","PeriodicalId":13853,"journal":{"name":"International Journal of ChemTech Research","volume":"107 1","pages":"247-252"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80828974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristic of Cowpea (Vigna unguiculata) ProteinConcentrates Protein Fraction on their Solubility 豇豆(Vigna unguiculata)蛋白质的特性及其溶解度

International Journal of ChemTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijctr.2019.130104

Ika Ratna Agustin, Yunianta, T. Estiasih

引用次数: 0

Exploring and Identifying the Effects of EntomopathogenicFungi to Rice black bugs, Scotinophara sp in Rice paddy inBolaang Monondow 博朗地区昆虫病原真菌对水稻黑虫(Scotinophara sp)影响的探索与鉴定

International Journal of ChemTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijctr.2019.130319

M. Ratulangi, J. Rimbing, B. Assa, Frangky Rorong

{"title":"Exploring and Identifying the Effects of Entomopathogenic\u0000Fungi to Rice black bugs, Scotinophara sp in Rice paddy in\u0000Bolaang Monondow","authors":"M. Ratulangi, J. Rimbing, B. Assa, Frangky Rorong","doi":"10.20902/ijctr.2019.130319","DOIUrl":"https://doi.org/10.20902/ijctr.2019.130319","url":null,"abstract":"Scotinophara sp is a major pest that damages rice fields in Bolaang Mongondow. The use of insecticides failed to stop the rice black bugs attacks. Entomopathogenic fungi can be used to reduce rice black bugs population. However, the function of the type of fungus that can eradicate rice black bugs was not yet identified. This experimental research was conducted to identify the types of fungus that attack rice black bugs by taking samples of nymphs and imago attacked by entomopathogenic fungi in Bolaang Mongondow Regency. Sampling of rice black bugs was done 3 times. Koch’s postulates test was employed to see the fungus that infect the rice black bugs. Samples were isolated on PDA media (Patato dextrose agar). Entomopathogenic fungi were purified, then inoculated on healthy rice black bugs. Rice black bugs infected with fungi were isolated again on PDA media. In a mass, of fungus colonies showed reddish white field and after being isolated on PDA media of the colony agregate, entomopathogenic Paecilomyces sp. fungus and Fusarium sp were found. Fungi as pathogenic agent was only found in Paecilomyces sp. The rice black bugs (Scotinophara sp.) were isolated on culture media and inoculation in healthy Scotinophara sp showed the same color of the colony during sampling of Scotinophara sp. infected with fungus. Both fungi were scattered at the location of Scotinophara sp infected with fungi.","PeriodicalId":13853,"journal":{"name":"International Journal of ChemTech Research","volume":"2 1","pages":"218-224"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74185852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Study on Potentiality of Polypyrrole compositeas Adsorbent for the removal of Acidic and Basic dyes fromAqueous solutions 聚吡咯复合吸附剂对水溶液中酸性和碱性染料去除率的比较研究

International Journal of ChemTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijctr.2019.130311

A. Geetha, N. Palanisamy

引用次数: 0

Photolytic Irradiation of Pharmaceutical Compound2 (-4 thaizolyl) benzimidazole 药用化合物2(-4噻唑基)苯并咪唑的光解辐照研究

International Journal of ChemTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijctr.2019.130305

Meena Chourey

引用次数: 0

Phytochemical Analysis and Anti-microbial Studies of LeafExtract of Terminalia arjuna using Spectroscopic Methods 光谱法分析苦参叶提取物的植物化学及抑菌活性

International Journal of ChemTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijctr.2019.130329

B. Anita

{"title":"Phytochemical Analysis and Anti-microbial Studies of Leaf\u0000Extract of Terminalia arjuna using Spectroscopic Methods","authors":"B. Anita","doi":"10.20902/ijctr.2019.130329","DOIUrl":"https://doi.org/10.20902/ijctr.2019.130329","url":null,"abstract":"From time immemorial plants have been used as potent therapeutic agents to treat various ailments in the Siddha and Ayurveda streams of medicine. Plants are rich sources of flavonoids, alkaloids, terpenoids and other related polyphenols. One such important plant used for treating heart ailments is Terminalia arjuna. The bark of this plant plays a vital role as cardiac tonic. It also possesses antimicrobial, cytotoxic and antidiabetic properties. The phytochemical activity of the secondary metabolites present in the bark of T.arjuna has been reported widely. But, the medical uses of leaf extract of the plant have seldom been reported. In this work, the ethanolic extract of leaf of T. arjuna has been analysed for the presence of different phytochemicals using FTIR, UV-Visible and GC-MS spectroscopic methods. The various functional groups present in the leaf extract have been identified initially using FTIR and UV-Vis spectra of leaf extract. Next, GC-MS studies revealed the complete structure of the twelve major phytoconstituents that were present in the leaf extract. In the next stage of the study, the therapeutic effect of the extract as potent anti-bacterial and antifungal agent has been studied. The presence of a flavonoid and ester groups in the leaf extract as revealed by the GC-MS analysis and the potential anti-fungal and anti-baterial activity of the extract shows that leaf extract of Terminalia arjuna has a great potential to be used as a therapeutic agent.","PeriodicalId":13853,"journal":{"name":"International Journal of ChemTech Research","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86745377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0